-
1
-
-
0037312920
-
IASPP oncoprotein is a key inhibitor of p53 conserved from worm to human
-
Bergamaschi D, Samuels Y, O'Neil NJ, Trigiante G, Crook T, Hsieh JK et al. iASPP oncoprotein is a key inhibitor of p53 conserved from worm to human. Nat Genet 2003; 33: 162-167
-
(2003)
Nat Genet
, vol.33
, pp. 162-167
-
-
Bergamaschi, D.1
Samuels, Y.2
O'Neil, N.J.3
Trigiante, G.4
Crook, T.5
Hsieh, J.K.6
-
2
-
-
17944379798
-
ASPP proteins specifically stimulate the apoptotic function of p53
-
Samuels-Lev Y, O'Connor DJ, Bergamaschi D, Trigiante G, Hsieh JK, Zhong S et al. ASPP proteins specifically stimulate the apoptotic function of p53. Mol Cell 2001; 8: 781-794
-
(2001)
Mol Cell
, vol.8
, pp. 781-794
-
-
Samuels-Lev, Y.1
O'Connor, D.J.2
Bergamaschi, D.3
Trigiante, G.4
Hsieh, J.K.5
Zhong, S.6
-
3
-
-
1642499353
-
ASPP1 and ASPP2: Common activators of p53 family members
-
Bergamaschi D, Samuels Y, Jin B, Duraisingham S, Crook T, Lu X. ASPP1 and ASPP2: common activators of p53 family members. Mol Cell Biol 2004; 24: 1341-1350
-
(2004)
Mol Cell Biol
, vol.24
, pp. 1341-1350
-
-
Bergamaschi, D.1
Samuels, Y.2
Jin, B.3
Duraisingham, S.4
Crook, T.5
Lu, X.6
-
4
-
-
63149117341
-
Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds
-
Kampa KM, Acoba JD, Chen D, Gay J, Lee H, Beemer K et al. Apoptosis-stimulating protein of p53 (ASPP2) heterozygous mice are tumor-prone and have attenuated cellular damage-response thresholds. Proc Natl Acad Sci USA 2009; 106: 4390-4395
-
(2009)
Proc Natl Acad Sci USA
, vol.106
, pp. 4390-4395
-
-
Kampa, K.M.1
Acoba, J.D.2
Chen, D.3
Gay, J.4
Lee, H.5
Beemer, K.6
-
5
-
-
84871946420
-
N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence
-
Wang Z, Liu Y, Takahashi M, Van Hook K, Kampa-Schittenhelm KM, Sheppard BC et al. N terminus of ASPP2 binds to Ras and enhances Ras/Raf/MEK/ERK activation to promote oncogene-induced senescence. Proc Natl Acad Sci USA 2013; 110: 312-317
-
(2013)
Proc Natl Acad Sci USA
, vol.110
, pp. 312-317
-
-
Wang, Z.1
Liu, Y.2
Takahashi, M.3
Van Hook, K.4
Kampa-Schittenhelm, K.M.5
Sheppard, B.C.6
-
6
-
-
84865191462
-
Autophagic activity dictates the cellular response to oncogenic RAS
-
Wang Y, Wang XD, Lapi E, Sullivan A, Jia W, He YW et al. Autophagic activity dictates the cellular response to oncogenic RAS. Proc Natl Acad Sci USA 2012; 109: 13325-13330
-
(2012)
Proc Natl Acad Sci USA
, vol.109
, pp. 13325-13330
-
-
Wang, Y.1
Wang, X.D.2
Lapi, E.3
Sullivan, A.4
Jia, W.5
He, Y.W.6
-
7
-
-
84862295360
-
Guidelines for the use and interpretation of assays for monitoring autophagy
-
Klionsky DJ, Abdalla FC, Abeliovich H, Abraham RT, Acevedo-Arozena A, Adeli K et al. Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy 2012; 8: 445-544
-
(2012)
Autophagy
, vol.8
, pp. 445-544
-
-
Klionsky, D.J.1
Abdalla, F.C.2
Abeliovich, H.3
Abraham, R.T.4
Acevedo-Arozena, A.5
Adeli, K.6
-
8
-
-
33745885329
-
DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
-
Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006; 126: 121-134
-
(2006)
Cell
, vol.126
, pp. 121-134
-
-
Crighton, D.1
Wilkinson, S.2
O'Prey, J.3
Syed, N.4
Smith, P.5
Harrison, P.R.6
-
9
-
-
84864667633
-
Bcl-2:Beclin 1 complex: Multiple, mechanisms regulating autophagy/ apoptosis toggle switch
-
Marquez RT, Xu L. Bcl-2:Beclin 1 complex: multiple, mechanisms regulating autophagy/ apoptosis toggle switch. Am J Cancer Res 2012; 2: 214-221
-
(2012)
Am J Cancer Res
, vol.2
, pp. 214-221
-
-
Marquez, R.T.1
Xu, L.2
-
10
-
-
78049486018
-
Autophagy in liver diseases
-
Rautou PE, Mansouri A, Lebrec D, Durand F, Valla D, Moreau R. Autophagy in liver diseases. J Hepatol 2010; 53: 1123-1134
-
(2010)
J Hepatol
, vol.53
, pp. 1123-1134
