메뉴 건너뛰기




Volumn 85, Issue , 2016, Pages 152-167

Mechanisms and biomaterials in pH-responsive tumour targeted drug delivery: A review

Author keywords

Intracellular delivery; PEG detachment; PH sensitive bond; PH sensitive nanocarriers; Protonation; Tumour targeted drug delivery

Indexed keywords

CHEMOTHERAPY; ENZYME ACTIVITY; PH SENSORS; PROTONATION; TUMORS;

EID: 84958167285     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2016.01.061     Document Type: Review
Times cited : (807)

References (209)
  • 2
    • 0037899935 scopus 로고    scopus 로고
    • Improving the evaluation of new cancer treatments: challenges and opportunities
    • Rothenberg M.L., Carbone D.P., Johnson D.H. Improving the evaluation of new cancer treatments: challenges and opportunities. Nat. Rev. Cancer 2003, 3:303-309.
    • (2003) Nat. Rev. Cancer , vol.3 , pp. 303-309
    • Rothenberg, M.L.1    Carbone, D.P.2    Johnson, D.H.3
  • 4
    • 71549171732 scopus 로고    scopus 로고
    • Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism
    • Pathania D., Millard M., Neamati N. Opportunities in discovery and delivery of anticancer drugs targeting mitochondria and cancer cell metabolism. Adv. Drug Deliv. Rev. 2009, 61:1250-1275.
    • (2009) Adv. Drug Deliv. Rev. , vol.61 , pp. 1250-1275
    • Pathania, D.1    Millard, M.2    Neamati, N.3
  • 5
    • 84921038571 scopus 로고    scopus 로고
    • Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications
    • Wicki A., Witzigmann D., Balasubramanian V., Huwyler J. Nanomedicine in cancer therapy: challenges, opportunities, and clinical applications. J. Control. Release 2015, 200:138-157.
    • (2015) J. Control. Release , vol.200 , pp. 138-157
    • Wicki, A.1    Witzigmann, D.2    Balasubramanian, V.3    Huwyler, J.4
  • 6
    • 84906785933 scopus 로고    scopus 로고
    • Stimuli-sensitive nanopreparations for combination cancer therapy
    • Jhaveri A., Deshpande P., Torchilin V. Stimuli-sensitive nanopreparations for combination cancer therapy. J. Control. Release 2014, 190:352-370.
    • (2014) J. Control. Release , vol.190 , pp. 352-370
    • Jhaveri, A.1    Deshpande, P.2    Torchilin, V.3
  • 7
    • 84919642689 scopus 로고    scopus 로고
    • Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment
    • Kanapathipillai M., Brock A., Ingber D.E. Nanoparticle targeting of anti-cancer drugs that alter intracellular signaling or influence the tumor microenvironment. Adv. Drug Deliv. Rev. 2014, 79-80:107-118.
    • (2014) Adv. Drug Deliv. Rev. , pp. 107-118
    • Kanapathipillai, M.1    Brock, A.2    Ingber, D.E.3
  • 9
    • 76149115554 scopus 로고    scopus 로고
    • Liposomal cancer therapy: exploiting tumor characteristics
    • Kaasgaard T., Andresen T. Liposomal cancer therapy: exploiting tumor characteristics. Expert Opin. Drug. Deliv. 2010, 7:225-243.
    • (2010) Expert Opin. Drug. Deliv. , vol.7 , pp. 225-243
    • Kaasgaard, T.1    Andresen, T.2
  • 10
    • 77954818815 scopus 로고    scopus 로고
    • Preparation, safety, pharmacokinetics and pharmacodynamics of liposomes containing Brucea Javanica Oil
    • Cui Y., Wu Z., Liu X., Ni R., Zhu X., Ma L., et al. Preparation, safety, pharmacokinetics and pharmacodynamics of liposomes containing Brucea Javanica Oil. AAPS Pharm. Sci. Tech. 2010, 11:878-884.
    • (2010) AAPS Pharm. Sci. Tech. , vol.11 , pp. 878-884
    • Cui, Y.1    Wu, Z.2    Liu, X.3    Ni, R.4    Zhu, X.5    Ma, L.6
  • 11
    • 0022858683 scopus 로고
    • A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs
    • Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res. 1986, 46:6387-6392.
    • (1986) Cancer Res. , vol.46 , pp. 6387-6392
    • Matsumura, Y.1    Maeda, H.2
  • 12
    • 77950279550 scopus 로고    scopus 로고
    • Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models
    • Fukumura D., Duda D.G., Munn L.L., Jain R.K. Tumor microvasculature and microenvironment: novel insights through intravital imaging in pre-clinical models. Microcirculation 2010, 17:206-225.
    • (2010) Microcirculation , vol.17 , pp. 206-225
    • Fukumura, D.1    Duda, D.G.2    Munn, L.L.3    Jain, R.K.4
  • 13
    • 60749121731 scopus 로고    scopus 로고
    • Multifunctional and stimuli-sensitive pharmaceutical nanocarriers
    • Torchilin V. Multifunctional and stimuli-sensitive pharmaceutical nanocarriers. Eur. J. Pharm. Biopharm. 2009, 71:431-444.
    • (2009) Eur. J. Pharm. Biopharm. , vol.71 , pp. 431-444
    • Torchilin, V.1
  • 14
    • 84901983377 scopus 로고    scopus 로고
    • PH-sensitive nano-systems for drug delivery in cancer therapy
    • Liu J., Huang Y., Kumar A., Tan A., Jin S., Mozhi A., et al. pH-sensitive nano-systems for drug delivery in cancer therapy. Biotechnol. Adv. 2014, 32:693-710.
    • (2014) Biotechnol. Adv. , vol.32 , pp. 693-710
    • Liu, J.1    Huang, Y.2    Kumar, A.3    Tan, A.4    Jin, S.5    Mozhi, A.6
  • 15
    • 84864622019 scopus 로고    scopus 로고
    • Multifunctional drug delivery system for targeting tumor and its acidic microenvironment
    • Shen M., Huang Y., Han L., Qin J., Fang X., Wang J., et al. Multifunctional drug delivery system for targeting tumor and its acidic microenvironment. J. Control. Release 2012, 161:884-892.
    • (2012) J. Control. Release , vol.161 , pp. 884-892
    • Shen, M.1    Huang, Y.2    Han, L.3    Qin, J.4    Fang, X.5    Wang, J.6
  • 16
    • 84881010090 scopus 로고    scopus 로고
    • Amphiphilic polycarbonate conjugates of doxorubicin with pH-sensitive hydrazone linker for controlled release
    • Jiang T., Li Y.M., Lv Y., Cheng Y.J., He F., Zhuo R.X. Amphiphilic polycarbonate conjugates of doxorubicin with pH-sensitive hydrazone linker for controlled release. Colloids Surf. B Biointerfaces 2013, 111C:542-548.
    • (2013) Colloids Surf. B Biointerfaces , vol.111C , pp. 542-548
    • Jiang, T.1    Li, Y.M.2    Lv, Y.3    Cheng, Y.J.4    He, F.5    Zhuo, R.X.6
  • 17
    • 0034996764 scopus 로고    scopus 로고
    • Long-circulating and target-specific nanoparticles: theory to practice
    • Moghimi S.M., Hunter A.C., Murray J.C. Long-circulating and target-specific nanoparticles: theory to practice. Pharmacol. Rev. 2001, 53:283-318.
    • (2001) Pharmacol. Rev. , vol.53 , pp. 283-318
    • Moghimi, S.M.1    Hunter, A.C.2    Murray, J.C.3
  • 18
    • 84935475002 scopus 로고    scopus 로고
    • The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes
    • Kierstead P.H., Okochi H., Venditto V.J., Chuong T.C., Kivimae S., Frechet J.M., et al. The effect of polymer backbone chemistry on the induction of the accelerated blood clearance in polymer modified liposomes. J. Control. Release 2015, 213:1-9.
    • (2015) J. Control. Release , vol.213 , pp. 1-9
    • Kierstead, P.H.1    Okochi, H.2    Venditto, V.J.3    Chuong, T.C.4    Kivimae, S.5    Frechet, J.M.6
  • 19
    • 84923641679 scopus 로고    scopus 로고
    • Post-insertion of poloxamer 188 strengthened liposomal membrane and reduced drug irritancy and in vivo precipitation, superior to PEGylation
    • Zhang W., Wang G., See E., Shaw J.P., Baguley B.C., Liu J., et al. Post-insertion of poloxamer 188 strengthened liposomal membrane and reduced drug irritancy and in vivo precipitation, superior to PEGylation. J. Control. Release 2015, 203:161-169.
    • (2015) J. Control. Release , vol.203 , pp. 161-169
    • Zhang, W.1    Wang, G.2    See, E.3    Shaw, J.P.4    Baguley, B.C.5    Liu, J.6
  • 20
    • 34548482374 scopus 로고    scopus 로고
    • Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential
    • Immordino M.L., Dosio F., Cattel L. Stealth liposomes: review of the basic science, rationale, and clinical applications, existing and potential. Int. J. Nanomedicine 2006, 1:297-315.
    • (2006) Int. J. Nanomedicine , vol.1 , pp. 297-315
    • Immordino, M.L.1    Dosio, F.2    Cattel, L.3
  • 21
    • 84864511390 scopus 로고    scopus 로고
    • PH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates
    • Felber A.E., Dufresne M.-H., Leroux J.-C. pH-sensitive vesicles, polymeric micelles, and nanospheres prepared with polycarboxylates. Adv. Drug Deliv. Rev. 2012, 64:979-992.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 979-992
    • Felber, A.E.1    Dufresne, M.-H.2    Leroux, J.-C.3
  • 22
    • 84861233382 scopus 로고    scopus 로고
    • Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications
    • Fleige E., Quadir M.A., Haag R. Stimuli-responsive polymeric nanocarriers for the controlled transport of active compounds: concepts and applications. Adv. Drug Deliv. Rev. 2012, 64:866-884.
    • (2012) Adv. Drug Deliv. Rev. , vol.64 , pp. 866-884
    • Fleige, E.1    Quadir, M.A.2    Haag, R.3
  • 23
    • 35448946098 scopus 로고    scopus 로고
    • Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology
    • Forgac M. Vacuolar ATPases: rotary proton pumps in physiology and pathophysiology. Nat. Rev. Mol. Cell Biol. 2007, 8:917-929.
    • (2007) Nat. Rev. Mol. Cell Biol. , vol.8 , pp. 917-929
    • Forgac, M.1
  • 24
    • 0001221508 scopus 로고
    • On respiratory impairment in cancer cells
    • Warburg O. On respiratory impairment in cancer cells. Science 1956, 124:269-270.
    • (1956) Science , vol.124 , pp. 269-270
    • Warburg, O.1
  • 25
    • 0021732164 scopus 로고
    • The relevance of tumour pH to the treatment of malignant disease
    • Wike-Hooley J.L., Haveman J., Reinhold H.S. The relevance of tumour pH to the treatment of malignant disease. Radiother. Oncol. 1984, 2:343-366.
    • (1984) Radiother. Oncol. , vol.2 , pp. 343-366
    • Wike-Hooley, J.L.1    Haveman, J.2    Reinhold, H.S.3
  • 26
    • 0024408986 scopus 로고
    • Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review
    • Vaupel P., Kallinowski F., Okunieff P. Blood flow, oxygen and nutrient supply, and metabolic microenvironment of human tumors: a review. Cancer Res. 1989, 49:6449-6465.
    • (1989) Cancer Res. , vol.49 , pp. 6449-6465
    • Vaupel, P.1    Kallinowski, F.2    Okunieff, P.3
  • 27
    • 0022535929 scopus 로고
    • Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells
    • Denny W.A., Wilson W.R. Considerations for the design of nitrophenyl mustards as agents with selective toxicity for hypoxic tumor cells. J. Med. Chem. 1986, 29:879-887.
    • (1986) J. Med. Chem. , vol.29 , pp. 879-887
    • Denny, W.A.1    Wilson, W.R.2
  • 28
    • 0025771650 scopus 로고
    • Are cancer cells acidic?
    • Griffiths J.R. Are cancer cells acidic?. Br. J. Cancer 1991, 64:425-427.
    • (1991) Br. J. Cancer , vol.64 , pp. 425-427
    • Griffiths, J.R.1
  • 30
    • 0024286746 scopus 로고
    • Regulation of intracellular pH in eukaryotic cells
    • Madshus I.H. Regulation of intracellular pH in eukaryotic cells. Biochem. J. 1988, 250:1-8.
    • (1988) Biochem. J. , vol.250 , pp. 1-8
    • Madshus, I.H.1
  • 31
    • 25844528025 scopus 로고    scopus 로고
    • The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis
    • Cardone R.A., Casavola V., Reshkin S.J. The role of disturbed pH dynamics and the Na+/H+ exchanger in metastasis. Nat. Rev. Cancer 2005, 5:786-795.
    • (2005) Nat. Rev. Cancer , vol.5 , pp. 786-795
    • Cardone, R.A.1    Casavola, V.2    Reshkin, S.J.3
  • 32
    • 33745303045 scopus 로고    scopus 로고
    • Hypoxia signalling in cancer and approaches to enforce tumour regression
    • Pouyssegur J., Dayan F., Mazure N.M. Hypoxia signalling in cancer and approaches to enforce tumour regression. Nature 2006, 441:437-443.
