메뉴 건너뛰기




Volumn 133, Issue 2, 2012, Pages 142-150

MicroRNAs in neurodegenerative diseases and their therapeutic potential

Author keywords

MicroRNA; Neurodegenerative disease; Polymorphism; Therapeutic

Indexed keywords

ALPHA SYNUCLEIN; ARGONAUTE 1 PROTEIN; ATAXIN 3; ATAXIN 7; COPPER ZINC SUPEROXIDE DISMUTASE; EXONUCLEASE; EXPORTIN 5; FIBROBLAST GROWTH FACTOR; FIBROBLAST GROWTH FACTOR 1; HISTONE DEACETYLASE 4; MICRORNA; MYOSTATIN; POLYGLUTAMINE; PROGRANULIN; RNA POLYMERASE; UNTRANSLATED RNA;

EID: 84856440598     PISSN: 01637258     EISSN: 1879016X     Source Type: Journal    
DOI: 10.1016/j.pharmthera.2011.10.002     Document Type: Review
Times cited : (191)

References (111)
  • 1
  • 2
    • 0037737975 scopus 로고    scopus 로고
    • MicroRNAs and other tiny endogenous RNAs in C. elegans
    • DOI 10.1016/S0960-9822(03)00287-2
    • V. Ambros, R.C. Lee, A. Lavanway, P.T. Williams, and D. Jewell MicroRNAs and other tiny endogenous RNAs in C. elegans Current Biology 13 10 2003 807 818 (Pubitemid 36573248)
    • (2003) Current Biology , vol.13 , Issue.10 , pp. 807-818
    • Ambros, V.1    Lee, R.C.2    Lavanway, A.3    Williams, P.T.4    Jewell, D.5
  • 5
    • 0347444723 scopus 로고    scopus 로고
    • MicroRNAs: Genomics, biogenesis, mechanism, and function
    • D.P. Bartel MicroRNAs: genomics, biogenesis, mechanism, and function Cell 116 2 2004 281 297
    • (2004) Cell , vol.116 , Issue.2 , pp. 281-297
    • Bartel, D.P.1
  • 6
    • 58249088751 scopus 로고    scopus 로고
    • MicroRNAs: Target recognition and regulatory functions
    • D.P. Bartel MicroRNAs: target recognition and regulatory functions Cell 136 2 2009 215 233
    • (2009) Cell , vol.136 , Issue.2 , pp. 215-233
    • Bartel, D.P.1
  • 7
    • 24044519710 scopus 로고    scopus 로고
    • The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: Implications for epithelial repair
    • DOI 10.1038/sj.onc.1208560, PII 1208560
    • H.D. Beer, M. Bittner, G. Niklaus, C. Munding, N. Max, and A. Goppelt The fibroblast growth factor binding protein is a novel interaction partner of FGF-7, FGF-10 and FGF-22 and regulates FGF activity: implications for epithelial repair Oncogene 24 34 2005 5269 5277 (Pubitemid 43080097)
    • (2005) Oncogene , vol.24 , Issue.34 , pp. 5269-5277
    • Beer, H.-D.1    Bittner, M.2    Niklaus, G.3    Munding, C.4    Max, N.5    Goppelt, A.6    Werner, S.7
  • 9
    • 33749078547 scopus 로고    scopus 로고
    • MicroRNA Pathways Modulate Polyglutamine-Induced Neurodegeneration
    • DOI 10.1016/j.molcel.2006.07.030, PII S1097276506005326
    • J. Bilen, N. Liu, B.G. Burnett, R.N. Pittman, and N.M. Bonini MicroRNA pathways modulate polyglutamine-induced neurodegeneration Molecular Cell 24 1 2006 157 163 (Pubitemid 44466675)
    • (2006) Molecular Cell , vol.24 , Issue.1 , pp. 157-163
    • Bilen, J.1    Liu, N.2    Burnett, B.G.3    Pittman, R.N.4    Bonini, N.M.5
  • 10
    • 38449100768 scopus 로고    scopus 로고
    • Small RNAs: Delivering the future
    • N. Blow Small RNAs: delivering the future Nature 450 7172 2007 1117 1120
    • (2007) Nature , vol.450 , Issue.7172 , pp. 1117-1120
    • Blow, N.1
  • 11
    • 55549114664 scopus 로고    scopus 로고
    • The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities
    • D. Bonci, V. Coppola, M. Musumeci, A. Addario, R. Giuffrida, and L. Memeo The miR-15a-miR-16-1 cluster controls prostate cancer by targeting multiple oncogenic activities Nature Medicine 14 11 2008 1271 1277
    • (2008) Nature Medicine , vol.14 , Issue.11 , pp. 1271-1277
    • Bonci, D.1    Coppola, V.2    Musumeci, M.3    Addario, A.4    Giuffrida, R.5    Memeo, L.6
  • 12
    • 0037418839 scopus 로고    scopus 로고
    • Bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    • DOI 10.1016/S0092-8674(03)00231-9
