메뉴 건너뛰기




Volumn 12, Issue 3, 2013, Pages 314-325

Dual programmed cell death pathways induced by p53 transactivation overcome resistance to oncolytic adenovirus in human osteosarcoma cells

Author keywords

[No Author keywords available]

Indexed keywords

CONTUSUGENE LADENOVEC; E1A PROTEIN; MICRORNA; OBP 301; OBP 702; ONCOLYTIC ADENOVIRUS; PROTEIN P21; PROTEIN P53; TELOMELYSIN; UNCLASSIFIED DRUG;

EID: 84874880655     PISSN: 15357163     EISSN: 15388514     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-12-0869     Document Type: Article
Times cited : (60)

References (50)
  • 1
    • 77953654549 scopus 로고    scopus 로고
    • The etiology of osteosarcoma
    • Ottaviani G, Jaffe N. The etiology of osteosarcoma. Cancer Treat Res 2009;152: 15-32.
    • (2009) Cancer Treat Res , vol.152 , pp. 15-32
    • Ottaviani, G.1    Jaffe, N.2
  • 2
    • 34249942232 scopus 로고    scopus 로고
    • Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report
    • Damron TA, Ward WG, Stewart A. Osteosarcoma, chondrosarcoma, and Ewing's sarcoma: National Cancer Data Base Report. Clin Orthop Relat Res 2007;459: 40-7.
    • (2007) Clin Orthop Relat Res , vol.459 , pp. 40-47
    • Damron, T.A.1    Ward, W.G.2    Stewart, A.3
  • 3
    • 33846981552 scopus 로고    scopus 로고
    • Improvement in histologic response but not survival in osteosarcomapatients treated with intensified chemotherapy: A randomized phase III trial of the European Osteosarcoma Intergroup
    • Lewis IJ, Nooij MA, Whelan J, Sydes MR, Grimer R, Hogendoorn PC, et al. Improvement in histologic response but not survival in osteosarcomapatients treated with intensified chemotherapy: a randomized phase III trial of the European Osteosarcoma Intergroup. J Natl Cancer Inst 2007;99: 112-28.
    • (2007) J Natl Cancer Inst , vol.99 , pp. 112-128
    • Lewis, I.J.1    Nooij, M.A.2    Whelan, J.3    Sydes, M.R.4    Grimer, R.5    Hogendoorn, P.C.6
  • 4
    • 33644505791 scopus 로고    scopus 로고
    • Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution
    • Bacci G, Longhi A, Versari M, Mercuri M, Briccoli A, Picci P. Prognostic factors for osteosarcoma of the extremity treated with neoadjuvant chemotherapy: 15-year experience in 789 patients treated at a single institution. Cancer 2006;106: 1154-61.
    • (2006) Cancer , vol.106 , pp. 1154-1161
    • Bacci, G.1    Longhi, A.2    Versari, M.3    Mercuri, M.4    Briccoli, A.5    Picci, P.6
  • 5
    • 0036467661 scopus 로고    scopus 로고
    • Prognostic factors in high-grade osteosarcoma of the extremities or trunk: An analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols
    • Bielack SS, Kempf-Bielack B, Delling G, Exner GU, Flege S, Helmke K, et al. Prognostic factors in high-grade osteosarcoma of the extremities or trunk: an analysis of 1,702 patients treated on neoadjuvant cooperative osteosarcoma study group protocols. J Clin Oncol 2002; 20: 776-90.
    • (2002) J Clin Oncol , vol.20 , pp. 776-790
    • Bielack, S.S.1    Kempf-Bielack, B.2    Delling, G.3    Exner, G.U.4    Flege, S.5    Helmke, K.6
  • 7
    • 84855500815 scopus 로고    scopus 로고
    • Is telomerase a viable target in cancer?
    • Buseman CM, Wright WE, Shay JW. Is telomerase a viable target in cancer? Mutat Res 2012;730: 90-7.
