-
1
-
-
0038387494
-
5-Fluorouracil: Mechanisms of action and clinical strategies
-
DOI 10.1038/nrc1074
-
Longley, D. B., Harkin, D. P. & Johnston, P. G. 5-fluorouracil: mechanisms of action and clinical strategies. Nat. Rev. Cancer 3, 330-338 (2003). (Pubitemid 37328853)
-
(2003)
Nature Reviews Cancer
, vol.3
, Issue.5
, pp. 330-338
-
-
Longley, D.B.1
Harkin, D.P.2
Johnston, P.G.3
-
2
-
-
80455155967
-
UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation
-
Pettersen, H. S. et al. UNG-initiated base excision repair is the major repair route for 5-fluorouracil in DNA, but 5-fluorouracil cytotoxicity depends mainly on RNA incorporation. Nucleic Acids Res. 39, 8430-8444 (2011).
-
(2011)
Nucleic Acids Res
, vol.39
, pp. 8430-8444
-
-
Pettersen, H.S.1
-
4
-
-
63049114271
-
Participation of DNA repair in the response to 5-fluorouracil
-
Wyatt, M. D. & Wilson, 3rd D. M. Participation of DNA repair in the response to 5-fluorouracil. Cell Mol. Life Sci. 66, 788-799 (2009).
-
(2009)
Cell Mol. Life Sci
, vol.66
, pp. 788-799
-
-
Wyatt, M.D.1
Wilson Iii., D.M.2
-
5
-
-
16244423009
-
Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts
-
DOI 10.1093/carcin/bgh347
-
Andersen, S. et al. Incorporation of dUMP into DNA is a major source of spontaneous DNA damage, while excision of uracil is not required for cytotoxicity of fluoropyrimidines in mouse embryonic fibroblasts. Carcinogenesis 26, 547-555 (2005). (Pubitemid 41214143)
-
(2005)
Carcinogenesis
, vol.26
, Issue.3
, pp. 547-555
-
-
Andersen, S.1
Heine, T.2
Sneve, R.3
Konig, I.4
Krokan, H.E.5
Epe, B.6
Nilsen, H.7
-
6
-
-
34547101263
-
Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2
-
DOI 10.1093/nar/gkm337
-
Hardeland, U., Kunz, C., Focke, F., Szadkowski, M. & Schar, P. Cell cycle regulation as a mechanism for functional separation of the apparently redundant uracil DNA glycosylases TDG and UNG2. Nucleic Acids Res. 35, 3859-3867 (2007). (Pubitemid 47244677)
-
(2007)
Nucleic Acids Research
, vol.35
, Issue.11
, pp. 3859-3867
-
-
Hardeland, U.1
Kunz, C.2
Focke, F.3
Szadkowski, M.4
Schar, P.5
-
7
-
-
65949089155
-
Base excision by thymine DNA glycosylase mediates DNAdirected cytotoxicity of 5-fluorouracil
-
Kunz, C. et al. Base excision by thymine DNA glycosylase mediates DNAdirected cytotoxicity of 5-fluorouracil. PLoS Biol. 7, e91 (2009).
-
(2009)
PLoS Biol
, vol.7
, pp. 91
-
-
Kunz, C.1
-
8
-
-
36549061567
-
5-Fluorouracil Is Efficiently Removed From DNA by the Base Excision and Mismatch Repair Systems
-
DOI 10.1053/j.gastro.2007.09.003, PII S0016508507016447
-
Fischer, F., Baerenfaller, K. & Jiricny, J. 5-Fluorouracil is efficiently removed from DNA by the base excision and mismatch repair systems. Gastroenterology 133, 1858-1868 (2007). (Pubitemid 350180806)
-
(2007)
Gastroenterology
, vol.133
, Issue.6
, pp. 1858-1868
-
-
Fischer, F.1
Baerenfaller, K.2
Jiricny, J.3
-
9
-
-
33646187811
-
The multifaceted mismatch-repair system
-
Jiricny, J. The multifaceted mismatch-repair system. Nature reviews. Mol. Cell Biol. 7, 335-346 (2006).
