Psammaplin A induces Sirtuin 1-dependent autophagic cell death in doxorubicin-resistant MCF-7/adr human breast cancer cells and xenografts

Biochimica et Biophysica Acta - General Subjects

Volumn 1850, Issue 2, 2015, Pages 401-410

  Kim, Hyung Sik ^a   Kim, Tae Hyung ^a   Kim, Hyuk Soon ^b   Kang, Yoon Jong ^a   Yoon, Sungpil ^c   Lee, Jaewon ^d   Choi, Wahn Soo ^b   Jung, Jee H ^d  

^a Sungkyunkwan University   (South Korea)

^b Konkuk University School of Medicine   (South Korea)

^c National Cancer Center   (South Korea)

^d Pusan National University   (South Korea)

Author keywords

Autophagy; Breast cancer; Doxorubicin; Drug resistant; SIRT1

Indexed keywords

AUTOPHAGY RELATED PROTEIN; DAMAGE REGULATED AUTOPHAGY MODULATOR; DOXORUBICIN; HYDROLASE INHIBITOR; MEMBRANE PROTEIN; NATURAL PRODUCT; NICOTINAMIDE; PROTEIN P53; PSAMMAPLIN A; SALERMIDE; SIRTINOL; SIRTUIN 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC ANTIBIOTIC; DISULFIDE; DRAM1 PROTEIN, HUMAN; SIRT1 PROTEIN, HUMAN; TP53 PROTEIN, HUMAN; TYROSINE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; AUTOPHAGY; BREAST CANCER; CANCER RESISTANCE; CELL CYCLE PROGRESSION; CELL DEATH; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DOSE COMPARISON; DRUG POTENCY; DRUG STRUCTURE; ENZYME ACTIVITY; ENZYME INDUCTION; FEMALE; FLOW CYTOMETRY; G2 PHASE CELL CYCLE CHECKPOINT; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; MCF 7 CELL LINE; MOUSE; MULTIDRUG RESISTANCE; NONHUMAN; PROTEIN ACETYLATION; PROTEIN ANALYSIS; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR XENOGRAFT; WESTERN BLOTTING; ACETYLATION; ANALOGS AND DERIVATIVES; ANIMAL; BIOSYNTHESIS; BREAST NEOPLASMS; CANCER TRANSPLANTATION; CELL CYCLE G2 PHASE; CELL DIVISION; DRUG EFFECTS; DRUG RESISTANCE; DRUG SCREENING; GENE EXPRESSION REGULATION; GENETICS; METABOLISM; NUDE MOUSE; PATHOLOGY; PROCEDURES; TUMOR CELL LINE; XENOGRAFT;

ACETYLATION; ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; AUTOPHAGY; BREAST NEOPLASMS; CELL DIVISION; CELL LINE, TUMOR; DISULFIDES; DOXORUBICIN; DRUG RESISTANCE, NEOPLASM; FEMALE; G2 PHASE; GENE EXPRESSION REGULATION, NEOPLASTIC; HETEROGRAFTS; HUMANS; MEMBRANE PROTEINS; MICE; MICE, NUDE; NEOPLASM TRANSPLANTATION; SIRTUIN 1; TUMOR SUPPRESSOR PROTEIN P53; TYROSINE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

EID: 84913601119     PISSN: 03044165     EISSN: 18728006     Source Type: Journal    
DOI: 10.1016/j.bbagen.2014.11.007     Document Type: Article

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