pH-Sensitive PEG lipids containing orthoester linkers: New potential tools for nonviral gene delivery

Journal of Controlled Release

Volumn 99, Issue 3, 2004, Pages 423-434

  Masson, Christophe ^a   Garinot, Marie ^a   Mignet, Nathalie ^a   Wetzer, Barbara ^a   Mailhe, Philippe ^a   Scherman, Daniel ^a   Bessodes, Michel ^a  

^a UNIVERSITÉ PARIS DESCARTES   (France)

Author keywords

Colloidal stabilization; Gene delivery; Lipoplex; pH sensitive PEG lipids; Tumor

Indexed keywords

INFLAMMATORY TISSUES; ORTHOESTER LINKAGES;

COLLOIDS; DEGRADATION; PH EFFECTS; POLYETHYLENE GLYCOLS; POSITIVE IONS; PRECIPITATION (CHEMICAL); SYNTHESIS (CHEMICAL); TISSUE;

LIPIDS;

ALPHA METHOXY OMEGA [N (2 METHYL 2 OCTADECYLOXY[1,3]DIOXAN 5 YL)AMIDO]POLYETHYLENE GLYCOL; ALPHA METHOXY OMEGA [N 2 (3 HYDROXYPROPYLCHOLESTERYLCARBAMATE) 2 METHYL[1,3]DIOXAN 5 YLAMIDO]POLYETHYLENE GLYCOL; CATION; DNA; ESTER; LIPID; MACROGOL; UNCLASSIFIED DRUG;

ACIDITY; ARTICLE; CONTROLLED STUDY; DRUG CONJUGATION; DRUG FORMULATION; DRUG SENSITIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENDOSOME; ENVIRONMENT; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; INFLAMMATION; ISOELECTRIC POINT; LIPID DEGRADATION; NONVIRAL GENE DELIVERY SYSTEM; PH; PRECIPITATION; PRIORITY JOURNAL; SOLID TUMOR;

CROSS-LINKING REAGENTS; DNA; ESTERS; FRANCE; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; HELA CELLS; HUMANS; HYDROGEN-ION CONCENTRATION; HYDROLYSIS; LIPID BILAYERS; LIPIDS; POLYETHYLENE GLYCOLS; TECHNOLOGY, PHARMACEUTICAL; TRANSFECTION;

EID: 4644323971     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2004.07.016     Document Type: Article

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