메뉴 건너뛰기




Volumn 6, Issue 2, 2013, Pages 124-160

siRNA genome screening approaches to therapeutic drug repositioning

Author keywords

Antiviral; Bacteria; Genome; Host genes; HTS; miRNA; Pathogen; Pathway; Reposition; Repurpose; RNAi; siRNA; Therapeutic; Virus

Indexed keywords

AMFEBUTAMONE; AMPHOTERICIN; ARSENIC; ASTEMIZOLE; AURANOFIN; CEFTRIAXONE; CLOSANTEL; COTRIMOXAZOLE; DAPOXETINE; DAPSONE; DIGOXIN; EFLORNITHINE; FOSMIDOMYCIN; FUMAGILLIN; HARMINE; ITRACONAZOLE; MEPACRINE; MILTEFOSINE; MYCOPHENOLIC ACID; NITROXOLINE; PAFURAMIDINE; PAROMOMYCIN; PENTAMIDINE; RALOXIFENE; RETINOIC ACID; RILUZOLE; SMALL INTERFERING RNA; SUTEZOLID; THALIDOMIDE;

EID: 84873112511     PISSN: None     EISSN: 14248247     Source Type: Journal    
DOI: 10.3390/ph6020124     Document Type: Review
Times cited : (25)

References (169)
  • 1
    • 70349482953 scopus 로고    scopus 로고
    • Novel trends in high-throughput screening
    • Mayr, L.M.; Bojanic, D. Novel trends in high-throughput screening. Curr. Opin. Pharmacol. 2009, 9, 580-588.
    • (2009) Curr. Opin. Pharmacol , vol.9 , pp. 580-588
    • Mayr, L.M.1    Bojanic, D.2
  • 2
    • 40649094486 scopus 로고    scopus 로고
    • Towards improving compound selection in structure-based virtual screening
    • Waszkowycz, B. Towards improving compound selection in structure-based virtual screening. Drug Discov. Today 2008, 13, 219-226.
    • (2008) Drug Discov. Today , vol.13 , pp. 219-226
    • Waszkowycz, B.1
  • 4
    • 4344668661 scopus 로고    scopus 로고
    • Drug repositioning: Identifying and developing new uses for existing drugs
    • Ashburn, T.T.; Thor, K.B. Drug repositioning: identifying and developing new uses for existing drugs. Nat. Rev. Drug Discov. 2004, 3, 673-683.
    • (2004) Nat. Rev. Drug Discov , vol.3 , pp. 673-683
    • Ashburn, T.T.1    Thor, K.B.2
  • 5
    • 33751544571 scopus 로고    scopus 로고
    • What's in a number?
    • Drews, J. What's in a number? Nat. Rev. Drug Discov. 2006, 5, 975-975.
    • (2006) Nat. Rev. Drug Discov , vol.5 , pp. 975
    • Drews, J.1
  • 6
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire, A.; Xu, S.; Montgomery, M.K.; Kostas, S.A.; Driver, S.E.; Mello, C.C. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998, 391, 806-811.
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 7
    • 60149088848 scopus 로고    scopus 로고
    • Origins and Mechanisms of miRNAs and siRNAs
    • Carthew, R.W.; Sontheimer, E.J. Origins and Mechanisms of miRNAs and siRNAs. Cell 2009, 136, 642-655.
    • (2009) Cell , vol.136 , pp. 642-655
    • Carthew, R.W.1    Sontheimer, E.J.2
  • 9
    • 0027751663 scopus 로고
    • The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee, R.C.; Feinbaum, R.L.; Ambros, V. The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993, 75, 843-854.
    • (1993) Cell , vol.75 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 10
    • 0035656688 scopus 로고    scopus 로고
    • Non-coding RNA genes and the modern RNA world
    • Eddy, S.R. Non-coding RNA genes and the modern RNA world. Nat. Rev. Genet. 2001, 2, 919-929.
    • (2001) Nat. Rev. Genet , vol.2 , pp. 919-929
    • Eddy, S.R.1
  • 12
    • 84867880308 scopus 로고    scopus 로고
    • MicroRNA regulatory networks and human disease
    • Mo, Y.-Y. MicroRNA regulatory networks and human disease. Cell. Mol. Life Sci. 2012, 69, 3529-3531.
    • (2012) Cell. Mol. Life Sci , vol.69 , pp. 3529-3531
    • Mo, Y.-Y.1
  • 16
    • 33745612464 scopus 로고    scopus 로고
    • Widespread siRNA off-target transcript silencing mediated by seed region sequence complementarity
    • Jackson, A.L.; Burchard, J.; Schelter, J.; Chau, B.N.; Cleary, M.; Lim, L.; Linsley, P.S. Widespread siRNA off-target transcript silencing mediated by seed region sequence complementarity. RNA 2006, 12, 1179-1187.
    • (2006) RNA , vol.12 , pp. 1179-1187
    • Jackson, A.L.1    Burchard, J.2    Schelter, J.3    Chau, B.N.4    Cleary, M.5    Lim, L.6    Linsley, P.S.7
  • 17
    • 0036544755 scopus 로고    scopus 로고
    • Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative posttranscriptional regulation
    • Lai, E.C. Micro RNAs are complementary to 3' UTR sequence motifs that mediate negative posttranscriptional regulation. Nat. Genet. 2002, 30, 363-364.
    • (2002) Nat. Genet , vol.30 , pp. 363-364
    • Lai, E.C.1
  • 18
    • 77949268292 scopus 로고    scopus 로고
    • Computational approaches for microRNA studies: A review
    • Li, L.; Xu, J.; Yang, D.; Tan, X.; Wang, H. Computational approaches for microRNA studies: a review. Mamm. Genome 2010, 21, 1-12.
    • (2010) Mamm. Genome , vol.21 , pp. 1-12
    • Li, L.1    Xu, J.2    Yang, D.3    Tan, X.4    Wang, H.5
  • 21
    • 0141750434 scopus 로고    scopus 로고
    • Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening
    • Aza-Blanc, P.; Cooper, C.L.; Wagner, K.; Batalov, S.; Deveraux, Q.L.; Cooke, M.P. Identification of Modulators of TRAIL-Induced Apoptosis via RNAi-Based Phenotypic Screening. Mol. Cell 2003, 12, 627-637.
    • (2003) Mol. Cell , vol.12 , pp. 627-637
    • Aza-Blanc, P.1    Cooper, C.L.2    Wagner, K.3    Batalov, S.4    Deveraux, Q.L.5    Cooke, M.P.6
  • 25
    • 19944430064 scopus 로고    scopus 로고
    • High-Throughput RNA Interference Strategies for Target Discovery and Validation by Using Synthetic Short Interfering RNAs: Functional Genomics Investigations of Biological Pathways
    • Sachse, C.; Krausz, E.; Krönke, A.; Hannus, M.; Walsh, A.; Grabner, A.; Ovcharenko, D.; Dorris, D.; Trudel, C.; Sönnichsen, B. et al. High-Throughput RNA Interference Strategies for Target Discovery and Validation by Using Synthetic Short Interfering RNAs: Functional Genomics Investigations of Biological Pathways. Methods Enzymol. 2005, 392, 242-277.
