Amphiphilic block copolymers bearing six-membered ortho ester ring in side chains as potential drug carriers: Synthesis, characterization, and in vivo toxicity evaluation

Journal of Biomaterials Science, Polymer Edition

Volumn 25, Issue 10, 2014, Pages 965-984

  Luo, Shi ^a   Tao, Yangyang ^a   Tang, Rupei ^a   Wang, Rui ^a   Ji, Weihang ^b   Wang, Chun ^b   Zhao, Youliang ^c  

^a JIANGNAN UNIVERSITY   (China)

^b University of Minnesota   (United States)

^c SOOCHOW UNIVERSITY   (China)

Author keywords

acid labile; drug carriers; micelles; ortho ester

Indexed keywords

BLOCK COPOLYMERS; CHAINS; CRITICAL MICELLE CONCENTRATION; DRUG DELIVERY; ESTERS; MICELLES; PH; PHYSIOLOGY; POLYETHYLENE OXIDES;

ACID-LABILE; ACIDIC ENVIRONMENT; AMPHIPHILIC BLOCK COPOLYMERS; DRUG CARRIER; INTRAPERITONEAL INJECTIONS; ORTHO ESTER; PHYSIOLOGICAL CONDITION; REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION;

POLYETHYLENE GLYCOLS;

(5 ETHYL 2 METHOXY [1,3]DIOXANE 5 YL) METHANOL; 2 METHYL ACRYLIC ACID 2 METHOXY 5 METHYL [1,3]DIOXIN 5 YLMETHYL ESTER; 2,2 BIS HYDROXYMETHYL BUTYRIC ACID ETHYL ESTER; 5 ETHYL 2 METHOXY [1,3]DIOXANE 5 CARBOXYLIC ACID ESTER; AMPHOPHILE; ASPARTATE AMINOTRANSFERASE; COPOLYMER; CREATININE; DRUG CARRIER; ESTER; LACTATE DEHYDROGENASE; MACROGOL; MONOMER; PACLITAXEL; POLY(2 METHYL ACRYLIC ACID 2 METHOXY 5 METHYL [1,3]DIOXIN 5 YLMETHYL ESTER); POLY(ETHYLENE GLYCOL) BLOCK POLY(2 METHYLACRYLICACID 2 METHOXY 5 METHYL [1,3]DIOXIN 5 YLMETHYL ESTE; POLYMETHACRYLIC ACID DERIVATIVE; UNCLASSIFIED DRUG; MACROGOL DERIVATIVE; MICELLE; NILE RED; OXAZINE DERIVATIVE; PHOSPHATIDYL-N-MONOMETHYLAMINOETHANOL; PHOSPHATIDYLETHANOLAMINE;

3T3 CELL LINE; ACUTE TOXICITY; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; BIOCOMPATIBILITY; CANCER THERAPY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL KILLING; CELL METABOLISM; CELL VIABILITY; CONTROLLED STUDY; CRITICAL MICELLE CONCENTRATION; CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG POTENCY; DRUG RELEASE; ENCAPSULATION; FEMALE; HYDROLYSIS; HYDROPHOBICITY; IN VITRO STUDY; IN VIVO STUDY; KIDNEY FUNCTION; LIVER FUNCTION; LUNG CANCER CELL LINE; MOUSE; NONHUMAN; PARTICLE SIZE; PH; POLYMERIZATION; PRIORITY JOURNAL; PROTON NUCLEAR MAGNETIC RESONANCE; SYNTHESIS; THERMOSTABILITY; UREA NITROGEN BLOOD LEVEL; ANIMAL; BODY WEIGHT; CHEMICAL PHENOMENA; CHEMISTRY; DRUG EFFECTS; HUMAN; MICELLE; TOXICITY; TOXICITY TESTING; TUMOR CELL LINE;

ANIMALS; BODY WEIGHT; CELL LINE, TUMOR; CHEMISTRY TECHNIQUES, SYNTHETIC; DRUG CARRIERS; ESTERS; FEMALE; HUMANS; HYDROPHOBIC AND HYDROPHILIC INTERACTIONS; MICE; MICELLES; NIH 3T3 CELLS; OXAZINES; PACLITAXEL; PHOSPHATIDYLETHANOLAMINES; POLYETHYLENE GLYCOLS; POLYMERIZATION; TOXICITY TESTS;

EID: 84903786903     PISSN: 09205063     EISSN: 15685624     Source Type: Journal    
DOI: 10.1080/09205063.2014.916095     Document Type: Article

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