    • (2006) Nature , vol.441 , pp. 437-443
    • Pouyssegur, J.1    Dayan, F.2    Mazure, N.M.3
  • 33
    • 84883182637 scopus 로고    scopus 로고
    • Disrupting proton dynamics and energy metabolism for cancer therapy
    • Parks S.K., Chiche J., Pouyssegur J. Disrupting proton dynamics and energy metabolism for cancer therapy. Nat. Rev. Cancer 2013, 13:611-623.
    • (2013) Nat. Rev. Cancer , vol.13 , pp. 611-623
    • Parks, S.K.1    Chiche, J.2    Pouyssegur, J.3
  • 34
    • 0030614893 scopus 로고    scopus 로고
    • Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation
    • Helmlinger G., Yuan F., Dellian M., Jain R.K. Interstitial pH and pO2 gradients in solid tumors in vivo: high-resolution measurements reveal a lack of correlation. Nat. Med. 1997, 3:177-182.
    • (1997) Nat. Med. , vol.3 , pp. 177-182
    • Helmlinger, G.1    Yuan, F.2    Dellian, M.3    Jain, R.K.4
  • 35
    • 84894444652 scopus 로고    scopus 로고
    • PH-sensitive polymeric micelles triggered drug release for extracellular and intracellular drug targeting delivery
    • Liu Y., Wang W., Yang J., Zhou C., Sun J. pH-sensitive polymeric micelles triggered drug release for extracellular and intracellular drug targeting delivery. Asian J. Pharm. Sci. 2013, 8:159-167.
    • (2013) Asian J. Pharm. Sci. , vol.8 , pp. 159-167
    • Liu, Y.1    Wang, W.2    Yang, J.3    Zhou, C.4    Sun, J.5
  • 36
    • 78649315943 scopus 로고    scopus 로고
    • To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery
    • Danhier F., Feron O., Préat V. To exploit the tumor microenvironment: passive and active tumor targeting of nanocarriers for anti-cancer drug delivery. J. Control. Release 2010, 148:135-146.
    • (2010) J. Control. Release , vol.148 , pp. 135-146
    • Danhier, F.1    Feron, O.2    Préat, V.3
  • 37
    • 71249135374 scopus 로고    scopus 로고
    • Nanotechnology for intracellular delivery and targeting
    • Springer, New York, M. de Villiers, P. Aramwit, G. Kwon (Eds.)
    • Torchilin V. Nanotechnology for intracellular delivery and targeting. Nanotechnology in Drug Delivery 2009, 313-346. Springer, New York. M. de Villiers, P. Aramwit, G. Kwon (Eds.).
    • (2009) Nanotechnology in Drug Delivery , pp. 313-346
    • Torchilin, V.1
  • 38
    • 66149140264 scopus 로고    scopus 로고
    • Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery
    • Onaca O., Enea R., Hughes D.W., Meier W. Stimuli-responsive polymersomes as nanocarriers for drug and gene delivery. Macromol. Biosci. 2009, 9:129-139.
    • (2009) Macromol. Biosci. , vol.9 , pp. 129-139
    • Onaca, O.1    Enea, R.2    Hughes, D.W.3    Meier, W.4
  • 40
    • 84862971080 scopus 로고    scopus 로고
    • Facile synthesis of acid-labile polymers with pendent ortho esters
    • Cheng J., Ji R., Gao S.-J., Du F.-S., Li Z.-C. Facile synthesis of acid-labile polymers with pendent ortho esters. Biomacromolecules 2012, 13:173-179.
    • (2012) Biomacromolecules , vol.13 , pp. 173-179
    • Cheng, J.1    Ji, R.2    Gao, S.-J.3    Du, F.-S.4    Li, Z.-C.5
  • 41
    • 0345357073 scopus 로고    scopus 로고
    • Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery
    • Bellocq N.C., Pun S.H., Jensen G.S., Davis M.E. Transferrin-containing, cyclodextrin polymer-based particles for tumor-targeted gene delivery. Bioconjug. Chem. 2003, 14:1122-1132.
    • (2003) Bioconjug. Chem. , vol.14 , pp. 1122-1132
    • Bellocq, N.C.1    Pun, S.H.2    Jensen, G.S.3    Davis, M.E.4
  • 42
    • 84925011782 scopus 로고    scopus 로고
    • PH-sensitive nanoparticles of poly(L-histidine)-poly(lactide-co-glycolide)-tocopheryl polyethylene glycol succinate for anti-tumor drug delivery
    • Li Z., Qiu L., Chen Q., Hao T., Qiao M., Zhao H., et al. pH-sensitive nanoparticles of poly(L-histidine)-poly(lactide-co-glycolide)-tocopheryl polyethylene glycol succinate for anti-tumor drug delivery. Acta Biomater. 2015, 11:137-150.
    • (2015) Acta Biomater. , vol.11 , pp. 137-150
    • Li, Z.1    Qiu, L.2    Chen, Q.3    Hao, T.4    Qiao, M.5    Zhao, H.6
  • 43
    • 84930179484 scopus 로고    scopus 로고
    • Enhanced pH-responsiveness, cellular trafficking, cytotoxicity and long-circulation of PEGylated liposomes with post-insertion technique using Gemcitabine as a model drug
    • Xu H., Paxton J.W., Wu Z. Enhanced pH-responsiveness, cellular trafficking, cytotoxicity and long-circulation of PEGylated liposomes with post-insertion technique using Gemcitabine as a model drug. Pharm. Res. 2015, 32:2428-2438.
    • (2015) Pharm. Res. , vol.32 , pp. 2428-2438
    • Xu, H.1    Paxton, J.W.2    Wu, Z.3
  • 44
    • 84888206128 scopus 로고    scopus 로고
    • Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor
    • Yin Q., Shen J., Zhang Z., Yu H., Li Y. Reversal of multidrug resistance by stimuli-responsive drug delivery systems for therapy of tumor. Adv. Drug Deliv. Rev. 2013, 65:1699-1715.
    • (2013) Adv. Drug Deliv. Rev. , vol.65 , pp. 1699-1715
    • Yin, Q.1    Shen, J.2    Zhang, Z.3    Yu, H.4    Li, Y.5
  • 45
    • 84901983377 scopus 로고    scopus 로고
    • PH-Sensitive nano-systems for drug delivery in cancer therapy
    • Liu J., Huang Y., Kumar A., Tan A., Jin S., Mozhi A., et al. pH-Sensitive nano-systems for drug delivery in cancer therapy. Biotechnol. Adv. 2014, 32:693-710.
    • (2014) Biotechnol. Adv. , vol.32 , pp. 693-710
    • Liu, J.1    Huang, Y.2    Kumar, A.3    Tan, A.4    Jin, S.5    Mozhi, A.6
  • 46
    • 39649120532 scopus 로고    scopus 로고
    • A review of stimuli-responsive nanocarriers for drug and gene delivery
    • Ganta S., Devalapally H., Shahiwala A., Amiji M. A review of stimuli-responsive nanocarriers for drug and gene delivery. J. Control. Release 2008, 126:187-204.
    • (2008) J. Control. Release , vol.126 , pp. 187-204
    • Ganta, S.1    Devalapally, H.2    Shahiwala, A.3    Amiji, M.4
  • 47
    • 84910090334 scopus 로고    scopus 로고
    • PEG-b-PCL copolymer micelles with the ability of pH-controlled negative-to-positive charge reversal for intracellular delivery of doxorubicin
    • Deng H., Liu J., Zhao X., Zhang Y., Liu J., Xu S., et al. PEG-b-PCL copolymer micelles with the ability of pH-controlled negative-to-positive charge reversal for intracellular delivery of doxorubicin. Biomacromolecules 2014, 15:4281-4292.
    • (2014) Biomacromolecules , vol.15 , pp. 4281-4292
    • Deng, H.1    Liu, J.2    Zhao, X.3    Zhang, Y.4    Liu, J.5    Xu, S.6
  • 48
    • 84937396579 scopus 로고    scopus 로고
    • Surface charge-reversible polyelectrolyte complex nanoparticles for hepatoma-targeting delivery of doxorubicin
    • Zhao X., Liu P., Song Q., Gong N., Yang L., Wu W.D. Surface charge-reversible polyelectrolyte complex nanoparticles for hepatoma-targeting delivery of doxorubicin. J. Mater. Chem. B 2015, 3:6185-6193.
    • (2015) J. Mater. Chem. B , vol.3 , pp. 6185-6193
    • Zhao, X.1    Liu, P.2    Song, Q.3    Gong, N.4    Yang, L.5    Wu, W.D.6
  • 49
    • 76249121949 scopus 로고    scopus 로고
    • Advances in the study of tumor pH-responsive polymeric micelles for cancer drug targeting delivery
    • Xu J.X., Tang J.B., Zhao L.H., Shen Y.Q. Advances in the study of tumor pH-responsive polymeric micelles for cancer drug targeting delivery. Yao xue xue bao = Acta Pharm. Sin. 2009, 44:1328-1335.
    • (2009) Yao xue xue bao = Acta Pharm. Sin. , vol.44 , pp. 1328-1335
    • Xu, J.X.1    Tang, J.B.2    Zhao, L.H.3    Shen, Y.Q.4
  • 50
    • 69949155656 scopus 로고    scopus 로고
    • A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo
    • Hatakeyama H., Ito E., Akita H., Oishi M., Nagasaki Y., Futaki S., et al. A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. J. Control. Release 2009, 139:127-132.
    • (2009) J. Control. Release , vol.139 , pp. 127-132
    • Hatakeyama, H.1    Ito, E.2    Akita, H.3    Oishi, M.4    Nagasaki, Y.5    Futaki, S.6
  • 51
    • 33846493607 scopus 로고    scopus 로고
    • Pegylation of liposomes favours the endosomal degradation of the delivered phosphodiester oligonucleotides
    • Remaut K., Lucas B., Braeckmans K., Demeester J., De Smedt S.C. Pegylation of liposomes favours the endosomal degradation of the delivered phosphodiester oligonucleotides. J. Control. Release 2007, 117:256-266.
    • (2007) J. Control. Release , vol.117 , pp. 256-266
    • Remaut, K.1    Lucas, B.2    Braeckmans, K.3    Demeester, J.4    De Smedt, S.C.5
  • 52
    • 84916886749 scopus 로고    scopus 로고
    • Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior
    • Li Y., Liu R., Yang J., Shi Y., Ma G., Zhang Z., et al. Enhanced retention and anti-tumor efficacy of liposomes by changing their cellular uptake and pharmacokinetics behavior. Biomaterials 2015, 41:1-14.
    • (2015) Biomaterials , vol.41 , pp. 1-14
    • Li, Y.1    Liu, R.2    Yang, J.3    Shi, Y.4    Ma, G.5    Zhang, Z.6
  • 53
    • 84878836924 scopus 로고    scopus 로고
    • The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors
    • Hatakeyama H., Akita H., Harashima H. The polyethyleneglycol dilemma: advantage and disadvantage of PEGylation of liposomes for systemic genes and nucleic acids delivery to tumors. Biol. Pharm. Bull. 2013, 36:892-899.
    • (2013) Biol. Pharm. Bull. , vol.36 , pp. 892-899
    • Hatakeyama, H.1    Akita, H.2    Harashima, H.3
  • 54
    • 84864696659 scopus 로고    scopus 로고
    • Nanotechnology applied to overcome tumor drug resistance
    • Gao Z., Zhang L., Sun Y. Nanotechnology applied to overcome tumor drug resistance. J. Control. Release 2012, 162:45-55.
    • (2012) J. Control. Release , vol.162 , pp. 45-55
    • Gao, Z.1    Zhang, L.2    Sun, Y.3
  • 56
    • 84875673769 scopus 로고    scopus 로고
    • Accelerated drug release and clearance of PEGylated epirubicin liposomes following repeated injections: a new challenge for sequential low-dose chemotherapy
    • Yang Q., Ma Y., Zhao Y., She Z., Wang L., Li J., et al. Accelerated drug release and clearance of PEGylated epirubicin liposomes following repeated injections: a new challenge for sequential low-dose chemotherapy. Int. J. Nanomedicine 2013, 8:1257-1268.
    • (2013) Int. J. Nanomedicine , vol.8 , pp. 1257-1268
    • Yang, Q.1    Ma, Y.2    Zhao, Y.3    She, Z.4    Wang, L.5    Li, J.6
  • 57
    • 40849138014 scopus 로고    scopus 로고
    • Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes
    • Ishida T., Kiwada H. Accelerated blood clearance (ABC) phenomenon upon repeated injection of PEGylated liposomes. Int. J. Pharm. 2008, 354:56-62.
    • (2008) Int. J. Pharm. , vol.354 , pp. 56-62
    • Ishida, T.1    Kiwada, H.2
  • 58
    • 77949272712 scopus 로고    scopus 로고
    • Accelerated blood clearance was not Induced for a gadolinium-containing PEG-poly(L-lysine)-based polymeric micelle in mice
    • Ma H., Shiraishi K., Minowa T., Kawano K., Yokoyama M., Hattori Y., et al. Accelerated blood clearance was not Induced for a gadolinium-containing PEG-poly(L-lysine)-based polymeric micelle in mice. Pharm. Res. 2010, 27:296-302.