    • (2005) Methods Enzymol , vol.392 , pp. 242-277
    • Sachse, C.1    Krausz, E.2    Krönke, A.3    Hannus, M.4    Walsh, A.5    Grabner, A.6    Ovcharenko, D.7    Dorris, D.8    Trudel, C.9    Sönnichsen, B.10
  • 27
    • 84860356330 scopus 로고    scopus 로고
    • Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells
    • Simpson, K.J.; Davis, G.M.; Boag, P.R. Comparative high-throughput RNAi screening methodologies in C. elegans and mammalian cells. N. Biotechnol. 2012, 29, 459-470.
    • (2012) N. Biotechnol , vol.29 , pp. 459-470
    • Simpson, K.J.1    Davis, G.M.2    Boag, P.R.3
  • 28
    • 77953626646 scopus 로고    scopus 로고
    • Genomic screening with RNAi: Results and challenges
    • Mohr, S.; Bakal, C.; Perrimon, N. Genomic screening with RNAi: results and challenges. Annu. Rev. Biochem. 2010, 79, 37-64.
    • (2010) Annu. Rev. Biochem , vol.79 , pp. 37-64
    • Mohr, S.1    Bakal, C.2    Perrimon, N.3
  • 29
    • 84867594876 scopus 로고    scopus 로고
    • RNAi screening: New approaches, understandings, and organisms
    • Mohr, S.E.; Perrimon, N. RNAi screening: new approaches, understandings, and organisms. Wiley Interdiscip. Rev. RNA 2012, 3, 145-158.
    • (2012) Wiley Interdiscip. Rev. RNA , vol.3 , pp. 145-158
    • Mohr, S.E.1    Perrimon, N.2
  • 30
    • 29144531173 scopus 로고    scopus 로고
    • The druggable genome: An update
    • Russ, A.P.; Lampel, S. The druggable genome: an update. Drug Discov. Today 2005, 10, 1607-1610.
    • (2005) Drug Discov. Today , vol.10 , pp. 1607-1610
    • Russ, A.P.1    Lampel, S.2
  • 31
    • 77149130553 scopus 로고    scopus 로고
    • Automated microscopy for high-content RNAi screening
    • Conrad, C.; Gerlich, D.W. Automated microscopy for high-content RNAi screening. J. Cell Biol. 2010, 188, 453-461.
    • (2010) J. Cell Biol , vol.188 , pp. 453-461
    • Conrad, C.1    Gerlich, D.W.2
  • 32
    • 58449134534 scopus 로고    scopus 로고
    • Small silencing RNAs: An expanding universe
    • Ghildiyal, M.; Zamore, P.D. Small silencing RNAs: an expanding universe. Nat. Rev. Genet. 2009, 10, 94-108.
    • (2009) Nat. Rev. Genet , vol.10 , pp. 94-108
    • Ghildiyal, M.1    Zamore, P.D.2
  • 35
    • 21344457432 scopus 로고    scopus 로고
    • RNA interference: From gene silencing to gene-specific therapeutics
    • Leung, R.K.; Whittaker, P.A. RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol. Ther. 2005, 107, 222-239.
    • (2005) Pharmacol. Ther , vol.107 , pp. 222-239
    • Leung, R.K.1    Whittaker, P.A.2
  • 37
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir, S.M.; Harborth, J.; Lendeckel, W.; Yalcin, A.; Weber, K.; Tuschl, T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001, 411, 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 38
    • 77953832371 scopus 로고    scopus 로고
    • Silencing of gene expression in cultured cells using small interfering RNAs
    • Chapter 27, Unit
    • Sakurai, K.; Chomchan, P.; Rossi, J.J. Silencing of gene expression in cultured cells using small interfering RNAs. Curr. Protoc. Cell Biol. 2010, Chapter 27, Unit 27 21 21-28.
    • (2010) Curr. Protoc. Cell Biol , vol.27 , Issue.21 , pp. 21-28
    • Sakurai, K.1    Chomchan, P.2    Rossi, J.J.3
  • 39
    • 84934438136 scopus 로고    scopus 로고
    • siRNA and DNA transfer to cultured cells
    • Gopalakrishnan, B.; Wolff, J. siRNA and DNA transfer to cultured cells. Methods Mol. Biol. 2009, 480, 31-52.
    • (2009) Methods Mol. Biol , vol.480 , pp. 31-52
    • Gopalakrishnan, B.1    Wolff, J.2
  • 41
    • 33846863764 scopus 로고    scopus 로고
    • Multiple strategies for gene transfer, expression, knockdown, and chromatin influence in mammalian cell lines and transgenic animals
    • Recillas-Targa, F. Multiple strategies for gene transfer, expression, knockdown, and chromatin influence in mammalian cell lines and transgenic animals. Mol. Biotechnol. 2006, 34, 337-354.
    • (2006) Mol. Biotechnol , vol.34 , pp. 337-354
    • Recillas-Targa, F.1
  • 44
    • 77956667224 scopus 로고    scopus 로고
    • Selective gene silencing by viral delivery of short hairpin
    • Sliva, K.; Schnierle, B.S. Selective gene silencing by viral delivery of short hairpin RNA. Virol. J. 2010, 7, 248.
    • (2010) RNA. Virol. J , vol.7 , pp. 248
    • Sliva, K.1    Schnierle, B.S.2
  • 45
    • 0026654682 scopus 로고
    • Human immunodeficiency virus infection of cells arrested in the cell cycle
    • Lewis, P.; Hensel, M.; Emerman, M. Human immunodeficiency virus infection of cells arrested in the cell cycle. EMBO J. 1992, 11, 3053-3058.
    • (1992) EMBO J , vol.11 , pp. 3053-3058
    • Lewis, P.1    Hensel, M.2    Emerman, M.3
  • 46
    • 0028055281 scopus 로고
    • Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus
    • Lewis, P.F.; Emerman, M. Passage through mitosis is required for oncoretroviruses but not for the human immunodeficiency virus. J. Virol. 1994, 68, 510-516.
    • (1994) J. Virol , vol.68 , pp. 510-516
    • Lewis, P.F.1    Emerman, M.2
  • 47
    • 0025279872 scopus 로고
    • Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection
    • Miller, D.G.; Adam, M.A.; Miller, A.D. Gene transfer by retrovirus vectors occurs only in cells that are actively replicating at the time of infection. Mol. Cell Biol. 1990, 10, 4239-4242.
    • (1990) Mol. Cell Biol , vol.10 , pp. 4239-4242
    • Miller, D.G.1    Adam, M.A.2    Miller, A.D.3
  • 48
    • 0036559334 scopus 로고    scopus 로고
    • Adenovirus as an integrating vector
    • Mitani, K.; Kubo, S. Adenovirus as an integrating vector. Curr. Gene Ther. 2002, 2, 135-144.