-
(2006)
Nature Reviews. Mol. Cell Biol
, vol.7
, pp. 335-346
-
-
Jiricny, J.1
-
10
-
-
77955277982
-
Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents
-
Skjeldam, H. K. et al. Loss of Caenorhabditis elegans UNG-1 uracil-DNA glycosylase affects apoptosis in response to DNA damaging agents. DNA Repair 9, 861-870 (2010).
-
(2010)
DNA Repair
, vol.9
, pp. 861-870
-
-
Skjeldam, H.K.1
-
11
-
-
33749245331
-
Abrogation of the CLK-2 checkpoint leads to tolerance to base-excision repair intermediates
-
DOI 10.1038/sj.embor.7400782, PII 7400782
-
Dengg, M. et al. Abrogation of the CLK-2 checkpoint leads to tolerance to baseexcision repair intermediates. EMBO Rep. 7, 1046-1051 (2006). (Pubitemid 44480522)
-
(2006)
EMBO Reports
, vol.7
, Issue.10
, pp. 1046-1051
-
-
Dengg, M.1
Garcia-Muse, T.2
Gill, S.G.3
Ashcroft, N.4
Boulton, S.J.5
Nilsen, H.6
-
12
-
-
0034674784
-
Steady-state regulation of the human DNA mismatch repair system
-
DOI 10.1074/jbc.M001140200
-
Chang, D. K., Ricciardiello, L., Goel, A., Chang, C. L. & Boland, C. R. Steadystate regulation of the human DNA mismatch repair system. J. Biol. Chem. 275, 18424-18431 (2000). (Pubitemid 30414800)
-
(2000)
Journal of Biological Chemistry
, vol.275
, Issue.24
, pp. 18424-18431
-
-
Chang, D.K.1
Ricciardiello, L.2
Goel, A.3
Chang, C.L.4
Boland, C.R.5
-
13
-
-
58049218570
-
Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans
-
Kim, S., Park, D. H. & Shim, J. Thymidylate synthase and dihydropyrimidine dehydrogenase levels are associated with response to 5-fluorouracil in Caenorhabditis elegans. Mol. Cell 26, 344-349 (2008).
-
(2008)
Mol. Cell
, vol.26
, pp. 344-349
-
-
Kim, S.1
Park, D.H.2
Shim, J.3
-
14
-
-
14844315930
-
A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation
-
DOI 10.1038/sj.onc.1208309
-
Xiao, Z., Xue, J., Sowin, T. J., Rosenberg, S. H. & Zhang, H. A novel mechanism of checkpoint abrogation conferred by Chk1 downregulation. Oncogene 24, 1403-1411 (2005). (Pubitemid 40343120)
-
(2005)
Oncogene
, vol.24
, Issue.8
, pp. 1403-1411
-
-
Xiao, Z.1
Xue, J.2
Sowin, T.J.3
Rosenberg, S.H.4
Zhang, H.5
-
15
-
-
79955674412
-
Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans
-
Erdelyi, P. et al. Shared developmental roles and transcriptional control of autophagy and apoptosis in Caenorhabditis elegans. J. Cell Sci. 124, 1510-1518 (2011).
-
(2011)
J. Cell Sci
, vol.124
, pp. 1510-1518
-
-
Erdelyi, P.1
-
16
-
-
57649228468
-
Autophagy and cell death in model organisms
-
Kourtis, N. & Tavernarakis, N. Autophagy and cell death in model organisms. Cell Death Differ. 16, 21-30 (2009).
-
(2009)
Cell Death Differ
, vol.16
, pp. 21-30
-
-
Kourtis, N.1
Tavernarakis, N.2
-
17
-
-
23944448372
-
Inactivation of the autophagy Gene bec-1 triggers apoptotic cell death in C. Elegans
-
DOI 10.1016/j.cub.2005.07.035, PII S0960982205007906
-
Takacs-Vellai, K. et al. Inactivation of the autophagy gene bec-1 triggers apoptotic cell death in C. elegans. Curr Biol. 15, 1513-1517 (2005). (Pubitemid 41187492)
-
(2005)
Current Biology
, vol.15
, Issue.16
, pp. 1513-1517
-
-
Takacs-Vellai, K.1
Vellai, T.2
Puoti, A.3
Passannante, M.4
Wicky, C.5
Streit, A.6
Kovacs, A.L.7
Muller, F.8
-
18
-
-
0035870257
-
Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function
-
Liang, X. H., Yu, J., Brown, K. & Levine, B. Beclin 1 contains a leucine-rich nuclear export signal that is required for its autophagy and tumor suppressor function. Cancer Res. 61, 3443-3449 (2001). (Pubitemid 32695039)
-
(2001)
Cancer Research
, vol.61
, Issue.8
, pp. 3443-3449
-
-
Xiao Huan Liang1
Yu, J.2
Brown, K.3
Levine, B.4
-
19
-
-
79952270884
-
HDACs link the DNA damage response, processing of doublestrand breaks and autophagy
-
Robert, T. et al. HDACs link the DNA damage response, processing of doublestrand breaks and autophagy. Nature 471, 74-79 (2011).