-
-
Rautou, P.E.1
Mansouri, A.2
Lebrec, D.3
Durand, F.4
Valla, D.5
Moreau, R.6
-
11
-
-
9144240441
-
Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene
-
Qu X, Yu J, Bhagat G, Furuya N, Hibshoosh H, Troxel A et al. Promotion of tumorigenesis by heterozygous disruption of the beclin 1 autophagy gene. J Clin Invest 2003; 112: 1809-1820
-
(2003)
J Clin Invest
, vol.112
, pp. 1809-1820
-
-
Qu, X.1
Yu, J.2
Bhagat, G.3
Furuya, N.4
Hibshoosh, H.5
Troxel, A.6
-
12
-
-
0032054744
-
CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum
-
Zinszner H, Kuroda M, Wang X, Batchvarova N, Lightfoot RT, Remotti H et al. CHOP is implicated in programmed cell death in response to impaired function of the endoplasmic reticulum. Genes Dev 1998; 12: 982-995
-
(1998)
Genes Dev
, vol.12
, pp. 982-995
-
-
Zinszner, H.1
Kuroda, M.2
Wang, X.3
Batchvarova, N.4
Lightfoot, R.T.5
Remotti, H.6
-
13
-
-
79952264011
-
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress
-
Tabas I, Ron D. Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol 2011; 13: 184-190
-
(2011)
Nat Cell Biol
, vol.13
, pp. 184-190
-
-
Tabas, I.1
Ron, D.2
-
14
-
-
79952073585
-
The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation
-
Tsukada J, Yoshida Y, Kominato Y, Auron PE. The CCAAT/enhancer (C/EBP) family of basic-leucine zipper (bZIP) transcription factors is a multifaceted highly-regulated system for gene regulation. Cytokine 2011; 54: 6-19
-
(2011)
Cytokine
, vol.54
, pp. 6-19
-
-
Tsukada, J.1
Yoshida, Y.2
Kominato, Y.3
Auron, P.E.4
-
15
-
-
0033634641
-
Perk is essential for translational regulation and cell survival during the unfolded protein response
-
Harding HP, Zhang Y, Bertolotti A, Zeng H, Ron D. Perk is essential for translational regulation and cell survival during the unfolded protein response. Mol Cell 2000; 5: 897-904
-
(2000)
Mol Cell
, vol.5
, pp. 897-904
-
-
Harding, H.P.1
Zhang, Y.2
Bertolotti, A.3
Zeng, H.4
Ron, D.5
-
16
-
-
0026546365
-
CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription
-
Ron D, Habener JF. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev 1992; 6: 439-453
-
(1992)
Genes Dev
, vol.6
, pp. 439-453
-
-
Ron, D.1
Habener, J.F.2
-
17
-
-
0032127493
-
Identification of novel stress-induced genes downstream of chop
-
Wang XZ, Kuroda M, Sok J, Batchvarova N, Kimmel R, Chung P et al. Identification of novel stress-induced genes downstream of chop. EMBO J 1998; 17: 3619-3630
-
(1998)
EMBO J
, vol.17
, pp. 3619-3630
-
-
Wang, X.Z.1
Kuroda, M.2
Sok, J.3
Batchvarova, N.4
Kimmel, R.5
Chung, P.6
-
18
-
-
57049117856
-
Cell death and endoplasmic reticulum stress: Disease relevance and therapeutic opportunities
-
Kim I, XuW, Reed JC. Cell death and endoplasmic reticulum stress: disease relevance and therapeutic opportunities. Nat Rev Drug Discov 2008; 7: 1013-1030
-
(2008)
Nat Rev Drug Discov
, vol.7
, pp. 1013-1030
-
-
Kim, I.1
Xu, W.2
Reed, J.C.3
-
19
-
-
1842843855
-
Roles of CHOP/GADD153 in endoplasmic reticulum stress
-
Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ 2004; 11: 381-389
-
(2004)
Cell Death Differ
, vol.11
, pp. 381-389
-
-
Oyadomari, S.1
Mori, M.2
-
20
-
-
33845991209
-
Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression
-
Portier BP, Taglialatela G. Bcl-2 localized at the nuclear compartment induces apoptosis after transient overexpression. J Biol Chem 2006; 281: 40493-40502
-
(2006)
J Biol Chem
, vol.281
, pp. 40493-40502
-
-
Portier, B.P.1
Taglialatela, G.2
-
21
-
-
84885172990
-
Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX
-
Liu K, Lou J, Wen T, Yin J, Xu B, Ding W et al. Depending on the stage of hepatosteatosis, p53 causes apoptosis primarily through either DRAM-induced autophagy or BAX. Liver Int 2013; 33: 1566-1574