    • (2010) Pharm. Res. , vol.27 , pp. 296-302
    • Ma, H.1    Shiraishi, K.2    Minowa, T.3    Kawano, K.4    Yokoyama, M.5    Hattori, Y.6
  • 60
    • 33748478337 scopus 로고    scopus 로고
    • Activation of the human complement system by cholesterol-rich and PEGylated liposomes-modulation of cholesterol-rich liposome-mediated complement activation by elevated serum LDL and HDL levels
    • Moein Moghimi S., Hamad I., Bunger R., Andresen T.L., Jorgensen K., Hunter A.C., et al. Activation of the human complement system by cholesterol-rich and PEGylated liposomes-modulation of cholesterol-rich liposome-mediated complement activation by elevated serum LDL and HDL levels. J. Liposome Res. 2006, 16:167-174.
    • (2006) J. Liposome Res. , vol.16 , pp. 167-174
    • Moein Moghimi, S.1    Hamad, I.2    Bunger, R.3    Andresen, T.L.4    Jorgensen, K.5    Hunter, A.C.6
  • 61
    • 0141927263 scopus 로고    scopus 로고
    • Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties
    • Moghimi S.M., Szebeni J. Stealth liposomes and long circulating nanoparticles: critical issues in pharmacokinetics, opsonization and protein-binding properties. Prog. Lipid Res. 2003, 42:463-478.
    • (2003) Prog. Lipid Res. , vol.42 , pp. 463-478
    • Moghimi, S.M.1    Szebeni, J.2
  • 62
    • 0037067136 scopus 로고    scopus 로고
    • Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers
    • Moghimi S.M. Chemical camouflage of nanospheres with a poorly reactive surface: towards development of stealth and target-specific nanocarriers. BBA - Mol. Cell Res. 2002, 1590:131-139.
    • (2002) BBA - Mol. Cell Res. , vol.1590 , pp. 131-139
    • Moghimi, S.M.1
  • 63
    • 33845639957 scopus 로고    scopus 로고
    • Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production
    • Moghimi S.M., Hamad I., Andresen T.L., Jorgensen K., Szebeni J. Methylation of the phosphate oxygen moiety of phospholipid-methoxy(polyethylene glycol) conjugate prevents PEGylated liposome-mediated complement activation and anaphylatoxin production. FASEB J. 2006, 20:2591-2593.
    • (2006) FASEB J. , vol.20 , pp. 2591-2593
    • Moghimi, S.M.1    Hamad, I.2    Andresen, T.L.3    Jorgensen, K.4    Szebeni, J.5
  • 64
    • 78649538085 scopus 로고    scopus 로고
    • Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering
    • Hamad I., Al-Hanbali O., Hunter A.C., Rutt K.J., Andresen T.L., Moghimi S.M. Distinct polymer architecture mediates switching of complement activation pathways at the nanosphere-serum interface: implications for stealth nanoparticle engineering. ACS Nano 2010, 4:6629-6638.
    • (2010) ACS Nano , vol.4 , pp. 6629-6638
    • Hamad, I.1    Al-Hanbali, O.2    Hunter, A.C.3    Rutt, K.J.4    Andresen, T.L.5    Moghimi, S.M.6
  • 66
    • 84865761047 scopus 로고    scopus 로고
    • Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system
    • Jager E., Jager A., Etrych T., Giacomelli F.C., Chytil P., Jigounov A., et al. Self-assembly of biodegradable copolyester and reactive HPMA-based polymers into nanoparticles as an alternative stealth drug delivery system. Soft Matter 2012, 8:9563-9575.
    • (2012) Soft Matter , vol.8 , pp. 9563-9575
    • Jager, E.1    Jager, A.2    Etrych, T.3    Giacomelli, F.C.4    Chytil, P.5    Jigounov, A.6
  • 68
    • 84903221307 scopus 로고    scopus 로고
    • 3-pH-responsive polymers: properties, synthesis and applications
    • Woodhead Publishing, M.R. Aguilar, J.S. Román (Eds.)
    • Reyes-Ortega F. 3-pH-responsive polymers: properties, synthesis and applications. Smart Polymers and Their Applications 2014, 45-92. Woodhead Publishing. M.R. Aguilar, J.S. Román (Eds.).
    • (2014) Smart Polymers and Their Applications , pp. 45-92
    • Reyes-Ortega, F.1
  • 69
    • 0035500592 scopus 로고    scopus 로고
    • On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes
    • Simões S., Slepushkin V., Düzgünes N., Pedroso de Lima M.C. On the mechanisms of internalization and intracellular delivery mediated by pH-sensitive liposomes. BBA Biomembr. 2001, 1515:23-37.
    • (2001) BBA Biomembr. , vol.1515 , pp. 23-37
    • Simões, S.1    Slepushkin, V.2    Düzgünes, N.3    Pedroso de Lima, M.C.4
  • 70
    • 84896875667 scopus 로고    scopus 로고
    • Multifunctional pH-sensitive polymeric nanoparticles for theranostics evaluated experimentally in cancer
    • Liu Y., Feng L., Liu T., Zhang L., Yao Y., Yu D., et al. Multifunctional pH-sensitive polymeric nanoparticles for theranostics evaluated experimentally in cancer. Nanoscale 2014, 6:3231-3242.
    • (2014) Nanoscale , vol.6 , pp. 3231-3242
    • Liu, Y.1    Feng, L.2    Liu, T.3    Zhang, L.4    Yao, Y.5    Yu, D.6
  • 71
    • 84944128466 scopus 로고    scopus 로고
    • Acid-disintegratable polymersomes of pH-responsive amphiphilic Diblock copolymers for intracellular drug delivery
    • Wang L., Liu G., Wang X., Hu J., Zhang G., Liu S. Acid-disintegratable polymersomes of pH-responsive amphiphilic Diblock copolymers for intracellular drug delivery. Macromole 2015, 48:7262-7272.
    • (2015) Macromole , vol.48 , pp. 7262-7272
    • Wang, L.1    Liu, G.2    Wang, X.3    Hu, J.4    Zhang, G.5    Liu, S.6
  • 72
    • 0035907178 scopus 로고    scopus 로고
    • New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties
    • Etrych T., Jelinkova M., Rihova B., Ulbrich K. New HPMA copolymers containing doxorubicin bound via pH-sensitive linkage: synthesis and preliminary in vitro and in vivo biological properties. J. Control. Release 2001, 73:89-102.
    • (2001) J. Control. Release , vol.73 , pp. 89-102
    • Etrych, T.1    Jelinkova, M.2    Rihova, B.3    Ulbrich, K.4
  • 73
    • 84896705839 scopus 로고    scopus 로고
    • Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide
    • Fei L., Yap L.-P., Conti P.S., Shen W.-C., Zaro J.L. Tumor targeting of a cell penetrating peptide by fusing with a pH-sensitive histidine-glutamate co-oligopeptide. Biomaterials 2014, 35:4082-4087.
    • (2014) Biomaterials , vol.35 , pp. 4082-4087
    • Fei, L.1    Yap, L.-P.2    Conti, P.S.3    Shen, W.-C.4    Zaro, J.L.5
  • 74
    • 84870020025 scopus 로고    scopus 로고
    • Poly(acrylic acid)-modified Fe3O4 microspheres for magnetic-targeted and pH-triggered anticancer drug delivery
    • Kang X.-J., Dai Y.-L., Ma P.-A., Yang D.-M., Li C.-X., Hou Z.-Y., et al. Poly(acrylic acid)-modified Fe3O4 microspheres for magnetic-targeted and pH-triggered anticancer drug delivery. Chem. Eur. J. 2012, 18:15676-15682.
    • (2012) Chem. Eur. J. , vol.18 , pp. 15676-15682
    • Kang, X.-J.1    Dai, Y.-L.2    Ma, P.-A.3    Yang, D.-M.4    Li, C.-X.5    Hou, Z.-Y.6
  • 75
    • 84859124346 scopus 로고    scopus 로고
    • Tumor accumulation, penetration, and antitumor response of cisplatin-loaded gelatin/poly(acrylic acid) nanoparticles
    • Ding D., Wang J., Zhu Z., Li R., Wu W., Liu B., et al. Tumor accumulation, penetration, and antitumor response of cisplatin-loaded gelatin/poly(acrylic acid) nanoparticles. ACS Appl. Mater. Interfaces 2012, 4:1838-1846.
    • (2012) ACS Appl. Mater. Interfaces , vol.4 , pp. 1838-1846
    • Ding, D.1    Wang, J.2    Zhu, Z.3    Li, R.4    Wu, W.5    Liu, B.6
  • 76
    • 23844454077 scopus 로고    scopus 로고
    • Cisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles
    • Yan X., Gemeinhart R.A. Cisplatin delivery from poly(acrylic acid-co-methyl methacrylate) microparticles. J. Control. Release 2005, 106:198-208.
    • (2005) J. Control. Release , vol.106 , pp. 198-208
    • Yan, X.1    Gemeinhart, R.A.2
  • 77
    • 84912565276 scopus 로고    scopus 로고
    • PH-sensitive stearoyl-PEG-poly(methacryloyl sulfadimethoxine) decorated liposomes for the delivery of gemcitabine to cancer cells
    • Bersani S., Vila-Caballer M., Brazzale C., Barattin M., Salmaso S. pH-sensitive stearoyl-PEG-poly(methacryloyl sulfadimethoxine) decorated liposomes for the delivery of gemcitabine to cancer cells. Eur. J. Pharm. Biopharm. 2014, 88:670-682.
    • (2014) Eur. J. Pharm. Biopharm. , vol.88 , pp. 670-682
    • Bersani, S.1    Vila-Caballer, M.2    Brazzale, C.3    Barattin, M.4    Salmaso, S.5
  • 78
    • 33751520245 scopus 로고    scopus 로고
    • Thermo- and pH-responsive polymers in drug delivery
    • Schmaljohann D. Thermo- and pH-responsive polymers in drug delivery. Adv. Drug Deliv. Rev. 2006, 58:1655-1670.
    • (2006) Adv. Drug Deliv. Rev. , vol.58 , pp. 1655-1670
    • Schmaljohann, D.1
  • 79
    • 84870508808 scopus 로고    scopus 로고
    • PH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells
    • Shalviri A., Raval G., Prasad P., Chan C., Liu Q., Heerklotz H., et al. pH-Dependent doxorubicin release from terpolymer of starch, polymethacrylic acid and polysorbate 80 nanoparticles for overcoming multi-drug resistance in human breast cancer cells. Eur. J. Pharm. Biopharm. 2012, 82:587-597.
    • (2012) Eur. J. Pharm. Biopharm. , vol.82 , pp. 587-597
    • Shalviri, A.1    Raval, G.2    Prasad, P.3    Chan, C.4    Liu, Q.5    Heerklotz, H.6
  • 80
    • 20944450473 scopus 로고    scopus 로고
    • NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel
    • Hamaguchi T., Matsumura Y., Suzuki M., Shimizu K., Goda R., Nakamura I., et al. NK105, a paclitaxel-incorporating micellar nanoparticle formulation, can extend in vivo antitumour activity and reduce the neurotoxicity of paclitaxel. Br. J. Cancer 2005, 92:1240-1246.
    • (2005) Br. J. Cancer , vol.92 , pp. 1240-1246
    • Hamaguchi, T.1    Matsumura, Y.2    Suzuki, M.3    Shimizu, K.4    Goda, R.5    Nakamura, I.6
  • 81
    • 84866735036 scopus 로고    scopus 로고
    • Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer
    • Kato K., Chin K., Yoshikawa T., Yamaguchi K., Tsuji Y., Esaki T., et al. Phase II study of NK105, a paclitaxel-incorporating micellar nanoparticle, for previously treated advanced or recurrent gastric cancer. Investig. New Drugs 2012, 30:1621-1627.
    • (2012) Investig. New Drugs , vol.30 , pp. 1621-1627
    • Kato, K.1    Chin, K.2    Yoshikawa, T.3    Yamaguchi, K.4    Tsuji, Y.5    Esaki, T.6
  • 82
    • 84901745389 scopus 로고    scopus 로고
    • The drug discovery by nanomedicine and its clinical experience
    • Matsumura Y. The drug discovery by nanomedicine and its clinical experience. Jpn. J. Clin. Oncol. 2014, 44:515-525.
    • (2014) Jpn. J. Clin. Oncol. , vol.44 , pp. 515-525
    • Matsumura, Y.1
  • 83
    • 22644450148 scopus 로고    scopus 로고
    • Novel pH-sensitive polymers containing sulfonamide groups
    • Park S.Y., Bae Y.H. Novel pH-sensitive polymers containing sulfonamide groups. Macromol. Rapid Commun. 1999, 20:269-273.
    • (1999) Macromol. Rapid Commun. , vol.20 , pp. 269-273
    • Park, S.Y.1    Bae, Y.H.2
  • 84
    • 40549135373 scopus 로고    scopus 로고
    • A biodegradable pH-sensitive micelle system for targeting acidic solid tumors
    • Sethuraman V.A., Lee M.C., Bae Y.H. A biodegradable pH-sensitive micelle system for targeting acidic solid tumors. Pharm. Res. 2008, 25:657-666.