    • J. Brennecke, D.R. Hipfner, A. Stark, R.B. Russell, and S.M. Cohen bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila Cell 113 1 2003 25 36 (Pubitemid 36411957)
    • (2003) Cell , vol.113 , Issue.1 , pp. 25-36
    • Brennecke, J.1    Hipfner, D.R.2    Stark, A.3    Russell, R.B.4    Cohen, S.M.5
  • 13
    • 3943102116 scopus 로고    scopus 로고
    • Unraveling the mechanisms involved in motor neuron degeneration in ALS
    • DOI 10.1146/annurev.neuro.27.070203.144244
    • L.I. Bruijn, T.M. Miller, and D.W. Cleveland Unraveling the mechanisms involved in motor neuron degeneration in ALS Annual Review of Neuroscience 27 2004 723 749 (Pubitemid 39050419)
    • (2004) Annual Review of Neuroscience , vol.27 , pp. 723-749
    • Bruijn, L.I.1    Miller, T.M.2    Cleveland, D.W.3
  • 14
    • 33751099034 scopus 로고    scopus 로고
    • RNAi therapeutics: A potential new class of pharmaceutical drugs
    • DOI 10.1038/nchembio839, PII NCHEMBIO839
    • D. Bumcrot, M. Manoharan, V. Koteliansky, and D.W. Sah RNAi therapeutics: a potential new class of pharmaceutical drugs Nature Chemical Biology 2 12 2006 711 719 (Pubitemid 44764213)
    • (2006) Nature Chemical Biology , vol.2 , Issue.12 , pp. 711-719
    • Bumcrot, D.1    Manoharan, M.2    Koteliansky, V.3    Sah, D.W.Y.4
  • 16
  • 17
    • 0141849876 scopus 로고    scopus 로고
    • Introduction to the transmissible spongiform encephalopathies or prion diseases
    • DOI 10.1093/bmb/66.1.1
    • B. Chesebro Introduction to the transmissible spongiform encephalopathies or prion diseases British Medical Bulletin 66 2003 1 20 (Pubitemid 37173488)
    • (2003) British Medical Bulletin , vol.66 , pp. 1-20
    • Chesebro, B.1
  • 21
    • 2442566370 scopus 로고    scopus 로고
    • Cytoplasmic foci are sites of mRNA decay in human cells
    • DOI 10.1083/jcb.200309008
    • N. Cougot, S. Babajko, and B. Seraphin Cytoplasmic foci are sites of mRNA decay in human cells The Journal of Cell Biology 165 1 2004 31 40 (Pubitemid 38649174)
    • (2004) Journal of Cell Biology , vol.165 , Issue.1 , pp. 31-40
    • Cougot, N.1    Babajko, S.2    Seraphin, B.3
  • 23
    • 43749120042 scopus 로고    scopus 로고
    • Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus
    • T.H. Davis, T.L. Cuellar, S.M. Koch, A.J. Barker, B.D. Harfe, and M.T. McManus Conditional loss of Dicer disrupts cellular and tissue morphogenesis in the cortex and hippocampus Journal of Neuroscience 28 17 2008 4322 4330
    • (2008) Journal of Neuroscience , vol.28 , Issue.17 , pp. 4322-4330
    • Davis, T.H.1    Cuellar, T.L.2    Koch, S.M.3    Barker, A.J.4    Harfe, B.D.5    McManus, M.T.6
  • 24
    • 34447559636 scopus 로고    scopus 로고
    • Interfering with disease: A progress report on siRNA-based therapeutics
    • DOI 10.1038/nrd2310, PII NRD2310
    • A. de Fougerolles, H.P. Vornlocher, J. Maraganore, and J. Lieberman Interfering with disease: a progress report on siRNA-based therapeutics Nature Reviews. Drug Discovery 6 6 2007 443 453 (Pubitemid 47064567)
    • (2007) Nature Reviews Drug Discovery , vol.6 , Issue.6 , pp. 443-453
    • De Fougerolles, A.1    Vornlocher, H.-P.2    Maraganore, J.3    Lieberman, J.4
  • 25
    • 77953701815 scopus 로고    scopus 로고
    • FGF20 rs12720208 SNP and microRNA-433 variation: No association with Parkinson's disease in Spanish patients
    • L. de Mena, L.F. Cardo, E. Coto, A. Miar, M. Diaz, and A.I. Corao FGF20 rs12720208 SNP and microRNA-433 variation: no association with Parkinson's disease in Spanish patients Neuroscience Letters 479 1 2010 22 25
    • (2010) Neuroscience Letters , vol.479 , Issue.1 , pp. 22-25
    • De Mena, L.1    Cardo, L.F.2    Coto, E.3    Miar, A.4    Diaz, M.5    Corao, A.I.6
  • 26
    • 77951249562 scopus 로고    scopus 로고
    • Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153
