Imaging of single cell responses to ER stress indicates that the relative dynamics of IRE1/XBP1 and PERK/ATF4 signalling rather than a switch between signalling branches determine cell survival

Cell Death and Differentiation

Volumn 22, Issue 9, 2015, Pages 1502-1516

  Walter, F ^a   Schmid, J ^a   Dussmann, H ^a   Concannon, C G ^a   Prehn, J H M ^a  

^a ROYAL COLLEGE OF SURGEONS IN IRELAND   (Ireland)

Author keywords

[No Author keywords available]

Indexed keywords

ACTIVATING TRANSCRIPTION FACTOR 4; CELL PROTEIN; MESSENGER RNA; PERK PROTEIN; PROTEIN IRE1; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG; X BOX BINDING PROTEIN 1; YELLOW FLUORESCENT PROTEIN; ATF4 PROTEIN, HUMAN; DNA BINDING PROTEIN; EIF2AK3 PROTEIN, HUMAN; ERN1 PROTEIN, HUMAN; MEMBRANE PROTEIN; PROTEIN KINASE R; PROTEIN SERINE THREONINE KINASE; REGULATORY FACTOR X TRANSCRIPTION FACTOR; RIBONUCLEASE; TRANSCRIPTION FACTOR; XBP1 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL DEATH; CELL SURVIVAL; ENDOPLASMIC RETICULUM; ENDOPLASMIC RETICULUM STRESS; HUMAN; HUMAN CELL; MOLECULAR DYNAMICS; NERVE CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN HOMEOSTASIS; PROTEIN PHOSPHORYLATION; PROTEIN PROCESSING; SIGNAL TRANSDUCTION; SINGLE CELL ANALYSIS; TIME LAPSE IMAGING; UNFOLDED PROTEIN RESPONSE; WESTERN BLOTTING; METABOLISM; PHYSIOLOGY; PROCEDURES; TUMOR CELL LINE;

ACTIVATING TRANSCRIPTION FACTOR 4; APOPTOSIS; CELL LINE, TUMOR; CELL SURVIVAL; DNA-BINDING PROTEINS; EIF-2 KINASE; ENDOPLASMIC RETICULUM STRESS; ENDORIBONUCLEASES; HUMANS; MEMBRANE PROTEINS; PROTEIN-SERINE-THREONINE KINASES; REGULATORY FACTOR X TRANSCRIPTION FACTORS; SIGNAL TRANSDUCTION; SINGLE-CELL ANALYSIS; TRANSCRIPTION FACTORS; UNFOLDED PROTEIN RESPONSE; X-BOX BINDING PROTEIN 1;

EID: 84938973534     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2014.241     Document Type: Article

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