    • (2008) Pharm. Res. , vol.25 , pp. 657-666
    • Sethuraman, V.A.1    Lee, M.C.2    Bae, Y.H.3
  • 87
    • 26444536288 scopus 로고    scopus 로고
    • Application of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes for gene transfer into human ovarian carcinoma cells
    • Verbaan F.J., Klouwenberg P.K., Steenis J.H.v., Snel C.J., Boerman O., Hennink W.E., et al. Application of poly(2-(dimethylamino)ethyl methacrylate)-based polyplexes for gene transfer into human ovarian carcinoma cells. Int. J. Pharm. 2005, 304:185-192.
    • (2005) Int. J. Pharm. , vol.304 , pp. 185-192
    • Verbaan, F.J.1    Klouwenberg, P.K.2    Steenis, J.3    Snel, C.J.4    Boerman, O.5    Hennink, W.E.6
  • 88
    • 78349301671 scopus 로고    scopus 로고
    • N-Boc-histidine-capped PLGA-PEG-PLGA as a smart polymer for drug delivery sensitive to tumor extracellular pH
    • Chang G., Li C., Lu W., Ding J. N-Boc-histidine-capped PLGA-PEG-PLGA as a smart polymer for drug delivery sensitive to tumor extracellular pH. Macromol. Biosci. 2010, 10:1248-1256.
    • (2010) Macromol. Biosci. , vol.10 , pp. 1248-1256
    • Chang, G.1    Li, C.2    Lu, W.3    Ding, J.4
  • 89
    • 34648846523 scopus 로고    scopus 로고
    • Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug Release and in vitro cytotoxicity against MCF-cells
    • Na K., Lee E.S., Bae Y.H. Self-organized nanogels responding to tumor extracellular pH: pH-dependent drug Release and in vitro cytotoxicity against MCF-cells. Bioconjug. Chem. 2007, 18:1568-1574.
    • (2007) Bioconjug. Chem. , vol.18 , pp. 1568-1574
    • Na, K.1    Lee, E.S.2    Bae, Y.H.3
  • 90
    • 84877764025 scopus 로고    scopus 로고
    • Dual stimuli-responsive poly(N-isopropylacrylamide)-b-poly(l-histidine) chimeric materials for the controlled delivery of doxorubicin into liver carcinoma
    • Johnson R.P., Jeong Y.I., John J.V., Chung C.-W., Kang D.H., Selvaraj M., et al. Dual stimuli-responsive poly(N-isopropylacrylamide)-b-poly(l-histidine) chimeric materials for the controlled delivery of doxorubicin into liver carcinoma. Biomacromolecules 2013, 14:1434-1443.
    • (2013) Biomacromolecules , vol.14 , pp. 1434-1443
    • Johnson, R.P.1    Jeong, Y.I.2    John, J.V.3    Chung, C.-W.4    Kang, D.H.5    Selvaraj, M.6
  • 91
    • 84895068665 scopus 로고    scopus 로고
    • Thermo- and pH-responsive copolymers based on PLGA-PEG-PLGA and poly(L-histidine): synthesis and in vitro characterization of copolymer micelles
    • Hong W., Chen D., Jia L., Gu J., Hu H., Zhao X., et al. Thermo- and pH-responsive copolymers based on PLGA-PEG-PLGA and poly(L-histidine): synthesis and in vitro characterization of copolymer micelles. Acta Biomater. 2014, 10:1259-1271.
    • (2014) Acta Biomater. , vol.10 , pp. 1259-1271
    • Hong, W.1    Chen, D.2    Jia, L.3    Gu, J.4    Hu, H.5    Zhao, X.6
  • 92
    • 0038106270 scopus 로고    scopus 로고
    • Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization
    • Lee E.S., Shin H.J., Na K., Bae Y.H. Poly(L-histidine)-PEG block copolymer micelles and pH-induced destabilization. J. Control. Release 2003, 90:363-374.
    • (2003) J. Control. Release , vol.90 , pp. 363-374
    • Lee, E.S.1    Shin, H.J.2    Na, K.3    Bae, Y.H.4
  • 93
    • 0021200295 scopus 로고
    • Polyhistidine mediates an acid-dependent fusion of negatively charged liposomes
    • Wang C.Y., Huang L. Polyhistidine mediates an acid-dependent fusion of negatively charged liposomes. Biochemistry 1984, 23:4409-4416.
    • (1984) Biochemistry , vol.23 , pp. 4409-4416
    • Wang, C.Y.1    Huang, L.2
  • 94
    • 33746584827 scopus 로고    scopus 로고
    • Histidine-conjugated poly(amino acid) derivatives for the novel endosomolytic delivery carrier of doxorubicin
    • Yang S.R., Lee H.J., Kim J.-D. Histidine-conjugated poly(amino acid) derivatives for the novel endosomolytic delivery carrier of doxorubicin. J. Control. Release 2006, 114:60-68.
    • (2006) J. Control. Release , vol.114 , pp. 60-68
    • Yang, S.R.1    Lee, H.J.2    Kim, J.-D.3
  • 95
    • 84883506356 scopus 로고    scopus 로고
    • PH-responsive and charge shielded cationic micelle of poly(l-histidine)-block-short branched PEI for acidic cancer treatment
    • Hu J., Miura S., Na K., Bae Y.H. pH-responsive and charge shielded cationic micelle of poly(l-histidine)-block-short branched PEI for acidic cancer treatment. J. Control. Release 2013, 172:69-76.
    • (2013) J. Control. Release , vol.172 , pp. 69-76
    • Hu, J.1    Miura, S.2    Na, K.3    Bae, Y.H.4
  • 96
    • 39049105552 scopus 로고    scopus 로고
    • Physicochemical characteristics of pH-sensitive poly(l-Histidine)-b-poly(ethylene glycol)/poly(l-Lactide)-b-poly(ethylene glycol) mixed micelles
    • Yin H., Lee E.S., Kim D., Lee K.H., Oh K.T., Bae Y.H. Physicochemical characteristics of pH-sensitive poly(l-Histidine)-b-poly(ethylene glycol)/poly(l-Lactide)-b-poly(ethylene glycol) mixed micelles. J. Control. Release 2008, 126:130-138.
    • (2008) J. Control. Release , vol.126 , pp. 130-138
    • Yin, H.1    Lee, E.S.2    Kim, D.3    Lee, K.H.4    Oh, K.T.5    Bae, Y.H.6
  • 97
    • 0030589158 scopus 로고    scopus 로고
    • Towards membrane protein design: pH-sensitive topology of histidine-containing polypeptides
    • Bechinger B. Towards membrane protein design: pH-sensitive topology of histidine-containing polypeptides. J. Mol. Biol. 1996, 263:768-775.
    • (1996) J. Mol. Biol. , vol.263 , pp. 768-775
    • Bechinger, B.1
  • 98
    • 84887598236 scopus 로고    scopus 로고
    • Polymer-liposome complexes with a functional hydrogen-bond cross-linker for preventing protein adsorption and improving tumor accumulation
    • Chiang Y.-T., Cheng Y.-T., Lu C.-Y., Yen Y.-W., Yu L.-Y., Yu K.-S., et al. Polymer-liposome complexes with a functional hydrogen-bond cross-linker for preventing protein adsorption and improving tumor accumulation. Chem. Mater. 2013, 25:4364-4372.
    • (2013) Chem. Mater. , vol.25 , pp. 4364-4372
    • Chiang, Y.-T.1    Cheng, Y.-T.2    Lu, C.-Y.3    Yen, Y.-W.4    Yu, L.-Y.5    Yu, K.-S.6
  • 99
    • 84899489899 scopus 로고    scopus 로고
    • PH-Responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy
    • Chiang Y.T., Lo C.L. pH-Responsive polymer-liposomes for intracellular drug delivery and tumor extracellular matrix switched-on targeted cancer therapy. Biomaterials 2014, 35:5414-5424.
    • (2014) Biomaterials , vol.35 , pp. 5414-5424
    • Chiang, Y.T.1    Lo, C.L.2
  • 100
    • 27144542045 scopus 로고    scopus 로고
    • Poly(ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations
    • Shenoy D., Little S., Langer R., Amiji M. Poly(ethylene oxide)-modified poly(β-amino ester) nanoparticles as a pH-sensitive system for tumor-targeted delivery of hydrophobic drugs. 1. In vitro evaluations. Mol. Pharm. 2005, 2:357-366.
    • (2005) Mol. Pharm. , vol.2 , pp. 357-366
    • Shenoy, D.1    Little, S.2    Langer, R.3    Amiji, M.4
  • 101
    • 77952669604 scopus 로고    scopus 로고
    • Tumoral acidic pH-responsive MPEG-poly(beta-amino ester) polymeric micelles for cancer targeting therapy
    • Min K.H., Kim J.H., Bae S.M., Shin H., Kim M.S., Park S., et al. Tumoral acidic pH-responsive MPEG-poly(beta-amino ester) polymeric micelles for cancer targeting therapy. J. Control. Release 2010, 144:259-266.
    • (2010) J. Control. Release , vol.144 , pp. 259-266
    • Min, K.H.1    Kim, J.H.2    Bae, S.M.3    Shin, H.4    Kim, M.S.5    Park, S.6
  • 102
    • 79960035017 scopus 로고    scopus 로고
    • Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems
    • Kim J., Oh Y., Lee K., Yun J., Park B., Oh K. Development of a pH-sensitive polymer using poly(aspartic acid-graft-imidazole)-block-poly(ethylene glycol) for acidic pH targeting systems. Macromol. Res. 2011, 19:453-460.
    • (2011) Macromol. Res. , vol.19 , pp. 453-460
    • Kim, J.1    Oh, Y.2    Lee, K.3    Yun, J.4    Park, B.5    Oh, K.6
  • 103
    • 66949179981 scopus 로고    scopus 로고
    • Thermo- and pH-sensitive comb-type grafted poly(N,N-diethylacrylamide-co-acrylic acid) hydrogels with rapid response behaviors
    • Liu H., Liu M., Ma L., Chen J. Thermo- and pH-sensitive comb-type grafted poly(N,N-diethylacrylamide-co-acrylic acid) hydrogels with rapid response behaviors. Eur. Polym. J. 2009, 45:2060-2067.
    • (2009) Eur. Polym. J. , vol.45 , pp. 2060-2067
    • Liu, H.1    Liu, M.2    Ma, L.3    Chen, J.4
  • 104
    • 77954387273 scopus 로고    scopus 로고
    • Degradable, pH-sensitive, membrane-destabilizing, comb-like polymers for intracellular delivery of nucleic acids
    • Lin Y.-L., Jiang G., Birrell L.K., El-Sayed M.E.H. Degradable, pH-sensitive, membrane-destabilizing, comb-like polymers for intracellular delivery of nucleic acids. Biomaterials 2010, 31:7150-7166.
    • (2010) Biomaterials , vol.31 , pp. 7150-7166
    • Lin, Y.-L.1    Jiang, G.2    Birrell, L.K.3    El-Sayed, M.E.H.4
  • 105
    • 84885395495 scopus 로고    scopus 로고
    • KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release
    • Xu Q., Huang W., Jiang L., Lei Z., Li X., Deng H. KGM and PMAA based pH-sensitive interpenetrating polymer network hydrogel for controlled drug release. Carbohydr. Polym. 2013, 97:565-570.
    • (2013) Carbohydr. Polym. , vol.97 , pp. 565-570
    • Xu, Q.1    Huang, W.2    Jiang, L.3    Lei, Z.4    Li, X.5    Deng, H.6
  • 106
    • 84873432793 scopus 로고    scopus 로고
    • A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy
    • Yuba E., Harada A., Sakanishi Y., Watarai S., Kono K. A liposome-based antigen delivery system using pH-sensitive fusogenic polymers for cancer immunotherapy. Biomaterials 2013, 34:3042-3052.
    • (2013) Biomaterials , vol.34 , pp. 3042-3052
    • Yuba, E.1    Harada, A.2    Sakanishi, Y.3    Watarai, S.4    Kono, K.5
  • 107
    • 44349138168 scopus 로고    scopus 로고
    • Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: their ability to sensitize stable liposomes to pH
    • Sakaguchi N., Kojima C., Harada A., Kono K. Preparation of pH-sensitive poly(glycidol) derivatives with varying hydrophobicities: their ability to sensitize stable liposomes to pH. Bioconjug. Chem. 2008, 19:1040-1048.
    • (2008) Bioconjug. Chem. , vol.19 , pp. 1040-1048
    • Sakaguchi, N.1    Kojima, C.2    Harada, A.3    Kono, K.4
  • 108
    • 33645522290 scopus 로고    scopus 로고
    • PH-Responsive PEG-Poly(β-amino ester) block copolymer micelles with a sharp transition
    • Kim M.S., Hwang S.J., Han J.K., Choi E.K., Park H.J., Kim J.S., et al. pH-Responsive PEG-Poly(β-amino ester) block copolymer micelles with a sharp transition. Macromol. Rapid Commun. 2006, 27:447-451.
    • (2006) Macromol. Rapid Commun. , vol.27 , pp. 447-451
    • Kim, M.S.1    Hwang, S.J.2    Han, J.K.3    Choi, E.K.4    Park, H.J.5    Kim, J.S.6
  • 109
    • 0034906068 scopus 로고    scopus 로고
    • Polymeric microspheres composed of pH/temperature-sensitive polymer complex
    • Kim E.J., Cho S.H., Yuk S.H. Polymeric microspheres composed of pH/temperature-sensitive polymer complex. Biomaterials 2001, 22:2495-2499.