    • E. Doxakis Post-transcriptional regulation of alpha-synuclein expression by mir-7 and mir-153 Journal of Biological Chemistry 285 17 2010 12726 12734
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.17 , pp. 12726-12734
    • Doxakis, E.1
  • 28
    • 34548316982 scopus 로고    scopus 로고
    • MicroRNA sponges: Competitive inhibitors of small RNAs in mammalian cells
    • DOI 10.1038/nmeth1079, PII NMETH1079
    • M.S. Ebert, J.R. Neilson, and P.A. Sharp MicroRNA sponges: competitive inhibitors of small RNAs in mammalian cells Nature Methods 4 9 2007 721 726 (Pubitemid 47338166)
    • (2007) Nature Methods , vol.4 , Issue.9 , pp. 721-726
    • Ebert, M.S.1    Neilson, J.R.2    Sharp, P.A.3
  • 29
    • 77951922861 scopus 로고    scopus 로고
    • Molecular diversity through RNA editing: A balancing act
    • S. Farajollahi, and S. Maas Molecular diversity through RNA editing: a balancing act Trends in Genetics 26 5 2010 221 230
    • (2010) Trends in Genetics , vol.26 , Issue.5 , pp. 221-230
    • Farajollahi, S.1    Maas, S.2
  • 30
    • 29144505309 scopus 로고    scopus 로고
    • Biochemistry: The widespread impact of mammalian microRNAs on mRNA repression and evolution
    • DOI 10.1126/science.1121158
    • K.K. Farh, A. Grimson, C. Jan, B.P. Lewis, W.K. Johnston, and L.P. Lim The widespread impact of mammalian MicroRNAs on mRNA repression and evolution Science 310 5755 2005 1817 1821 (Pubitemid 41814382)
    • (2005) Science , vol.310 , Issue.5755 , pp. 1817-1821
    • Farh, K.K.-H.1    Grimson, A.2    Jan, C.3    Lewis, B.P.4    Johnston, W.K.5    Lim, L.P.6    Burge, C.B.7    Bartel, D.P.8
  • 34
    • 77957361864 scopus 로고    scopus 로고
    • Targeting microRNAs in cancer: Rationale, strategies and challenges
    • R. Garzon, G. Marcucci, and C.M. Croce Targeting microRNAs in cancer: rationale, strategies and challenges Nature Reviews. Drug Discovery 9 10 2010 775 789
    • (2010) Nature Reviews. Drug Discovery , vol.9 , Issue.10 , pp. 775-789
    • Garzon, R.1    Marcucci, G.2    Croce, C.M.3
  • 36
    • 77955152366 scopus 로고    scopus 로고
    • Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression
    • S. Gehrke, Y. Imai, N. Sokol, and B. Lu Pathogenic LRRK2 negatively regulates microRNA-mediated translational repression Nature 466 7306 2010 637 641
    • (2010) Nature , vol.466 , Issue.7306 , pp. 637-641
    • Gehrke, S.1    Imai, Y.2    Sokol, N.3    Lu, B.4
  • 38
    • 45149107487 scopus 로고    scopus 로고
    • Mechanisms of neurodegeneration in Huntington's disease
    • DOI 10.1111/j.1460-9568.2008.06310.x
    • J.M. Gil, and A.C. Rego Mechanisms of neurodegeneration in Huntington's disease European Journal of Neuroscience 27 11 2008 2803 2820 (Pubitemid 351832229)
    • (2008) European Journal of Neuroscience , vol.27 , Issue.11 , pp. 2803-2820
    • Gil, J.M.1    Rego, A.C.2
  • 39
    • 64549109671 scopus 로고    scopus 로고
    • Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells
    • T. Haraguchi, Y. Ozaki, and H. Iba Vectors expressing efficient RNA decoys achieve the long-term suppression of specific microRNA activity in mammalian cells Nucleic Acids Research 37 6 2009 e43
    • (2009) Nucleic Acids Research , vol.37 , Issue.6 , pp. 43
    • Haraguchi, T.1    Ozaki, Y.2    Iba, H.3
  • 42
    • 77957735016 scopus 로고    scopus 로고
    • Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration
    • S.S. Hebert, A.S. Papadopoulou, P. Smith, M.C. Galas, E. Planel, and A.N. Silahtaroglu Genetic ablation of Dicer in adult forebrain neurons results in abnormal tau hyperphosphorylation and neurodegeneration Human Molecular Genetics 19 20 2010 3959 3969
    • (2010) Human Molecular Genetics , vol.19 , Issue.20 , pp. 3959-3969
    • Hebert, S.S.1    Papadopoulou, A.S.2    Smith, P.3    Galas, M.C.4    Planel, E.5    Silahtaroglu, A.N.6
  • 44