    • (2002) Curr. Gene Ther , vol.2 , pp. 135-144
    • Mitani, K.1    Kubo, S.2
  • 49
    • 11844283958 scopus 로고    scopus 로고
    • Adeno-associated virus vectors for short hairpin RNA expression
    • Grimm, D.; Pandey, K.; Kay, M.A. Adeno-associated virus vectors for short hairpin RNA expression. Methods Enzymol. 2005, 392, 381-405.
    • (2005) Methods Enzymol , vol.392 , pp. 381-405
    • Grimm, D.1    Pandey, K.2    Kay, M.A.3
  • 50
  • 51
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • Bartel, D.P. MicroRNAs: genomics, biogenesis, mechanism, and function. Cell 2004, 116, 281-297.
    • (2004) Cell , vol.116 , pp. 281-297
    • Bartel, D.P.1
  • 53
    • 0142173075 scopus 로고    scopus 로고
    • Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells
    • Saxena, S.; Jonsson, Z.O.; Dutta, A. Small RNAs with imperfect match to endogenous mRNA repress translation. Implications for off-target activity of small inhibitory RNA in mammalian cells. J. Biol. Chem. 2003, 278, 44312-44319.
    • (2003) J. Biol. Chem , vol.278 , pp. 44312-44319
    • Saxena, S.1    Jonsson, Z.O.2    Dutta, A.3
  • 54
    • 80355148655 scopus 로고    scopus 로고
    • MISSION esiRNA for RNAi Screening in Mammalian Cells
    • Theis, M.; Buchholz, F. MISSION esiRNA for RNAi Screening in Mammalian Cells. J. Vis. Exp. 2010, 39, pii: 2008.
    • (2010) J. Vis. Exp , vol.39 , pp. 2008
    • Theis, M.1    Buchholz, F.2
  • 56
    • 1542306855 scopus 로고    scopus 로고
    • Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase
    • Kim, D.H.; Longo, M.; Han, Y.; Lundberg, P.; Cantin, E.; Rossi, J.J. Interferon induction by siRNAs and ssRNAs synthesized by phage polymerase. Nat. Biotechnol. 2004, 22, 321-325.
    • (2004) Nat. Biotechnol , vol.22 , pp. 321-325
    • Kim, D.H.1    Longo, M.2    Han, Y.3    Lundberg, P.4    Cantin, E.5    Rossi, J.J.6
  • 58
    • 34447306000 scopus 로고    scopus 로고
    • Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing
    • Bartlett, D.W.; Davis, M.E. Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing. Biotechnol. Bioeng. 2007, 97, 909-921.
    • (2007) Biotechnol. Bioeng , vol.97 , pp. 909-921
    • Bartlett, D.W.1    Davis, M.E.2
  • 59
    • 48549105152 scopus 로고    scopus 로고
    • Modifications in small interfering RNA that separate immunostimulation from RNA interference
    • Eberle, F.; Giessler, K.; Deck, C.; Heeg, K.; Peter, M.; Richert, C.; Dalpke, A.H. Modifications in small interfering RNA that separate immunostimulation from RNA interference. J. Immunol. 2008, 180, 3229-3237.
    • (2008) J. Immunol , vol.180 , pp. 3229-3237
    • Eberle, F.1    Giessler, K.2    Deck, C.3    Heeg, K.4    Peter, M.5    Richert, C.6    Dalpke, A.H.7
  • 63
    • 65749119809 scopus 로고    scopus 로고
    • Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy
    • Takahashi, Y.; Nishikawa, M.; Takakura, Y. Nonviral vector-mediated RNA interference: Its gene silencing characteristics and important factors to achieve RNAi-based gene therapy. Adv. Drug Deliv. Rev. 2009, 61, 760-766.
    • (2009) Adv. Drug Deliv. Rev , vol.61 , pp. 760-766
    • Takahashi, Y.1    Nishikawa, M.2    Takakura, Y.3
  • 64
    • 0036752785 scopus 로고    scopus 로고
    • RNAi in human cells: Basic structural and functional features of small interfering RNA
    • Chiu, Y.L.; Rana, T.M. RNAi in human cells: basic structural and functional features of small interfering RNA. Mol. Cell 2002, 10, 549-561.
    • (2002) Mol. Cell , vol.10 , pp. 549-561
    • Chiu, Y.L.1    Rana, T.M.2
  • 65
    • 83555166124 scopus 로고    scopus 로고
    • Subcellular fate and off-target effects of siRNA, shRNA, and miRNA
    • Singh, S.; Narang, A.S.; Mahato, R.I. Subcellular fate and off-target effects of siRNA, shRNA, and miRNA. Pharm. Res. 2011, 28, 2996-3015.
    • (2011) Pharm. Res , vol.28 , pp. 2996-3015
    • Singh, S.1    Narang, A.S.2    Mahato, R.I.3
  • 66
    • 0001469617 scopus 로고    scopus 로고
    • Retroviridae: The Retroviruses and Their Replication
    • Knipe, D. M.; Howley, P.M., Eds.; Lippincott Williams & Wilkins: Philadelphia, PA
    • Goff, S.P. Retroviridae: The Retroviruses and Their Replication. In Fields Virology; Knipe, D. M.; Howley, P.M., Eds.; Lippincott Williams & Wilkins: Philadelphia, PA, 2001; Vol. 2, pp. 1871-1940.
    • (2001) Fields Virology , vol.2 , pp. 1871-1940
    • Goff, S.P.1
  • 68
    • 23844442475 scopus 로고    scopus 로고
    • Genome-wide RNAi screen for host factors required for intracellular bacterial infection
    • Agaisse, H.; Burrack, L.S.; Philips, J.A.; Rubin, E.J.; Perrimon, N.; Higgins, D.E. Genome-wide RNAi screen for host factors required for intracellular bacterial infection. Science 2005, 309, 1248-1251.
    • (2005) Science , vol.309 , pp. 1248-1251
    • Agaisse, H.1    Burrack, L.S.2    Philips, J.A.3    Rubin, E.J.4    Perrimon, N.5    Higgins, D.E.6
  • 69
    • 80051516633 scopus 로고    scopus 로고
    • RNAi screen reveals host cell kinases specifically involved in Listeria monocytogenes spread from cell to cell
    • Chong, R.; Squires, R.; Swiss, R.; Agaisse, H. RNAi screen reveals host cell kinases specifically involved in Listeria monocytogenes spread from cell to cell. PLoS One 2011, 6, e23399.
    • (2011) PLoS One , pp. 6
    • Chong, R.1    Squires, R.2    Swiss, R.3    Agaisse, H.4
  • 70
    • 23844531867 scopus 로고    scopus 로고
    • Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection
    • Philips, J.A.; Rubin, E.J.; Perrimon, N. Drosophila RNAi screen reveals CD36 family member required for mycobacterial infection. Science 2005, 309, 1251-1253.
    • (2005) Science , vol.309 , pp. 1251-1253
    • Philips, J.A.1    Rubin, E.J.2    Perrimon, N.3
  • 71
    • 38649109427 scopus 로고    scopus 로고
    • Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection
    • Koo, I.C.; Ohol, Y.M.; Wu, P.; Morisaki, J.H.; Cox, J.S.; Brown, E.J. Role for lysosomal enzyme beta-hexosaminidase in the control of mycobacteria infection. Proc. Natl. Acad. Sci. USA 2008, 105, 710-715.