    • (2001) Biomaterials , vol.22 , pp. 2495-2499
    • Kim, E.J.1    Cho, S.H.2    Yuk, S.H.3
  • 110
    • 84907534892 scopus 로고    scopus 로고
    • Synthesis and characterization of monodispersed P(St-co-DMAEMA) nanoparticles as pH-sensitive drug delivery system
    • Hu Y., Wang J., Zhang H., Jiang G., Kan C. Synthesis and characterization of monodispersed P(St-co-DMAEMA) nanoparticles as pH-sensitive drug delivery system. Mater. Sci. Eng. 2014, 45:1-7.
    • (2014) Mater. Sci. Eng. , vol.45 , pp. 1-7
    • Hu, Y.1    Wang, J.2    Zhang, H.3    Jiang, G.4    Kan, C.5
  • 111
    • 80051786334 scopus 로고    scopus 로고
    • Drug release behaviors of a pH sensitive semi-interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and star poly[2-(dimethylamino)ethyl methacrylate]
    • Wu W., Liu J., Cao S., Tan H., Li J., Xu F., et al. Drug release behaviors of a pH sensitive semi-interpenetrating polymer network hydrogel composed of poly(vinyl alcohol) and star poly[2-(dimethylamino)ethyl methacrylate]. Int. J. Pharm. 2011, 416:104-109.
    • (2011) Int. J. Pharm. , vol.416 , pp. 104-109
    • Wu, W.1    Liu, J.2    Cao, S.3    Tan, H.4    Li, J.5    Xu, F.6
  • 112
    • 84930433440 scopus 로고    scopus 로고
    • A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery
    • Paliwal S.R., Paliwal R., Vyas S.P. A review of mechanistic insight and application of pH-sensitive liposomes in drug delivery. Drug Deliv. 2015, 22:231-242.
    • (2015) Drug Deliv. , vol.22 , pp. 231-242
    • Paliwal, S.R.1    Paliwal, R.2    Vyas, S.P.3
  • 113
    • 0036162267 scopus 로고    scopus 로고
    • PH-sensitive, serum-stable and long-circulating liposomes as a new drug delivery system
    • Hong M.S., Lim S.J., Oh Y.K., Kim C.K. pH-sensitive, serum-stable and long-circulating liposomes as a new drug delivery system. J. Pharm. Pharmacol. 2002, 54:51-58.
    • (2002) J. Pharm. Pharmacol. , vol.54 , pp. 51-58
    • Hong, M.S.1    Lim, S.J.2    Oh, Y.K.3    Kim, C.K.4
  • 114
    • 0018797519 scopus 로고
    • Lipid polymorphism and the functional roles of lipids in biological membranes
    • Cullis P.R., de Kruijff B. Lipid polymorphism and the functional roles of lipids in biological membranes. Biochim. Biophys. Acta 1979, 559:399-420.
    • (1979) Biochim. Biophys. Acta , vol.559 , pp. 399-420
    • Cullis, P.R.1    de Kruijff, B.2
  • 115
    • 0020724194 scopus 로고
    • Calorimetric studies of the gel-fluid (beta-alpha) and lamellar-inverted hexagonal (alpha-HII) phase transitions in dialkyl- and diacylphosphatidylethanolamines
    • Seddon J.M., Cevc G., Marsh D. Calorimetric studies of the gel-fluid (beta-alpha) and lamellar-inverted hexagonal (alpha-HII) phase transitions in dialkyl- and diacylphosphatidylethanolamines. Biochemistry 1983, 22:1280-1289.
    • (1983) Biochemistry , vol.22 , pp. 1280-1289
    • Seddon, J.M.1    Cevc, G.2    Marsh, D.3
  • 116
    • 84865472739 scopus 로고    scopus 로고
    • Membrane lipid composition regulates tubulin interaction with mitochondrial voltage-dependent anion channel
    • Rostovtseva T.K., Gurnev P.A., Chen M.Y., Bezrukov S.M. Membrane lipid composition regulates tubulin interaction with mitochondrial voltage-dependent anion channel. J. Biol. Chem. 2012, 287:29589-29598.
    • (2012) J. Biol. Chem. , vol.287 , pp. 29589-29598
    • Rostovtseva, T.K.1    Gurnev, P.A.2    Chen, M.Y.3    Bezrukov, S.M.4
  • 118
    • 0021988229 scopus 로고
    • Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes
    • Lai M.Z., Duzgunes N., Szoka F.C. Effects of replacement of the hydroxyl group of cholesterol and tocopherol on the thermotropic behavior of phospholipid membranes. Biochemistry 1985, 24:1646-1653.
    • (1985) Biochemistry , vol.24 , pp. 1646-1653
    • Lai, M.Z.1    Duzgunes, N.2    Szoka, F.C.3
  • 119
    • 0031800381 scopus 로고    scopus 로고
    • Novel applications of liposomes
    • Lasic D.D. Novel applications of liposomes. Trends Biotechnol. 1998, 16:307-321.
    • (1998) Trends Biotechnol. , vol.16 , pp. 307-321
    • Lasic, D.D.1
  • 120
    • 84870362208 scopus 로고    scopus 로고
    • Encapsulation of cisplatin in long-circulating and pH-sensitive liposomes improves its antitumor effect and reduces acute toxicity
    • Leite E.A., Souza C.M., Carvalho-Junior A.D., Coelho L.G., Lana A.M., Cassali G.D., et al. Encapsulation of cisplatin in long-circulating and pH-sensitive liposomes improves its antitumor effect and reduces acute toxicity. Int. J. Nanomedicine 2012, 7:5259-5269.
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 5259-5269
    • Leite, E.A.1    Souza, C.M.2    Carvalho-Junior, A.D.3    Coelho, L.G.4    Lana, A.M.5    Cassali, G.D.6
  • 121
    • 84855739069 scopus 로고    scopus 로고
    • Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy
    • Zhang C., Wang W., Liu T., Wu Y., Guo H., Wang P., et al. Doxorubicin-loaded glycyrrhetinic acid-modified alginate nanoparticles for liver tumor chemotherapy. Biomaterials 2012, 33:2187-2196.
    • (2012) Biomaterials , vol.33 , pp. 2187-2196
    • Zhang, C.1    Wang, W.2    Liu, T.3    Wu, Y.4    Guo, H.5    Wang, P.6
  • 122
    • 84900832470 scopus 로고    scopus 로고
    • A robust pH-sensitive drug carrier: aqueous micelles mineralized by calcium phosphate based on chitosan
    • Lv Y., Huang H., Yang B., Liu H., Li Y., Wang J. A robust pH-sensitive drug carrier: aqueous micelles mineralized by calcium phosphate based on chitosan. Carbohydr. Polym. 2014, 111:101-107.
    • (2014) Carbohydr. Polym. , vol.111 , pp. 101-107
    • Lv, Y.1    Huang, H.2    Yang, B.3    Liu, H.4    Li, Y.5    Wang, J.6
  • 123
    • 77953476310 scopus 로고    scopus 로고
    • Preparation and pharmacodynamics of stearic acid and poly (lactic-co-glycolic acid) grafted chitosan oligosaccharide micelles for 10-hydroxycamptothecin
    • Zhou Y.Y., Du Y.Z., Wang L., Yuan H., Zhou J.P., Hu F.Q. Preparation and pharmacodynamics of stearic acid and poly (lactic-co-glycolic acid) grafted chitosan oligosaccharide micelles for 10-hydroxycamptothecin. Int. J. Pharm. 2010, 393:143-151.
    • (2010) Int. J. Pharm. , vol.393 , pp. 143-151
    • Zhou, Y.Y.1    Du, Y.Z.2    Wang, L.3    Yuan, H.4    Zhou, J.P.5    Hu, F.Q.6
  • 124
    • 79953050650 scopus 로고    scopus 로고
    • In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel
    • Liu J., Li H., Chen D., Jin X., Zhao X., Zhang C., et al. In vivo evaluation of novel chitosan graft polymeric micelles for delivery of paclitaxel. Drug Deliv. 2011, 18:181-189.
    • (2011) Drug Deliv. , vol.18 , pp. 181-189
    • Liu, J.1    Li, H.2    Chen, D.3    Jin, X.4    Zhao, X.5    Zhang, C.6
  • 125
    • 84885372418 scopus 로고    scopus 로고
    • A pH-sensitive gene delivery system based on folic acid-PEG-chitosan - PAMAM-plasmid DNA complexes for cancer cell targeting
    • Wang M., Hu H., Sun Y., Qiu L., Zhang J., Guan G., et al. A pH-sensitive gene delivery system based on folic acid-PEG-chitosan - PAMAM-plasmid DNA complexes for cancer cell targeting. Biomaterials 2013, 34:10120-10132.
    • (2013) Biomaterials , vol.34 , pp. 10120-10132
    • Wang, M.1    Hu, H.2    Sun, Y.3    Qiu, L.4    Zhang, J.5    Guan, G.6
  • 126
    • 84942843417 scopus 로고    scopus 로고
    • A pH-responsive drug-delivery platform based on glycol chitosan-coated liposomes
    • Yan L., Crayton S.H., Thawani J.P., Amirshaghaghi A., Tsourkas A., Cheng Z. A pH-responsive drug-delivery platform based on glycol chitosan-coated liposomes. Small 2015, 11:4870-4874.
    • (2015) Small , vol.11 , pp. 4870-4874
    • Yan, L.1    Crayton, S.H.2    Thawani, J.P.3    Amirshaghaghi, A.4    Tsourkas, A.5    Cheng, Z.6
  • 128
    • 84867402736 scopus 로고    scopus 로고
    • Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery
    • Jiang T., Zhang Z., Zhang Y., Lv H., Zhou J., Li C., et al. Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery. Biomaterials 2012, 33:9246-9258.
    • (2012) Biomaterials , vol.33 , pp. 9246-9258
    • Jiang, T.1    Zhang, Z.2    Zhang, Y.3    Lv, H.4    Zhou, J.5    Li, C.6
  • 129
    • 84897547884 scopus 로고    scopus 로고
    • Novel pH-sensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: in vitro study
    • Ouahab A., Cheraga N., Onoja V., Shen Y., Tu J. Novel pH-sensitive charge-reversal cell penetrating peptide conjugated PEG-PLA micelles for docetaxel delivery: in vitro study. Int. J. Pharm. 2014, 466:233-245.
    • (2014) Int. J. Pharm. , vol.466 , pp. 233-245
    • Ouahab, A.1    Cheraga, N.2    Onoja, V.3    Shen, Y.4    Tu, J.5
  • 131
    • 0030890748 scopus 로고    scopus 로고
    • Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers
    • Wyman T.B., Nicol F., Zelphati O., Scaria P.V., Plank C., Szoka F.C. Design, synthesis, and characterization of a cationic peptide that binds to nucleic acids and permeabilizes bilayers. Biochemistry 1997, 36:3008-3017.
    • (1997) Biochemistry , vol.36 , pp. 3008-3017
    • Wyman, T.B.1    Nicol, F.2    Zelphati, O.3    Scaria, P.V.4    Plank, C.5    Szoka, F.C.6
  • 132
    • 84862870761 scopus 로고    scopus 로고
    • Oligomerized alpha-helical KALA peptides with pendant arms bearing cell-adhesion, DNA-binding and endosome-buffering domains as efficient gene transfection vectors
    • Guo X.D., Wiradharma N., Liu S.Q., Zhang L.J., Khan M., Qian Y., et al. Oligomerized alpha-helical KALA peptides with pendant arms bearing cell-adhesion, DNA-binding and endosome-buffering domains as efficient gene transfection vectors. Biomaterials 2012, 33:6284-6291.
    • (2012) Biomaterials , vol.33 , pp. 6284-6291
    • Guo, X.D.1    Wiradharma, N.2    Liu, S.Q.3    Zhang, L.J.4    Khan, M.5    Qian, Y.6
  • 133
    • 5244286664 scopus 로고    scopus 로고
    • Peptide-mediated release of folate-targeted liposome contents from endosomal compartments
    • Vogel K., Wang S., Lee R.J., Chmielewski J., Low P.S. Peptide-mediated release of folate-targeted liposome contents from endosomal compartments. J. Am. Chem. Soc. 1996, 118:1581-1586.
    • (1996) J. Am. Chem. Soc. , vol.118 , pp. 1581-1586
    • Vogel, K.1    Wang, S.2    Lee, R.J.3    Chmielewski, J.4    Low, P.S.5
  • 134
    • 84862902284 scopus 로고    scopus 로고
    • A multifunctional envelope-type nanodevice for use in nanomedicine: concept and applications
    • Nakamura T., Akita H., Yamada Y., Hatakeyama H., Harashima H. A multifunctional envelope-type nanodevice for use in nanomedicine: concept and applications. Acc. Chem. Res. 2012, 45:1113-1121.
    • (2012) Acc. Chem. Res. , vol.45 , pp. 1113-1121
    • Nakamura, T.1    Akita, H.2    Yamada, Y.3    Hatakeyama, H.4    Harashima, H.5
  • 135
    • 79957912413 scopus 로고    scopus 로고
    • Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA
    • Sakurai Y., Hatakeyama H., Sato Y., Akita H., Takayama K., Kobayashi S., et al. Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA. Biomaterials 2011, 32:5733-5742.