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • G. Hutvagner, and P.D. Zamore A microRNA in a multiple-turnover RNAi enzyme complex Science 297 5589 2002 2056 2060
    • (2002) Science , vol.297 , Issue.5589 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 45
    • 0037786542 scopus 로고    scopus 로고
    • Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice
    • DOI 10.1016/S0169-328X(03)00162-1
    • D.Y. Hwang, P. Ardayfio, U.J. Kang, E.V. Semina, and K.S. Kim Selective loss of dopaminergic neurons in the substantia nigra of Pitx3-deficient aphakia mice Brain Research. Molecular Brain Research 114 2 2003 123 131 (Pubitemid 36773553)
    • (2003) Molecular Brain Research , vol.114 , Issue.2 , pp. 123-131
    • Hwang, D.-Y.1    Ardayfio, P.2    Kang, U.J.3    Semina, E.V.4    Kim, K.-S.5
  • 46
    • 70349783572 scopus 로고    scopus 로고
    • Antagomirzymes: Oligonucleotide enzymes that specifically silence microRNA function
    • V.M. Jadhav, V. Scaria, and S. Maiti Antagomirzymes: oligonucleotide enzymes that specifically silence microRNA function Angewandte Chemie (International Ed. in English) 48 14 2009 2557 2560
    • (2009) Angewandte Chemie (International Ed. in English) , vol.48 , Issue.14 , pp. 2557-2560
    • Jadhav, V.M.1    Scaria, V.2    Maiti, S.3
  • 49
    • 70350708160 scopus 로고    scopus 로고
    • Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system
    • Y. Kawase-Koga, G. Otaegi, and T. Sun Different timings of Dicer deletion affect neurogenesis and gliogenesis in the developing mouse central nervous system Developmental Dynamics 238 11 2009 2800 2812
    • (2009) Developmental Dynamics , vol.238 , Issue.11 , pp. 2800-2812
    • Kawase-Koga, Y.1    Otaegi, G.2    Sun, T.3
  • 50
    • 34548537573 scopus 로고    scopus 로고
    • A microRNA feedback circuit in midbrain dopamine neurons
    • J. Kim, K. Inoue, J. Ishii, W.B. Vanti, S.V. Voronov, and E. Murchison A microRNA feedback circuit in midbrain dopamine neurons Science 317 5842 2007 1220 1224
    • (2007) Science , vol.317 , Issue.5842 , pp. 1220-1224
    • Kim, J.1    Inoue, K.2    Ishii, J.3    Vanti, W.B.4    Voronov, S.V.5    Murchison, E.6
  • 52
    • 74049098309 scopus 로고    scopus 로고
    • Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains
    • D.E. Kuhn, G.J. Nuovo, A.V. Terry Jr., M.M. Martin, G.E. Malana, and S.E. Sansom Chromosome 21-derived microRNAs provide an etiological basis for aberrant protein expression in human Down syndrome brains Journal of Biological Chemistry 285 2 2010 1529 1543
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.2 , pp. 1529-1543
    • Kuhn, D.E.1    Nuovo, G.J.2    Terry Jr., A.V.3    Martin, M.M.4    Malana, G.E.5    Sansom, S.E.6
  • 54
    • 61349156118 scopus 로고    scopus 로고
    • Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis
    • T.J. Kwiatkowski Jr., D.A. Bosco, A.L. Leclerc, E. Tamrazian, C.R. Vanderburg, and C. Russ Mutations in the FUS/TLS gene on chromosome 16 cause familial amyotrophic lateral sclerosis Science 323 5918 2009 1205 1208
    • (2009) Science , vol.323 , Issue.5918 , pp. 1205-1208
    • Kwiatkowski Jr., T.J.1    Bosco, D.A.2    Leclerc, A.L.3    Tamrazian, E.4    Vanderburg, C.R.5    Russ, C.6
  • 55
    • 10344248903 scopus 로고    scopus 로고
    • The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis
    • DOI 10.1016/j.cub.2004.11.001, PII S0960982204008693
    • M. Landthaler, A. Yalcin, and T. Tuschl The human DiGeorge syndrome critical region gene 8 and its D. melanogaster homolog are required for miRNA biogenesis Current Biology 14 23 2004 2162 2167 (Pubitemid 39623200)
    • (2004) Current Biology , vol.14 , Issue.23 , pp. 2162-2167
    • Landthaler, M.1    Yalcin, A.2    Tuschl, T.3
  • 57
    • 0035955366 scopus 로고    scopus 로고
    • An extensive class of small RNAs in Caenorhabditis elegans
    • DOI 10.1126/science.1065329
