메뉴 건너뛰기




Volumn 55, Issue 2, 2016, Pages 220-229

Rheb promotes cancer cell survival through p27Kip1-dependent activation of autophagy

Author keywords

MTORC1 independent; N terminal of p27; Rheb GTPase

Indexed keywords

CYCLIN DEPENDENT KINASE INHIBITOR 1B; RHEB PROTEIN; SMALL INTERFERING RNA; CDKN1B PROTEIN, HUMAN; LIGHT CHAIN 3, HUMAN; MICROTUBULE ASSOCIATED PROTEIN; MONOMERIC GUANINE NUCLEOTIDE BINDING PROTEIN; NEUROPEPTIDE; RHEB PROTEIN, HUMAN;

EID: 84955184800     PISSN: 08991987     EISSN: 10982744     Source Type: Journal    
DOI: 10.1002/mc.22272     Document Type: Article
Times cited : (27)

References (43)
  • 2
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan D, Weinberg RA. Hallmarks of cancer: The next generation. Cell 2011; 144:646-674.
    • (2011) Cell , vol.144 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 3
    • 25444440875 scopus 로고    scopus 로고
    • The role of autophagy in cancer development and response to therapy
    • Kondo Y, Kanzawa T, Sawaya R, Kondo S. The role of autophagy in cancer development and response to therapy. Nat Rev Cancer 2005; 5:726-734.
    • (2005) Nat Rev Cancer , vol.5 , pp. 726-734
    • Kondo, Y.1    Kanzawa, T.2    Sawaya, R.3    Kondo, S.4
  • 4
    • 33846794896 scopus 로고    scopus 로고
    • Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma
    • Amaravadi RK, Yu D, Lum JJ, et al. Autophagy inhibition enhances therapy-induced apoptosis in a Myc-induced model of lymphoma. J Clin Invest 2007; 117:326-336.
    • (2007) J Clin Invest , vol.117 , pp. 326-336
    • Amaravadi, R.K.1    Yu, D.2    Lum, J.J.3
  • 5
    • 77950509348 scopus 로고    scopus 로고
    • Autophagy and tumorigenesis
    • Chen N, Debnath J. Autophagy and tumorigenesis. FEBS Lett 2010; 584:1427-1435.
    • (2010) FEBS Lett , vol.584 , pp. 1427-1435
    • Chen, N.1    Debnath, J.2
  • 7
    • 77952766891 scopus 로고    scopus 로고
    • Autophagy: Assays and artifacts
    • Barth S, Glick D, Macleod KF. Autophagy: Assays and artifacts. J Pathol 2010; 221:117-124.
    • (2010) J Pathol , vol.221 , pp. 117-124
    • Barth, S.1    Glick, D.2    Macleod, K.F.3
  • 8
  • 9
    • 84873675067 scopus 로고    scopus 로고
    • The ULK1 complex: sensing nutrient signals for autophagy activation
    • Wong PM, Puente C, Ganley IG, Jiang X. The ULK1 complex: sensing nutrient signals for autophagy activation. Autophagy 2013; 9:124-137.
    • (2013) Autophagy , vol.9 , pp. 124-137
    • Wong, P.M.1    Puente, C.2    Ganley, I.G.3    Jiang, X.4
  • 10
    • 84856800302 scopus 로고    scopus 로고
    • Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks
    • Alers S, Loffler AS, Wesselborg S, Stork B. Role of AMPK-mTOR-Ulk1/2 in the regulation of autophagy: Cross talk, shortcuts, and feedbacks. Mol Cell Biol 2012; 32:2-11.
    • (2012) Mol Cell Biol , vol.32 , pp. 2-11
    • Alers, S.1    Loffler, A.S.2    Wesselborg, S.3    Stork, B.4
  • 11
    • 33947250696 scopus 로고    scopus 로고
    • The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis
    • Liang J, Shao SH, Xu ZX, et al. The energy sensing LKB1-AMPK pathway regulates p27(kip1) phosphorylation mediating the decision to enter autophagy or apoptosis. Nat Cell Biol 2007; 9:218-224.
    • (2007) Nat Cell Biol , vol.9 , pp. 218-224
    • Liang, J.1    Shao, S.H.2    Xu, Z.X.3
  • 12
    • 70449710913 scopus 로고    scopus 로고
    • P27 as Jekyll and Hyde: Regulation of cell cycle and cell motility
    • Larrea MD, Wander SA, Slingerland JM. P27 as Jekyll and Hyde: Regulation of cell cycle and cell motility. Cell Cycle 2009; 8:3455-3461.
    • (2009) Cell Cycle , vol.8 , pp. 3455-3461
    • Larrea, M.D.1    Wander, S.A.2    Slingerland, J.M.3
  • 13
    • 77953035951 scopus 로고    scopus 로고
    • AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability
    • Short JD, Dere R, Houston KD, et al. AMPK-mediated phosphorylation of murine p27 at T197 promotes binding of 14-3-3 proteins and increases p27 stability. Mol Carcinog 2010; 49:14-13.
    • (2010) Mol Carcinog , vol.49 , pp. 13-14
    • Short, J.D.1    Dere, R.2    Houston, K.D.3
  • 14
    • 0041356888 scopus 로고    scopus 로고
    • Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner
    • Castro AF, Rebhun JF, Clark GJ, Quilliam LA. Rheb binds tuberous sclerosis complex 2 (TSC2) and promotes S6 kinase activation in a rapamycin- and farnesylation-dependent manner. J Biol Chem 2003; 278:32493-32496.
    • (2003) J Biol Chem , vol.278 , pp. 32493-32496
    • Castro, A.F.1    Rebhun, J.F.2    Clark, G.J.3    Quilliam, L.A.4
  • 15
    • 44449161481 scopus 로고    scopus 로고
    • The TSC1-TSC2 complex: a molecular switchboard controlling cell growth
    • Huang J, Manning BD. The TSC1-TSC2 complex: a molecular switchboard controlling cell growth. Biochem J 2008; 412:179-190.
    • (2008) Biochem J , vol.412 , pp. 179-190
    • Huang, J.1    Manning, B.D.2
  • 16
    • 49849087494 scopus 로고    scopus 로고
    • Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma
    • Lu KH, Wu W, Dave B, et al. Loss of tuberous sclerosis complex-2 function and activation of mammalian target of rapamycin signaling in endometrial carcinoma. Clin Cancer Res 2008; 14:2543-2550.
    • (2008) Clin Cancer Res , vol.14 , pp. 2543-2550
    • Lu, K.H.1    Wu, W.2    Dave, B.3
  • 17
    • 50049123842 scopus 로고    scopus 로고
    • Tumorigenic activity and therapeutic inhibition of Rheb GTPase
    • Mavrakis KJ, Zhu H, Silva RL, et al. Tumorigenic activity and therapeutic inhibition of Rheb GTPase. Genes Dev 2008; 22:2178-2188.
    • (2008) Genes Dev , vol.22 , pp. 2178-2188
    • Mavrakis, K.J.1    Zhu, H.2    Silva, R.L.3
  • 18
    • 50049125036 scopus 로고    scopus 로고
    • Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events
    • Nardella C, Chen Z, Salmena L, et al. Aberrant Rheb-mediated mTORC1 activation and Pten haploinsufficiency are cooperative oncogenic events. Genes Dev 2008; 22:2172-2177.
    • (2008) Genes Dev , vol.22 , pp. 2172-2177
    • Nardella, C.1    Chen, Z.2    Salmena, L.3
  • 19
    • 78650305038 scopus 로고    scopus 로고
    • Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: Implications for cell proliferation and tumorigenesis
    • Lacher MD, Pincheira R, Zhu Z, et al. Rheb activates AMPK and reduces p27Kip1 levels in Tsc2-null cells via mTORC1-independent mechanisms: Implications for cell proliferation and tumorigenesis. Oncogene 2010; 29:6543-6556.
    • (2010) Oncogene , vol.29 , pp. 6543-6556
    • Lacher, M.D.1    Pincheira, R.2    Zhu, Z.3
  • 20
    • 80053332722 scopus 로고    scopus 로고
    • Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer
    • Lacher MD, Pincheira RJ, Castro AF. Consequences of interrupted Rheb-to-AMPK feedback signaling in tuberous sclerosis complex and cancer. Small GTPases 2011; 2:211-216.
    • (2011) Small GTPases , vol.2 , pp. 211-216
    • Lacher, M.D.1    Pincheira, R.J.2    Castro, A.F.3
  • 21
    • 79953280262 scopus 로고    scopus 로고
    • Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis
    • Neuman NA, Henske EP. Non-canonical functions of the tuberous sclerosis complex-Rheb signalling axis. EMBO Mol Med 2011; 3:189-200.
    • (2011) EMBO Mol Med , vol.3 , pp. 189-200
    • Neuman, N.A.1    Henske, E.P.2
  • 22
    • 84877578621 scopus 로고    scopus 로고
    • Rheb regulates mitophagy induced by mitochondrial energetic status
    • Melser S, Chatelain EH, Lavie J, et al. Rheb regulates mitophagy induced by mitochondrial energetic status. Cell Metab 2013; 17:719-730.