    • (2011) Biomaterials , vol.32 , pp. 5733-5742
    • Sakurai, Y.1    Hatakeyama, H.2    Sato, Y.3    Akita, H.4    Takayama, K.5    Kobayashi, S.6
  • 136
    • 79959972712 scopus 로고    scopus 로고
    • Prodrugs for improving tumor targetability and efficiency
    • Mahato R., Tai W., Cheng K. Prodrugs for improving tumor targetability and efficiency. Adv. Drug Deliv. Rev. 2011, 63:659-670.
    • (2011) Adv. Drug Deliv. Rev. , vol.63 , pp. 659-670
    • Mahato, R.1    Tai, W.2    Cheng, K.3
  • 137
    • 79955465276 scopus 로고    scopus 로고
    • Block copolymer micelles with acid-labile ortho ester side-chains: synthesis, characterization, and enhanced drug delivery to human glioma cells
    • Tang R., Ji W., Panus D., Palumbo R.N., Wang C. Block copolymer micelles with acid-labile ortho ester side-chains: synthesis, characterization, and enhanced drug delivery to human glioma cells. J. Control. Release 2011, 151:18-27.
    • (2011) J. Control. Release , vol.151 , pp. 18-27
    • Tang, R.1    Ji, W.2    Panus, D.3    Palumbo, R.N.4    Wang, C.5
  • 138
    • 84886751441 scopus 로고    scopus 로고
    • Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds
    • Sun T.M., Wang Y.C., Wang F., Du J.Z., Mao C.Q., Sun C.Y., et al. Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds. Biomaterials 2014, 35:836-845.
    • (2014) Biomaterials , vol.35 , pp. 836-845
    • Sun, T.M.1    Wang, Y.C.2    Wang, F.3    Du, J.Z.4    Mao, C.Q.5    Sun, C.Y.6
  • 139
    • 15244345124 scopus 로고    scopus 로고
    • PH-Responsive copolymer assemblies for controlled release of doxorubicin
    • Gillies E.R., Frechet J.M. pH-Responsive copolymer assemblies for controlled release of doxorubicin. Bioconjug. Chem. 2005, 16:361-368.
    • (2005) Bioconjug. Chem. , vol.16 , pp. 361-368
    • Gillies, E.R.1    Frechet, J.M.2
  • 140
    • 84868522927 scopus 로고    scopus 로고
    • Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics
    • Shin J., Shum P., Grey J., Fujiwara S.-I., Malhotra G.S., González-Bonet A., et al. Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable pH sensitivity: synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics. Mol. Pharm. 2012, 9:3266-3276.
    • (2012) Mol. Pharm. , vol.9 , pp. 3266-3276
    • Shin, J.1    Shum, P.2    Grey, J.3    Fujiwara, S.-I.4    Malhotra, G.S.5    González-Bonet, A.6
  • 141
    • 0141921478 scopus 로고    scopus 로고
    • Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids
    • Shin J., Shum P., Thompson D.H. Acid-triggered release via dePEGylation of DOPE liposomes containing acid-labile vinyl ether PEG-lipids. J. Control. Release 2003, 91:187-200.
    • (2003) J. Control. Release , vol.91 , pp. 187-200
    • Shin, J.1    Shum, P.2    Thompson, D.H.3
  • 142
    • 84867541874 scopus 로고    scopus 로고
    • Acid-triggered release via dePEGylation of fusogenic liposomes mediated by heterobifunctional phenyl-substituted vinyl ethers with tunable pH-sensitivity
    • Kim H.-K., Van den Bossche J., Hyun S.-H., Thompson D.H. Acid-triggered release via dePEGylation of fusogenic liposomes mediated by heterobifunctional phenyl-substituted vinyl ethers with tunable pH-sensitivity. Bioconjug. Chem. 2012, 23:2071-2077.
    • (2012) Bioconjug. Chem. , vol.23 , pp. 2071-2077
    • Kim, H.-K.1    Van den Bossche, J.2    Hyun, S.-H.3    Thompson, D.H.4
  • 143
    • 36248943575 scopus 로고    scopus 로고
    • "Smart" drug carriers: PEGylated TATp-modified pH-sensitive liposomes
    • Kale A.A., Torchilin V.P. "Smart" drug carriers: PEGylated TATp-modified pH-sensitive liposomes. J. Liposome Res. 2007, 17:197-203.
    • (2007) J. Liposome Res. , vol.17 , pp. 197-203
    • Kale, A.A.1    Torchilin, V.P.2
  • 144
    • 84897373234 scopus 로고    scopus 로고
    • Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: impact of the carrier structure onto synergistic action in the treatment of solid tumours
    • Etrych T., Subr V., Laga R., Rihova B., Ulbrich K. Polymer conjugates of doxorubicin bound through an amide and hydrazone bond: impact of the carrier structure onto synergistic action in the treatment of solid tumours. Eur. J. Pharm. Sci. 2014, 58:1-12.
    • (2014) Eur. J. Pharm. Sci. , vol.58 , pp. 1-12
    • Etrych, T.1    Subr, V.2    Laga, R.3    Rihova, B.4    Ulbrich, K.5
  • 145
    • 68549115148 scopus 로고    scopus 로고
    • Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery
    • Prabaharan M., Grailer J.J., Pilla S., Steeber D.A., Gong S. Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery. Biomaterials 2009, 30:5757-5766.
    • (2009) Biomaterials , vol.30 , pp. 5757-5766
    • Prabaharan, M.1    Grailer, J.J.2    Pilla, S.3    Steeber, D.A.4    Gong, S.5
  • 146
    • 84895069070 scopus 로고    scopus 로고
    • A tumoral acidic pH-responsive drug delivery system based on a novel photosensitizer (fullerene) for in vitro and in vivo chemo-photodynamic therapy
    • Shi J., Liu Y., Wang L., Gao J., Zhang J., Yu X., et al. A tumoral acidic pH-responsive drug delivery system based on a novel photosensitizer (fullerene) for in vitro and in vivo chemo-photodynamic therapy. Acta Biomater. 2014, 10:1280-1291.
    • (2014) Acta Biomater. , vol.10 , pp. 1280-1291
    • Shi, J.1    Liu, Y.2    Wang, L.3    Gao, J.4    Zhang, J.5    Yu, X.6
  • 147
    • 84888784541 scopus 로고    scopus 로고
    • Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage
    • Nakamura H., Etrych T., Chytil P., Ohkubo M., Fang J., Ulbrich K., et al. Two step mechanisms of tumor selective delivery of N-(2-hydroxypropyl)methacrylamide copolymer conjugated with pirarubicin via an acid-cleavable linkage. J. Control. Release 2014, 174:81-87.
    • (2014) J. Control. Release , vol.174 , pp. 81-87
    • Nakamura, H.1    Etrych, T.2    Chytil, P.3    Ohkubo, M.4    Fang, J.5    Ulbrich, K.6
  • 148
    • 73249127797 scopus 로고    scopus 로고
    • Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel
    • Alani A.W.G., Bae Y., Rao D.A., Kwon G.S. Polymeric micelles for the pH-dependent controlled, continuous low dose release of paclitaxel. Biomaterials 2010, 31:1765-1772.
    • (2010) Biomaterials , vol.31 , pp. 1765-1772
    • Alani, A.W.G.1    Bae, Y.2    Rao, D.A.3    Kwon, G.S.4
  • 150
    • 67349169756 scopus 로고    scopus 로고
    • Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivo
    • Sawant R.R., Torchilin V.P. Enhanced cytotoxicity of TATp-bearing paclitaxel-loaded micelles in vitro and in vivo. Int. J. Pharm. 2009, 374:114-118.
    • (2009) Int. J. Pharm. , vol.374 , pp. 114-118
    • Sawant, R.R.1    Torchilin, V.P.2
  • 151
    • 84893440984 scopus 로고    scopus 로고
    • Synthesis and in vitro evaluation of a pH-sensitive PLA-PEG-folate based polymeric micelle for controlled delivery of docetaxel
    • Hami Z., Amini M., Ghazi-Khansari M., Rezayat S.M., Gilani K. Synthesis and in vitro evaluation of a pH-sensitive PLA-PEG-folate based polymeric micelle for controlled delivery of docetaxel. Colloids Surf. B Biointerfaces 2014, 116:309-317.
    • (2014) Colloids Surf. B Biointerfaces , vol.116 , pp. 309-317
    • Hami, Z.1    Amini, M.2    Ghazi-Khansari, M.3    Rezayat, S.M.4    Gilani, K.5
  • 152
    • 56249097260 scopus 로고    scopus 로고
    • Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA - PEG nanoparticles
    • Dhar S., Gu F.X., Langer R., Farokhza O.C., Lippard S.J. Targeted delivery of cisplatin to prostate cancer cells by aptamer functionalized Pt(IV) prodrug-PLGA - PEG nanoparticles. Proc. Natl. Acad. Sci. U. S. A. 2008, 105:17356-17361.
    • (2008) Proc. Natl. Acad. Sci. U. S. A. , vol.105 , pp. 17356-17361
    • Dhar, S.1    Gu, F.X.2    Langer, R.3    Farokhza, O.C.4    Lippard, S.J.5
  • 153
    • 80054771399 scopus 로고    scopus 로고
    • Polymer micelles with hydrazone-ester dual linkers for tunable release of dexamethasone
    • Howard M.D., Ponta A., Eckman A., Jay M., Bae Y. Polymer micelles with hydrazone-ester dual linkers for tunable release of dexamethasone. Pharm. Res. 2011, 28:2435-2446.
    • (2011) Pharm. Res. , vol.28 , pp. 2435-2446
    • Howard, M.D.1    Ponta, A.2    Eckman, A.3    Jay, M.4    Bae, Y.5
  • 154
    • 84890560256 scopus 로고    scopus 로고
    • HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy
    • Kostková H., Etrych T., Říhová B., Kostka L., Starovoytová L., Kovář M., et al. HPMA copolymer conjugates of DOX and mitomycin C for combination therapy: physicochemical characterization, cytotoxic effects, combination index analysis, and anti-tumor efficacy. Macromol. Biosci. 2013, 13:1648-1660.
    • (2013) Macromol. Biosci. , vol.13 , pp. 1648-1660
    • Kostková, H.1    Etrych, T.2    Říhová, B.3    Kostka, L.4    Starovoytová, L.5    Kovář, M.6
  • 155
    • 84870378512 scopus 로고    scopus 로고
    • PH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system
    • Chen D., Sun K., Mu H., Tang M., Liang R., Wang A., et al. pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system. Int. J. Nanomedicine 2012, 7:2621-2630.
    • (2012) Int. J. Nanomedicine , vol.7 , pp. 2621-2630
    • Chen, D.1    Sun, K.2    Mu, H.3    Tang, M.4    Liang, R.5    Wang, A.6
  • 156
    • 84856635210 scopus 로고    scopus 로고
    • Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon
    • Chen D., Liu W., Shen Y., Mu H., Zhang Y., Liang R., et al. Effects of a novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-responsive double smart mPEG lipid derivative on ABC phenomenon. Int. J. Nanomedicine 2011, 6:2053-2061.
    • (2011) Int. J. Nanomedicine , vol.6 , pp. 2053-2061
    • Chen, D.1    Liu, W.2    Shen, Y.3    Mu, H.4    Zhang, Y.5    Liang, R.6
  • 157
    • 33846594736 scopus 로고    scopus 로고
    • The 6-maleimidocaproyl hydrazone derivative of doxorubicin (DOXO-EMCH) is superior to free doxorubicin with respect to cardiotoxicity and mitochondrial damage
    • Lebrecht D., Geist A., Ketelsen U.P., Haberstroh J., Setzer B., Kratz F., et al. The 6-maleimidocaproyl hydrazone derivative of doxorubicin (DOXO-EMCH) is superior to free doxorubicin with respect to cardiotoxicity and mitochondrial damage. Int. J. Cancer 2007, 120:927-934.
    • (2007) Int. J. Cancer , vol.120 , pp. 927-934
    • Lebrecht, D.1    Geist, A.2    Ketelsen, U.P.3    Haberstroh, J.4    Setzer, B.5    Kratz, F.6
  • 158
    • 34249980937 scopus 로고    scopus 로고
    • DOXO-EMCH (INNO-206): the first albumin-binding prodrug of doxorubicin to enter clinical trials
    • Kratz F. DOXO-EMCH (INNO-206): the first albumin-binding prodrug of doxorubicin to enter clinical trials. Expert Opin. Investig. Drugs 2007, 16:855-866.
    • (2007) Expert Opin. Investig. Drugs , vol.16 , pp. 855-866
    • Kratz, F.1
  • 159
    • 84925498887 scopus 로고    scopus 로고
    • Smart hybrid materials by conjugation of responsive polymers to biomacromolecules
    • Cobo I., Li M., Sumerlin B.S., Perrier S. Smart hybrid materials by conjugation of responsive polymers to biomacromolecules. Nat. Mater. 2015, 14:143-159.
