Autophagy inhibition enhances apoptosis triggered by BO-1051, an N-mustard derivative, and involves the ATM signaling pathway

Biochemical Pharmacology

Volumn 81, Issue 5, 2011, Pages 594-605

  Chen, Li Hsin ^a   Loong, Che Chuan ^b   Su, Tsann Long ^c   Lee, Yi Jang ^a   Chu, Pei Ming ^d   Tsai, Ming Long ^a   Tsai, Ping Hsin ^a   Tu, Pang Hsien ^c   Chi, Chin Wen ^a,b   Lee, Hsin Chen ^a   Chiou, Shih Hwa ^a,b  

^a NATIONAL YANG MING UNIVERSITY   (Taiwan)

^b TAIPEI VETERANS GENERAL HOSPITAL   (Taiwan)

^c INSTITUTE OF BIOMEDICAL SCIENCES   (Taiwan)

^d NATIONAL DEFENSE MEDICAL CENTER   (Taiwan)

Author keywords

Apoptosis; ATM; Autophagy; Hepatoma; N mustard

Indexed keywords

ATM PROTEIN; BETA ACTIN; BO 1051; CASPASE; CASPASE 3; CASPASE 7; CHECKPOINT KINASE 2; CHLORMETHINE DERIVATIVE; CISPLATIN; DOXORUBICIN; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; SMALL INTERFERING RNA; TUBULIN; UNCLASSIFIED DRUG;

APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CELL CULTURE; CELL PROTECTION; CONTROLLED STUDY; DNA DAMAGE; DOUBLE STRANDED DNA BREAK; HUMAN; HUMAN CELL; LIVER CARCINOMA; PRIORITY JOURNAL; SIGNAL TRANSDUCTION;

ANTINEOPLASTIC AGENTS; APOPTOSIS; AUTOPHAGY; CARCINOMA, HEPATOCELLULAR; CELL CYCLE PROTEINS; CELL LINE, TUMOR; DNA DAMAGE; DNA-BINDING PROTEINS; HUMANS; LIVER NEOPLASMS; NITROGEN MUSTARD COMPOUNDS; PROTEIN-SERINE-THREONINE KINASES; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS;

EID: 79551473364     PISSN: 00062952     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bcp.2010.12.011     Document Type: Article

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