-
(2011)
Nature
, vol.471
, pp. 74-79
-
-
Robert, T.1
-
20
-
-
33645293158
-
Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos
-
Holway, A. H., Kim, S. H., La Volpe, A. & Michael, W. M. Checkpoint silencing during the DNA damage response in Caenorhabditis elegans embryos. J. Cell Biol. 172, 999-1008 (2006).
-
(2006)
J. Cell Biol
, vol.172
, pp. 999-1008
-
-
Holway, A.H.1
Kim, S.H.2
La Volpe, A.3
Michael, W.M.4
-
21
-
-
77951248778
-
Chemotherapeutic drugs inhibit ribosome biogenesis at various levels
-
Burger, K. et al. Chemotherapeutic drugs inhibit ribosome biogenesis at various levels. J. Biol. Chem. 285, 12416-12425 (2010).
-
(2010)
J. Biol. Chem
, vol.285
, pp. 12416-12425
-
-
Burger, K.1
-
22
-
-
33750472331
-
Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae
-
DOI 10.1534/genetics.106.062117
-
Seiser, R. M. et al. Ltv1 is required for efficient nuclear export of the ribosomal small subunit in Saccharomyces cerevisiae. Genetics 174, 679-691 (2006). (Pubitemid 44656459)
-
(2006)
Genetics
, vol.174
, Issue.2
, pp. 679-691
-
-
Seiser, R.M.1
Sundberg, A.E.2
Wollam, B.J.3
Zobel-Thropp, P.4
Baldwin, K.5
Spector, M.D.6
Lycan, D.E.7
-
23
-
-
39749166975
-
DNA repair pathways as targets for cancer therapy
-
DOI 10.1038/nrc2342, PII NRC2342
-
Helleday, T., Petermann, E., Lundin, C., Hodgson, B. & Sharma, R. A. DNA repair pathways as targets for cancer therapy. Nat. Rev. Cancer 8, 193-204 (2008). (Pubitemid 351301852)
-
(2008)
Nature Reviews Cancer
, vol.8
, Issue.3
, pp. 193-204
-
-
Helleday, T.1
Petermann, E.2
Lundin, C.3
Hodgson, B.4
Sharma, R.A.5
-
24
-
-
0348140585
-
Abasic sites in DNA: Repair and biological consequences in Saccharomyces cerevisiae
-
DOI 10.1016/j.dnarep.2003.10.002
-
Boiteux, S. & Guillet, M. Abasic sites in DNA: repair and biological consequences in Saccharomyces cerevisiae. DNA Repair 3, 1-12 (2004). (Pubitemid 38021990)
-
(2004)
DNA Repair
, vol.3
, Issue.1
, pp. 1-12
-
-
Boiteux, S.1
Guillet, M.2
-
25
-
-
84887626853
-
DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals
-
doi:10.1038/cdd.2013.126
-
Lans, H. et al. DNA damage leads to progressive replicative decline but extends the life span of long-lived mutant animals. Cell Death Differ. doi:10.1038/cdd.2013.126 (2013).
-
(2013)
Cell Death Differ
-
-
Lans, H.1
-
26
-
-
51849109383
-
The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine
-
Liu, A., Yoshioka, K., Salerno, V. & Hsieh, P. The mismatch repair-mediated cell cycle checkpoint response to fluorodeoxyuridine. J. Cell Biochem. 105, 245-254 (2008).
