Polymer vesicles in vivo: Correlations with PEG molecular weight

Journal of Controlled Release

Volumn 90, Issue 3, 2003, Pages 323-334

  Photos, Peter J ^a   Bacakova, Lucie ^a,c   Discher, Bohdana ^a   Bates, Frank S ^b   Discher, Dennis E ^a  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF MINNESOTA   (United States)

^c INSTITUTE OF PHYSIOLOGY   (Czech Republic)

Author keywords

Circulation times; Long circulating; PEGylation; Polymersomes; Stealth liposomes

Indexed keywords

BLOCK COPOLYMERS; HYDROPHILICITY; LIPIDS; MOLECULAR WEIGHT; PROTEINS;

VESICLES;

POLYETHYLENE GLYCOLS;

AMPHOPHILE; LIPOSOME; MACROGOL; POLYMER;

ADSORPTION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG STABILITY; DRUG UPTAKE; IN VITRO STUDY; IN VIVO STUDY; LIPID VESICLE; MICELLE; MOLECULAR WEIGHT; NONHUMAN; OPSONIZATION; PHAGOCYTE; PRIORITY JOURNAL; RAT;

EID: 0037768710     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(03)00201-3     Document Type: Article

References (61)

1. Blume G., Cevc G. Liposomes for the sustained drug release in vivo. Biochim. Biophys. Acta. 1029:1990;91-97.
2. Klibanov A.L., Maruyama K., Torchilin V.P., et al. Amphipathic polyethyleneglycols effectively prolong the circulation time of liposomes. FEBS Lett. 268:1990;235-237.
3. Allen T.M., Hansen C., Martin F., Redemann C., Yau-Young A. Liposomes containing synthetic lipid derivatives of poly(ethylene glycol) show prolonged circulation half-lives in vivo. Biochim. Biophys. Acta. 1066:1991;29-36.
4. Torchilin V.P., Shtilman M.I., Trubetskoy V.S., Whiteman K., Milstein A.M. Amphiphilic vinyl polymers effectively prolong liposome circulation time in vivo. Biochim. Biophys. Acta. 1195:1994;181-184.
5. Blume G., Cevc G. Molecular mechanism of the lipid vesicles longevity in vivo. Biochim. Biophys. Acta. 1146:1993;157-168.
6. Woodle M.C. Surface-modified liposomes - assessment and characterization for increased stability and prolonged blood-circulation. Chem. Phys. Lipids. 64:(1-3):1993;249-262.
7. Shimada K., Matsuo S., Sadzuka Y., et al. Determination of incorporated amounts of poly(ethylene glycol)-derivatized lipids in liposomes for the physicochemical characterization of Stealth liposomes. Int. J. Pharm. 203:(1/2):2000;255-263.
8. Bedu-Addo F.K., Tang P., Xu Y., Huang L. Effect of polyethyleneglycol chain length and phospholipid acyl chain composition on the interaction of polyethyleneglycol-phospholipid conjugates with phospholipid: implications in liposomal drug delivery. Pharm. Res. 13:1996;710-717.
9. Bradley A.J., Devine D.V., Ansell S.M., et al. Inhibition of liposome-induced complement activation by incorporated poly(ethylene glycol) lipids. Arch. Biochem. Biophys. 357:(2):1998;185-194.
10. Montesano G., Bartucci R., Belsito S., et al. Lipid membrane expansion and micelle formation by polymer-grafted lipids: scaling with polymer length studied by spin-label electron spin resonance. Biophys. J. 80:(3):2001;1372-1383.
11. Woodle M.C., Matthay K.K., Newman M.S., et al. Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes. Biochim. Biophys. Acta. 1105:(2):1992;193-200.
12. Discher B.M., Bermudez H., Hammer D.A., et al. Cross-linked polymersome membranes: vesicles with broadly adjustable properties. J. Phys. Chem. B. 106:(11):2002;2848-2854.
13. Bermudez H., Brannan A.K., Hammer D.A., et al. Molecular weight dependence of polymersome membrane structure, elasticity, and stability. Macromolecules. 35:(21):2002;8203-8208.
14. Lee J.H., Kopecek J., Andrade J.D. Protein-resistant surfaces prepared by PEG-containing block copolymer surfactants. J. Biomed. Mater. Res. 23:(3):1989;351-368.
15. Chonn A., Semple S.C., Cullis P.R. Association of blood proteins with large unilamellar liposomes in vivo - relation to circulation lifetimes. J. Biol. Chem. 267:(26):1992;18759-18765.
16. Liu D.X., Liu F., Song Y.K. Recognition and clearance of liposomes containing phosphatidylserine are mediated by serum opsonin. Biochim. Biophys. Acta - Biomembranes. 1235:1995;140-146.
