S100A8-targeting siRNA enhances arsenic trioxide-induced myeloid leukemia cell death by down-regulating autophagy

International Journal of Molecular Medicine

Volumn 29, Issue 1, 2012, Pages 65-72

  Yang, Liangchun ^a   Yang, Minghua ^a   Zhang, Hong ^a   Wang, Zhuo ^a   Yu, Yan ^a   Xie, Min ^a   Zhao, Mingyi ^a   Liu, Liying ^a   Cao, Lizhi ^a  

^a CENTRAL SOUTH UNIVERSITY   (China)

Author keywords

Autophagy; Bcl 2; Beclin1; Drug resistance; Leukemia; Reactive oxygen species; S100A8

Indexed keywords

ARSENIC TRIOXIDE; CALGRANULIN A; DOXORUBICIN; MESSENGER RNA; PROTEIN BCL 2; PROTEIN P62; REACTIVE OXYGEN METABOLITE; SMALL INTERFERING RNA; VINCRISTINE;

ACUTE MYELOBLASTIC LEUKEMIA; APOPTOSIS; ARTICLE; AUTOPHAGY; CANCER CHEMOTHERAPY; CELL ISOLATION; CELL VIABILITY; CHEMOSENSITIVITY; CHILD; CHILDHOOD CANCER; CLINICAL ARTICLE; CONTROLLED STUDY; DOWN REGULATION; DRUG CYTOTOXICITY; GENE SILENCING; HUMAN; HUMAN CELL; INHIBITION KINETICS; LIGHT CHAIN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

ACTIVE TRANSPORT, CELL NUCLEUS; APOPTOSIS; APOPTOSIS REGULATORY PROTEINS; ARSENICALS; AUTOPHAGY; CALGRANULIN A; DOWN-REGULATION; DRUG SYNERGISM; FLOW CYTOMETRY; HL-60 CELLS; HUMANS; K562 CELLS; LEUKEMIA, MYELOID, ACUTE; MEMBRANE PROTEINS; OXIDES; PROTO-ONCOGENE PROTEINS C-BCL-2; REACTIVE OXYGEN SPECIES; RNA, SMALL INTERFERING; TRANSFECTION; TUMOR CELLS, CULTURED;

EID: 84855180031     PISSN: 11073756     EISSN: 1791244X     Source Type: Journal    
DOI: 10.3892/ijmm.2011.806     Document Type: Article

References (48)

