BRCA1 deficiency induces protective autophagy to mitigate stress and provides a mechanism for BRCA1 haploinsufficiency in tumorigenesis

Cancer Letters

Volumn 346, Issue 1, 2014, Pages 139-147

  Tang, Maggie K S ^a   Kwong, Ava ^a,b   Tam, Kar Fai ^a   Cheung, Annie N Y ^a   Ngan, Hextan Y S ^a   Xia, Weiliang ^c,d   Wong, Alice S T ^a  

^a UNIVERSITY OF HONG KONG   (Hong Kong)

^b Department of Surgery University of Hong Kong ^*  (Hong Kong)

^c SHANGHAI JIAO TONG UNIVERSITY   (China)

^d SHANGHAI JIAO TONG UNIVERSITY SCHOOL OF MEDICINE   (China)

Author keywords

Autophagy; BRCA1; Breast cancer; Ovarian cancer; Survival

Indexed keywords

BRCA1 PROTEIN;

ARTICLE; AUTOPHAGOSOME; AUTOPHAGY; BREAST CANCER; CANCER GROWTH; CANCER SURVIVAL; CARCINOGENESIS; CELL STRESS; CELL SURVIVAL; CELL VACUOLE; CONTROLLED STUDY; CULTURE MEDIUM; ENDOPLASMIC RETICULUM; FEMALE; GENETIC PREDISPOSITION; HAPLOINSUFFICIENCY; HUMAN; HUMAN CELL; OVARY CANCER; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; STRESS; TRANSMISSION ELECTRON MICROSCOPY; WESTERN BLOTTING;

AUTOPHAGY; BRCA1; BREAST CANCER; OVARIAN CANCER; SURVIVAL;

AUTOPHAGY; BLOTTING, WESTERN; BRCA1 PROTEIN; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; ENDOPLASMIC RETICULUM STRESS; FEMALE; HAPLOINSUFFICIENCY; HUMANS; IMMUNOPRECIPITATION; MICROSCOPY, ELECTRON, TRANSMISSION; OVARIAN NEOPLASMS; RNA, SMALL INTERFERING; TRANSFECTION;

EID: 84894608381     PISSN: 03043835     EISSN: 18727980     Source Type: Journal    
DOI: 10.1016/j.canlet.2013.12.026     Document Type: Article

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