    • (2015) Nat. Mater. , vol.14 , pp. 143-159
    • Cobo, I.1    Li, M.2    Sumerlin, B.S.3    Perrier, S.4
  • 160
    • 84858141870 scopus 로고    scopus 로고
    • Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging
    • Hoffmann S., Vystrcilova L., Ulbrich K., Etrych T., Caysa H., Mueller T., et al. Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release: synthesis and characterization of distribution and tumor accumulation in mice by noninvasive multispectral optical imaging. Biomacromolecules 2012, 13:652-663.
    • (2012) Biomacromolecules , vol.13 , pp. 652-663
    • Hoffmann, S.1    Vystrcilova, L.2    Ulbrich, K.3    Etrych, T.4    Caysa, H.5    Mueller, T.6
  • 161
    • 84887107521 scopus 로고    scopus 로고
    • Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II: impact of release rate on biodistribution
    • Chytil P., Hoffmann S., Schindler L., Kostka L., Ulbrich K., Caysa H., et al. Dual fluorescent HPMA copolymers for passive tumor targeting with pH-sensitive drug release II: impact of release rate on biodistribution. J. Control. Release 2013, 172:504-512.
    • (2013) J. Control. Release , vol.172 , pp. 504-512
    • Chytil, P.1    Hoffmann, S.2    Schindler, L.3    Kostka, L.4    Ulbrich, K.5    Caysa, H.6
  • 162
    • 84901444459 scopus 로고    scopus 로고
    • Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles
    • Zhou Z., Li L., Yang Y., Xu X., Huang Y. Tumor targeting by pH-sensitive, biodegradable, cross-linked N-(2-hydroxypropyl) methacrylamide copolymer micelles. Biomaterials 2014, 35:6622-6635.
    • (2014) Biomaterials , vol.35 , pp. 6622-6635
    • Zhou, Z.1    Li, L.2    Yang, Y.3    Xu, X.4    Huang, Y.5
  • 163
    • 84880760316 scopus 로고    scopus 로고
    • NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin
    • Takahashi A., Yamamoto Y., Yasunaga M., Koga Y., Kuroda J., Takigahira M., et al. NC-6300, an epirubicin-incorporating micelle, extends the antitumor effect and reduces the cardiotoxicity of epirubicin. Cancer Sci. 2013, 104:920-925.
    • (2013) Cancer Sci. , vol.104 , pp. 920-925
    • Takahashi, A.1    Yamamoto, Y.2    Yasunaga, M.3    Koga, Y.4    Kuroda, J.5    Takigahira, M.6
  • 164
    • 78650220844 scopus 로고    scopus 로고
    • Improved anti-tumor activity of stabilized anthracycline polymeric micelle formulation, NC-6300
    • Harada M., Bobe I., Saito H., Shibata N., Tanaka R., Hayashi T., et al. Improved anti-tumor activity of stabilized anthracycline polymeric micelle formulation, NC-6300. Cancer Sci. 2011, 102:192-199.
    • (2011) Cancer Sci. , vol.102 , pp. 192-199
    • Harada, M.1    Bobe, I.2    Saito, H.3    Shibata, N.4    Tanaka, R.5    Hayashi, T.6
  • 165
    • 84875258437 scopus 로고    scopus 로고
    • The anti-tumor efficiency of poly(L-glutamic acid) dendrimers with polyhedral oligomeric silsesquioxane cores
    • Pu Y., Chang S., Yuan H., Wang G., He B., Gu Z. The anti-tumor efficiency of poly(L-glutamic acid) dendrimers with polyhedral oligomeric silsesquioxane cores. Biomaterials 2013, 34:3658-3666.
    • (2013) Biomaterials , vol.34 , pp. 3658-3666
    • Pu, Y.1    Chang, S.2    Yuan, H.3    Wang, G.4    He, B.5    Gu, Z.6
  • 166
    • 84886751441 scopus 로고    scopus 로고
    • Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds
    • Sun T.-M., Wang Y.-C., Wang F., Du J.-Z., Mao C.-Q., Sun C.-Y., et al. Cancer stem cell therapy using doxorubicin conjugated to gold nanoparticles via hydrazone bonds. Biomaterials 2014, 35:836-845.
    • (2014) Biomaterials , vol.35 , pp. 836-845
    • Sun, T.-M.1    Wang, Y.-C.2    Wang, F.3    Du, J.-Z.4    Mao, C.-Q.5    Sun, C.-Y.6
  • 167
    • 67649183483 scopus 로고    scopus 로고
    • Preparation of multifunctional drug carrier for tumor-specific uptake and enhanced intracellular delivery through the conjugation of weak acid labile linker
    • Ding C., Gu J., Qu X., Yang Z. Preparation of multifunctional drug carrier for tumor-specific uptake and enhanced intracellular delivery through the conjugation of weak acid labile linker. Bioconjug. Chem. 2009, 20:1163-1170.
    • (2009) Bioconjug. Chem. , vol.20 , pp. 1163-1170
    • Ding, C.1    Gu, J.2    Qu, X.3    Yang, Z.4
  • 168
    • 79952382437 scopus 로고    scopus 로고
    • A pH-responsive superamphiphile based on dynamic covalent bonds
    • Wang C., Wang G., Wang Z., Zhang X. A pH-responsive superamphiphile based on dynamic covalent bonds. Chem. Eur. J. 2011, 17:3322-3325.
    • (2011) Chem. Eur. J. , vol.17 , pp. 3322-3325
    • Wang, C.1    Wang, G.2    Wang, Z.3    Zhang, X.4
  • 169
    • 84919668203 scopus 로고    scopus 로고
    • The development, characterization and in vivo anti-ovarian cancer activity of poly(propylene imine) (PPI)-antibody conjugates containing encapsulated paclitaxel
    • Jain N.K., Tare M.S., Mishra V., Tripathi P.K. The development, characterization and in vivo anti-ovarian cancer activity of poly(propylene imine) (PPI)-antibody conjugates containing encapsulated paclitaxel. Nanomed. Nanotechnol. Biol. Med. 2015, 11:207-218.
    • (2015) Nanomed. Nanotechnol. Biol. Med. , vol.11 , pp. 207-218
    • Jain, N.K.1    Tare, M.S.2    Mishra, V.3    Tripathi, P.K.4
  • 170
    • 84905229814 scopus 로고    scopus 로고
    • PH-responsive polymer-drug conjugates as multifunctional micelles for cancer-drug delivery
    • Yang K., Wei H., Ying-Qian L., Yuan M., Min-Min F., Li-Sheng D., et al. pH-responsive polymer-drug conjugates as multifunctional micelles for cancer-drug delivery. Nanotechnology 2014, 25:335101.
    • (2014) Nanotechnology , vol.25 , pp. 335101
    • Yang, K.1    Wei, H.2    Ying-Qian, L.3    Yuan, M.4    Min-Min, F.5    Li-Sheng, D.6
  • 171
    • 65249179433 scopus 로고    scopus 로고
    • Development of an oxime bond containing daunorubicin-gonadotropin-releasing hormone-iii conjugate as a potential anticancer drug
    • Szabó I., Manea M., Orbán E., Csámpai A., Bosze S., Szabó R., et al. Development of an oxime bond containing daunorubicin-gonadotropin-releasing hormone-iii conjugate as a potential anticancer drug. Bioconjug. Chem. 2009, 20:656-665.
    • (2009) Bioconjug. Chem. , vol.20 , pp. 656-665
    • Szabó, I.1    Manea, M.2    Orbán, E.3    Csámpai, A.4    Bosze, S.5    Szabó, R.6
  • 172
    • 80053949397 scopus 로고    scopus 로고
    • Oxime linkage: a robust tool for the design of pH-sensitive polymeric drug carriers
    • Jin Y., Song L., Su Y., Zhu L., Pang Y., Qiu F., et al. Oxime linkage: a robust tool for the design of pH-sensitive polymeric drug carriers. Biomacromolecules 2011, 12:3460-3468.
    • (2011) Biomacromolecules , vol.12 , pp. 3460-3468
    • Jin, Y.1    Song, L.2    Su, Y.3    Zhu, L.4    Pang, Y.5    Qiu, F.6
  • 173
    • 0037805217 scopus 로고    scopus 로고
    • Aconityl-derived polymers for biomedical applications. Modeling study of cis-trans isomerisation
    • Zloh M., Dinand E., Brocchini S. Aconityl-derived polymers for biomedical applications. Modeling study of cis-trans isomerisation. Theor. Chem. Acc. 2003, 109:206-212.
    • (2003) Theor. Chem. Acc. , vol.109 , pp. 206-212
    • Zloh, M.1    Dinand, E.2    Brocchini, S.3
  • 174
    • 0019786031 scopus 로고
    • Cis-aconityl spacer between daunomycin and macromolecular carriers: a model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate
    • Shen W.-C., Ryser H.J.P. Cis-aconityl spacer between daunomycin and macromolecular carriers: a model of pH-sensitive linkage releasing drug from a lysosomotropic conjugate. Biochem. Biophys. Res. Commun. 1981, 102:1048-1054.
    • (1981) Biochem. Biophys. Res. Commun. , vol.102 , pp. 1048-1054
    • Shen, W.-C.1    Ryser, H.J.P.2
  • 175
    • 0036403725 scopus 로고    scopus 로고
    • Competitive reactions during amine addition to cis-Aconityl anhydride
    • Dinand E., Zloh M., Brocchini S. Competitive reactions during amine addition to cis-Aconityl anhydride. Aust. J. Chem. 2002, 55:467-474.
    • (2002) Aust. J. Chem. , vol.55 , pp. 467-474
    • Dinand, E.1    Zloh, M.2    Brocchini, S.3
  • 176
    • 33748759803 scopus 로고    scopus 로고
    • Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification
    • Chytil P., Etrych T., Koňák Č., Šírová M., Mrkvan T., Říhová B., et al. Properties of HPMA copolymer-doxorubicin conjugates with pH-controlled activation: effect of polymer chain modification. J. Control. Release 2006, 115:26-36.
    • (2006) J. Control. Release , vol.115 , pp. 26-36
    • Chytil, P.1    Etrych, T.2    Koňák, Č.3    Šírová, M.4    Mrkvan, T.5    Říhová, B.6
  • 177
    • 37849016204 scopus 로고    scopus 로고
    • Synthesis of poly(vinyl alcohol)-doxorubicin conjugates containing cis-aconityl acid-cleavable bond and its isomer dependent doxorubicin release
    • Kakinoki A., Kaneo Y., Ikeda Y., Tanaka T., Fujita K. Synthesis of poly(vinyl alcohol)-doxorubicin conjugates containing cis-aconityl acid-cleavable bond and its isomer dependent doxorubicin release. Biol. Pharm. Bull. 2008, 31:103-110.
    • (2008) Biol. Pharm. Bull. , vol.31 , pp. 103-110
    • Kakinoki, A.1    Kaneo, Y.2    Ikeda, Y.3    Tanaka, T.4    Fujita, K.5
  • 178
    • 0037130252 scopus 로고    scopus 로고
    • Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages
    • Yoo H.S., Lee E.A., Park T.G. Doxorubicin-conjugated biodegradable polymeric micelles having acid-cleavable linkages. J. Control. Release 2002, 82:17-27.
    • (2002) J. Control. Release , vol.82 , pp. 17-27
    • Yoo, H.S.1    Lee, E.A.2    Park, T.G.3
  • 179
    • 72149091705 scopus 로고    scopus 로고
    • Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style
    • Zhu S., Hong M., Tang G., Qian L., Lin J., Jiang Y., et al. Partly PEGylated polyamidoamine dendrimer for tumor-selective targeting of doxorubicin: the effects of PEGylation degree and drug conjugation style. Biomaterials 2010, 31:1360-1371.
    • (2010) Biomaterials , vol.31 , pp. 1360-1371
    • Zhu, S.1    Hong, M.2    Tang, G.3    Qian, L.4    Lin, J.5    Jiang, Y.6
  • 181
    • 84902912195 scopus 로고    scopus 로고
    • Chapter 13-polyacetals
    • Elsevier, Oxford, S.G. Kumbar, C.T. Laurencin, M. Deng (Eds.)
    • Carmali S., Brocchini S. Chapter 13-polyacetals. Natural and Synthetic Biomedical Polymers 2014, 219-233. Elsevier, Oxford. S.G. Kumbar, C.T. Laurencin, M. Deng (Eds.).
    • (2014) Natural and Synthetic Biomedical Polymers , pp. 219-233
    • Carmali, S.1    Brocchini, S.2
  • 182
    • 33845550303 scopus 로고
    • Protecting groups in organic synthesis. Part 8. Conversion of aldehydes into geminal diacetates
    • Kochhar K.S., Bal B.S., Deshpande R.P., Rajadhyaksha S.N., Pinnick H.W. Protecting groups in organic synthesis. Part 8. Conversion of aldehydes into geminal diacetates. J. Org. Chem. 1983, 48:1765-1767.
    • (1983) J. Org. Chem. , vol.48 , pp. 1765-1767
    • Kochhar, K.S.1    Bal, B.S.2    Deshpande, R.P.3    Rajadhyaksha, S.N.4    Pinnick, H.W.5
  • 183
    • 0007951974 scopus 로고
    • Preparation of polyacetals by the reaction of divinyl ethers and polyols
    • Heller J., Penhale D.W.H., Helwing R.F. Preparation of polyacetals by the reaction of divinyl ethers and polyols. J. Polym. Sci. 1980, 18:293-297.