    • R.C. Lee, and V. Ambros An extensive class of small RNAs in Caenorhabditis elegans Science 294 5543 2001 862 864 (Pubitemid 33032105)
    • (2001) Science , vol.294 , Issue.5543 , pp. 862-864
    • Lee, R.C.1    Ambros, V.2
  • 58
    • 8144225486 scopus 로고    scopus 로고
    • MicroRNA genes are transcribed by RNA polymerase II
    • DOI 10.1038/sj.emboj.7600385
    • Y. Lee, M. Kim, J. Han, K.H. Yeom, S. Lee, and S.H. Baek MicroRNA genes are transcribed by RNA polymerase II EMBO Journal 23 20 2004 4051 4060 (Pubitemid 39472426)
    • (2004) EMBO Journal , vol.23 , Issue.20 , pp. 4051-4060
    • Lee, Y.1    Kim, M.2    Han, J.3    Yeom, K.-H.4    Lee, S.5    Baek, S.H.6    Kim, V.N.7
  • 59
    • 1842816517 scopus 로고    scopus 로고
    • Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways
    • DOI 10.1016/S0092-8674(04)00261-2, PII S0092867404002612
    • Y.S. Lee, K. Nakahara, J.W. Pham, K. Kim, Z. He, and E.J. Sontheimer Distinct roles for Drosophila Dicer-1 and Dicer-2 in the siRNA/miRNA silencing pathways Cell 117 1 2004 69 81 (Pubitemid 38469899)
    • (2004) Cell , vol.117 , Issue.1 , pp. 69-81
    • Lee, Y.S.1    Nakahara, K.2    Pham, J.W.3    Kim, K.4    He, Z.5    Sontheimer, E.J.6    Carthew, R.W.7
  • 60
    • 52949137369 scopus 로고    scopus 로고
    • MiR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis
    • Y. Lee, R.C. Samaco, J.R. Gatchel, C. Thaller, H.T. Orr, and H.Y. Zoghbi miR-19, miR-101 and miR-130 co-regulate ATXN1 levels to potentially modulate SCA1 pathogenesis Nature Neuroscience 11 10 2008 1137 1139
    • (2008) Nature Neuroscience , vol.11 , Issue.10 , pp. 1137-1139
    • Lee, Y.1    Samaco, R.C.2    Gatchel, J.R.3    Thaller, C.4    Orr, H.T.5    Zoghbi, H.Y.6
  • 61
    • 77956903474 scopus 로고    scopus 로고
    • MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice
    • Electronic publication ahead of print
    • W. Liu, C. Liu, J. Zhu, P. Shu, B. Yin, and Y. Gong MicroRNA-16 targets amyloid precursor protein to potentially modulate Alzheimer's-associated pathogenesis in SAMP8 mice Neurobiology of Aging 2010 Electronic publication ahead of print
    • (2010) Neurobiology of Aging
    • Liu, W.1    Liu, C.2    Zhu, J.3    Shu, P.4    Yin, B.5    Gong, Y.6
  • 63
    • 79151483332 scopus 로고    scopus 로고
    • MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed
    • J.M. Long, and D.K. Lahiri MicroRNA-101 downregulates Alzheimer's amyloid-beta precursor protein levels in human cell cultures and is differentially expressed Biochemical and Biophysical Research Communications 404 4 2011 889 895
    • (2011) Biochemical and Biophysical Research Communications , vol.404 , Issue.4 , pp. 889-895
    • Long, J.M.1    Lahiri, D.K.2
  • 64
    • 33847203593 scopus 로고    scopus 로고
    • Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus
    • W.J. Lukiw Micro-RNA speciation in fetal, adult and Alzheimer's disease hippocampus Neuroreport 18 3 2007 297 300
    • (2007) Neuroreport , vol.18 , Issue.3 , pp. 297-300
    • Lukiw, W.J.1
  • 65
    • 34250167627 scopus 로고    scopus 로고
    • MicroRNA gets down to business
    • G.S. Mack MicroRNA gets down to business Nature Biotechnology 25 6 2007 631 638
    • (2007) Nature Biotechnology , vol.25 , Issue.6 , pp. 631-638
    • MacK, G.S.1
  • 67
    • 1242318826 scopus 로고    scopus 로고
    • Sequence-specific inhibition of microRNA-and siRNA-induced RNA silencing
    • DOI 10.1261/rna.5235104
    • G. Meister, M. Landthaler, Y. Dorsett, and T. Tuschl Sequence-specific inhibition of microRNA- and siRNA-induced RNA silencing RNA 10 3 2004 544 550 (Pubitemid 38241013)
    • (2004) RNA , vol.10 , Issue.3 , pp. 544-550
    • Meister, G.1    Landthaler, M.2    Dorsett, Y.3    Tuschl, T.4
  • 68
    • 79960135400 scopus 로고    scopus 로고
    • MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function