    • (2012) Mutat Res , vol.730 , pp. 90-97
    • Buseman, C.M.1    Wright, W.E.2    Shay, J.W.3
  • 8
    • 74049111326 scopus 로고    scopus 로고
    • Telomeres and telomerase in cancer
    • Artandi SE, DePinho RA. Telomeres and telomerase in cancer. Carcinogenesis 2010;31: 9-18.
    • (2010) Carcinogenesis , vol.31 , pp. 9-18
    • Artandi, S.E.1    Depinho, R.A.2
  • 11
    • 17344363008 scopus 로고    scopus 로고
    • Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas
    • Nakayama J, Tahara H, Tahara E, Saito M, Ito K, Nakamura H, et al. Telomerase activation by hTRT in human normal fibroblasts and hepatocellular carcinomas. Nat Genet 1998;18: 65-8.
    • (1998) Nat Genet , vol.18 , pp. 65-68
    • Nakayama, J.1    Tahara, H.2    Tahara, E.3    Saito, M.4    Ito, K.5    Nakamura, H.6
  • 13
    • 76349086193 scopus 로고    scopus 로고
    • A phase i study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors
    • Nemunaitis J, Tong AW, Nemunaitis M, Senzer N, Phadke AP, Bedell C, et al. A phase I study of telomerase-specific replication competent oncolytic adenovirus (telomelysin) for various solid tumors. Mol Ther 2010;18: 429-34.
    • (2010) Mol Ther , vol.18 , pp. 429-434
    • Nemunaitis, J.1    Tong, A.W.2    Nemunaitis, M.3    Senzer, N.4    Phadke, A.P.5    Bedell, C.6
  • 14
    • 79953326730 scopus 로고    scopus 로고
    • Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas
    • Sasaki T, Tazawa H, Hasei J, Kunisada T, Yoshida A, Hashimoto Y, et al. Preclinical evaluation of telomerase-specific oncolytic virotherapy for human bone and soft tissue sarcomas. Clin Cancer Res 2011;17: 1828-38.
    • (2011) Clin Cancer Res , vol.17 , pp. 1828-1838
    • Sasaki, T.1    Tazawa, H.2    Hasei, J.3    Kunisada, T.4    Yoshida, A.5    Hashimoto, Y.6
  • 15
    • 79959770652 scopus 로고    scopus 로고
    • Efficient virotherapy for osteosarcoma by telomerase-specific oncolytic adenovirus
    • Li G, Kawashima H, Ogose A, Ariizumi T, Xu Y, Hotta T, et al. Efficient virotherapy for osteosarcoma by telomerase-specific oncolytic adenovirus. J Cancer Res Clin Oncol 2011;137: 1037-51.
    • (2011) J Cancer Res Clin Oncol , vol.137 , pp. 1037-1051
    • Li, G.1    Kawashima, H.2    Ogose, A.3    Ariizumi, T.4    Xu, Y.5    Hotta, T.6
  • 16
    • 65349103899 scopus 로고    scopus 로고
    • Blinded by the light: The growing complexity of p53
    • Vousden KH, Prives C. Blinded by the light: the growing complexity of p53. Cell 2009;137: 413-31.
    • (2009) Cell , vol.137 , pp. 413-431
    • Vousden, K.H.1    Prives, C.2
  • 17
    • 38049148611 scopus 로고    scopus 로고
    • Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy
    • Fujiwara K, Daido S, Yamamoto A, Kobayashi R, Yokoyama T, Aoki H, et al. Pivotal role of the cyclin-dependent kinase inhibitor p21WAF1/CIP1 in apoptosis and autophagy. J Biol Chem 2008;283: 388-97.
    • (2008) J Biol Chem , vol.283 , pp. 388-397
    • Fujiwara, K.1    Daido, S.2    Yamamoto, A.3    Kobayashi, R.4    Yokoyama, T.5    Aoki, H.6
  • 18
    • 0030902111 scopus 로고    scopus 로고
    • Holbrook NJ. p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells
    • Gorospe M, Cirielli C, Wang X, Seth P, Capogrossi MC, Holbrook NJ. p21(Waf1/Cip1) protects against p53-mediated apoptosis of human melanoma cells. Oncogene 1997;14: 929-35.