17. McNeil H.P., Simpson R.J., Chesterman C.N., et al. Antiphospholipid antibodies are directed against a complex antigen that includes a lipid-binding inhibitor of coagulation - beta-2-glycoprotein-i (apolipoprotein-h). Proc. Natl. Acad. Sci. USA. 87:(11):1990;4120-4124.
18. Szebeni J., Stafil G.L., Fontana J.L., et al. Liposome-induced acute cardiopulmonary distress in swine is mediated by complement. Circulation. 98:(17):1998;685.
19. Mori A., Klibanov A.L., Torchilin V.P., et al. Influence of the steric barrier activity of amphipathic poly(ethyleneglycol) and ganglioside GM1 on the circulation time of liposomes and on the target binding of immunoliposomes in vivo. FEBS Lett. 284:(2):1991;263-266.
20. Santaella C., Frezard F., Vierling P., et al. Extended in-vivo blood-circulation time of fluorinated liposomes. FEBS Lett. 336:(3):1993;481-484.
21. Allen T.M. Liposomal drug formulations - rationale for development and what we can expect for the future. Drugs. 56:(5):1998;747-756.
22. Allen T.M., Hansen C. Pharmacokinetics of Stealth versus conventional liposomes - effect of dose. Biochim. Biophys. Acta. 1068:(2):1991;133-141.
23. Oja C.D., Semple S.C., Chonn A., et al. Influence of dose on liposome clearance: critical role of blood proteins. Biochim. Biophys. Acta - Biomembranes. 1281:(1):1996;31-37.
24. Litzinger D.C., Buiting A.M.J., Vanrooijen N., et al. Effect of liposome size on the circulation time and intraorgan distribution of amphipathic poly(ethylene glycol)-containing liposomes. Biochim. Biophys. Acta - Biomembranes. 1190:(1):1994;99-107.
25. Klibanov A.L., Maruyama K., Beckerleg A.M., et al. Activity of amphipathic poly(ethylene glycol)-5000 to prolong the circulation time of liposomes depends on the liposome size and is unfavorable for immunoliposome binding to target. Biochim. Biophys. Acta. 1062:(2):1991;142-148.
26. Woodle M.C., Matthay K.K., Newman M.S., et al. Versatility in lipid compositions showing prolonged circulation with sterically stabilized liposomes. Biochim. Biophys. Acta. 1105:(2):1992;193-200.
27. Levchenko T.S., Rammohan R., Lukyanov A.N., et al. Liposome clearance in mice: the effect of a separate and combined presence of surface charge and polymer coating. Int. J. Pharm. 240:(1/2):2002;95-102.
28. Vermehren C., Jorgensen K., Frokjaer S. Influence of lipopolymer concentration on liposome degradation and blood clearance. Int. J. Pharm. 183:(1):1999;13-16.
29. Senior J., Delgado C., Fisher D., et al. Influence of surface hydrophilicity of liposomes on their interaction with plasma-protein and clearance from the circulation - studies with poly(ethylene glycol)-coated vesicles. Biochim. Biophys. Acta. 1062:(1):1991;77-82.
30. Semple S.C., Chonn A., Cullis P.R. Interactions of liposomes and lipid-based carrier systems with blood proteins: relation to clearance behaviour in vivo. Adv. Drug Deliv. Rev. 32:1998;3-17.
31. Lee J.C.-M., Bermudez H., Discher B.M., et al. Preparation, stability, and in vitro performance of vesicles made with diblock copolymers. Biotechnol. Bioeng. 73:(2):2001;135-145.
32. Ertel S.I., Ratner B.D., Kaul A., et al. In-vitro study of the intrinsic toxicity of synthetic surfaces to cells. J. Biomed. Mater. Res. 28:(6):1994;667-675.
33. Kidane A., McPherson T., Shim H.S., et al. Surface modification of polyethylene terephthalate using PEG-polybutadiene-PEG triblock copolymers. Colloids and Surfaces B. 18:(3/4):2000;347-353.
34. Kidane A., Park K. Complement activation by PEG-grafted glass surfaces. J. Biomed. Mater. Res. 48:(5):1999;640-647.
35. Hillmyer M.A., Bates F.S. Synthesis and characterization of model polyalkane-poly(ethylene oxide) block copolymers. Macromolecules. 29:(22):1996;6994-7002.
36. Discher B.M., Won Y.Y., Ege D.S., et al. Polymersomes: tough vesicles made from diblock copolymers. Science. 284:(5417):1999;1143-1146.
37. Hatzack F., Rasmussen S.K. High-performance thin-layer chromatography method for inositol phosphate analysis. J. Chromatogr. B. 736:(1/2):2000;221-229.
