A pH-sensitive gene delivery system based on folic acid-PEG-chitosan- PAMAM-plasmid DNA complexes for cancercelltargeting

Biomaterials

Volumn 34, Issue 38, 2013, Pages 10120-10132

  Wang, Mingyue ^a   Hu, Haiyang ^a   Sun, Yuqi ^a,c   Qiu, Lipeng ^a   Zhang, Jie ^a   Guan, Guannan ^a   Zhao, Xiuli ^a   Qiao, Mingxi ^a   Cheng, Liang ^b   Cheng, Lifang ^b   Chen, Dawei ^b  

^a SHENYANG PHARMACEUTICAL UNIVERSITY   (China)

^b SOOCHOW UNIVERSITY   (China)

^c JINZHOU MEDICAL UNIVERSITY   (China)

Author keywords

Gene delivery system; Gene transfection; Lysosomal escape; Nuclear locating sequence; Tumor targeting

Indexed keywords

GENE DELIVERY SYSTEMS; GENE TRANSFECTION; LYSOSOMAL ESCAPE; NUCLEAR LOCATING SEQUENCE; TUMOR TARGETING;

CELLS; CHITOSAN; CYTOLOGY; ELECTROPHORESIS; ENZYME ACTIVITY; GENE EXPRESSION; GENE TRANSFER; ORGANIC ACIDS; TITRATION; TUMORS;

MOLECULAR BIOLOGY;

4 [5 (4 METHYL 1 PIPERAZINYL)[2,5' BI 1H BENZIMIDAZOL] 2' YL]PHENOL; CHITOSAN; DEOXYRIBONUCLEASE I; FOLIC ACID; HEPARIN; HIGH MOBILITY GROUP B1 PROTEIN; LUCIFERASE; MACROGOL; PLASMID DNA; POLYAMIDOAMINE; RED FLUORESCENT PROTEIN;

AGAR GEL ELECTROPHORESIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CANCER CELL; CELLULAR DISTRIBUTION; COMPETITIVE INHIBITION; CONTROLLED STUDY; DRUG CYTOTOXICITY; ENZYME ACTIVITY; ENZYME ASSAY; FEMALE; FLUORESCENCE; GENE EXPRESSION; GENE TARGETING; GENETIC TRANSFECTION; IN VITRO GENE TRANSFER; IN VITRO STUDY; IN VIVO GENE TRANSFER; LYSOSOME; MOUSE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PARTICLE SIZE; PH; PRIORITY JOURNAL; PROTEIN EXPRESSION; TITRIMETRY; TUMOR XENOGRAFT;

MUS MUSCULUS;

GENE DELIVERY SYSTEM; GENE TRANSFECTION; LYSOSOMAL ESCAPE; NUCLEAR LOCATING SEQUENCE; TUMOR TARGETING;

ANIMALS; CELL LINE, TUMOR; CHITOSAN; DENDRIMERS; DNA; FEMALE; FOLIC ACID; GENE TRANSFER TECHNIQUES; HEP G2 CELLS; HUMANS; MICE; MICE, NUDE; PLASMIDS; POLYETHYLENE GLYCOLS;

EID: 84885372418     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2013.09.006     Document Type: Article

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