The antioxidant function of sestrins is mediated by promotion of autophagic degradation of Keap1 and Nrf2 activation and by inhibition of mTORC1

Free Radical Biology and Medicine

Volumn 88, Issue Part B, 2015, Pages 205-211

  Rhee, Sue Goo ^a   Bae, Soo Han ^a  

^a Yonsei University College of Medicine   (South Korea)

Author keywords

Autophagy; Free radicals; Keap1; mTORC1; Nrf2; p62; Sestrin

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; ADENYLATE KINASE; AMINO ACID; ANTIOXIDANT; CCAAT ENHANCER BINDING PROTEIN BETA; HYPOXIA INDUCIBLE FACTOR 1; KELCH LIKE ECH ASSOCIATED PROTEIN 1; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR GAMMA COACTIVATOR 1ALPHA; PROTEIN P53; PROTEIN P62; REACTIVE OXYGEN METABOLITE; RHEB PROTEIN; SESTRIN; SESTRIN 1; SESTRIN 2; SESTRIN 3; TRANSCRIPTION FACTOR FOXO; TRANSCRIPTION FACTOR NRF2; TUBERIN; UNCLASSIFIED DRUG; HEAT SHOCK PROTEIN; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; SIGNAL PEPTIDE; TARGET OF RAPAMYCIN KINASE;

ANTIOXIDANT ACTIVITY; AUTOPHAGY; CELL STRESS; ENZYME PHOSPHORYLATION; GENE EXPRESSION; GENETIC TRANSCRIPTION; HUMAN; LYSOSOME; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN LOCALIZATION; REVIEW; SIGNAL TRANSDUCTION; TRANSCRIPTION INITIATION; UPREGULATION; ANIMAL; METABOLISM; OXIDATIVE STRESS; PHYSIOLOGY;

ANIMALS; ANTIOXIDANTS; AUTOPHAGY; HEAT-SHOCK PROTEINS; HUMANS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MULTIPROTEIN COMPLEXES; NF-E2-RELATED FACTOR 2; OXIDATIVE STRESS; SIGNAL TRANSDUCTION; TOR SERINE-THREONINE KINASES;

EID: 84969781294     PISSN: 08915849     EISSN: 18734596     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2015.06.007     Document Type: Review

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