    • (2008) Proc. Natl. Acad. Sci. USA , vol.105 , pp. 710-715
    • Koo, I.C.1    Ohol, Y.M.2    Wu, P.3    Morisaki, J.H.4    Cox, J.S.5    Brown, E.J.6
  • 72
    • 77954039582 scopus 로고    scopus 로고
    • Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen
    • Jayaswal, S.; Kamal, M.A.; Dua, R.; Gupta, S.; Majumdar, T.; Das, G.; Kumar, D.; Rao, K.V. Identification of host-dependent survival factors for intracellular Mycobacterium tuberculosis through an siRNA screen. PLoS Pathog. 2010, 6, e1000839.
    • (2010) PLoS Pathog , pp. 6
    • Jayaswal, S.1    Kamal, M.A.2    Dua, R.3    Gupta, S.4    Majumdar, T.5    Das, G.6    Kumar, D.7    Rao, K.V.8
  • 73
    • 77649112187 scopus 로고    scopus 로고
    • Genome-wide nalysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis
    • Kumar, D.; Nath, L.; Kamal, M.A.; Varshney, A.; Jain, A.; Singh, S.; Rao, K.V. Genome-wide nalysis of the host intracellular network that regulates survival of Mycobacterium tuberculosis. Cell 2010, 140, 731-743.
    • (2010) Cell , vol.140 , pp. 731-743
    • Kumar, D.1    Nath, L.2    Kamal, M.A.3    Varshney, A.4    Jain, A.5    Singh, S.6    Rao, K.V.7
  • 74
    • 36048985618 scopus 로고    scopus 로고
    • RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection
    • Derre, I.; Pypaert, M.; Dautry-Varsat, A.; Agaisse, H. RNAi screen in Drosophila cells reveals the involvement of the Tom complex in Chlamydia infection. PLoS Pathog. 2007, 3, 1446-1458.
    • (2007) PLoS Pathog , vol.3 , pp. 1446-1458
    • Derre, I.1    Pypaert, M.2    Dautry-Varsat, A.3    Agaisse, H.4
  • 75
    • 42949086499 scopus 로고    scopus 로고
    • RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry
    • Elwell, C.A.; Ceesay, A.; Kim, J.H.; Kalman, D.; Engel, J.N. RNA interference screen identifies Abl kinase and PDGFR signaling in Chlamydia trachomatis entry. PLoS Pathog. 2008, 4, e1000021.
    • (2008) PLoS Pathog , vol.4
    • Elwell, C.A.1    Ceesay, A.2    Kim, J.H.3    Kalman, D.4    Engel, J.N.5
  • 77
    • 70049104688 scopus 로고    scopus 로고
    • Caenorhabditis elegans semi-automated liquid screen reveals a specialized role for he chemotaxis gene cheb2 in pseudomonas aeruginosa virulence
    • Garvis, S.; Munder, A.; Ball, G.; de Bentzmann, S.; Wiehlmann, L.; Ewbank, J.J.; Tummler, B.; Filloux, A. Caenorhabditis elegans semi-automated liquid screen reveals a specialized role for he chemotaxis gene cheb2 in pseudomonas aeruginosa virulence. PLoS Pathog. 2009, 5, e1000540.
    • (2009) PLoS Pathog , vol.5
    • Garvis, S.1    Munder, A.2    Ball, G.3    de Bentzmann, S.4    Wiehlmann, L.5    Ewbank, J.J.6    Tummler, B.7    Filloux, A.8
  • 78
    • 42949162611 scopus 로고    scopus 로고
    • RNAi screen reveals an Abl kinase dependent host cell pathway involved in Pseudomonas aeruginosa internalization
    • Pielage, J.F.; Powell, K.R.; Kalman, D.; Engel, J.N. RNAi screen reveals an Abl kinase dependent host cell pathway involved in Pseudomonas aeruginosa internalization. PLoS Pathog. 2008, 4, e1000031.
    • (2008) PLoS Pathog , vol.4
    • Pielage, J.F.1    Powell, K.R.2    Kalman, D.3    Engel, J.N.4
  • 80
    • 84862225655 scopus 로고    scopus 로고
    • Human genome-wide RNAi screen for host factors that modulate intracellular Salmonella growth
    • Thornbrough, J.M.; Hundley, T.; Valdivia, R.; Worley, M.J. Human genome-wide RNAi screen for host factors that modulate intracellular Salmonella growth. PLoS One 2012, 7, e38097.
    • (2012) PLoS One , vol.7
    • Thornbrough, J.M.1    Hundley, T.2    Valdivia, R.3    Worley, M.J.4
  • 81
    • 48249132855 scopus 로고    scopus 로고
    • RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication
    • Qin, Q.M.; Pei, J.; Ancona, V.; Shaw, B.D.; Ficht, T.A.; de Figueiredo, P. RNAi screen of endoplasmic reticulum-associated host factors reveals a role for IRE1alpha in supporting Brucella replication. PLoS Pathog. 2008, 4, e1000110.
    • (2008) PLoS Pathog , vol.4
    • Qin, Q.M.1    Pei, J.2    Ancona, V.3    Shaw, B.D.4    Ficht, T.A.5    de Figueiredo, P.6
  • 82
    • 84863116601 scopus 로고    scopus 로고
    • Genome-wide RNAi screen in IFN-gamma-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis
    • Zhou, H.; DeLoid, G.; Browning, E.; Gregory, D.J.; Tan, F.; Bedugnis, A.S.; Imrich, A.; Koziel, H.; Kramnik, I.; Lu, Q. et al. Genome-wide RNAi screen in IFN-gamma-treated human macrophages identifies genes mediating resistance to the intracellular pathogen Francisella tularensis. PLoS One 2012, 7, e31752.
    • (2012) PLoS One , vol.7
    • Zhou, H.1    Deloid, G.2    Browning, E.3    Gregory, D.J.4    Tan, F.5    Bedugnis, A.S.6    Imrich, A.7    Koziel, H.8    Kramnik, I.9    Lu, Q.10
  • 83
    • 31144437860 scopus 로고    scopus 로고
    • Identification of Drosophila gene products required for phagocytosis of Candida albicans
    • Stroschein-Stevenson, S.L.; Foley, E.; O'Farrell, P.H.; Johnson, A.D. Identification of Drosophila gene products required for phagocytosis of Candida albicans. PLoS Biol. 2006, 4, e4.
    • (2006) PLoS Biol , vol.4
    • Stroschein-Stevenson, S.L.1    Foley, E.2    O'Farrell, P.H.3    Johnson, A.D.4
  • 84
    • 79959848082 scopus 로고    scopus 로고
    • Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans
    • Qin, Q.M.; Luo, J.; Lin, X.; Pei, J.; Li, L.; Ficht, T.A.; de Figueiredo, P. Functional analysis of host factors that mediate the intracellular lifestyle of Cryptococcus neoformans. PLoS Pathog. 2011, 7, e1002078.