    • (1980) J. Polym. Sci. , vol.18 , pp. 293-297
    • Heller, J.1    Penhale, D.W.H.2    Helwing, R.F.3
  • 184
    • 0344063545 scopus 로고    scopus 로고
    • Polyacetal-doxorubicin conjugates designed for ph-dependent degradation
    • Tomlinson R., Heller J., Brocchini S., Duncan R. Polyacetal-doxorubicin conjugates designed for ph-dependent degradation. Bioconjug. Chem. 2003, 14:1096-1106.
    • (2003) Bioconjug. Chem. , vol.14 , pp. 1096-1106
    • Tomlinson, R.1    Heller, J.2    Brocchini, S.3    Duncan, R.4
  • 185
    • 84870251049 scopus 로고    scopus 로고
    • Core-crosslinked pH-sensitive degradable micelles: a promising approach to resolve the extracellular stability versus intracellular drug release dilemma
    • Wu Y., Chen W., Meng F., Wang Z., Cheng R., Deng C., et al. Core-crosslinked pH-sensitive degradable micelles: a promising approach to resolve the extracellular stability versus intracellular drug release dilemma. J. Control. Release 2012, 164:338-345.
    • (2012) J. Control. Release , vol.164 , pp. 338-345
    • Wu, Y.1    Chen, W.2    Meng, F.3    Wang, Z.4    Cheng, R.5    Deng, C.6
  • 186
    • 27944508780 scopus 로고    scopus 로고
    • Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle
    • Heffernan M.J., Murthy N. Polyketal nanoparticles: a new pH-sensitive biodegradable drug delivery vehicle. Bioconjug. Chem. 2005, 16:1340-1342.
    • (2005) Bioconjug. Chem. , vol.16 , pp. 1340-1342
    • Heffernan, M.J.1    Murthy, N.2
  • 187
    • 38849091277 scopus 로고    scopus 로고
    • An acid-labile block copolymer of PDMAEMA and PEG as potential carrier for intelligent gene delivery systems
    • Lin S., Du F., Wang Y., Ji S., Liang D., Yu L., et al. An acid-labile block copolymer of PDMAEMA and PEG as potential carrier for intelligent gene delivery systems. Biomacromolecules 2008, 9:109-115.
    • (2008) Biomacromolecules , vol.9 , pp. 109-115
    • Lin, S.1    Du, F.2    Wang, Y.3    Ji, S.4    Liang, D.5    Yu, L.6
  • 188
    • 84893805504 scopus 로고    scopus 로고
    • Novel pH-sensitive biodegradable polymeric drug delivery systems based on ketal polymers
    • Chen D., Wang H. Novel pH-sensitive biodegradable polymeric drug delivery systems based on ketal polymers. J. Nanosci. Nanotechnol. 2014, 14:983-989.
    • (2014) J. Nanosci. Nanotechnol. , vol.14 , pp. 983-989
    • Chen, D.1    Wang, H.2
  • 189
    • 61849136126 scopus 로고    scopus 로고
    • Cytoplasmic delivery of liposomal contents mediated by an acid-labile cholesterol-vinyl ether-PEG conjugate
    • Boomer J.A., Qualls M.M., Inerowicz H.D., Haynes R.H., Patri V.S., Kim J.-M., et al. Cytoplasmic delivery of liposomal contents mediated by an acid-labile cholesterol-vinyl ether-PEG conjugate. Bioconjug. Chem. 2009, 20:47-59.
    • (2009) Bioconjug. Chem. , vol.20 , pp. 47-59
    • Boomer, J.A.1    Qualls, M.M.2    Inerowicz, H.D.3    Haynes, R.H.4    Patri, V.S.5    Kim, J.-M.6
  • 190
    • 84879517827 scopus 로고    scopus 로고
    • PH-Responsive biodegradable assemblies containing tunable phenyl-substituted vinyl ethers for use as efficient gene delivery vehicles
    • Kim H.-K., Thompson D.H., Jang H.S., Chung Y.J., Van den Bossche J. pH-Responsive biodegradable assemblies containing tunable phenyl-substituted vinyl ethers for use as efficient gene delivery vehicles. ACS Appl. Mater. Interfaces 2013, 5:5648-5658.
    • (2013) ACS Appl. Mater. Interfaces , vol.5 , pp. 5648-5658
    • Kim, H.-K.1    Thompson, D.H.2    Jang, H.S.3    Chung, Y.J.4    Van den Bossche, J.5
  • 191
    • 0013692188 scopus 로고
    • Poly (ortho esters)
    • Springer, Berlin Heidelberg, R. Langer, N. Peppas (Eds.)
    • Heller J. Poly (ortho esters). Biopolymers I 1993, 41-92. Springer, Berlin Heidelberg. R. Langer, N. Peppas (Eds.).
    • (1993) Biopolymers I , pp. 41-92
    • Heller, J.1
  • 192
    • 4644323971 scopus 로고    scopus 로고
    • PH-sensitive PEG lipids containing orthoester linkers: new potential tools for nonviral gene delivery
    • Masson C., Garinot M., Mignet N., Wetzer B., Mailhe P., Scherman D., et al. pH-sensitive PEG lipids containing orthoester linkers: new potential tools for nonviral gene delivery. J. Control. Release 2004, 99:423-434.
    • (2004) J. Control. Release , vol.99 , pp. 423-434
    • Masson, C.1    Garinot, M.2    Mignet, N.3    Wetzer, B.4    Mailhe, P.5    Scherman, D.6
  • 193
    • 85052182677 scopus 로고    scopus 로고
    • Incorporation of Poly(ethylene glycol )Lipid into Lipoplexes
    • Informa Healthcare
    • Nathalie M., Mamonjy C., Michel B., Daniel S. Incorporation of Poly(ethylene glycol )Lipid into Lipoplexes. Liposome Technology 2006, vol. II:273-292. Informa Healthcare.
    • (2006) Liposome Technology , vol.2 , pp. 273-292
    • Nathalie, M.1    Mamonjy, C.2    Michel, B.3    Daniel, S.4
  • 194
    • 0035078410 scopus 로고    scopus 로고
    • Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG-diortho ester-lipid conjugate
    • Guo X., Szoka F.C. Steric stabilization of fusogenic liposomes by a low-pH sensitive PEG-diortho ester-lipid conjugate. Bioconjug. Chem. 2001, 12:291-300.
    • (2001) Bioconjug. Chem. , vol.12 , pp. 291-300
    • Guo, X.1    Szoka, F.C.2
  • 195
    • 30744443940 scopus 로고    scopus 로고
    • Acid-triggered transformation of diortho ester phosphocholine liposome
    • Huang Z., Guo X., Li W., MacKay J.A., Szoka F.C. Acid-triggered transformation of diortho ester phosphocholine liposome. J. Am. Chem. Soc. 2006, 128:60-61.
    • (2006) J. Am. Chem. Soc. , vol.128 , pp. 60-61
    • Huang, Z.1    Guo, X.2    Li, W.3    MacKay, J.A.4    Szoka, F.C.5
  • 196
    • 0037339370 scopus 로고    scopus 로고
    • Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid
    • Guo X., Andrew MacKay J., Szoka F.C. Mechanism of pH-triggered collapse of phosphatidylethanolamine liposomes stabilized by an ortho ester polyethyleneglycol lipid. Biophys. J. 2003, 84:1784-1795.
    • (2003) Biophys. J. , vol.84 , pp. 1784-1795
    • Guo, X.1    Andrew MacKay, J.2    Szoka, F.C.3
  • 197
    • 84903786903 scopus 로고    scopus 로고
    • Amphiphilic block copolymers bearing six-membered ortho ester ring in side chains as potential drug carriers: synthesis, characterization, and in vivo toxicity evaluation
    • Luo S., Tao Y., Tang R., Wang R., Ji W., Wang C., et al. Amphiphilic block copolymers bearing six-membered ortho ester ring in side chains as potential drug carriers: synthesis, characterization, and in vivo toxicity evaluation. J. Biomater. Sci. Polym. Ed. 2014, 25:965-984.
    • (2014) J. Biomater. Sci. Polym. Ed. , vol.25 , pp. 965-984
    • Luo, S.1    Tao, Y.2    Tang, R.3    Wang, R.4    Ji, W.5    Wang, C.6
  • 198
    • 80053051201 scopus 로고    scopus 로고
    • Synthesis and physicochemical characterization of amphiphilic block copolymers bearing acid-sensitive orthoester linkage as the drug carrier
    • Thambi T., Deepagan V.G., Yoo C.K., Park J.H. Synthesis and physicochemical characterization of amphiphilic block copolymers bearing acid-sensitive orthoester linkage as the drug carrier. Polymer 2011, 52:4753-4759.
    • (2011) Polymer , vol.52 , pp. 4753-4759
    • Thambi, T.1    Deepagan, V.G.2    Yoo, C.K.3    Park, J.H.4
  • 199
    • 84860324474 scopus 로고    scopus 로고
    • Novel pH-sensitive cationic lipids with linear ortho ester linkers for gene delivery
    • Chen H., Zhang H., Thor D., Rahimian R., Guo X. Novel pH-sensitive cationic lipids with linear ortho ester linkers for gene delivery. Eur. J. Med. Chem. 2012, 52:159-172.
    • (2012) Eur. J. Med. Chem. , vol.52 , pp. 159-172
    • Chen, H.1    Zhang, H.2    Thor, D.3    Rahimian, R.4    Guo, X.5
  • 200
    • 0034717253 scopus 로고    scopus 로고
    • The relative rate of hydrolysis of a series of acyclic and six-membered cyclic acetals, ketals, orthoesters, and orthocarbonates
    • Deslongchamps P., Dory Y.L., Li S. The relative rate of hydrolysis of a series of acyclic and six-membered cyclic acetals, ketals, orthoesters, and orthocarbonates. Tetrahedron 2000, 56:3533-3537.
    • (2000) Tetrahedron , vol.56 , pp. 3533-3537
    • Deslongchamps, P.1    Dory, Y.L.2    Li, S.3
  • 202
    • 5044235051 scopus 로고    scopus 로고
    • Poly(ortho esters) - from concept to reality
    • Heller J., Barr J. Poly(ortho esters) - from concept to reality. Biomacromolecules 2004, 5:1625-1632.
    • (2004) Biomacromolecules , vol.5 , pp. 1625-1632
    • Heller, J.1    Barr, J.2
  • 203
    • 79751534054 scopus 로고    scopus 로고
    • Synthesis and characterization of new poly(ortho ester amidine) copolymers for nonviral gene delivery
    • Tang R., Ji W., Wang C. Synthesis and characterization of new poly(ortho ester amidine) copolymers for nonviral gene delivery. Polymer 2011, 52:921-932.
    • (2011) Polymer , vol.52 , pp. 921-932
    • Tang, R.1    Ji, W.2    Wang, C.3
  • 204
    • 84901679088 scopus 로고    scopus 로고
    • Folic acid-conjugated pH/temperature/redox multi-stimuli responsive polymer microspheres for delivery of anti-cancer drug
    • Li R., Feng F., Wang Y., Yang X., Yang X., Yang V.C. Folic acid-conjugated pH/temperature/redox multi-stimuli responsive polymer microspheres for delivery of anti-cancer drug. J. Colloid Interface Sci. 2014, 429:34-44.
    • (2014) J. Colloid Interface Sci. , vol.429 , pp. 34-44
    • Li, R.1    Feng, F.2    Wang, Y.3    Yang, X.4    Yang, X.5    Yang, V.C.6
  • 205
    • 84897840575 scopus 로고    scopus 로고
    • Doxorubicin-conjugated core-shell magnetite nanoparticles as dual-targeting carriers for anticancer drug delivery
    • Sadighian S., Rostamizadeh K., Hosseini-Monfared H., Hamidi M. Doxorubicin-conjugated core-shell magnetite nanoparticles as dual-targeting carriers for anticancer drug delivery. Colloids Surf. B Biointerfaces 2014, 117:406-413.
    • (2014) Colloids Surf. B Biointerfaces , vol.117 , pp. 406-413
    • Sadighian, S.1    Rostamizadeh, K.2    Hosseini-Monfared, H.3    Hamidi, M.4
  • 208
    • 84859211943 scopus 로고    scopus 로고
    • Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study
    • Martin N.K., Robey I.F., Gaffney E.A., Gillies R.J., Gatenby R.A., Maini P.K. Predicting the safety and efficacy of buffer therapy to raise tumour pHe: an integrative modelling study. Br. J. Cancer 2012, 106:1280-1287.
    • (2012) Br. J. Cancer , vol.106 , pp. 1280-1287
    • Martin, N.K.1    Robey, I.F.2    Gaffney, E.A.3    Gillies, R.J.4    Gatenby, R.A.5    Maini, P.K.6
  • 209
    • 33745110220 scopus 로고    scopus 로고
    • Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics
    • Gerweck L.E., Vijayappa S., Kozin S. Tumor pH controls the in vivo efficacy of weak acid and base chemotherapeutics. Mol. Cancer Ther. 2006, 5:1275-1279.
    • (2006) Mol. Cancer Ther. , vol.5 , pp. 1275-1279
    • Gerweck, L.E.1    Vijayappa, S.2    Kozin, S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.