    • (1997) Oncogene , vol.14 , pp. 929-935
    • Gorospe, M.1    Cirielli, C.2    Wang, X.3    Seth, P.4    Capogrossi, M.C.5
  • 19
    • 0029832231 scopus 로고    scopus 로고
    • In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug
    • Blagosklonny MV, el-Deiry WS. In vitro evaluation of a p53-expressing adenovirus as an anti-cancer drug. Int J Cancer 1996;67: 386-92.
    • (1996) Int J Cancer , vol.67 , pp. 386-392
    • Blagosklonny, M.V.1    El-Deiry, W.S.2
  • 20
    • 0030787004 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene therapy in nasopharyngeal cancer
    • Zeng Y, Prabhu N, Meng R, Eldeiry W. Adenovirus-mediated p53 gene therapy in nasopharyngeal cancer. Int J Oncol 1997;11: 221-6.
    • (1997) Int J Oncol , vol.11 , pp. 221-226
    • Zeng, Y.1    Prabhu, N.2    Meng, R.3    Eldeiry, W.4
  • 21
    • 0031750168 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma
    • Clayman GL, el-Naggar AK, Lippman SM, Henderson YC, Frederick M, Merritt JA, et al. Adenovirus-mediated p53 gene transfer in patients with advanced recurrent head and neck squamous cell carcinoma. J Clin Oncol 1998;16: 2221-32.
    • (1998) J Clin Oncol , vol.16 , pp. 2221-2232
    • Clayman, G.L.1    El-Naggar, A.K.2    Lippman, S.M.3    Henderson, Y.C.4    Frederick, M.5    Merritt, J.A.6
  • 23
    • 33744529601 scopus 로고    scopus 로고
    • Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma
    • Shimada H, Matsubara H, Shiratori T, Shimizu T, Miyazaki S, Okazumi S, et al. Phase I/II adenoviral p53 gene therapy for chemoradiation resistant advanced esophageal squamous cell carcinoma. Cancer Sci 2006;97: 554-61.
    • (2006) Cancer Sci , vol.97 , pp. 554-561
    • Shimada, H.1    Matsubara, H.2    Shiratori, T.3    Shimizu, T.4    Miyazaki, S.5    Okazumi, S.6
  • 24
    • 33645829571 scopus 로고    scopus 로고
    • Multicenter phase i study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer
    • Fujiwara T, Tanaka N, Kanazawa S, Ohtani S, Saijo Y, Nukiwa T, et al. Multicenter phase I study of repeated intratumoral delivery of adenoviral p53 in patients with advanced non-small-cell lung cancer. J Clin Oncol 2006;24: 1689-99.
    • (2006) J Clin Oncol , vol.24 , pp. 1689-1699
    • Fujiwara, T.1    Tanaka, N.2    Kanazawa, S.3    Ohtani, S.4    Saijo, Y.5    Nukiwa, T.6
  • 25
    • 77953450592 scopus 로고    scopus 로고
    • Preclinical evaluation of differentially targeting dual virotherapy for human solid cancer
    • Sakai R, Kagawa S, Yamasaki Y, Kojima T, Uno F, Hashimoto Y, et al. Preclinical evaluation of differentially targeting dual virotherapy for human solid cancer. Mol Cancer Ther 2010;9: 1884-93.
    • (2010) Mol Cancer Ther , vol.9 , pp. 1884-1893
    • Sakai, R.1    Kagawa, S.2    Yamasaki, Y.3    Kojima, T.4    Uno, F.5    Hashimoto, Y.6
  • 26
    • 84865474540 scopus 로고    scopus 로고
    • A novel apoptotic mechanism of genetically engineered adenovirus- mediated tumour-specific p53 overexpression through E1Adependent p21 and MDM2 suppression
    • Yamasaki Y, Tazawa H, Hashimoto Y, Kojima T, Kuroda S, Yano S, et al. A novel apoptotic mechanism of genetically engineered adenovirus- mediated tumour-specific p53 overexpression through E1Adependent p21 and MDM2 suppression. Eur J Cancer 2012;48: 2282-91.
