Amphiphilic multi-arm-block copolymer conjugated with doxorubicin via pH-sensitive hydrazone bond for tumor-targeted drug delivery

Biomaterials

Volumn 30, Issue 29, 2009, Pages 5757-5766

  Prabaharan, Mani ^a   Grailer, Jamison J ^b   Pilla, Srikanth ^a   Steeber, Douglas A ^b   Gong, Shaoqin ^a  

^a University of Wisconsin Milwaukee   (United States)

^b UNIVERSITY OF WISCONSIN MILWAUKEE   (United States)

Author keywords

Cellular uptake; Cytotoxicity; Drug delivery; pH sensitive; Tumor targeted; Unimolecular micelles

Indexed keywords

ACIDIC ENVIRONMENT; ACIDIC MEDIUMS; AMPHIPHILIC BLOCK COPOLYMERS; AMPHIPHILICS; ANTICANCER DRUG; ASPARTATES; CANCER CELLS; CELLULAR UPTAKE; DEGRADATION STUDY; DOXORUBICIN; DRUG MOLECULES; ENDOSOMAL COMPARTMENTS; ENVIRONMENTAL PH; HYDRAZONE BONDS; HYDRAZONES; HYDROPHOBIC SEGMENT; HYPERBRANCHED; IN-VIVO; MAMMARY CARCINOMA CELL; NANOCARRIERS; PH-SENSITIVE; POLY(ETHYLENE GLYCOL); POLYMER FRAGMENTS; RECEPTOR-MEDIATED ENDOCYTOSIS; RELEASE PROFILES; RELEASE RATE; TARGETED DRUG DELIVERY; TEM; UNIMOLECULAR MICELLES;

BLOCK COPOLYMERS; CELL CULTURE; CELL MEMBRANES; COPOLYMERIZATION; CYTOTOXICITY; DENDRIMERS; DRUG DELIVERY; DYNAMIC LIGHT SCATTERING; ETHYLENE; ETHYLENE GLYCOL; LIGHT TRANSMISSION; MICELLES; ORGANIC POLYMERS; POLYETHYLENE OXIDES; POLYMER BLENDS; POTENTIOMETRIC SENSORS; TRANSMISSION ELECTRON MICROSCOPY; TUMORS;

POLYETHYLENE GLYCOLS;

DOXORUBICIN; FOLATE RECEPTOR; FOLIC ACID; HYDRAZONE DERIVATIVE; MACROGOL;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; BREAST CARCINOMA; CANCER CELL CULTURE; CANCER THERAPY; CONJUGATION; CONTROLLED STUDY; COVALENT BOND; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG FORMULATION; DRUG RELEASE; DRUG STABILITY; DRUG TARGETING; DRUG UPTAKE; ENDOCYTOSIS; IN VIVO STUDY; MICELLE; MOUSE; NONHUMAN; PARTICLE SIZE; PH; PRIORITY JOURNAL;

ANIMALS; BREAST NEOPLASMS; CELL LINE, TUMOR; CELL SURVIVAL; DOXORUBICIN; DRUG CARRIERS; FEMALE; HYDRAZONES; HYDROGEN-ION CONCENTRATION; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MATERIALS TESTING; MICE; POLYETHYLENE GLYCOLS;

EID: 68549115148     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2009.07.020     Document Type: Article

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