    • E. Minones-Moyano, S. Porta, G. Escaramis, R. Rabionet, S. Iraola, and B. Kagerbauer MicroRNA profiling of Parkinson's disease brains identifies early downregulation of miR-34b/c which modulate mitochondrial function Human Molecular Genetics 20 15 2011 3067 3078
    • (2011) Human Molecular Genetics , vol.20 , Issue.15 , pp. 3067-3078
    • Minones-Moyano, E.1    Porta, S.2    Escaramis, G.3    Rabionet, R.4    Iraola, S.5    Kagerbauer, B.6
  • 70
    • 77954996105 scopus 로고    scopus 로고
    • MiR-107 is reduced in Alzheimer's disease brain neocortex: Validation study
    • P.T. Nelson, and W.X. Wang MiR-107 is reduced in Alzheimer's disease brain neocortex: validation study Journal of Alzheimer's Disease 21 1 2010 75 79
    • (2010) Journal of Alzheimer's Disease , vol.21 , Issue.1 , pp. 75-79
    • Nelson, P.T.1    Wang, W.X.2
  • 73
    • 77953312769 scopus 로고    scopus 로고
    • Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation
    • J. Nunez-Iglesias, C.C. Liu, T.E. Morgan, C.E. Finch, and X.J. Zhou Joint genome-wide profiling of miRNA and mRNA expression in Alzheimer's disease cortex reveals altered miRNA regulation PLoS One 5 2 2010 e8898
    • (2010) PLoS One , vol.5 , Issue.2 , pp. 8898
    • Nunez-Iglesias, J.1    Liu, C.C.2    Morgan, T.E.3    Finch, C.E.4    Zhou, X.J.5
  • 74
    • 0037447999 scopus 로고    scopus 로고
    • Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c
    • DOI 10.1002/jnr.10592
    • S. Ohmachi, T. Mikami, M. Konishi, A. Miyake, and N. Itoh Preferential neurotrophic activity of fibroblast growth factor-20 for dopaminergic neurons through fibroblast growth factor receptor-1c Journal of Neuroscience Research 72 4 2003 436 443 (Pubitemid 36523418)
    • (2003) Journal of Neuroscience Research , vol.72 , Issue.4 , pp. 436-443
    • Ohmachi, S.1    Mikami, T.2    Konishi, M.3    Miyake, A.4    Itoh, N.5
  • 76
    • 33646027887 scopus 로고    scopus 로고
    • LNA-modified oligonucleotides mediate specific inhibition of microRNA function
    • U.A. Orom, S. Kauppinen, and A.H. Lund LNA-modified oligonucleotides mediate specific inhibition of microRNA function Gene 372 2006 137 141
    • (2006) Gene , vol.372 , pp. 137-141
    • Orom, U.A.1    Kauppinen, S.2    Lund, A.H.3
  • 77
    • 34547692622 scopus 로고    scopus 로고
    • Trinucleotide repeat disorders
    • DOI 10.1146/annurev.neuro.29.051605.113042
    • H.T. Orr, and H.Y. Zoghbi Trinucleotide repeat disorders Annual Review of Neuroscience 30 2007 575 621 (Pubitemid 47218768)
    • (2007) Annual Review of Neuroscience , vol.30 , pp. 575-621
    • Orr, H.T.1    Zoghbi, H.Y.2
  • 78
    • 58149375393 scopus 로고    scopus 로고
    • The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease
    • A.N. Packer, Y. Xing, S.Q. Harper, L. Jones, and B.L. Davidson The bifunctional microRNA miR-9/miR-9* regulates REST and CoREST and is downregulated in Huntington's disease Journal of Neuroscience 28 53 2008 14341 14346
    • (2008) Journal of Neuroscience , vol.28 , Issue.53 , pp. 14341-14346
    • Packer, A.N.1    Xing, Y.2    Harper, S.Q.3    Jones, L.4    Davidson, B.L.5
  • 82
    • 0023620006 scopus 로고
    • Gene dosage of the amyloid β precursor protein in Alzheimer's disease
    • M.B. Podlisny, G. Lee, and D.J. Selkoe Gene dosage of the amyloid beta precursor protein in Alzheimer's disease Science 238 4827 1987 669 671 (Pubitemid 17158297)
    • (1987) Science , vol.238 , Issue.4827 , pp. 669-671
    • Podlisny, M.B.1    Lee, G.2    Selkoe, D.J.3
  • 83
    • 77952585703 scopus 로고    scopus 로고
    • MicroRNAs as a molecular basis for mental retardation. Alzheimer's and prion diseases
    • P. Provost MicroRNAs as a molecular basis for mental retardation. Alzheimer's and prion diseases Brain Research 1338 2010 58 66
    • (2010) Brain Research , vol.1338 , pp. 58-66
    • Provost, P.1
  • 84