    • (2011) PLoS Pathog , vol.7
    • Qin, Q.M.1    Luo, J.2    Lin, X.3    Pei, J.4    Li, L.5    Ficht, T.A.6    de Figueiredo, P.7
  • 90
    • 33646007995 scopus 로고    scopus 로고
    • Stable RNA interference f host thrombospondin-1 blocks Trypanosoma cruzi infection
    • Simmons, K.J.; Nde, P.N.; Kleshchenko, Y.Y.; Lima, M.F.; Villalta, F. Stable RNA interference f host thrombospondin-1 blocks Trypanosoma cruzi infection. FEBS Lett. 2006, 580, 2365-2370.
    • (2006) FEBS Lett , vol.580 , pp. 2365-2370
    • Simmons, K.J.1    Nde, P.N.2    Kleshchenko, Y.Y.3    Lima, M.F.4    Villalta, F.5
  • 91
    • 61949248734 scopus 로고    scopus 로고
    • Silencing cytokeratin 18 gene inhibits intracellular replication of Trypanosoma cruzi in HeLa cells but not binding and invasion of trypanosomes
    • Claser, C.; Curcio, M.; de Mello, S.M.; Silveira, E.V.; Monteiro, H.P.; Rodrigues, M.M. Silencing cytokeratin 18 gene inhibits intracellular replication of Trypanosoma cruzi in HeLa cells but not binding and invasion of trypanosomes. BMC Cell Biol. 2008, 9, 68.
    • (2008) BMC Cell Biol , vol.9 , pp. 68
    • Claser, C.1    Curcio, M.2    de Mello, S.M.3    Silveira, E.V.4    Monteiro, H.P.5    Rodrigues, M.M.6
  • 92
    • 67149146439 scopus 로고    scopus 로고
    • A new Houdini act: Multiple routes for HIV-1 escape from rnai-mediated inhibition
    • Berkhout, B. A new Houdini act: Multiple routes for HIV-1 escape from rnai-mediated inhibition. Future Microbiol. 2009, 4, 151-154.
    • (2009) Future Microbiol , vol.4 , pp. 151-154
    • Berkhout, B.1
  • 93
    • 55249098418 scopus 로고    scopus 로고
    • HIV evades RNA interference directed at TAR by an indirect compensatory mechanism
    • Leonard, J.N.; Shah, P.S.; Burnett, J.C.; Schaffer, D.V. HIV evades RNA interference directed at TAR by an indirect compensatory mechanism. Cell Host Microbe 2008, 4, 484-494.
    • (2008) Cell Host Microbe , vol.4 , pp. 484-494
    • Leonard, J.N.1    Shah, P.S.2    Burnett, J.C.3    Schaffer, D.V.4
  • 94
    • 18144372773 scopus 로고    scopus 로고
    • Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5
    • Ping, Y.H.; Chu, C.Y.; Cao, H.; Jacque, J.M.; Stevenson, M.; Rana, T.M. Modulating HIV-1 replication by RNA interference directed against human transcription elongation factor SPT5. Retrovirology 2004, 1, 46.
    • (2004) Retrovirology , vol.1 , pp. 46
    • Ping, Y.H.1    Chu, C.Y.2    Cao, H.3    Jacque, J.M.4    Stevenson, M.5    Rana, T.M.6
  • 96
    • 33645960667 scopus 로고    scopus 로고
    • UnPAKing human immunodeficiency virus (HIV) replication: Using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection
    • Nguyen, D.G.; Wolff, K.C.; Yin, H.; Caldwell, J.S.; Kuhen, K.L. UnPAKing human immunodeficiency virus (HIV) replication: using small interfering RNA screening to identify novel cofactors and elucidate the role of group I PAKs in HIV infection. J. Virol. 2006, 80, 130-137.
    • (2006) J. Virol , vol.80 , pp. 130-137
    • Nguyen, D.G.1    Wolff, K.C.2    Yin, H.3    Caldwell, J.S.4    Kuhen, K.L.5
  • 99
    • 77949530684 scopus 로고    scopus 로고
    • Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells
    • Rato, S.; Maia, S.; Brito, P.M.; Resende, L.; Pereira, C.F.; Moita, C.; Freitas, R.P.; Moniz-Pereira, J.; Hacohen, N.; Moita, L.F. et al. Novel HIV-1 knockdown targets identified by an enriched kinases/phosphatases shRNA library using a long-term iterative screen in Jurkat T-cells. PLoS One 2010, 5, e9276.
    • (2010) PLoS One , vol.5
    • Rato, S.1    Maia, S.2    Brito, P.M.3    Resende, L.4    Pereira, C.F.5    Moita, C.6    Freitas, R.P.7    Moniz-Pereira, J.8    Hacohen, N.9    Moita, L.F.10
  • 100
    • 78650904206 scopus 로고    scopus 로고
    • Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors
    • Eekels, J.J.; Geerts, D.; Jeeninga, R.E.; Berkhout, B. Long-term inhibition of HIV-1 replication with RNA interference against cellular co-factors. Antiviral Res. 2011, 89, 43-53.
    • (2011) Antiviral Res , vol.89 , pp. 43-53
    • Eekels, J.J.1    Geerts, D.2    Jeeninga, R.E.3    Berkhout, B.4
  • 101
    • 79952949357 scopus 로고    scopus 로고
    • siRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integration
    • Espeseth, A.S.; Fishel, R.; Hazuda, D.; Huang, Q.; Xu, M.; Yoder, K.; Zhou, H. siRNA screening of a targeted library of DNA repair factors in HIV infection reveals a role for base excision repair in HIV integration. PLoS One 2011, 6, e17612.
    • (2011) PLoS One , vol.6
    • Espeseth, A.S.1    Fishel, R.2    Hazuda, D.3    Huang, Q.4    Xu, M.5    Yoder, K.6    Zhou, H.7
  • 110
    • 74549150609 scopus 로고    scopus 로고
    • RNA interference and single particle tracking analysis of hepatitis C virus endocytosis
    • Coller, K.E.; Berger, K.L.; Heaton, N.S.; Cooper, J.D.; Yoon, R.; Randall, G. RNA interference and single particle tracking analysis of hepatitis C virus endocytosis. PLoS Pathog. 2009, 5, e1000702.
    • (2009) PLoS Pathog , vol.5
    • Coller, K.E.1    Berger, K.L.2    Heaton, N.S.3    Cooper, J.D.4    Yoon, R.5    Randall, G.6
  • 112
    • 67649356905 scopus 로고    scopus 로고
    • Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening
    • Kolokoltsov, A.A.; Saeed, M.F.; Freiberg, A.N.; Holbrook, M.R.; Davey, R.A. Identification of novel cellular targets for therapeutic intervention against Ebola virus infection by siRNA screening. Drug Dev. Res. 2009, 70, 255-265.