    • (2012) Eur J Cancer , vol.48 , pp. 2282-2291
    • Yamasaki, Y.1    Tazawa, H.2    Hashimoto, Y.3    Kojima, T.4    Kuroda, S.5    Yano, S.6
  • 27
    • 38949116994 scopus 로고    scopus 로고
    • Establishment of biological and pharmacokinetic assays of telomerase-specific replication-selective adenovirus
    • Hashimoto Y, Watanabe Y, Shirakiya Y, Uno F, Kagawa S, Kawamura H, et al. Establishment of biological and pharmacokinetic assays of telomerase-specific replication-selective adenovirus. Cancer Sci 2008;99: 385-90.
    • (2008) Cancer Sci , vol.99 , pp. 385-390
    • Hashimoto, Y.1    Watanabe, Y.2    Shirakiya, Y.3    Uno, F.4    Kagawa, S.5    Kawamura, H.6
  • 28
    • 0025024111 scopus 로고
    • Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: A novel mechanism for E1A trans-activation
    • Bagchi S, Raychaudhuri P, Nevins Jr. Adenovirus E1A proteins can dissociate heteromeric complexes involving the E2F transcription factor: a novel mechanism for E1A trans-activation. Cell 1990;62: 659-69.
    • (1990) Cell , vol.62 , pp. 659-669
    • Bagchi, S.1    Raychaudhuri, P.2    Nevins, J.R.3
  • 29
    • 77955462456 scopus 로고    scopus 로고
    • Checks and balances: E2F-microRNA crosstalk in cancer control
    • Emmrich S, Putzer BM. Checks and balances: E2F-microRNA crosstalk in cancer control. Cell Cycle 2010;9: 2555-67.
    • (2010) Cell Cycle , vol.9 , pp. 2555-2567
    • Emmrich, S.1    Putzer, B.M.2
  • 30
    • 54249158400 scopus 로고    scopus 로고
    • Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling
    • Petrocca F, Vecchione A, Croce CM. Emerging role of miR-106b-25/miR-17-92 clusters in the control of transforming growth factor beta signaling. Cancer Res 2008;68: 8191-4.
    • (2008) Cancer Res , vol.68 , pp. 8191-8194
    • Petrocca, F.1    Vecchione, A.2    Croce, C.M.3
  • 31
    • 84867866754 scopus 로고    scopus 로고
    • Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis
    • Tazawa H, Yano S, Yoshida R, Yamasaki Y, Sasaki T, Hashimoto Y, et al. Genetically engineered oncolytic adenovirus induces autophagic cell death through an E2F1-microRNA-7-epidermal growth factor receptor axis. Int J Cancer 2012;131: 2939-50.
    • (2012) Int J Cancer , vol.131 , pp. 2939-2950
    • Tazawa, H.1    Yano, S.2    Yoshida, R.3    Yamasaki, Y.4    Sasaki, T.5    Hashimoto, Y.6
  • 32
    • 33745885329 scopus 로고    scopus 로고
    • DRAM, a p53-induced modulator of autophagy, is critical for apoptosis
    • Crighton D, Wilkinson S, O'Prey J, Syed N, Smith P, Harrison PR, et al. DRAM, a p53-induced modulator of autophagy, is critical for apoptosis. Cell 2006;126: 121-34.
    • (2006) Cell , vol.126 , pp. 121-134
    • Crighton, D.1    Wilkinson, S.2    O'Prey, J.3    Syed, N.4    Smith, P.5    Harrison, P.R.6
  • 33
    • 33846650370 scopus 로고    scopus 로고
    • Clinical Trial Results with Oncolytic Virotherapy: A century of promise, a decade of progress
    • Liu TC, Galanis E,Kirn D. Clinical trial results with oncolytic virotherapy: a century of promise, a decade of progress. Nat Clin Pract Oncol 2007;4: 101-17.