    • 56049083010 scopus 로고    scopus 로고
    • Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia
    • R. Rademakers, J.L. Eriksen, M. Baker, T. Robinson, Z. Ahmed, and S.J. Lincoln Common variation in the miR-659 binding-site of GRN is a major risk factor for TDP43-positive frontotemporal dementia Human Molecular Genetics 17 23 2008 3631 3642
    • (2008) Human Molecular Genetics , vol.17 , Issue.23 , pp. 3631-3642
    • Rademakers, R.1    Eriksen, J.L.2    Baker, M.3    Robinson, T.4    Ahmed, Z.5    Lincoln, S.J.6
  • 89
    • 52949119537 scopus 로고    scopus 로고
    • MicroRNA target site polymorphisms and human disease
    • P. Sethupathy, and F.S. Collins MicroRNA target site polymorphisms and human disease Trends in Genetics 24 10 2008 489 497
    • (2008) Trends in Genetics , vol.24 , Issue.10 , pp. 489-497
    • Sethupathy, P.1    Collins, F.S.2
  • 90
    • 0037968357 scopus 로고    scopus 로고
    • Decapping and decay of messenger RNA occur in cytoplasmic processing bodies
    • DOI 10.1126/science.1082320
    • U. Sheth, and R. Parker Decapping and decay of messenger RNA occur in cytoplasmic processing bodies Science 300 5620 2003 805 808 (Pubitemid 36532117)
    • (2003) Science , vol.300 , Issue.5620 , pp. 805-808
    • Sheth, U.1    Parker, R.2
  • 91
    • 77952336221 scopus 로고    scopus 로고
    • Aberrant microRNA expression in the brains of neurodegenerative diseases: MiR-29a decreased in Alzheimer disease brains targets neurone navigator 3
    • M. Shioya, S. Obayashi, H. Tabunoki, K. Arima, Y. Saito, and T. Ishida Aberrant microRNA expression in the brains of neurodegenerative diseases: miR-29a decreased in Alzheimer disease brains targets neurone navigator 3 Neuropathology and Applied Neurobiology 36 4 2010 320 330
    • (2010) Neuropathology and Applied Neurobiology , vol.36 , Issue.4 , pp. 320-330
    • Shioya, M.1    Obayashi, S.2    Tabunoki, H.3    Arima, K.4    Saito, Y.5    Ishida, T.6
  • 93
    • 80053167649 scopus 로고    scopus 로고
    • MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy
    • P.Y. Smith, C. Delay, J. Girard, M.A. Papon, E. Planel, and N. Sergeant MicroRNA-132 loss is associated with tau exon 10 inclusion in progressive supranuclear palsy Human Molecular Genetics 20 20 2011 4016 4024
    • (2011) Human Molecular Genetics , vol.20 , Issue.20 , pp. 4016-4024
    • Smith, P.Y.1    Delay, C.2    Girard, J.3    Papon, M.A.4    Planel, E.5    Sergeant, N.6
  • 95
    • 77952675535 scopus 로고    scopus 로고
    • MicroRNAs and deregulated gene expression networks in neurodegeneration
    • K.C. Sonntag MicroRNAs and deregulated gene expression networks in neurodegeneration Brain Research 1338 2010 48 57
    • (2010) Brain Research , vol.1338 , pp. 48-57
    • Sonntag, K.C.1
  • 99
    • 34249302620 scopus 로고    scopus 로고
    • Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells
    • DOI 10.1038/ncb1596, PII NCB1596
    • H. Valadi, K. Ekstrom, A. Bossios, M. Sjostrand, J.J. Lee, and J.O. Lotvall Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells Nature Cell Biology 9 6 2007 654 659 (Pubitemid 47214727)
    • (2007) Nature Cell Biology , vol.9 , Issue.6 , pp. 654-659
    • Valadi, H.1    Ekstrom, K.2    Bossios, A.3    Sjostrand, M.4    Lee, J.J.5    Lotvall, J.O.6
  • 101
    • 61349162349 scopus 로고    scopus 로고
    • Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6
    • C. Vance, B. Rogelj, T. Hortobagyi, K.J. De Vos, A.L. Nishimura, and J. Sreedharan Mutations in FUS, an RNA processing protein, cause familial amyotrophic lateral sclerosis type 6 Science 323 5918 2009 1208 1211
    • (2009) Science , vol.323 , Issue.5918 , pp. 1208-1211
    • Vance, C.1    Rogelj, B.2    Hortobagyi, T.3    De Vos, K.J.4    Nishimura, A.L.5    Sreedharan, J.6
  • 102
    • 70350455062 scopus 로고    scopus 로고