    • (2009) Drug Dev. Res , vol.70 , pp. 255-265
    • Kolokoltsov, A.A.1    Saeed, M.F.2    Freiberg, A.N.3    Holbrook, M.R.4    Davey, R.A.5
  • 113
    • 77954666136 scopus 로고    scopus 로고
    • A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics
    • Moser, T.S.; Jones, R.G.; Thompson, C.B.; Coyne, C.B.; Cherry, S. A kinome RNAi screen identified AMPK as promoting poxvirus entry through the control of actin dynamics. PLoS Pathog. 2010, 6, e1000954.
    • (2010) PLoS Pathog , vol.6
    • Moser, T.S.1    Jones, R.G.2    Thompson, C.B.3    Coyne, C.B.4    Cherry, S.5
  • 115
    • 77951227183 scopus 로고    scopus 로고
    • RNA interference modulates replication of dengue virus in Drosophila melanogaster cells
    • Mukherjee, S.; Hanley, K.A. RNA interference modulates replication of dengue virus in Drosophila melanogaster cells. BMC Microbiol. 2010, 10, 127.
    • (2010) BMC Microbiol , vol.10 , pp. 127
    • Mukherjee, S.1    Hanley, K.A.2
  • 116
    • 13844250535 scopus 로고    scopus 로고
    • Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition
    • Cherry, S.; Doukas, T.; Armknecht, S.; Whelan, S.; Wang, H.; Sarnow, P.; Perrimon, N. Genome-wide RNAi screen reveals a specific sensitivity of IRES-containing RNA viruses to host translation inhibition. Genes Dev. 2005, 19, 445-452.
    • (2005) Genes Dev , vol.19 , pp. 445-452
    • Cherry, S.1    Doukas, T.2    Armknecht, S.3    Whelan, S.4    Wang, H.5    Sarnow, P.6    Perrimon, N.7
  • 117
    • 34547770279 scopus 로고    scopus 로고
    • New uses for old drugs
    • Chong, C.R.; Sullivan, D.J., Jr. New uses for old drugs. Nature 2007, 448, 645-646.
    • (2007) Nature , vol.448 , pp. 645-646
    • Chong, C.R.1    Sullivan Jr., D.J.2
  • 119
    • 38049141270 scopus 로고    scopus 로고
    • Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening
    • Supekova, L.; Supek, F.; Lee, J.; Chen, S.; Gray, N.; Pezacki, J.P.; Schlapbach, A.; Schultz, P.G. Identification of human kinases involved in hepatitis C virus replication by small interference RNA library screening. J. Biol. Chem. 2008, 283, 29-36.
    • (2008) J. Biol. Chem , vol.283 , pp. 29-36
    • Supekova, L.1    Supek, F.2    Lee, J.3    Chen, S.4    Gray, N.5    Pezacki, J.P.6    Schlapbach, A.7    Schultz, P.G.8
  • 122
    • 77649248469 scopus 로고    scopus 로고
    • Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression
    • Smith, J.A.; White, E.A.; Sowa, M.E.; Powell, M.L.; Ottinger, M.; Harper, J.W.; Howley, P.M. Genome-wide siRNA screen identifies SMCX, EP400, and Brd4 as E2-dependent regulators of human papillomavirus oncogene expression. Proc. Natl. Acad. Sci. USA 2010, 107, 3752-3757.
    • (2010) Proc. Natl. Acad. Sci. USA , vol.107 , pp. 3752-3757
    • Smith, J.A.1    White, E.A.2    Sowa, M.E.3    Powell, M.L.4    Ottinger, M.5    Harper, J.W.6    Howley, P.M.7
  • 123
    • 78751484574 scopus 로고    scopus 로고
    • Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers
    • Coyne, C.B.; Bozym, R.; Morosky, S.A.; Hanna, S.L.; Mukherjee, A.; Tudor, M.; Kim, K.S.; Cherry, S. Comparative RNAi screening reveals host factors involved in enterovirus infection of polarized endothelial monolayers. Cell Host Microbe 2011, 9, 70-82.
    • (2011) Cell Host Microbe , vol.9 , pp. 70-82
    • Coyne, C.B.1    Bozym, R.2    Morosky, S.A.3    Hanna, S.L.4    Mukherjee, A.5    Tudor, M.6    Kim, K.S.7    Cherry, S.8
  • 126
    • 77249096377 scopus 로고    scopus 로고
    • Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus
    • Ang, F.; Wong, A.P.; Ng, M.M.; Chu, J.J. Small interference RNA profiling reveals the essential role of human membrane trafficking genes in mediating the infectious entry of dengue virus. Virol. J. 2010, 7, 24.
    • (2010) Virol. J , vol.7 , pp. 24
    • Ang, F.1    Wong, A.P.2    Ng, M.M.3    Chu, J.J.4
  • 127
  • 129
    • 61449172037 scopus 로고    scopus 로고
    • Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources
    • Huang, D.W.; Sherman, B.T.; Lempicki, R.A. Systematic and integrative analysis of large gene lists using DAVID bioinformatics resources. Nat. Protocols 2008, 4, 44-57.
    • (2008) Nat. Protocols , vol.4 , pp. 44-57
    • Huang, D.W.1    Sherman, B.T.2    Lempicki, R.A.3
  • 130
    • 84861123691 scopus 로고    scopus 로고
    • Ten years of pathway analysis: Current approaches and outstanding challenges
    • Khatri, P.; Sirota, M.; Butte, A.J. Ten years of pathway analysis: current approaches and outstanding challenges. PLoS Comput. Biol. 2012, 8, e1002375.
    • (2012) PLoS Comput. Biol , vol.8
    • Khatri, P.1    Sirota, M.2    Butte, A.J.3
  • 132
    • 0037374498 scopus 로고    scopus 로고
    • The price of innovation: New estimates of drug development costs
    • DiMasi, J.A.; Hansen, R.W.; Grabowski, H.G. The price of innovation: new estimates of drug development costs. J. Health. Econ. 2003, 22, 151-185.
    • (2003) J. Health. Econ , vol.22 , pp. 151-185
    • Dimasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3
  • 133
    • 0028895424 scopus 로고
    • Research and development costs for new drugs by therapeutic category. A study of the US pharmaceutical industry
    • DiMasi, J.A.; Hansen, R.W.; Grabowski, H.G.; Lasagna, L. Research and development costs for new drugs by therapeutic category. A study of the US pharmaceutical industry. Pharmacoeconomics 1995, 7, 152-169.
    • (1995) Pharmacoeconomics , vol.7 , pp. 152-169
    • Dimasi, J.A.1    Hansen, R.W.2    Grabowski, H.G.3    Lasagna, L.4
  • 134
    • 79957880949 scopus 로고    scopus 로고
    • Mining for therapeutic gold
    • Collins, F.S. Mining for therapeutic gold. Nat. Rev. Drug Discov. 2011, 10, 397.
    • (2011) Nat. Rev. Drug Discov , vol.10 , pp. 397
    • Collins, F.S.1
  • 136
    • 0023109808 scopus 로고
    • Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. A progress report
    • Yarchoan, R.; Broder, S. Development of antiretroviral therapy for the acquired immunodeficiency syndrome and related disorders. A progress report. N. Engl. J. Med. 1987, 316, 557-564.