    • (2007) Nat Clin Pract Oncol , vol.4 , pp. 101-117
    • Liu, T.C.1    Galanis Ekirn, D.2
  • 35
    • 66649098691 scopus 로고    scopus 로고
    • A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells
    • Idogawa M, Sasaki Y, Suzuki H, Mita H, Imai K, Shinomura Y, et al. A single recombinant adenovirus expressing p53 and p21-targeting artificial microRNAs efficiently induces apoptosis in human cancer cells. Clin Cancer Res 2009;15: 3725-32.
    • (2009) Clin Cancer Res , vol.15 , pp. 3725-3732
    • Idogawa, M.1    Sasaki, Y.2    Suzuki, H.3    Mita, H.4    Imai, K.5    Shinomura, Y.6
  • 36
    • 0034801802 scopus 로고    scopus 로고
    • Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells
    • Chattopadhyay D, Ghosh MK, Mal A, Harter ML. Inactivation of p21 by E1A leads to the induction of apoptosis in DNA-damaged cells. J Virol 2001;75: 9844-56.
    • (2001) J Virol , vol.75 , pp. 9844-9856
    • Chattopadhyay, D.1    Ghosh, M.K.2    Mal, A.3    Harter, M.L.4
  • 37
    • 70349437076 scopus 로고    scopus 로고
    • P53 and E2f: Partners in life and death
    • Polager S, Ginsberg D. p53 and E2f: partners in life and death. Nat Rev Cancer 2009;9: 738-48.
    • (2009) Nat Rev Cancer , vol.9 , pp. 738-748
    • Polager, S.1    Ginsberg, D.2
  • 38
    • 0028222124 scopus 로고
    • P53 and E2F-1 cooperate to mediate apoptosis
    • WuX, Levine AJ. p53 and E2F-1 cooperate to mediate apoptosis. Proc Natl Acad Sci U S A 1994;91: 3602-6.
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 3602-3606
    • Wu, X.1    Levine, A.J.2
  • 39
    • 0033927808 scopus 로고    scopus 로고
    • Induction of apoptosis in human esophageal cancer cells by sequential transfer of the wild-type p53 and E2F-1 genes: Involvement of p53 accumulation via ARF-mediated MDM2 down-regulation
    • Itoshima T, Fujiwara T, Waku T, Shao J, Kataoka M, Yarbrough WG, et al. Induction of apoptosis in human esophageal cancer cells by sequential transfer of the wild-type p53 and E2F-1 genes: involvement of p53 accumulation via ARF-mediated MDM2 down-regulation. Clin Cancer Res 2000;6: 2851-9.
    • (2000) Clin Cancer Res , vol.6 , pp. 2851-2859
    • Itoshima, T.1    Fujiwara, T.2    Waku, T.3    Shao, J.4    Kataoka, M.5    Yarbrough, W.G.6
  • 40
    • 77957756784 scopus 로고    scopus 로고
    • E2F1 inhibits MDM2 expression in a p53- dependent manner
    • Tian X, Chen Y, Hu W, Wu M. E2F1 inhibits MDM2 expression in a p53- dependent manner. Cell Signal 2011;23: 193-200.
    • (2011) Cell Signal , vol.23 , pp. 193-200
    • Tian, X.1    Chen, Y.2    Hu, W.3    Wu, M.4
  • 43
    • 65549102006 scopus 로고    scopus 로고
    • Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells
    • Salvatori L, Caporuscio F, Coroniti G, Starace G, Frati L, Russo MA, et al. Down-regulation of epidermal growth factor receptor induced by estrogens and phytoestrogens promotes the differentiation of U2OS human osteosarcoma cells. J Cell Physiol 2009;220: 35-44.