-
(2008)
J. Cell Biochem
, vol.105
, pp. 245-254
-
-
Liu, A.1
Yoshioka, K.2
Salerno, V.3
Hsieh, P.4
-
27
-
-
0037086643
-
Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover
-
DOI 10.1093/emboj/21.6.1456
-
Hardeland, U., Steinacher, R., Jiricny, J. & Schar, P. Modification of the human thymine-DNA glycosylase by ubiquitin-like proteins facilitates enzymatic turnover. EMBO J. 21, 1456-1464 (2002). (Pubitemid 34246524)
-
(2002)
EMBO Journal
, vol.21
, Issue.6
, pp. 1456-1464
-
-
Hardeland, U.1
Steinacher, R.2
Jiricny, J.3
Schar, P.4
-
28
-
-
84866265794
-
Noncanonical mismatch repair as a source of genomic instability in human cells
-
Pena-Diaz, J. et al. Noncanonical mismatch repair as a source of genomic instability in human cells. Mol. Cell 47, 669-680 (2012).
-
(2012)
Mol. Cell
, vol.47
, pp. 669-680
-
-
Pena-Diaz, J.1
-
29
-
-
65249161710
-
Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation
-
Schanz, S., Castor, D., Fischer, F. & Jiricny, J. Interference of mismatch and base excision repair during the processing of adjacent U/G mispairs may play a key role in somatic hypermutation. Proc. Natl Acad. Sci. USA 106, 5593-5598 (2009).
-
(2009)
Proc. Natl Acad. Sci. USA
, vol.106
, pp. 5593-5598
-
-
Schanz, S.1
Castor, D.2
Fischer, F.3
Jiricny, J.4
-
30
-
-
19344378245
-
Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation
-
DOI 10.1016/j.dnarep.2005.02.005, PII S1568786405000704
-
Shatilla, A., Leduc, A., Yang, X. & Ramotar, D. Identification of two apurinic/apyrimidinic endonucleases from Caenorhabditis elegans by cross-species complementation. DNA Repair 4, 655-670 (2005). (Pubitemid 40720308)
-
(2005)
DNA Repair
, vol.4
, Issue.6
, pp. 655-670
-
-
Shatilla, A.1
Leduc, A.2
Yang, X.3
Ramotar, D.4
-
31
-
-
84867218574
-
Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1
-
Yang, X. et al. Functional characterization of the Caenorhabditis elegans DNA repair enzyme APN-1. DNA Repair 11, 811-822 (2012).
-
(2012)
DNA Repair
, vol.11
, pp. 811-822
-
-
Yang, X.1
-
32
-
-
80051744669
-
The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol eta in response to oxidative DNA damage in human cells
-
Zlatanou, A. et al. The hMsh2-hMsh6 complex acts in concert with monoubiquitinated PCNA and Pol eta in response to oxidative DNA damage in human cells. Mol. Cell 43, 649-662 (2011).
-
(2011)
Mol. Cell
, vol.43
, pp. 649-662
-
-
Zlatanou, A.1
-
33
-
-
79451470915
-
Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability
-
Arczewska, K. D. et al. Caenorhabditis elegans NDX-4 is a MutT-type enzyme that contributes to genomic stability. DNA Repair 10, 176-187 (2011).
-
(2011)
DNA Repair
, vol.10
, pp. 176-187
-
-
Arczewska, K.D.1
-
34
-
-
38449093531
-
-
(ed. WormBook) (The C. elegans Research Community WormBook doi/10.1895/wormbook.1.105.1
-
Duerr, J. S. in Immunohistochemistry. (ed. WormBook) (The C. elegans Research Community, WormBook 2006), doi/10.1895/wormbook.1.105.1 http://www.wormbook.org.
-
(2006)
Immunohistochemistry
-
-
Duerr, J.S.1
-
35
-
-
0037099013
-
A novel linker histone-like protein is associated with cytoplasmic filaments in Caenorhabditis elegans
-
Jedrusik, M. A., Vogt, S., Claus, P. & Schulze, E. A novel linker histone-like protein is associated with cytoplasmic filaments in Caenorhabditis elegans. J. Cell Sci. 115, 2881-2891 (2002).
-
(2002)
J. Cell Sci
, vol.115
, pp. 2881-2891
-
-
Jedrusik, M.A.1
Vogt, S.2
Claus, P.3
Schulze, E.4
|