Retrovirus-mediated wild-type p53 gene transfer to tumors of patients with lung cancer

Nature Medicine

Volumn 2, Issue 9, 1996, Pages 985-991

  Roth, J A ^a   Nguyen, D ^a   Lawrence, D D ^a   Kemp, B L ^a   Carrasco, C H ^a   Ferson, D Z ^a   Hong, W K ^a   Komaki, R ^a   Lee, J J ^a   Nesbitt, J C ^a   Pisters, K M W ^a   Putnam, J B ^a   Schea, R ^a   Shin, D M ^a   Walsh, G L ^a   Dolormente, M M ^a   Han, C I ^a   Martin, F D ^a   Yen, N ^a   Xu, K ^a   Stephens, L C ^a   Mcdonnell, T J ^a   Mukhopadhyay, T ^a   Cai, D ^a   more..

^a UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN P53;

ADULT; AGED; ARTICLE; CLINICAL ARTICLE; CLINICAL TRIAL; GENE THERAPY; GENE TRANSFER; HUMAN; HUMAN TISSUE; LUNG NON SMALL CELL CANCER; MALE; PRIORITY JOURNAL; TREATMENT OUTCOME;

AGED; BASE SEQUENCE; CARCINOMA, NON-SMALL-CELL LUNG; DNA PRIMERS; GENE THERAPY; GENE TRANSFER TECHNIQUES; GENES, P53; GENETIC VECTORS; HUMANS; LUNG NEOPLASMS; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; RETROVIRIDAE;

UNIDENTIFIED RETROVIRUS;

EID: 9544244796     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0996-985     Document Type: Article

References (41)