    • (2009) J Cell Physiol , vol.220 , pp. 35-44
    • Salvatori, L.1    Caporuscio, F.2    Coroniti, G.3    Starace, G.4    Frati, L.5    Russo, M.A.6
  • 44
    • 37549048038 scopus 로고    scopus 로고
    • Zoledronic acid inhibits osteosarcoma growth in an orthotopic model
    • Dass CR, Choong PF. Zoledronic acid inhibits osteosarcoma growth in an orthotopic model. Mol Cancer Ther 2007;6: 3263-70.
    • (2007) Mol Cancer Ther , vol.6 , pp. 3263-3270
    • Dass, C.R.1    Choong, P.F.2
  • 45
    • 66149165883 scopus 로고    scopus 로고
    • Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model
    • Labrinidis A, Hay S, Liapis V, Ponomarev V, Findlay DM, Evdokiou A. Zoledronic acid inhibits both the osteolytic and osteoblastic components of osteosarcoma lesions in a mouse model. Clin Cancer Res 2009;15: 3451-61.
    • (2009) Clin Cancer Res , vol.15 , pp. 3451-3461
    • Labrinidis, A.1    Hay, S.2    Liapis, V.3    Ponomarev, V.4    Findlay, D.M.5    Evdokiou, A.6
  • 46
    • 33746266848 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma
    • Ternovoi VV, Curiel DT, Smith BF, Siegal GP. Adenovirus-mediated p53 tumor suppressor gene therapy of osteosarcoma. Lab Invest 2006;86: 748-66.
    • (2006) Lab Invest , vol.86 , pp. 748-766
    • Ternovoi, V.V.1    Curiel, D.T.2    Smith, B.F.3    Siegal, G.P.4
  • 47
    • 17544363106 scopus 로고    scopus 로고
    • Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes
    • Hellwinkel OJ, Muller J, Pollmann A, Kabisch H. Osteosarcoma cell lines display variable individual reactions on wildtype p53 and Rb tumour-suppressor transgenes. J Gene Med 2005;7: 407-19.
    • (2005) J Gene Med , vol.7 , pp. 407-419
    • Hellwinkel, O.J.1    Muller, J.2    Pollmann, A.3    Kabisch, H.4
  • 48
    • 33645028210 scopus 로고    scopus 로고
    • Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: Sensitization to cisplatin and doxorubicin
    • Ganjavi H, Gee M, Narendran A, Parkinson N, Krishnamoorthy M, Freedman MH, et al. Adenovirus-mediated p53 gene therapy in osteosarcoma cell lines: sensitization to cisplatin and doxorubicin. Cancer Gene Ther 2006;13: 415-9.
    • (2006) Cancer Gene Ther , vol.13 , pp. 415-419
    • Ganjavi, H.1    Gee, M.2    Narendran, A.3    Parkinson, N.4    Krishnamoorthy, M.5    Freedman, M.H.6
  • 49
    • 54249104991 scopus 로고    scopus 로고
    • Autophagy: A novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model
    • Lambert LA, Qiao N, Hunt KK, Lambert DH, Mills GB, Meijer L, et al. Autophagy: a novel mechanism of synergistic cytotoxicity between doxorubicin and roscovitine in a sarcoma model. Cancer Res 2008;68: 7966-74.
    • (2008) Cancer Res , vol.68 , pp. 7966-7974
    • Lambert, L.A.1    Qiao, N.2    Hunt, K.K.3    Lambert, D.H.4    Mills, G.B.5    Meijer, L.6
  • 50
    • 54549084575 scopus 로고    scopus 로고
    • Toxicology profiles of a novel p53-armed replication-competent oncolytic adenovirus in rodents, felids, and nonhuman primates
    • Su C, Cao H, Tan S, Huang Y, Jia X, Jiang L, et al. Toxicology profiles of a novel p53-armed replication-competent oncolytic adenovirus in rodents, felids, and nonhuman primates. Toxicol Sci 2008;106: 242-50.
    • (2008) Toxicol Sci , vol.106 , pp. 242-250
    • Su, C.1    Cao, H.2    Tan, S.3    Huang, Y.4    Jia, X.5    Jiang, L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.