Acid-labile mPEG-vinyl ether-1,2-dioleylglycerol lipids with tunable ph sensitivity: Synthesis and structural effects on hydrolysis rates, DOPE liposome release performance, and pharmacokinetics

Molecular Pharmaceutics

Volumn 9, Issue 11, 2012, Pages 3266-3276

  Shin, Junhwa ^a,c   Shum, Pochi ^a,d   Grey, Jessica ^a,e   Fujiwara, Shin Ichi ^a,f   Malhotra, Guarov S ^b   González Bonet, Andres ^a   Hyun, Seok Hee ^a   Moase, Elaine ^b   Allen, Theresa M ^b   Thompson, David H ^a  

^a PURDUE UNIVERSITY   (United States)

^b UNIVERSITY OF ALBERTA   (Canada)

^c Korea Atomic Energy Research Institute   (South Korea)

^d Cerulean Pharma Inc   (United States)

^e GE Appliance Park   (United States)

^f OSAKA DENTAL UNIVERSITY   (Japan)

Author keywords

dePEGylation; drug delivery; mPEG lipid; vinyl ether hydrolysis

Indexed keywords

1,2 DIOLEOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; 3 METHOXYPOLY(ETHYLENE GLYCOL)VINYLETHER 1,2 DIOLEYLGLYCEROL; CALCEIN; LIPOSOME; PHOSPHATIDYLETHANOLAMINE; POLYMER; RADIOPHARMACEUTICAL AGENT; TYRAMINYLINULIN I 125; UNCLASSIFIED DRUG;

ARTICLE; CIRCULATION; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HYDROLYSIS; DRUG RELEASE; IN VITRO STUDY; IN VIVO STUDY; KINETICS; PH; PRIORITY JOURNAL; SYNTHESIS;

ACIDS; ANIMALS; BLOOD CIRCULATION TIME; DIGLYCERIDES; FEMALE; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LIPIDS; LIPOSOMES; MICE; MICE, INBRED BALB C; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; TISSUE DISTRIBUTION; VINYL COMPOUNDS;

EID: 84868522927     PISSN: 15438384     EISSN: 15438392     Source Type: Journal    
DOI: 10.1021/mp300326z     Document Type: Article

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