Endosomal escape and the knockdown efficiency of liposomal-siRNA by the fusogenic peptide shGALA

Biomaterials

Volumn 32, Issue 24, 2011, Pages 5733-5742

  Sakurai, Yu ^a   Hatakeyama, Hiroto ^a   Sato, Yusuke ^a   Akita, Hidetaka ^a   Takayama, Kentaro ^b   Kobayashi, Sachiko ^b   Futaki, Shiroh ^b   Harashima, Hideyoshi ^a  

^a HOKKAIDO UNIVERSITY   (Japan)

^b KYOTO UNIVERSITY   (Japan)

Author keywords

Liposome; Membrane fusion; Multi functional envelop type nano device (MEND); Peptide; SiRNA delivery

Indexed keywords

BODY WEIGHT; CANCER THERAPY; CELLULAR UPTAKE; CLINICAL DEVELOPMENT; CULTURED CELL; DELIVERY SYSTEMS; GENE SILENCING; IN-VIVO; INHIBITION OF TUMOR GROWTH; INTRACELLULAR TRAFFICKING; MEMBRANE FUSION; MULTI-FUNCTIONAL; NANO DEVICE; SIRNA DELIVERY; SYSTEMIC ADMINISTRATION; TARGET GENES; THERAPEUTIC AGENTS; TUMOR TISSUES;

BIOCHEMISTRY; CELL MEMBRANES; CLARIFICATION; DISEASES; GENETIC ENGINEERING; GLYCOLS; PEPTIDES; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; RNA; TUMORS;

GENE THERAPY;

GALA PEPTIDE; MACROGOL; PEPTIDE; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CANCER GENE THERAPY; CANCER INHIBITION; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG RETENTION; ENDOSOME; FEMALE; GENE SILENCING; GENE TARGETING; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; IN VIVO STUDY; LIVER TOXICITY; MALE; MEMBRANE FUSION; MOUSE; MULTIFUNCTIONAL ENVELOPE TYPE NANODEVICE; NANODEVICE; NONHUMAN; PRIORITY JOURNAL; RETICULOENDOTHELIAL SYSTEM; TUMOR; TUMOR VOLUME;

ANIMALS; CELL LINE, TUMOR; ENDOSOMES; GENE SILENCING; HELA CELLS; HUMANS; LIPOSOMES; MALE; MICE; MICE, INBRED ICR; MICE, NUDE; PEPTIDES; POLYETHYLENE GLYCOLS; RNA, SMALL INTERFERING;

EID: 79957912413     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.04.047     Document Type: Article

References (35)