    • The beta-secretase enzyme BACE in health and Alzheimer's disease: Regulation, cell biology, function, and therapeutic potential
    • R. Vassar, D.M. Kovacs, R. Yan, and P.C. Wong The beta-secretase enzyme BACE in health and Alzheimer's disease: regulation, cell biology, function, and therapeutic potential Journal of Neuroscience 29 41 2009 12787 12794
    • (2009) Journal of Neuroscience , vol.29 , Issue.41 , pp. 12787-12794
    • Vassar, R.1    Kovacs, D.M.2    Yan, R.3    Wong, P.C.4
  • 103
    • 77953319294 scopus 로고    scopus 로고
    • MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons
    • E. Vilardo, C. Barbato, M. Ciotti, C. Cogoni, and F. Ruberti MicroRNA-101 regulates amyloid precursor protein expression in hippocampal neurons Journal of Biological Chemistry 285 24 2010 18344 18351
    • (2010) Journal of Biological Chemistry , vol.285 , Issue.24 , pp. 18344-18351
    • Vilardo, E.1    Barbato, C.2    Ciotti, M.3    Cogoni, C.4    Ruberti, F.5
  • 105
    • 79451474371 scopus 로고    scopus 로고
    • Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: White matter versus gray matter
    • W.X. Wang, Q. Huang, Y. Hu, A.J. Stromberg, and P.T. Nelson Patterns of microRNA expression in normal and early Alzheimer's disease human temporal cortex: white matter versus gray matter Acta Neuropathologica 121 2 2011 193 205
    • (2011) Acta Neuropathologica , vol.121 , Issue.2 , pp. 193-205
    • Wang, W.X.1    Huang, Q.2    Hu, Y.3    Stromberg, A.J.4    Nelson, P.T.5
  • 106
    • 38749095507 scopus 로고    scopus 로고
    • The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of β-site amyloid precursor protein-cleaving enzyme 1
    • DOI 10.1523/JNEUROSCI.5065-07.2008
    • W.X. Wang, B.W. Rajeev, A.J. Stromberg, N. Ren, G. Tang, and Q. Huang The expression of microRNA miR-107 decreases early in Alzheimer's disease and may accelerate disease progression through regulation of beta-site amyloid precursor protein-cleaving enzyme 1 Journal of Neuroscience 28 5 2008 1213 1223 (Pubitemid 351186356)
    • (2008) Journal of Neuroscience , vol.28 , Issue.5 , pp. 1213-1223
    • Wang, W.-X.1    Rajeev, B.W.2    Stromberg, A.J.3    Ren, N.4    Tang, G.5    Huang, Q.6    Rigoutsos, I.7    Nelson, P.T.8
  • 107
    • 40749145370 scopus 로고    scopus 로고
    • Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein
    • G. Wang, J.M. van der Walt, G. Mayhew, Y.J. Li, S. Zuchner, and W.K. Scott Variation in the miRNA-433 binding site of FGF20 confers risk for Parkinson disease by overexpression of alpha-synuclein American Journal of Human Genetics 82 2 2008 283 289
    • (2008) American Journal of Human Genetics , vol.82 , Issue.2 , pp. 283-289
    • Wang, G.1    Van Der Walt, J.M.2    Mayhew, G.3    Li, Y.J.4    Zuchner, S.5    Scott, W.K.6
  • 108
    • 67651120265 scopus 로고    scopus 로고
    • FGF20 and Parkinson's disease: No evidence of association or pathogenicity via alpha-synuclein expression
    • C. Wider, J.C. Dachsel, A.I. Soto, M.G. Heckman, N.N. Diehl, and M. Yue FGF20 and Parkinson's disease: no evidence of association or pathogenicity via alpha-synuclein expression Movement Disorders 24 3 2009 455 459
    • (2009) Movement Disorders , vol.24 , Issue.3 , pp. 455-459
    • Wider, C.1    Dachsel, J.C.2    Soto, A.I.3    Heckman, M.G.4    Diehl, N.N.5    Yue, M.6
  • 109
    • 72149131804 scopus 로고    scopus 로고
    • MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice
    • A.H. Williams, G. Valdez, V. Moresi, X. Qi, J. McAnally, and J.L. Elliott MicroRNA-206 delays ALS progression and promotes regeneration of neuromuscular synapses in mice Science 326 5959 2009 1549 1554
    • (2009) Science , vol.326 , Issue.5959 , pp. 1549-1554
    • Williams, A.H.1    Valdez, G.2    Moresi, V.3    Qi, X.4    McAnally, J.5    Elliott, J.L.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.