PKN3 is required for malignant prostate cell growth downstream of activated PI 3-kinase

EMBO Journal

Volumn 23, Issue 16, 2004, Pages 3303-3313

  Leenders, Frauke ^a   Möpert, Kristin ^a   Schmiedeknecht, Anett ^a   Santel, Ansgar ^a   Czauderna, Frank ^a   Aleku, Manuela ^a   Penschuck, Silke ^a,d   Dames, Sibylle ^a   Sternberger, Maria ^a   Röhl, Thomas ^a   Wellmann, Axel ^b   Arnold, Wolfgang ^a   Giese, Klaus ^a   Kaufmann, Jörg ^a   Klippel, Anke ^a,c  

^a Atugen AG   (Germany)

^b UNIVERSITY HOSPITAL BONN   (Germany)

^c Atugen AG   (Germany)

^d H LUNDBECK A S   (Denmark)

Author keywords

3D cell culture; Metastasis; Orthotopic prostate tumor model; Phosphoinositide 3 kinase; PTEN

Indexed keywords

PHOSPHATIDYLINOSITOL 3 KINASE; PHOSPHATIDYLINOSITOL 3,4,5 TRISPHOSPHATE 3 PHOSPHATASE; PROTEIN KINASE C; RNA; SHORT HAIRPIN RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER GROWTH; CATALYSIS; CELL GROWTH; EFFECTOR CELL; ENZYME ACTIVATION; ENZYME ANALYSIS; EXTRACELLULAR MATRIX; GENE EXPRESSION PROFILING; LYMPH NODE METASTASIS; MALE; MALIGNANT NEOPLASTIC DISEASE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROSTATE CANCER; SIGNAL TRANSDUCTION; TUMOR MODEL; TUMOR SUPPRESSOR GENE;

1-PHOSPHATIDYLINOSITOL 3-KINASE; ANIMALS; BASEMENT MEMBRANE; CATALYSIS; CELL DIVISION; CELL LINE, TUMOR; CELL TRANSFORMATION, NEOPLASTIC; DISEASE MODELS, ANIMAL; ENZYME ACTIVATION; GENE EXPRESSION REGULATION, NEOPLASTIC; HUMANS; LYMPHATIC METASTASIS; MALE; MICE; MICE, KNOCKOUT; PROSTATIC NEOPLASMS; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES; PROTEIN-TYROSINE-PHOSPHATASE; PROTO-ONCOGENE PROTEINS; PROTO-ONCOGENE PROTEINS C-AKT; PTEN PHOSPHOHYDROLASE; SIGNAL TRANSDUCTION; TUMOR SUPPRESSOR PROTEINS; UP-REGULATION;

ANIMALIA;

EID: 20844438509     PISSN: 02614189     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.emboj.7600345     Document Type: Article

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