Block copolymer micelles with acid-labile ortho ester side-chains: Synthesis, characterization, and enhanced drug delivery to human glioma cells

Journal of Controlled Release

Volumn 151, Issue 1, 2011, Pages 18-27

  Tang, Rupei ^a,b   Ji, Weihang ^a   Panus, David ^a   Palumbo, R Noelle ^a   Wang, Chun ^a  

^a University of Minnesota   (United States)

^b JIANGNAN UNIVERSITY   (China)

Author keywords

Anticancer drug delivery; Block copolymer; Glioma; Micelles; Ortho ester

Indexed keywords

ACID-LABILE; AMPHIPHILIC DIBLOCK COPOLYMERS; ANTI-CANCER DRUG DELIVERY; ANTICANCER DRUG; AQUEOUS BUFFER; BIPHASIC; BLOCK COPOLYMER MICELLES; CANCER CELLS; CORE SHELL STRUCTURE; DIBLOCK COPOLYMER; DOSE-DEPENDENT; DOXORUBICIN; DRUG CONCENTRATION; DRUG RELEASE; GLIOMA; GLIOMA CELLS; IN-VITRO; MTT ASSAYS; NANOCARRIERS; ORTHO ESTER; PH-RESPONSIVE; PHYSIOLOGICAL PH; POLYMER CHAINS; POLYMETHACRYLATES; PROTON NMR; SIDE CHAINS; SIDE-CHAIN; SUSTAINED RELEASE;

ATOM TRANSFER RADICAL POLYMERIZATION; BLOCK COPOLYMERS; COPOLYMERIZATION; CRITICAL MICELLE CONCENTRATION; DRUG DELIVERY; DRUG DOSAGE; DRUG PRODUCTS; ESTERIFICATION; ESTERS; ETHYLENE; ETHYLENE GLYCOL; FLUORESCENCE SPECTROSCOPY; FREE RADICAL REACTIONS; PH EFFECTS; PHYSIOLOGY; PLASTIC PRODUCTS; POLYETHYLENE GLYCOLS; POLYETHYLENE OXIDES; TUMORS;

MICELLES;

COPOLYMER; DOXORUBICIN; MACROGOL; POLY(ETHYLENE GLYCOL) BLOCK POLY(2 ETHOXYTETRAHYDROFURAN 2 YLOXYETHYLMETHACRYLATE); POLY(ORTHO ESTER); POLYMETHACRYLIC ACID DERIVATIVE; PYRENE; UNCLASSIFIED DRUG;

ACIDIFICATION; ACIDITY; AQUEOUS SOLUTION; ARTICLE; ATOM TRANSFER RADICAL POLYMERIZATION; CARBON NUCLEAR MAGNETIC RESONANCE; CELL KILLING; CELL NUCLEUS; CHEMICAL STRUCTURE; CONCENTRATION RESPONSE; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG POTENCY; ENDOSOME; FLUORESCENCE SPECTROSCOPY; GLIOMA CELL; HUMAN; HUMAN CELL; HYDROLYSIS; HYDROPHILICITY; LYSOSOME; MICELLE; MOLECULAR STABILITY; MULTIDRUG RESISTANCE; PH; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SUSTAINED DRUG RELEASE; SYNTHESIS;

ANTIBIOTICS, ANTINEOPLASTIC; CELL LINE, TUMOR; CELL SURVIVAL; DELAYED-ACTION PREPARATIONS; DOXORUBICIN; GLIOMA; HUMANS; HYDROGEN-ION CONCENTRATION; MICELLES; POLYETHYLENE GLYCOLS; POLYMETHACRYLIC ACIDS;

EID: 79955465276     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jconrel.2010.12.005     Document Type: Article

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