pH and temperature dual-sensitive liposome gel based on novel cleavable mPEG-Hz-CHEMS polymeric vaginal delivery system

International Journal of Nanomedicine

Volumn 7, Issue , 2012, Pages 2621-2630

  Chen, Daquan ^a   Sun, Kaoxiang ^a   Mu, Hongjie ^a   Tang, Mingtan ^b   Liang, Rongcai ^a   Wang, Aiping ^a   Zhou, Shasha ^a   Sun, Haijun ^a   Zhao, Feng ^a   Yao, Jianwen ^a   Liu, Wanhui ^a  

^a YANTAI UNIVERSITY   (China)

^b SHANDONG UNIVERSITY   (China)

Author keywords

Liposome gel; mPEG Hz CHEMS polymer; pH sensitive liposomes; Thermosensitive; Vaginal delivery

Indexed keywords

ARCTIGENIN; CHOLESTEROL HYDROGEN SUCCINATE; HYDRAZONE DERIVATIVE; MACROGOL 2000; METHOXY POLYETHYLENE GLYCOL 2000; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG ADMINISTRATION ROUTE; GEL; IN VITRO STUDY; INFRARED SPECTROSCOPY; LIPOSOMAL DELIVERY; MICROENCAPSULATION; PH; PHYSICAL CHEMISTRY; SUSTAINED DRUG RELEASE; TEMPERATURE SENSITIVITY;

ANALYSIS OF VARIANCE; CALORIMETRY, DIFFERENTIAL SCANNING; CELL SURVIVAL; CHOLESTEROL ESTERS; FURANS; HEK293 CELLS; HUMANS; HYDRAZONES; HYDROGEN-ION CONCENTRATION; LIGNANS; LIPOSOMES; NANOPARTICLES; PHASE TRANSITION; POLYETHYLENE GLYCOLS; TEMPERATURE; VAGINAL CREAMS, FOAMS, AND JELLIES;

EID: 84870378512     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/IJN.S31757     Document Type: Article

References (17)

1. Awale S, Lu J, Kalauni SK, et al. Identification of arctigenin as an antitumor agent having the ability to eliminate the tolerance of cancer cells to nutrient starvation. Cancer Res. 2006;66:1751-1757.
2. Cho MK, Jang YP, Kim YC, Kim SG. Arctigenin, a phenylpropanoid dibenzylbutyrolactone lignan, inhibits MAP kinases and AP-1 activation via potent MKK inhibition: the role in TNF-vvinhibition. Int Immunopharmacol. 2004;4:1419-1429.
3. Matsumoto T, Hosono-Nishiyama K, Yamada H. Anti-proliferative and apoptotic effects of butyrolactone lignans from Arctium lappa on leukemic cells. Planta Med. 2006;72:276-278.
4. Yang L-M, Lin S-J, Yang T-H, Lee K-H. Synthesis and anti-HIV activity of dibenzyl butyrolactone lignans. Bioorg Med Chem Lett. 1996;8:941-944.
5. Zhao F, Wang L, Liu K. In vitro anti-inflammatory effects of arctigenin, a lignan from Arctium lappa L, through inhibition on iNOS pathway. J Ethnopharmacol. 2009;122:457-462.
6. Hardy E, Jiménez AL, de Pádua KS, Zaneveld LJ. Women's preferences for vaginal antimicrobial contraceptives. III. Choice of a formulation, applicator, and packaging. Contraception. 1998;58:245-249.
7. Kim YT, Shin BK, Garripelli VK, et al. A thermosensitive vaginal gel formulation with HPfCD for the pH-dependent release and solubilization of amphotericin B. Eur J Pharm Sci. 2010;41:399-406.
8. Pavelic Z, Skalko-Basnet N, Jalsenjak I. Characterisation and in vitro evaluation of bioadhesive liposome gels for local therapy of vaginitis. Int J Pharm. 2005;301:140-148.
9. Pavelic Z, Skalko-Basnet N, Schubert R. Liposomal gels for vaginal drug delivery. Int J Pharm. 2001;219:139-149.
10. Chen D, Liu W, Shen Y, et al. Effects of novel pH-sensitive liposome with cleavable esterase-catalyzed and pH-response double smart mPEG-Hz-CHEMS on ABC phenomenon. Int J Nanomedicine. 2011;6:2053-2061.
11. Chen D, Jiang X, Huang Y, Zhang C, Ping Q. pH-Sensitive mPEG-Hzcholesterol conjugates as a liposome delivery system. J Bioact Compat Polym. 2010;25:527-542.
12. Chen D, Jiang X, Liu J, Jin X, Zhang C, Ping Q. In vivo evaluation of novel pH-sensitive mPEG-Hz-Chol conjugate in liposomes: pharmacokinetics, tissue distribution, efficacy assessment. Artif Cells Blood Substit Immobil Biotechnol. 2010;38:136-142.
13. Park JS, Oh YK, Yoon H, Kim JM, Kim CK. In situ gelling and mucoadhesive polymer vehicles for controlled intranasal delivery of plasmid DNA. J Biomed Mater Res. 2002;59:144-151.
14. Garripelli VK, Kim JK, Namgung R, Kim WJ, Repka MA, Jo S. A novel thermosensitive polymer with pH-dependent degradation for drug delivery. Acta Biomater. 2010;6:477-485.
15. Chang JY, Oh YK, Kong HS, et al. Prolonged antifungal effects of clotrimazole-containing mucoadhesive thermosensitive gels on vaginitis. J Control Release. 2002;82:39-50.
16. Bilensoy E, Rouf MA, Vural I, Sen M, Hincal AA. Mucoadhesive, thermosensitive, prolonged-release vaginal gel for clotrimazole: beta-cyclodextrin complex. AAPS Pharm Sci Tech. 2006;7:E38.
17. Kim HK, Kim YT, Cho YH, et al. Cytotoxicity evaluation on hydrogels for medical devices based on the International Organization for Standardization. Journal of Korean Pharmaceutical Sciences. 2009;39:127-131.