1. Codogno P and Meijer AJ: Autophagy and signaling: their role in cell survival and cell death. Cell Death Differ 12: 1509-1518, 2005. (Pubitemid 41553987)
2. Levine B and Kroemer G: Autophagy in the pathogenesis of disease. Cell 132: 27-42, 2008.
3. Mizushima N, Yoshimori T and Levine B: Methods in mammalian autophagy research. Cell 140: 313-326, 2010.
4. White E and DiPaola RS: The double-edged sword of autophagy modulation in cancer. Clin Cancer Res 15: 5208-5216, 2009.
5. Liu L, Yang M, Kang R, et al.: DAMP-mediated autophagy contributes to drug resistance. Autophagy 7: 112-114, 2010.
6. Wang J, Lian H, Zhao Y, Kauss MA and Spindel S: Vitamin D3 induces autophagy of human myeloid leukemia cells. J Biol Chem 283: 25596-25605, 2008.
7. Schäfer BW and Heizmann CW: The S100 family of EF-hand calcium-binding proteins: functions and pathology. Trends Biochem Sci 21: 134-140, 1996.
8. Schäfer BW, Wicki R, Engelkamp D, Mattei MG and Heizmann CW: Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics 25: 638-643, 1995.
9. Foell D, Wittkowski H, Vogl T and Roth J: S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules. J Leukoc Biol 81: 28-37, 2007. (Pubitemid 46021248)
10. Kerkhoff C, Klempt M and Sorg C: Novel insights into structure and function of MRP8 (S100A8) and MRP14 (S100A9). Biochim Biophys Acta 1448: 200-211, 1998. (Pubitemid 29052193)
11. Yong HY and Moon A: Roles of calcium-binding proteins, S100A8 and S100A9, in invasive phenotype of human gastric cancer cells. Arch Pharm Res 30: 75-81, 2007.
12. Yao R, Lopez-Beltran A, Maclennan GT, Montironi R, Eble JN and Cheng L: Expression of S100 protein family members in the pathogenesis of bladder tumors. Anticancer Res 27: 3051-3058, 2007. (Pubitemid 47607526)
13. Tolson JP, Flad T, Gnau V, et al.: Differential detection of S100A8 in transitional cell carcinoma of the bladder by pair wise tissue proteomic and immunohistochemical analysis. Proteomics 6: 697-708, 2006. (Pubitemid 43208048)
14. Yamazaki M, Yui S and Mikami M: Purification and characterization of the cytotoxic factor in rat peritoneal exudate cells: its identification as the calcium binding protein complex, calprotectin. J Leukoc Biol l58: 307-316, 1995.
15. Yamazaki M, Yui S and Mikami M: Induction of apoptotic cell death in mouse lymphoma and human leukemia cell lines by a calcium-binding protein complex, calprotectin, derived from inflammatory peritoneal exudate cells. J Leukoc Biol 58: 650-658, 1995. (Pubitemid 26033854)
16. Cross SS, Hamdy FC, Deloulme JC and Rehman I: Expression of S100 proteins in normal human tissues and common cancers using tissue microarrays: S100A6, S100A8, S100A9 and S100A11 are all overexpressed in common cancers. Histopathology 46: 256-269, 2005. (Pubitemid 40343172)
17. Rafii S and Lyden D: S100 chemokines mediate bookmarking of premetastatic niches. Nat Cell Biol 8: 1321-1323, 2006. (Pubitemid 44835105)
18. Ghavaami S, Eshragi M, Ande SR, et al.: S100A8/S100A9 induces autophagy and apoptosis via ROS-mediated cross-talk between mitochondria and lysosomes that involves BNIP3. Cell Res 20: 314-331, 2010.
19. Mosmann T: Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxicity assays. J Immunol Methods 5: 55-63, 1983.
20. Tang D, Kang R, Xiao W, Wang H, Calderwood SK and Xiao X: The anti-inflammatory effects of heat shock protein 72 involve inhibition of high-mobility-group box 1 release and proinflammatory function in macrophages. J Immunol 179: 1236-1244, 2007.
21. Kang R, Tang D, Yu Y, et al.: WAVE1 regulates Bcl-2 localization and phosphorylation in leukemia cells. Leukemia 24: 177-186, 2010.
22. Livesey KM, Tang D, Zeh HJ and Lotze MT: Autophagy inhibition in combination cancer treatment. Curr Opin Investig Drugs 10: 1269-1279, 2009.
23. Maclean KH, Dorsey FC, Cleveland JL and Kastan MB: Targeting lysosomal degradation induces p53-dependent cell death and prevents cancer in mouse models of lymphomagenesis. J Clin Invest 118: 79-88, 2008.
