A tumoral acidic pH-responsive drug delivery system based on a novel photosensitizer (fullerene) for in vitro and in vivo chemo-photodynamic therapy

Acta Biomaterialia

Volumn 10, Issue 3, 2014, Pages 1280-1291

  Shi, Jinjin ^a   Liu, Yan ^a   Wang, Lei ^a   Gao, Jun ^a   Zhang, Jing ^a   Yu, Xiaoyuan ^a   Ma, Rou ^a   Liu, Ruiyuan ^a   Zhang, Zhenzhong ^a  

^a ZHENGZHOU UNIVERSITY   (China)

Author keywords

Fullerene; Nanocarrier; pH responsive; Photodynamic therapy; Synergistic effect

Indexed keywords

CADMIUM COMPOUNDS; CHEMOTHERAPY; CONTROLLED DRUG DELIVERY; II-VI SEMICONDUCTORS; PHOTODYNAMIC THERAPY; PHOTOSENSITIZERS; TARGETED DRUG DELIVERY; TUMORS;

ACIDIC PH; ANTI-TUMOR EFFICACY; DOXORUBICIN; DRUG-DELIVERY SYSTEMS; NANOCARRIERS; PH-RESPONSIVE; PHOTOSENSITISER; POLY(ETHYLENEIMINE); SYNERGISTIC EFFECT; TUMOR-TARGETING;

FULLERENES;

DOXORUBICIN; FULLERENE; HYDRAZONE DERIVATIVE; NANOPARTICLE; POLYETHYLENEIMINE; REACTIVE OXYGEN METABOLITE; FULLERENE DERIVATIVE; PHOTOSENSITIZING AGENT;

ACIDITY; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CHEMOTHERAPY; CANCER INHIBITION; CHEMOTHERAPY; CONJUGATE; CONTROLLED STUDY; DNA FRAGMENTATION; DRUG CONJUGATION; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DISTRIBUTION; DRUG EFFICACY; DRUG RELEASE; DRUG SYNTHESIS; IN VITRO STUDY; IN VIVO STUDY; LASER; MELANOMA; MOUSE; NONHUMAN; PHOTODYNAMIC THERAPY; PHOTOTOXICITY; PRIORITY JOURNAL; ANIMAL; ANTIBODY SPECIFICITY; CELL DEATH; CHEMISTRY; DRUG EFFECTS; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; INFRARED SPECTROSCOPY; INTRACELLULAR SPACE; MELANOMA, EXPERIMENTAL; METABOLISM; PATHOLOGY; PH; PHOTOCHEMOTHERAPY; SYNTHESIS; TISSUE DISTRIBUTION; TUMOR VOLUME;

MURINAE; MUS;

ANIMALS; CELL DEATH; DNA FRAGMENTATION; DOXORUBICIN; DRUG DELIVERY SYSTEMS; ENDOCYTOSIS; FEMALE; FLOW CYTOMETRY; FULLERENES; HYDROGEN-ION CONCENTRATION; INTRACELLULAR SPACE; LASERS; MELANOMA, EXPERIMENTAL; MICE; ORGAN SPECIFICITY; PHOTOCHEMOTHERAPY; PHOTOSENSITIZING AGENTS; POLYETHYLENEIMINE; REACTIVE OXYGEN SPECIES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; TISSUE DISTRIBUTION; TUMOR BURDEN;

EID: 84895069070     PISSN: 17427061     EISSN: 18787568     Source Type: Journal    
DOI: 10.1016/j.actbio.2013.10.037     Document Type: Article

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