Dual-functional liposomes based on pH-responsive cell-penetrating peptide and hyaluronic acid for tumor-targeted anticancer drug delivery

Biomaterials

Volumn 33, Issue 36, 2012, Pages 9246-9258

  Jiang, Tianyue ^a   Zhang, Zhenhai ^b   Zhang, Yinlong ^a   Lv, Huixia ^a   Zhou, Jianping ^a   Li, Caocao ^a   Hou, Lulu ^a   Zhang, Qiang ^c  

^a CHINA PHARMACEUTICAL UNIVERSITY   (China)

^b Jiangsu Province Academy of Traditional Chinese Medicine   (China)

^c PEKING UNIVERSITY HEALTH SCIENCE CENTER   (China)

Author keywords

Cell penetrating peptides; Hyaluronic acid; Liposomes; PH response; Tumor targeted drug delivery

Indexed keywords

ACTIVE TARGETING; ANTI-CANCER DRUG DELIVERY; ANTI-TUMOR EFFICACY; CELL-PENETRATING PEPTIDE; CELLULAR UPTAKE EFFICIENCY; CONFOCAL LASER SCANNING MICROSCOPY; ELECTROSTATIC EFFECT; HEPATIC CARCINOMA; HYALURONIC ACIDS; HYDROPHOBIC INTERACTIONS; IN-VIVO; IN-VIVO IMAGING; INTRACELLULAR TRAFFICKING; LIPOSOMAL NANOCARRIERS; NEAR-INFRARED DYES; PH RESPONSE; PH SENSITIVE; PH-RESPONSIVE; PLASMA PROTEIN; POSITIVE CHARGES; RAPID DEGRADATION; TUMOR MICROENVIRONMENT; TUMOR SITE; TUMOR TARGETING; TUMOR XENOGRAFTS;

AMINO ACIDS; CELLS; CONFOCAL MICROSCOPY; CYTOLOGY; DRUG DELIVERY; ENZYME ACTIVITY; LIPOSOMES; PEPTIDES; ZETA POTENTIAL;

TUMORS;

ARGININE; CELL PENETRATING PEPTIDE; COUMARIN; HISTIDINE; HYALURONIC ACID; HYALURONIDASE; LIPOSOME; NEAR INFRARED DYE 15; PACLITAXEL; PLASMA PROTEIN; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ANTIPROLIFERATIVE ACTIVITY; ARTICLE; CANCER LOCALIZATION; CELL MIGRATION; CONFOCAL LASER MICROSCOPY; CONTROLLED STUDY; CYTOPLASM; CYTOTOXICITY; DEGRADATION; DRUG ACCUMULATION; DRUG DELIVERY SYSTEM; DRUG EFFICACY; DRUG SCREENING; ENDOSOME; HYDROPHOBICITY; IN VIVO STUDY; LIVER CELL CARCINOMA; LYSOSOME; MALE; MOUSE; NANOFABRICATION; NONHUMAN; PH; PRIORITY JOURNAL; STATIC ELECTRICITY; TUMOR MICROENVIRONMENT; TUMOR XENOGRAFT; VISCOSITY; ZETA POTENTIAL;

ANIMALS; ANTINEOPLASTIC AGENTS; CELL LINE; CELL-PENETRATING PEPTIDES; HEMOLYSIS; HEP G2 CELLS; HUMANS; HYALURONIC ACID; HYDROGEN-ION CONCENTRATION; LIPOSOMES; MALE; MICE; MICE, INBRED BALB C; MICE, NUDE; XENOGRAFT MODEL ANTITUMOR ASSAYS;

MURINAE; MUS;

EID: 84867402736     PISSN: 01429612     EISSN: 18785905     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2012.09.027     Document Type: Article

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