The CD40-autophagy pathway is needed for host protection despite IFN-γ-dependent immunity and CD40 induces autophagy via control of P21 levels

PLoS ONE

Volumn 5, Issue 12, 2010, Pages

  Portillo, Jose Andres C ^a   Okenka, Genevieve ^a   Reed, Erin ^a   Subauste, Angela ^b   Van Grol, Jennifer ^a   Gentil, Katrin ^a   Komatsu, Masaaki ^c   Tanaka, Keiji ^c   Landreth, Gary ^a   Levine, Beth ^d   Subauste, Carlos S ^a  

^a CASE WESTERN RESERVE UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

^c TOKYO METROPOLITAN INSTITUTE OF MEDICAL SCIENCE   (Japan)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

AUTOPHAGY PROTEIN 7; BECLIN 1; CD40 ANTIGEN; GAMMA INTERFERON; GUANOSINE TRIPHOSPHATASE; INDUCIBLE NITRIC OXIDE SYNTHASE; NITRIC OXIDE; PROTEIN P21; REGULATOR PROTEIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG; APOPTOSIS REGULATORY PROTEIN; BECN1 PROTEIN, MOUSE; NOS2 PROTEIN, MOUSE; P21 ACTIVATED KINASE;

ADAPTIVE IMMUNITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; AUTOPHAGY; CELLULAR IMMUNITY; CONTROLLED STUDY; DISEASE PREDISPOSITION; DOWN REGULATION; FEMALE; HOST RESISTANCE; HOST SUSCEPTIBILITY; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN DEGRADATION; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION; T LYMPHOCYTE; TOXOPLASMA GONDII; TOXOPLASMOSIS; UPREGULATION; ANIMAL; BIOSYNTHESIS; C57BL MOUSE; CHEMISTRY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION; GENETICS; IMMUNE SYSTEM; METABOLISM; PARASITOLOGY; PHAGOSOME; TOXOPLASMA;

MUS; TOXOPLASMA GONDII;

ANIMALS; ANTIGENS, CD40; APOPTOSIS REGULATORY PROTEINS; AUTOPHAGY; GENE EXPRESSION REGULATION; GENETIC PREDISPOSITION TO DISEASE; IMMUNE SYSTEM; INTERFERON-GAMMA; MICE; MICE, INBRED C57BL; NITRIC OXIDE SYNTHASE TYPE II; P21-ACTIVATED KINASES; PHAGOSOMES; TOXOPLASMA; TOXOPLASMOSIS; TUMOR NECROSIS FACTOR-ALPHA;

EID: 79251517741     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0014472     Document Type: Article

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