    • (1987) N. Engl. J. Med , vol.316 , pp. 557-564
    • Yarchoan, R.1    Broder, S.2
  • 137
    • 84867445885 scopus 로고    scopus 로고
    • NCATS launches drug repurposing program
    • Allison, M. NCATS launches drug repurposing program. Nat. Biotechnol. 2012, 30, 571-572.
    • (2012) Nat. Biotechnol , vol.30 , pp. 571-572
    • Allison, M.1
  • 138
    • 79955428497 scopus 로고    scopus 로고
    • The NCGC pharmaceutical collection: A comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics
    • Huang, R.; Southall, N.; Wang, Y.; Yasgar, A.; Shinn, P.; Jadhav, A.; Nguyen, D.T.; Austin, C.P. The NCGC pharmaceutical collection: a comprehensive resource of clinically approved drugs enabling repurposing and chemical genomics. Sci. Transl. Med. 2011, 3, 80ps16.
    • (2011) Sci. Transl. Med , vol.3
    • Huang, R.1    Southall, N.2    Wang, Y.3    Yasgar, A.4    Shinn, P.5    Jadhav, A.6    Nguyen, D.T.7    Austin, C.P.8
  • 139
    • 84862264271 scopus 로고    scopus 로고
    • National Institute of Neurological Disorders and Stroke Common Data Element Project approach and methods
    • Grinnon, S.T.; Miller, K.; Marler, J.R.; Lu, Y.; Stout, A.; Odenkirchen, J.; Kunitz, S. National Institute of Neurological Disorders and Stroke Common Data Element Project approach and methods. Clin. Trials 2012, 9, 322-329.
    • (2012) Clin. Trials , vol.9 , pp. 322-329
    • Grinnon, S.T.1    Miller, K.2    Marler, J.R.3    Lu, Y.4    Stout, A.5    Odenkirchen, J.6    Kunitz, S.7
  • 142
    • 0030572496 scopus 로고    scopus 로고
    • Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction
    • Terrett, N.K.; Bell, A.S.; Brown, D.; Ellis, P. Sildenafil (VIAGRATM), a potent and selective inhibitor of type 5 cGMP phosphodiesterase with utility for the treatment of male erectile dysfunction. Bioorg. Med. Chem. Lett. 1996, 6, 1819-1824.
    • (1996) Bioorg. Med. Chem. Lett , vol.6 , pp. 1819-1824
    • Terrett, N.K.1    Bell, A.S.2    Brown, D.3    Ellis, P.4
  • 143
    • 0032428991 scopus 로고    scopus 로고
    • Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction
    • Goldenberg, M.M. Safety and efficacy of sildenafil citrate in the treatment of male erectile dysfunction. Clin. Ther. 1998, 20, 1033-1048.
    • (1998) Clin. Ther , vol.20 , pp. 1033-1048
    • Goldenberg, M.M.1
  • 144
    • 4644287454 scopus 로고    scopus 로고
    • Sildenafil: Emerging Cardiovascular Indications
    • Raja, S.G.; Nayak, S.H. Sildenafil: Emerging Cardiovascular Indications. Ann. Thorac. Surg. 2004, 78, 1496-1506.
    • (2004) Ann. Thorac. Surg , vol.78 , pp. 1496-1506
    • Raja, S.G.1    Nayak, S.H.2
  • 145
    • 77955706291 scopus 로고    scopus 로고
    • Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers
    • Wallis, R.S.; Jakubiec, W.M.; Kumar, V.; Silvia, A.M.; Paige, D.; Dimitrova, D.; Li, X.; Ladutko, L.; Campbell, S.; Friedland, G. et al. Pharmacokinetics and whole-blood bactericidal activity against Mycobacterium tuberculosis of single doses of PNU-100480 in healthy volunteers. J. Infect. Dis. 2010, 202, 745-751.
    • (2010) J. Infect. Dis , vol.202 , pp. 745-751
    • Wallis, R.S.1    Jakubiec, W.M.2    Kumar, V.3    Silvia, A.M.4    Paige, D.5    Dimitrova, D.6    Li, X.7    Ladutko, L.8    Campbell, S.9    Friedland, G.10
  • 146
    • 84863042675 scopus 로고    scopus 로고
    • Susceptibility of Mycobacterium tuberculosis to sulfamethoxazole, trimethoprim and their combination over a 12 year period in Taiwan
    • Huang, T.S.; Kunin, C.M.; Yan, B.S.; Chen, Y.S.; Lee, S.S.; Syu, W., Jr. Susceptibility of Mycobacterium tuberculosis to sulfamethoxazole, trimethoprim and their combination over a 12 year period in Taiwan. J. Antimicrob. Chemother. 2012, 67, 633-637.
    • (2012) J. Antimicrob. Chemother , vol.67 , pp. 633-637
    • Huang, T.S.1    Kunin, C.M.2    Yan, B.S.3    Chen, Y.S.4    Lee, S.S.5    Syu, W.6
  • 148
    • 79953695916 scopus 로고    scopus 로고
    • In silico repositioning of approved drugs for rare and neglected diseases
    • Ekins, S.; Williams, A.J.; Krasowski, M.D.; Freundlich, J.S. In silico repositioning of approved drugs for rare and neglected diseases. Drug Discov. Today 2011, 16, 298-310.
    • (2011) Drug Discov. Today , vol.16 , pp. 298-310
    • Ekins, S.1    Williams, A.J.2    Krasowski, M.D.3    Freundlich, J.S.4
  • 149
    • 80255132658 scopus 로고    scopus 로고
    • Serological biochemical markers of surrogate efficacy and safety as a novel approach to drug repositioning
    • Henriksen, K.; Christiansen, C.; Karsdal, M.A. Serological biochemical markers of surrogate efficacy and safety as a novel approach to drug repositioning. Drug Discov. Today 2011, 16, 967-975.
    • (2011) Drug Discov. Today , vol.16 , pp. 967-975
    • Henriksen, K.1    Christiansen, C.2    Karsdal, M.A.3
  • 151
    • 77954275723 scopus 로고    scopus 로고
    • ToppCluster: A multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems
    • Kaimal, V.; Bardes, E.E.; Tabar, S.C.; Jegga, A.G.; Aronow, B.J. ToppCluster: a multiple gene list feature analyzer for comparative enrichment clustering and network-based dissection of biological systems. Nucleic Acids Res. 2010, 38, W96-W102.
    • (2010) Nucleic Acids Res , vol.38
    • Kaimal, V.1    Bardes, E.E.2    Tabar, S.C.3    Jegga, A.G.4    Aronow, B.J.5
  • 152
  • 153
    • 0037425564 scopus 로고    scopus 로고
    • Mortality associated with influenza and respiratory syncytial virus in the United States
    • Thompson, W.W.; Shay, D.K.; Weintraub, E.; Brammer, L.; Cox, N.; Anderson, L.J.; Fukuda, K. Mortality associated with influenza and respiratory syncytial virus in the United States. JAMA 2003, 289, 179-186.