1. Lares M.R., Rossi J.J., Ouellet D.L. RNAi and small interfering RNAs in human disease therapeutic applications. Trends Biotechnol 2010, 28(11):570-579.
2. Kim D.H., Rossi J.J. Strategies for silencing human disease using RNA interference. Nat Rev Genet 2007, 8(3):173-184.
3. Whitehead K.A., Langer R., Anderson D.G. Knocking down barriers: advances in siRNA delivery. Nat Rev Drug Discov 2009, 8(2):129-138.
4. Gao S., Dagnaes-Hansen F., Nielsen E.J., Wengel J., Besenbacher F., Howard K.A., et al. The effect of chemical modification and nanoparticle formulation on stability and biodistribution of siRNA in mice. Mol Ther 2009, 17(7):1225-1233.
5. Weickmann J.L., Glitz D.G. Human ribonucleases. Quantitation of pancreatic-like enzymes in serum, urine, and organ preparations. J Biol Chem 1982, 257(15):8705-8710.
6. Huh M.S., Lee S.Y., Park S., Lee S., Chung H., Lee S., et al. Tumor-homing glycol chitosan/polyethylenimine nanoparticles for the systemic delivery of siRNA in tumor-bearing mice. J Control Release 2010, 144(2):134-143.
7. Suh M.S., Shim G., Lee H.Y., Han S.E., Yu Y.H., Choi Y., et al. Anionic amino acid-derived cationic lipid for siRNA delivery. J Control Release 2009, 140(3):268-276.
8. Tsai L.R., Chen M.H., Chien C.T., Chen M.K., Lin F.S., Lin K.M., et al. A single-monomer derived linear-like PEI-co-PEG for siRNA delivery and silencing. Biomaterials 2011, 32(14):3647-3653.
9. Nakamura Y., Kogure K., Futaki S., Harashima H. Octaarginine-modified multifunctional envelope-type nano device for siRNA. J Control Release 2007, 119(3):360-367.
10. Matsumura Y., Maeda H. A new concept for macromolecular therapeutics in cancer chemotherapy: mechanism of tumoritropic accumulation of proteins and the antitumor agent smancs. Cancer Res 1986, 46(12 Pt 1):6387-6392.
11. Maeda H., Matsumura Y. Tumoritropic and lymphotropic principles of macromolecular drugs. Crit Rev Ther Drug Carrier Syst 1989, 6(3):193-210.
12. Maeda H., Wu J., Sawa T., Matsumura Y., Hori K. Tumor vascular permeability and the EPR effect in macromolecular therapeutics: a review. J Control Release 2000, 65(1-2):271-284.
13. Mishra S., Webster P., Davis M.E. PEGylation significantly affects cellular uptake and intracellular trafficking of non-viral gene delivery particles. Eur J Cell Biol 2004, 83(3):97-111.
14. Remaut K., Lucas B., Braeckmans K., Demeester J., De Smedt S.C. Pegylation of liposomes favours the endosomal degradation of the delivered phosphodiester oligonucleotides. J Control Release 2007, 117(2):256-266.
15. Hatakeyama H., Akita H., Harashima H. A multifunctional envelope type nano device (MEND) for gene delivery to tumours based on the EPR effect: a strategy for overcoming the PEG dilemma. Adv Drug Deliv Rev 2010, 63(3):152-160.
16. Choi J.S., MacKay J.A., Szoka F.C. Low-pH-sensitive PEG-stabilized plasmid-lipid nanoparticles: preparation and characterization. Bioconjug Chem 2003, 14(2):420-429.
17. Kirpotin D., Hong K., Mullah N., Papahadjopoulos D., Zalipsky S. Liposomes with detachable polymer coating: destabilization and fusion of dioleoylphosphatidylethanolamine vesicles triggered by cleavage of surface-grafted poly(ethylene glycol). FEBS Lett 1996, 388(2-3):115-118.
18. Kuai R., Yuan W., Qin Y., Chen H., Tang J., Yuan M., et al. Efficient delivery of payload into tumor cells in a controlled manner by TAT and thiolytic cleavable PEG co-modified liposomes. Mol Pharmacol 2010, 7(5):1816-1826.
19. Hatakeyama H., Akita H., Ito E., Hayashi Y., Oishi M., Nagasaki Y., et al. Systemic delivery of siRNA to tumors using a lipid nanoparticle containing a tumor-specific cleavable PEG-lipid. Biomaterials 2011, 32(18):4306-4316.
20. Kakudo T., Chaki S., Futaki S., Nakase I., Akaji K., Kawakami T., et al. Transferrin-modified liposomes equipped with a pH-sensitive fusogenic peptide: an artificial viral-like delivery system. Biochemistry 2004, 43(19):5618-5628.
21. Subbarao N.K., Parente R.A., Szoka F.C., Nadasdi L., Pongracz K. pH-dependent bilayer destabilization by an amphipathic peptide. Biochemistry 1987, 26(11):2964-2972.
22. Sakurai Y., Hatakeyama H., Akita H., Oishi M., Nagasaki Y., Futaki S., et al. Efficient short interference RNA delivery to tumor cells using a combination of octaarginine, GALA and tumor-specific, cleavable polyethylene glycol system. Biol Pharm Bull 2009, 32(5):928-932.
23. Hatakeyama H., Ito E., Akita H., Oishi M., Nagasaki Y., Futaki S., et al. A pH-sensitive fusogenic peptide facilitates endosomal escape and greatly enhances the gene silencing of siRNA-containing nanoparticles in vitro and in vivo. J Control Release 2009, 139(2):127-132.
24. Futaki S., Ohashi W., Suzuki T., Niwa M., Tanaka S., Ueda K., et al. Stearylated arginine-rich peptides: a new class of transfection systems. Bioconjug Chem 2001, 12(6):1005-1011.
25. Futaki S., Ishikawa T., Niwa M., Kitagawa K., Yagami T. Embodying a stable alpha-helical protein structure through efficient chemical ligation via thioether formation. Bioorg Med Chem 1997, 5(9):1883-1891.
26. Takei Y., Kadomatsu K., Yuzawa Y., Matsuo S., Muramatsu T. A small interfering RNA targeting vascular endothelial growth factor as cancer therapeutics. Cancer Res 2004, 64(10):3365-3370.
27. Hatakeyama H., Akita H., Kogure K., Oishi M., Nagasaki Y., Kihira Y., et al. Development of a novel systemic gene delivery system for cancer therapy with a tumor-specific cleavable PEG-lipid. Gene Ther 2007, 14(1):68-77.
28. Robbins M., Judge A., MacLachlan I. siRNA and innate immunity. Oligonucleotides 2009, 19(2):89-102.
29. Choi H.S., Huh J., Jo W.H. pH-induced helix-coil transition of amphipathic polypeptide and its association with the lipid bilayer: electrostatic energy calculation. Biomacromolecules 2006, 7(1):403-406.
30. Sugiyama I., Sadzuka Y. Characterization of novel mixed polyethyleneglycol modified liposomes. Biol Pharm Bull 2007, 30(1):208-211.
31. Maruyama K. Intracellular targeting delivery of liposomal drugs to solid tumors based on EPR effects. Adv Drug Deliv Rev 2010, 63(3):161-169.
32. Mellman I., Fuchs R., Helenius A. Acidification of the endocytic and exocytic pathways. Annu Rev Biochem 1986, 55:663-700.
33. Allen T.M., Hansen C. Pharmacokinetics of stealth versus conventional liposomes: effect of dose. Biochim Biophys Acta 1991, 1068(2):133-141.
34. Diebold S.S., Kaisho T., Hemmi H., Akira S. Reis e Sousa C. Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA. Science 2004, 303(5663):1529-1531.
35. Hatakeyama H., Ito E., Yamamoto M., Akita H., Hayashi Y., Kajimoto K., et al. A DNA microarray based analysis of the host response to a non-viral gene carrier: a strategy for improving the immune response. Mol. Ther. 2011, 10.1038/mt.2011.24.