1. Mukhopadhyay, T., Tainsky, M , Cavender, A.C. & Roth, J.A. Specific inhibition of K-ras expression and tumorigenicity of lung cancer cells by antisense RNA. Cancer Res. 51, 1744-1748 (1991).
2. Takahashi, T. et al. Wild-type but not mutant p53 suppresses the growth of human lung cancer cells bearing multiple genetic lesions. Cancer Res. 52, 2340-2343 (1992).
3. Goyette, M.C. et al. Progression of colorectal cancer is associated with multiple tumor suppressor gene defects but inhibition of tumorigenicity is accomplished by correction of any single defect via chromosome transfer. Mol. Cell. Biol. 12, 1387-1395 (1992).
4. Weinberg, R A. Tumor suppressor genes Science 254, 1138-1145 (1992).
5. Bishop, J.M. Molecular themes in oncogenesis Cell 64, 235-248 (1991).
6. Knudson, A G Jr. Mutation and cancer. Statistical study of retinoblastoma. Proc. Natl. Acad. Sci. USA 68, 820-823 (1971).
7. Cai, D.W., Mukhopadhyay, T., Liu, Y.J., Fujiwara, T. & Roth, J.A. Stable expression of the wild-type p53 gene in human lung cancer cells after retrovirus-mediated gene transfer. Hum. Gene Ther. 4, 617-624 (1993).
8. Hollstein, M., Sidransky, D., Vogelstein, B. & Harris, C C. p53 mutations in human cancers Science 253, 49-53 (1991).
9. Fujiwara, T. et al. Therapeutic effect of a retroviral wild-type p53 expression vector in an orthotopic lung cancer model. J. Natl. Cancer Inst. 86, 1458-1462 (1994).
10. Zhang, W. et al. High-efficiency gene transfer and high-level expression of wild-type p53 in human lung cancer cells mediated by recombinant adenovirus. Cancer Gene Ther. 1, 5-13 (1994).
11. Liu, T J. et al. Growth suppression of human head and neck cancer cells by the introduction of a wild-type p53 gene via a recombinant adenovirus. Cancer Res. 54, 3662-3667 (1994).
12. Zhang, Y.J., Mukhopadhyay, T., Donehower, L W., Georges, R.N. & Roth, J.A. Retroviral vector-mediated transduction of K-ras antisense RNA into human lung cancer cells inhibits expression of the malignant phenotype Hum. Gene Ther. 4, 451-460 (1993).
13. Kitamura, H. et al Proliferative potential and p53 overexpression in precursor and early stage lesions of bronchioloalveolar lung carcinoma. Am. J Pathol. 146, 876-887 (1995).
14. Tamiya, T et al Transgene inheritance and retroviral infection contribute to the efficiency of gene expression in solid tumors inoculated with retroviral vector producer cells Gene Ther. 2, 531-538 (1995)
15. Knol, J.A. et al. Incorporation of 5-bromo-2′-deoxyuridine into colorectal liver metastases and liver in patients receiving a 7-day hepatic arterial infusion. Cancer Res. 55, 3687-3691 (1995).
16. Fujiwara, T et al. A retroviral wild-type p53 expression vector penetrates human lung cancer spheroids and inhibits growth by inducing apoptosis. Cancer Res. 53, 4129-4133 (1993).
17. Cusack, J C., Zhang, W , Cristiano, R.J. & Roth, J.A. High levels of gene expression in human large cell lung center tumors following intralesional injection of recombinant adenovirus. Cancer Gene Ther. (in the press).
18. Yonish-Rouach, E. et al. Wild-type p53 induces apoptosis of myeloid leukemic cells that is inhibited by interleukin-6 Nature 352, 345-347 (1991)
19. Shaw, P. et al. Induction of apoptosis by wild-type p53 in a human colon tumor-derived cell line. Proc. Natl. Acad. Sci. USA 89, 4495-4499 (1992)
20. Debbas, M & White, E. Wild-type p53 mediates apoptosis by E1A, which is inhibited by E1B. Genes Dev. 7, 546-554 (1993).
21. Owenschaub, L.B. et al. Wild-type human p53 and a temperature-sensitive mutant induce Fas/APO-1 expression. Mol. Cell Biol. 15, 3032-3040 (1995).
22. Wang, J., Bucana, C D., Roth, J.A & Zhang, W.W. Apoptosis induced in human osteosarcoma cells is one of the mechanisms for the cytocidal effect of Ad5CMV-p53. Cancer Gene Ther. 2, 9-17 (1995).
23. Diller, L. et al. p53 functions as a cell cycle control protein in osteosarcomas. Mol. Cell. Biol. 10, 5772-5781 (1990).
24. Livingstone, L R et al. Altered cell cycle arrest and gene amplification potential X accompany loss of wild-type p53. Cell 70, 923-935 (1992).
25. Yin, Y.X., Tainsky, M.A., Bischoff, F.Z., Strong, L.C. & Wahl, G.M. Wild-type p53 restores cell cycle control and inhibits gene amplification in cells with mutant p53 alleles. Cell 70, 937-948 (1992).
26. Kuerbitz, S.J., Plunkett, B S., Walsh, W.V. & Kastan, M.B. Wild-type p53 is a cell cycle checkpoint determinant following irradiation. Proc. Natl Acad. Sci. USA 89, 7491-7495 (1992).
27. Kastan, M.B et al. A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia Cell 71, 587-597 (1992).
28. Johnson, L G et al. In vitro assessment of variables affecting the efficiency and efficacy of adenovirus-mediated gene transfer to cystic fibrosis airway epithelia. Hum Gene Ther. 7, 51-59 (1996).
29. Dillman, R O. et al. A randomized trial of induction chemotherapy plus high-dose radiation versus radiation alone in stage III non-small-cell lung cancer. N. Engl. J. Med. 323, 940-945 (1990).
30. Fujiwara, T et al. Induction of chemosensitivity in human lung cancer cells in vivo by adenoviral-mediated transfer of the wild-type p53 gene. Cancer Res. 54, 2287-2291 (1994).
31. Schneider, P.M. et al. Mutations of p53 in Barrett's esophagus and Barrett's cancer: A prospective study of ninety-eight cases. J. Thorac. Cardiovasc Surg. 111, 3233231; discussion 33131;3 (1996)
32. Casson, A.G. et al. p53 gene mutations in Barrett's epithelium and esophageal cancer. Cancer Res. 51, 4495-4499 (1991).
33. Sundaresan, V et al. p53 and chromosome-3 abnormalities, characteristic of malignant lung tumours, are detectable in preinvasive lesions of the bronchus. Oncogene 7, 1989-1997 (1992).
34. Kishimoto, Y. et al. Allele-specific loss in chromosome 9p loci in preneoplastic lesions accompanying non-small-cell lung cancers. J. Natl Cancer Inst. 87, 1224-1229 (1995).
35. Vahakangas, K.H. et al. Mutations of p53 and ras genes in radon-associated lung cancer from uranium miners. Lancet 339, 575-580 (1992).
36. Roth, J.A. Recombinant DNA Advisory Committee Minutes of meeting of September 14315, 1992. Hum Gene Ther. 4, 365-389 (1993)
37. Roth, J A Modification of tumor suppressor gene expression in non-small cell lung cancer (NSCLC) with a retroviral vector expressing wildtype (normal) p53. Hum. Gene Ther. 7, 861-874 (1996).
38. Miller, A.D. & Rosman, G.J Improved retroviral vectors for gene transfer and expression. Biotechniques 7, 980-990 (1989).
39. Cornetta, K. & Anderson, W.F. Protamine sulfate as an effective alternative to polybrene in retroviral-mediated gene-transfer: Implications for human gene therapy. J. Virol. Methods 23, 187-194 (1989).
40. Chung, K Y. et al. Discordant p53 gene mutations in primary head and neck cancers and corresponding second primary cancers of the upper aerodigestive tract. Cancer Res. 53, 1676-1683 (1993)
41. Ajani, J.A., Welch, S.R., Raber, M N., Fields, W.S. & Krakoff, I.H. Comprehensive criteria for assessing therapy-induced toxicity. Cancer Invest. 8, 147-159 (1990)