38. Evans E. Kinetics of granulocyte phagocytosis - rate limited by cytoplasmic viscosity and constrained by cell-size. Cell Motil. Cytoskeleton. 14:(4):1989;544-551.
39. Discher D.E., Eisenberg A. Polymer vesicles. Science. 297:(5583):2002;967-973.
40. Li X.G., Hirsh D.J., Cabral-Lilly D., et al. Doxorubicin physical state in solution and inside liposomes loaded via a pH gradient. Biochim. Biophys. Acta - Biomembranes. 1415:(1):1998;23-40.
41. Oldenborg P.A., Zheleznyak A., Fang Y.F., et al. Role of CD47 as a marker of self on red blood cells. Science. 288:(5473):2000;2051.
42. Akerman M.E., Chan W.C.-W., Laakkonen P., et al. Nanocrystal targeting in vivo. Proc. Natl. Acad. Sci. USA. 99:(20):2002;12617-12621.
43. Efremova N.V., Bondurant B., O'Brien D.F., et al. Measurements of interbilayer forces and protein adsorption on uncharged lipid bilayers displaying poly(ethylene glycol) chains. Biochemistry. 39:2000;3441-3451.
44. P.J. Photos, D.E. Discher, manuscript in preparation.
45. Kiwada H., Miyajima T., Kato Y. Studies on the uptake mechanism of liposomes by perfused-rat-liver. 2. An indispensable factor for liver uptake in serum. Chem. Pharm. Bull. 3:1987;1189-1195.
46. Price M.E., Cornelius R.M., Brash J.L. Protein adsorption to polyethylene glycol modified liposomes from fibrinogen solution and from plasma. Biochim. Biophys. Acta - Biomembranes. 1512:(2):2001;191-205.
47. Johnstone S.A., Masin D., Mayer L., et al. Surface-associated serum proteins inhibit the uptake of phosphatidylserine and poly(ethylene glycol) liposomes by mouse macrophages. Biochim. Biophys. Acta - Biomembranes. 1513:(1):2001;25-37.
48. Hajduk D.A., Kossuth M.B., Hillmyer M.A., et al. Complex phase behavior in aqueous solutions of poly(ethylene oxide)-poly(ethylethylene) block copolymers. J. Phys. Chem. B. 102:(22):1998;4269-4276.
49. F.A. Ahmed, I. Omaswa, F.S. Bates et al., Self-porating polymer vesicles, manuscript in preparation.
50. Cima L.G. Polymer substrates for controlled biological interactions. J. Cell. Biochem. 56:(2):1994;155-161.
51. Gravekamp C., Santoli D., Vreugdenhil R., et al. Efforts to produce human cytotoxic T-cell hybridomas by electrofusion and PEG fusion. Hybridoma. 6:(2):1987;121-133.
52. Lindner J.R., Coggins M.P., Kaul S., et al. Microbubble persistence in the microcirculation during ischemia/reperfusion and inflammation is caused by integrin- and complement-mediated adherence to activated leukocytes. Circulation. 101:(6):2002;668-675.
53. Klibanov A.L., Hughes M.S., Marsh J.N., et al. Targeting of ultrasound contrast material - an in vitro feasibility study. Acta Radiol. 38:1997;113-120.
54. Kaasgaard T., Mouritsen O.G., Jorgensen K. Screening effect of PEG on avidin binding to liposome surface receptors. Int. J. Pharm. 214:(1/2):2001;63-65.
55. Malmsten M., Emoto K., Van Alstine J.M. Effect of chain density on inhibition of protein adsorption by poly(ethylene glycol) based coatings. J. Colloid Interface Sci. 202:(2):1998;507-517.
56. F. Ahmed, A. Hategan, D.E. Discher et al., Block copolymer assemblies with crosslink stabilization: from single component monolayers to bilayer blends with PEO-PLA, Langmuir, submitted for publication.
57. Gabizon A., Catane R., Uziely R., et al. Prolonged circulation time and enhanced accumulation in malignant exudates of doxorubicin encapsulated in polyethylene-glycol coated liposomes. Cancer Res. 54:(4):1994;987-992.
58. Shah S.S., Zhu K.J., Pitt C.G. Poly-dl-lactic acid-polyethylene-glycol block-copolymers - the influence of polyethylene-glycol on the degradation of poly-dl-lactic acid. J. Biomater. Sci. Polym. E. 5:(5):1994;421-431.
59. Discher D.E., Eisenberg A. Polymer vesicles. Science. 297:(5583):2002;967-973.
60. Napoli A., Tirelli N., Wehrli E., et al. Lyotropic behavior in water of amphiphilic ABA triblock copolymers based on poly(propylene sulfide) and poly(ethylene glycol). Langmuir. 18:(22):2002;8324-8329.
61. Najafi F., Sarbolouki M.N. Biodegradable micelles/polymersomes from fumaric/sebacic acids and poly(ethylene glycol). Biomaterials. 24:2003;1175-1182.