24. Bellodi C, Lidonnici MR, Hamilton A, et al.: Targeting autophagy potentiates tyrosine kinase inhibitor-induced cell death in Philadelphia chromosome-positive cells, including primary CML stem cells. J Clin Invest 119: 1109-1123, 2009.
25. Carew JS, Nawrocki ST, Kahue CN, et al.: Targeting autophagy augments the anticancer activity of the histone deacetylase inhibitor SAHA to overcome Bcr-Abl-mediated drug resistance. Blood 110: 313-322, 2007. (Pubitemid 47026849)
26. Ito H, Daido S, Kanzawa T, Kondo S and Kondo Y: Radiation-induced autophagy is associated with LC3 and its inhibition sensitizes malignant glioma cells. Int J Oncol 26: 1401-1410, 2005.
27. Apel A, Herr I, Schwarz H, Rodemann HP and Mayer A: Blocked autophagy sensitizes resistant carcinoma cells to radiation therapy. Cancer Res 68: 1485-1494, 2008. (Pubitemid 351346857)
28. Kihara A, Kabeya Y, Ohsumi Y and Yoshimori T: Beclin-phosphatidylinositol 3-kinase complex functions at the trans-Golgi network. EMBO Rep 2: 330-335, 2001. (Pubitemid 32401529)
29. Donohue TM Jr: Autophagy and ethanol-induced liver injury. World J Gastroenterol 15: 1178-1185, 2009.
30. Pankiv S, Clausen TH, Lamark T, et al.: p62/SQSTM1 binds directly to Atg8/LC3 to facilitate degradation of ubiquitinated protein aggregates by autophagy. J Biol Chem 282: 24131-24145, 2007. (Pubitemid 47328003)
31. Mathew R, Karp CM, Beaudoin B, et al.: Autophagy suppresses tumorigenesis through elimination of p62. Cell 137: 1062-1075, 2009.
32. Mizushima N and T Yoshimori: How to interpret LC3 immunoblotting. Autophagy 3: 542-545, 2007. (Pubitemid 350060049)
33. Platanias LC: Biological responses to arsenic compounds. J Biol Chem 284: 18583-18587, 2009.
34. Thorburn A: Apoptosis and autophagy: regulatory connections between two supposedly different processes. Apoptosis 13: 1-9, 2008.
35. Scherz-Shouval R and Z Elazer: ROS, mitochondria and the regulation of autophagy. Trends Cell Biol 17: 422-427, 2007. (Pubitemid 47499043)
36. Pattingre S, Tassa A, Qu X, et al.: Bcl-2 antiapoptotic protein inhibits Beclin1-dependent autophagy. Cell 122: 927-939, 2005. (Pubitemid 41345209)
37. 3) in the treatment of acute promyelocytic leukemia (APL): II. Clinical efficacy and pharmacokinetics in relapsed patients. Blood 89: 3354-3360, 1997.
38. 3) in the orthotopic metastasis model of androgen-independent prostate cancer. Cancer Res 61: 5432-5440, 2001.
39. Uslu R, Sanli UA, Sezgin C, et al.: Arsenic trioxide-mediated cytotoxicity and apoptosis in prostate and ovarian carcinoma cell lines. Clin Cancer Res 6: 4957-4964, 2000. (Pubitemid 32110442)
40. Shen ZY, Shen J, Cai WJ, Hong C and Zheng MH: The alteration of mitochondria is an early event of arsenic trioxide induced apoptosis in esophageal carcinoma cells. Int J Mol Med 5: 155-158, 2000.
41. Ross DD: Novel mechanisms of drug resistance in leukemia. Leukemia 14: 467-473, 2000.
42. Cui JW, Wang J, He K, et al.: Proteomic analysis of human acute leukemia cells: insight into their classification. Clin Cancer Res 10: 6887-6896, 2004. (Pubitemid 39383038)
43. Nicolas E, Ramus C, Berthier S, et al.: Expression of S100A8 in leukemia cells predicts poor survival in de novo AML patients. Leukemia 25: 57-65, 2011.
44. Kondo Y, Kanzawa T, Sawaya R and Kondo S: The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 5: 726-734, 2005. (Pubitemid 41486365)
45. Vazquez-Martin A, Oliveras-Ferraros C and Menendez JA: Autophagy facilitates the development of breast cancer resistance to the anti-HER2 monoclonal antibody trastuzumab. PLoS One 4: e6251, 2009.
46. Song J, Qu Z, Guo X, et al.: Hypoxia-induced autophagy contributes to the chemoresistance of hepatocellular carcinoma cells. Autophagy 5: 1131-1144, 2009.
47. Lesser MP: Oxidative stress in marine environments: biochemistry and physiological ecology. Annu Rev Physiol 68: 253-278, 2006.
48. Ozben T: Oxidative stress and apoptosis: impact on cancer therapy. J Pharm Sci 96: 2181-2196, 2007.