Post-insertion of poloxamer 188 strengthened liposomal membrane and reduced drug irritancy and in vivo precipitation, superior to PEGylation

Journal of Controlled Release

Volumn 203, Issue , 2015, Pages 161-169

  Zhang, Wenli ^a,b   Wang, Guangji ^b   See, Esther ^a   Shaw, John P ^a   Baguley, Bruce C ^c   Liu, Jianping ^b   Amirapu, Satya ^a   Wu, Zimei ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

^b CHINA PHARMACEUTICAL UNIVERSITY   (China)

^c UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

Drug retention; Irritation; PEGylated liposomes; Phlebitis; Poloxamer 188; Post injection precipitation

Indexed keywords

CHEMOTHERAPY; CYCLODEXTRINS; ETHYLENE; LIPOSOMES; PHOSPHOLIPIDS; RATS;

DRUG RETENTION; IRRITATION; PEGYLATED LIPOSOMES; PHLEBITIS; POLOXAMER; POST INJECTION;

LOADING;

AMMONIUM SULFATE; ASULACRINE ISETHIONATE; CYCLODEXTRIN; DOXORUBICIN; GLUCOSE; LIPOSOME; MACROGOL; PHOSPHOLIPID; POLOXAMER; AMSACRINE; ANTINEOPLASTIC AGENT; ASULACRINE; MACROGOL DERIVATIVE;

ANIMAL EXPERIMENT; ANIMAL MODEL; AREA UNDER THE CURVE; ARTICLE; BLOOD CLOT; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG COATING; DRUG DISTRIBUTION; DRUG FORMULATION; DRUG HALF LIFE; DRUG RELEASE; DRUG RETENTION; DRUG SOLUBILITY; DRUG STABILITY; DRUG TOLERABILITY; EDEMA; ENCAPSULATION; HISTOCOMPATIBILITY; IN VIVO STUDY; LIPOSOMAL DELIVERY; LIPOSOME MEMBRANE; MALE; NEW ZEALAND WHITE (RABBIT); NONHUMAN; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; RAT; TOXICITY TESTING; ZETA POTENTIAL; ADVERSE EFFECTS; ANALOGS AND DERIVATIVES; ANIMAL; CHEMICALLY INDUCED; CHEMISTRY; INFUSION PUMP; INJECTION; PHLEBITIS; RABBIT; SPRAGUE DAWLEY RAT;

AMSACRINE; ANIMALS; ANTINEOPLASTIC AGENTS; CHEMICAL PRECIPITATION; INFUSION PUMPS; INJECTIONS; LIPOSOMES; MALE; PHLEBITIS; POLOXAMER; POLYETHYLENE GLYCOLS; RABBITS; RATS, SPRAGUE-DAWLEY;

EID: 84923641679     PISSN: 01683659     EISSN: 18734995     Source Type: Journal    
DOI: 10.1016/j.jconrel.2015.02.026     Document Type: Article

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