-
(2013)
Liver Int
, vol.33
, pp. 1566-1574
-
-
Liu, K.1
Lou, J.2
Wen, T.3
Yin, J.4
Xu, B.5
Ding, W.6
-
22
-
-
73449083762
-
Epigenetic silence of ankyrin-repeatcontaining, SH3-domain-containing, and proline-rich-region-containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma
-
Zhao J, Wu G, Bu F, Lu B, Liang A, Cao L et al. Epigenetic silence of ankyrin-repeatcontaining, SH3-domain-containing, and proline-rich-region- containing protein 1 (ASPP1) and ASPP2 genes promotes tumor growth in hepatitis B virus-positive hepatocellular carcinoma. Hepatology 2010; 51: 142-153
-
(2010)
Hepatology
, vol.51
, pp. 142-153
-
-
Zhao, J.1
Wu, G.2
Bu, F.3
Lu, B.4
Liang, A.5
Cao, L.6
-
23
-
-
0029928173
-
Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element
-
Ubeda M, Wang XZ, Zinszner H, Wu I, Habener JF, Ron D. Stress-induced binding of the transcriptional factor CHOP to a novel DNA control element. Mol Cell Biol 1996; 16: 1479-1489
-
(1996)
Mol Cell Biol
, vol.16
, pp. 1479-1489
-
-
Ubeda, M.1
Wang, X.Z.2
Zinszner, H.3
Wu, I.4
Habener, J.F.5
Ron, D.6
-
24
-
-
0032696587
-
CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins
-
Ubeda M, Vallejo M, Habener JF. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol 1999; 19: 7589-7599
-
(1999)
Mol Cell Biol
, vol.19
, pp. 7589-7599
-
-
Ubeda, M.1
Vallejo, M.2
Habener, J.F.3
-
25
-
-
0035947596
-
Bcl-2 prevents bax oligomerization in the mitochondrial outer membrane
-
Mikhailov V, Mikhailova M, Pulkrabek DJ, Dong Z, Venkatachalam MA, Saikumar P. Bcl-2 prevents Bax oligomerization in the mitochondrial outer membrane. J Biol Chem 2001; 276: 18361-18374
-
(2001)
J Biol Chem
, vol.276
, pp. 18361-18374
-
-
Mikhailov, V.1
Mikhailova, M.2
Pulkrabek, D.J.3
Dong, Z.4
Venkatachalam, M.A.5
Saikumar, P.6
-
26
-
-
0000906170
-
Induction of autophagy and inhibition of tumorigenesis by beclin 1
-
Liang XH, Jackson S, Seaman M, Brown K, Kempkes B, Hibshoosh H et al. Induction of autophagy and inhibition of tumorigenesis by beclin 1. Nature 1999; 402: 672-676
-
(1999)
Nature
, vol.402
, pp. 672-676
-
-
Liang, X.H.1
Jackson, S.2
Seaman, M.3
Brown, K.4
Kempkes, B.5
Hibshoosh, H.6
-
27
-
-
0345166111
-
Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor
-
Yue Z, Jin S, Yang C, Levine AJ, Heintz N. Beclin 1, an autophagy gene essential for early embryonic development, is a haploinsufficient tumor suppressor. Proc Natl Acad Sci USA 2003; 100: 15077-15082
-
(2003)
Proc Natl Acad Sci USA
, vol.100
, pp. 15077-15082
-
-
Yue, Z.1
Jin, S.2
Yang, C.3
Levine, A.J.4
Heintz, N.5
-
28
-
-
79955377420
-
Autophagydeficient mice develop multiple liver tumors
-
Takamura A, Komatsu M, Hara T, Sakamoto A, Kishi C, Waguri S et al. Autophagydeficient mice develop multiple liver tumors. Genes Dev 2011; 25: 795-800
-
(2011)
Genes Dev
, vol.25
, pp. 795-800
-
-
Takamura, A.1
Komatsu, M.2
Hara, T.3
Sakamoto, A.4
Kishi, C.5
Waguri, S.6
-
29
-
-
34249056243
-
P73 regulates DRAM-independent autophagy that does not contribute to programmed cell death
-
Crighton D, O'Prey J, Bell HS, Ryan KM. p73 regulates DRAM-independent autophagy that does not contribute to programmed cell death. Cell Death Differ 2007; 14: 1071-1079
-
(2007)
Cell Death Differ
, vol.14
, pp. 1071-1079
-
-
Crighton, D.1
O'Prey, J.2
Bell, H.S.3
Ryan, K.M.4
-
30
-
-
33645729664
-
The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells
-
Chen D, Yu Z, Zhu Z, Lopez CD. The p53 pathway promotes efficient mitochondrial DNA base excision repair in colorectal cancer cells. Cancer Res 2006; 66: 3485-3494
-
(2006)
Cancer Res
, vol.66
, pp. 3485-3494
-
-
Chen, D.1
Yu, Z.2
Zhu, Z.3
Lopez, C.D.4
|