    • (2013) Cell Metab , vol.17 , pp. 719-730
    • Melser, S.1    Chatelain, E.H.2    Lavie, J.3
  • 23
    • 16644393375 scopus 로고    scopus 로고
    • Cell cycle regulatory protein p27KIP1 is a substrate and interacts with the protein kinase CK2
    • Tapia JC, Bolanos-Garcia VM, Sayed M, Allende CC, Allende JE. Cell cycle regulatory protein p27KIP1 is a substrate and interacts with the protein kinase CK2. J Cell Biochem 2004; 91:865-879.
    • (2004) J Cell Biochem , vol.91 , pp. 865-879
    • Tapia, J.C.1    Bolanos-Garcia, V.M.2    Sayed, M.3    Allende, C.C.4    Allende, J.E.5
  • 24
    • 79955755460 scopus 로고    scopus 로고
    • Conversation between apoptosis and autophagy: "Is it your turn or mine?
    • Giansanti V, Torriglia A, Scovassi AI. Conversation between apoptosis and autophagy: "Is it your turn or mine?" Apoptosis 2011; 16:321-333.
    • (2011) Apoptosis , vol.16 , pp. 321-333
    • Giansanti, V.1    Torriglia, A.2    Scovassi, A.I.3
  • 25
    • 84862257733 scopus 로고    scopus 로고
    • The crosstalk between autophagy and apoptosis: Where does this lead
    • Gordy C, He YW. The crosstalk between autophagy and apoptosis: Where does this lead. Protein Cell 2012; 3:17-27.
    • (2012) Protein Cell , vol.3 , pp. 17-27
    • Gordy, C.1    He, Y.W.2
  • 26
    • 76349090912 scopus 로고    scopus 로고
    • The IKK complex contributes to the induction of autophagy
    • Criollo A, Senovilla L, Authier H, et al. The IKK complex contributes to the induction of autophagy. EMBO J 2010; 29:619-631.
    • (2010) EMBO J , vol.29 , pp. 619-631
    • Criollo, A.1    Senovilla, L.2    Authier, H.3
  • 27
    • 0038433304 scopus 로고    scopus 로고
    • Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2
    • Garami A, Zwartkruis FJ, Nobukuni T, et al. Insulin activation of Rheb, a mediator of mTOR/S6K/4E-BP signaling, is inhibited by TSC1 and 2. Molecular cell 2003; 11:1457-1466.
    • (2003) Molecular cell , vol.11 , pp. 1457-1466
    • Garami, A.1    Zwartkruis, F.J.2    Nobukuni, T.3
  • 28
    • 84864960912 scopus 로고    scopus 로고
    • Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger
    • Mathew R, White E. Autophagy, stress, and cancer metabolism: what doesn't kill you makes you stronger. Cold Spring Harb Symp Quant Biol 2011; 76:389-396.
    • (2011) Cold Spring Harb Symp Quant Biol , vol.76 , pp. 389-396
    • Mathew, R.1    White, E.2
  • 29
    • 18244362311 scopus 로고    scopus 로고
    • Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin
    • Saito K, Araki Y, Kontani K, Nishina H, Katada T. Novel role of the small GTPase Rheb: Its implication in endocytic pathway independent of the activation of mammalian target of rapamycin. J Biochem 2005; 137:423-430.
    • (2005) J Biochem , vol.137 , pp. 423-430
    • Saito, K.1    Araki, Y.2    Kontani, K.3    Nishina, H.4    Katada, T.5
  • 30
    • 77951768486 scopus 로고    scopus 로고
    • Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids
    • Sancak Y, Bar-Peled L, Zoncu R, et al. Ragulator-Rag complex targets mTORC1 to the lysosomal surface and is necessary for its activation by amino acids. Cell 2010; 141:290-303.
    • (2010) Cell , vol.141 , pp. 290-303
    • Sancak, Y.1    Bar-Peled, L.2    Zoncu, R.3
  • 31
  • 32
    • 63349098256 scopus 로고    scopus 로고
    • Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells
    • Wu YC, Wu WK, Li Y, et al. Inhibition of macroautophagy by bafilomycin A1 lowers proliferation and induces apoptosis in colon cancer cells. Biochem Biophys Res Commun 2009; 382:451-456.
    • (2009) Biochem Biophys Res Commun , vol.382 , pp. 451-456
    • Wu, Y.C.1    Wu, W.K.2    Li, Y.3
  • 33
    • 80053428657 scopus 로고    scopus 로고
    • Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency
    • Kim JH, Kim HY, Lee YK, et al. Involvement of mitophagy in oncogenic K-Ras-induced transformation: Overcoming a cellular energy deficit from glucose deficiency. Autophagy 2011; 7:1187-1198.
    • (2011) Autophagy , vol.7 , pp. 1187-1198
    • Kim, J.H.1    Kim, H.Y.2    Lee, Y.K.3
  • 34
    • 0037809355 scopus 로고    scopus 로고
    • Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells
    • Komata T, Kanzawa T, Takeuchi H, et al. Antitumour effect of cyclin-dependent kinase inhibitors (p16(INK4A), p18(INK4C), p19(INK4D), p21(WAF1/CIP1) and p27(KIP1)) on malignant glioma cells. Br J Cancer 2003; 88 1277-1280.
    • (2003) Br J Cancer , vol.88 , pp. 1277-1280
    • Komata, T.1    Kanzawa, T.2    Takeuchi, H.3
  • 35
    • 84902440212 scopus 로고    scopus 로고
    • P27 protects metabolically-stressed cardiomyocytes from apoptosis by promoting autophagy
    • Sun X, Momen A, Wu J, et al. P27 protects metabolically-stressed cardiomyocytes from apoptosis by promoting autophagy. J Biol Chem 2014; 289(24):16924-16935.
    • (2014) J Biol Chem , vol.289 , Issue.24 , pp. 16924-16935
    • Sun, X.1    Momen, A.2    Wu, J.3
  • 37
    • 41149150219 scopus 로고    scopus 로고
    • The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy
    • Chu IM, Hengst L, Slingerland JM. The Cdk inhibitor p27 in human cancer: prognostic potential and relevance to anticancer therapy. Nat Rev Cancer 2008; 8:253-267.
    • (2008) Nat Rev Cancer , vol.8 , pp. 253-267
    • Chu, I.M.1    Hengst, L.2    Slingerland, J.M.3
  • 38
    • 73649145175 scopus 로고    scopus 로고
    • The function of p27 KIP1 during tumor development
    • Lee J, Kim SS. The function of p27 KIP1 during tumor development. Exp Mol Med 2009; 41:765-771.
    • (2009) Exp Mol Med , vol.41 , pp. 765-771
    • Lee, J.1    Kim, S.S.2
  • 39
    • 53049083680 scopus 로고    scopus 로고
    • AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27
    • Short JD, Houston KD, Dere R, et al. AMP-activated protein kinase signaling results in cytoplasmic sequestration of p27. Cancer Res 2008; 68:6496-6506.
    • (2008) Cancer Res , vol.68 , pp. 6496-6506
    • Short, J.D.1    Houston, K.D.2    Dere, R.3
  • 40
    • 77952576359 scopus 로고    scopus 로고
    • Negative regulation of Vps34 by Cdk mediated phosphorylation
    • Furuya T, Kim M, Lipinski M, et al. Negative regulation of Vps34 by Cdk mediated phosphorylation. Mol Cell 2010; 38:500-511.
    • (2010) Mol Cell , vol.38 , pp. 500-511
    • Furuya, T.1    Kim, M.2    Lipinski, M.3
  • 41
    • 84885708052 scopus 로고    scopus 로고
    • MTORC1 status dictates tumor response to targeted therapeutics
    • Kelsey I, Manning BD. MTORC1 status dictates tumor response to targeted therapeutics. Sci Signal 2013; 6:pe31.
    • (2013) Sci Signal , vol.6 , pp. pe31
    • Kelsey, I.1    Manning, B.D.2
  • 42
    • 56249147509 scopus 로고    scopus 로고
    • Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation
    • Choo AY, Yoon SO, Kim SG, Roux PP, Blenis J. Rapamycin differentially inhibits S6Ks and 4E-BP1 to mediate cell-type-specific repression of mRNA translation. Proc Natl Acad Sci U S A 2008; 105:17414-17419.
    • (2008) Proc Natl Acad Sci U S A , vol.105 , pp. 17414-17419
    • Choo, A.Y.1    Yoon, S.O.2    Kim, S.G.3    Roux, P.P.4    Blenis, J.5
  • 43
    • 84897033468 scopus 로고    scopus 로고
    • Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors
    • Ducker GS, Atreya CE, Simko JP, et al. Incomplete inhibition of phosphorylation of 4E-BP1 as a mechanism of primary resistance to ATP-competitive mTOR inhibitors. Oncogene 2014; 33:1590-1600.
    • (2014) Oncogene , vol.33 , pp. 1590-1600
    • Ducker, G.S.1    Atreya, C.E.2    Simko, J.P.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.