    • (2003) JAMA , vol.289 , pp. 179-186
    • Thompson, W.W.1    Shay, D.K.2    Weintraub, E.3    Brammer, L.4    Cox, N.5    Anderson, L.J.6    Fukuda, K.7
  • 154
    • 40849130832 scopus 로고    scopus 로고
    • Current and future antiviral therapy of severe seasonal and avian influenza
    • Beigel, J.; Bray, M. Current and future antiviral therapy of severe seasonal and avian influenza. Antiviral Res. 2008, 78, 91-102.
    • (2008) Antiviral Res , vol.78 , pp. 91-102
    • Beigel, J.1    Bray, M.2
  • 155
    • 0035286968 scopus 로고    scopus 로고
    • Zanamivir and oseltamivir: Two new options for the treatment and prevention of influenza
    • Dreitlein, W.B.; Maratos, J.; Brocavich, J. Zanamivir and oseltamivir: two new options for the treatment and prevention of influenza. Clin. Ther. 2001, 23, 327-355.
    • (2001) Clin. Ther , vol.23 , pp. 327-355
    • Dreitlein, W.B.1    Maratos, J.2    Brocavich, J.3
  • 156
    • 14744294434 scopus 로고    scopus 로고
    • Novel strategies for prevention and treatment of influenza
    • Kandel, R.; Hartshorn, K.L. Novel strategies for prevention and treatment of influenza. Expert Opin. Ther. Targets 2005, 9, 1-22.
    • (2005) Expert Opin. Ther. Targets , vol.9 , pp. 1-22
    • Kandel, R.1    Hartshorn, K.L.2
  • 157
    • 77955447364 scopus 로고    scopus 로고
    • Antiviral Compounds In the Pipeline to Tackle H1N1 Influenza Infection
    • Beigel, J.H. Antiviral Compounds In the Pipeline to Tackle H1N1 Influenza Infection. Drugs Future 2010, 35, 385-392.
    • (2010) Drugs Future , vol.35 , pp. 385-392
    • Beigel, J.H.1
  • 159
    • 84872022700 scopus 로고    scopus 로고
    • Targeting the Organic Anion Transporter-3 (OAT3) with Probenecid as a Novel Anti-Influenza A Virus Strategy
    • doi: 10.1128/AAC.01532-12
    • Perwitasari, O.; Yan, X.; Johnson, S.; White, C.; Brooks, P.; Tompkins, S.M.; Tripp, R.A. Targeting the Organic Anion Transporter-3 (OAT3) with Probenecid as a Novel Anti-Influenza A Virus Strategy. Antimicrob. Agents Chemother. 2012, doi: 10.1128/AAC.01532-12.
    • (2012) Antimicrob. Agents Chemother
    • Perwitasari, O.1    Yan, X.2    Johnson, S.3    White, C.4    Brooks, P.5    Tompkins, S.M.6    Tripp, R.A.7
  • 160
    • 0028833352 scopus 로고
    • Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules
    • Dantzler, W.H.; Evans, K.K.; Wright, S.H. Kinetics of interactions of para-aminohippurate, probenecid, cysteine conjugates and N-acetyl cysteine conjugates with basolateral organic anion transporter in isolated rabbit proximal renal tubules. J. Pharmacol. Exp. Ther. 1995, 272, 663-672.
    • (1995) J. Pharmacol. Exp. Ther , vol.272 , pp. 663-672
    • Dantzler, W.H.1    Evans, K.K.2    Wright, S.H.3
  • 161
    • 33947365498 scopus 로고    scopus 로고
    • Emerging therapies in the long-term management of hyperuricaemia and gout
    • Stamp, L.K.; O'Donnell, J.L.; Chapman, P.T. Emerging therapies in the long-term management of hyperuricaemia and gout. Intern. Med. J. 2007, 37, 258-266.
    • (2007) Intern. Med. J , vol.37 , pp. 258-266
    • Stamp, L.K.1    O'Donnell, J.L.2    Chapman, P.T.3
  • 162
    • 0036135044 scopus 로고    scopus 로고
    • The Anti-Influenza Drug Oseltamivir Exhibits Low Potential to Induce Pharmacokinetic Drug Interactions via Renal Secretion-Correlation of in Vivo and in Vitro Studies
    • Hill, G.; Cihlar, T.; Oo, C.; Ho, E.S.; Prior, K.; Wiltshire, H.; Barrett, J.; Liu, B.; Ward, P. The Anti-Influenza Drug Oseltamivir Exhibits Low Potential to Induce Pharmacokinetic Drug Interactions via Renal Secretion-Correlation of in Vivo and in Vitro Studies. Drug Metab. Dispos. 2002, 30, 13-19.
    • (2002) Drug Metab. Dispos , vol.30 , pp. 13-19
    • Hill, G.1    Cihlar, T.2    Oo, C.3    Ho, E.S.4    Prior, K.5    Wiltshire, H.6    Barrett, J.7    Liu, B.8    Ward, P.9
  • 164
    • 47549093163 scopus 로고    scopus 로고
    • Population pharmacokinetics of oseltamivir when coadministered with probenecid
    • Rayner, C.R.; Chanu, P.; Gieschke, R.; Boak, L.M.; Jonsson, E.N. Population pharmacokinetics of oseltamivir when coadministered with probenecid. J. Clin. Pharmacol. 2008, 48, 935-947.
    • (2008) J. Clin. Pharmacol , vol.48 , pp. 935-947
    • Rayner, C.R.1    Chanu, P.2    Gieschke, R.3    Boak, L.M.4    Jonsson, E.N.5
  • 165
    • 84863713469 scopus 로고    scopus 로고
    • Ebola and Marburg hemorrhagic fevers: Neglected tropical diseases?
    • MacNeil, A.; Rollin, P.E. Ebola and Marburg hemorrhagic fevers: neglected tropical diseases? PLoS Negl. Trop. Dis. 2012, 6, e1546.
    • (2012) PLoS Negl. Trop. Dis , vol.6
    • Macneil, A.1    Rollin, P.E.2
  • 166
    • 0024672299 scopus 로고
    • Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad- spectrum antiviral drug
    • Huggins, J.W. Prospects for treatment of viral hemorrhagic fevers with ribavirin, a broad- spectrum antiviral drug. Rev. Infect. Dis. 1989, 11 Suppl 4, S750-761.
    • (1989) Rev. Infect. Dis , vol.11 , Issue.4 SUPPL.
    • Huggins, J.W.1
  • 167
    • 84859171807 scopus 로고    scopus 로고
    • MYC on the path to cancer
    • Dang, C.V. MYC on the path to cancer. Cell 2012, 149, 22-35.
    • (2012) Cell , vol.149 , pp. 22-35
    • Dang, C.V.1
  • 168
    • 0037541152 scopus 로고    scopus 로고
    • The MYC oncogene as a cancer drug target
    • Hermeking, H. The MYC oncogene as a cancer drug target. Curr. Cancer Drug Targets 2003, 3, 163-175.
    • (2003) Curr. Cancer Drug Targets , vol.3 , pp. 163-175
    • Hermeking, H.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.