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Volumn 21, Issue 4, 2013, Pages 816-824

Enhanced intrapulmonary delivery of anticancer siRNA for lung cancer therapy using cationic ethylphosphocholine-based nanolipoplexes

Author keywords

[No Author keywords available]

Indexed keywords

1,2 DI O OCTADECENYL 3 TRIMETHYLAMMONIUM PROPANE; 1,2 DIOLEOYL 3 TRIMETHYLAMMONIOPROPANE; 1,2 DIOLEOYL SN GLYCERO 3 PHOSPHOETHANOLAMINE; 3 BETA [N (N',N' DIMETHYLAMINO ETHANE)CARBAMOYL]CHOLESTEROL; CHOLESTEROL; DIOLEOYL SN GLYCERO 3 ETHYLPHOSPHOCHOLINE; LIPOSOME; MESSENGER RNA; PROTEIN MCL 1; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 84878559366     PISSN: 15250016     EISSN: 15250024     Source Type: Journal    
DOI: 10.1038/mt.2013.10     Document Type: Article
Times cited : (56)

References (45)
  • 1
    • 78651314500 scopus 로고    scopus 로고
    • Potential clinical applications of siRNA technique: Benefts and limitations
    • Chen, SH and Zhaori, G (2011). Potential clinical applications of siRNA technique: benefts and limitations. Eur J Clin Invest 41: 221-232.
    • (2011) Eur J Clin Invest , vol.41 , pp. 221-232
    • Chen, S.H.1    Zhaori, G.2
  • 2
    • 80052627990 scopus 로고    scopus 로고
    • Current progress of siRNA/shRNA therapeutics in clinical trials
    • Burnett, JC, Rossi, JJ and Tiemann, K (2011). Current progress of siRNA/shRNA therapeutics in clinical trials. Biotechnol J 6: 1130-1146.
    • (2011) Biotechnol J , vol.6 , pp. 1130-1146
    • Burnett, J.C.1    Rossi, J.J.2    Tiemann, K.3
  • 3
    • 67649295505 scopus 로고    scopus 로고
    • SiRNA delivery systems for cancer treatment
    • Oh, YK and Park, TG (2009). siRNA delivery systems for cancer treatment. Adv Drug Deliv Rev 61: 850-862.
    • (2009) Adv Drug Deliv Rev , vol.61 , pp. 850-862
    • Oh, Y.K.1    Park, T.G.2
  • 4
    • 78649659237 scopus 로고    scopus 로고
    • Delivery of siRNA therapeutics: Barriers and carriers
    • Wang, J, Lu, Z, Wientjes, MG and Au, JL (2010). Delivery of siRNA therapeutics: barriers and carriers. AAPS J 12: 492-503.
    • (2010) AAPS J , vol.12 , pp. 492-503
    • Wang, J.1    Lu, Z.2    Wientjes, M.G.3    Au, J.L.4
  • 5
    • 78449309070 scopus 로고    scopus 로고
    • Effcient and targeted delivery of siRNA in vivo
    • Shim, MS and Kwon, YJ (2010). Effcient and targeted delivery of siRNA in vivo. FEBS J 277: 4814-4827.
    • (2010) FEBS J , vol.277 , pp. 4814-4827
    • Shim, M.S.1    Kwon, Y.J.2
  • 6
    • 51049084639 scopus 로고    scopus 로고
    • Inhalable siRNA: Potential as a therapeutic agent in the lungs
    • Durcan, N, Murphy, C and Cryan, SA (2008). Inhalable siRNA: potential as a therapeutic agent in the lungs. Mol Pharm 5: 559-566.
    • (2008) Mol Pharm , vol.5 , pp. 559-566
    • Durcan, N.1    Murphy, C.2    Cryan, S.A.3
  • 7
    • 84856956282 scopus 로고    scopus 로고
    • Delivery of siRNA to the mouse lung via a functionalized lipopolyamine
    • Polach, KJ, Matar, M, Rice, J, Slobodkin, G, Sparks, J, Congo, R et al. (2012). Delivery of siRNA to the mouse lung via a functionalized lipopolyamine. Mol Ther 20: 91-100.
    • (2012) Mol Ther , vol.20 , pp. 91-100
    • Polach, K.J.1    Matar, M.2    Rice, J.3    Slobodkin, G.4    Sparks, J.5    Congo, R.6
  • 8
    • 84863928267 scopus 로고    scopus 로고
    • Nonviral pulmonary delivery of siRNA
    • Merkel, OM and Kissel, T (2012). Nonviral pulmonary delivery of siRNA. Acc Chem Res 45: 961-970.
    • (2012) Acc Chem Res , vol.45 , pp. 961-970
    • Merkel, O.M.1    Kissel, T.2
  • 9
    • 84858438407 scopus 로고    scopus 로고
    • Pulmonary delivery of therapeutic siRNA
    • Lam, JK, Liang, W and Chan, HK (2012). Pulmonary delivery of therapeutic siRNA. Adv Drug Deliv Rev 64: 1-15.
    • (2012) Adv Drug Deliv Rev , vol.64 , pp. 1-15
    • Lam, J.K.1    Liang, W.2    Chan, H.K.3
  • 10
    • 82955233645 scopus 로고    scopus 로고
    • Uptake, effcacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense
    • Moschos, SA, Frick, M, Taylor, B, Turnpenny, P, Graves, H, Spink, KG et al. (2011). Uptake, effcacy, and systemic distribution of naked, inhaled short interfering RNA (siRNA) and locked nucleic acid (LNA) antisense. Mol Ther 19: 2163-2168.
    • (2011) Mol Ther , vol.19 , pp. 2163-2168
    • Moschos, S.A.1    Frick, M.2    Taylor, B.3    Turnpenny, P.4    Graves, H.5    Spink, K.G.6
  • 11
    • 46349111796 scopus 로고    scopus 로고
    • Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis
    • Xu, CX, Jere, D, Jin, H, Chang, SH, Chung, YS, Shin, JY et al. (2008). Poly(ester amine)-mediated, aerosol-delivered Akt1 small interfering RNA suppresses lung tumorigenesis. Am J Respir Crit Care Med 178: 60-73.
    • (2008) Am J Respir Crit Care Med , vol.178 , pp. 60-73
    • Xu, C.X.1    Jere, D.2    Jin, H.3    Chang, S.H.4    Chung, Y.S.5    Shin, J.Y.6
  • 12
    • 79955468361 scopus 로고    scopus 로고
    • Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice
    • Beyerle, A, Braun, A, Merkel, O, Koch, F, Kissel, T and Stoeger, T (2011). Comparative in vivo study of poly(ethylene imine)/siRNA complexes for pulmonary delivery in mice. J Control Release 151: 51-56.
    • (2011) J Control Release , vol.151 , pp. 51-56
    • Beyerle, A.1    Braun, A.2    Merkel, O.3    Koch, F.4    Kissel, T.5    Stoeger, T.6
  • 13
    • 84855837134 scopus 로고    scopus 로고
    • Design of an inhalable dry powder formulation of DOTAP-modifed PLGA nanoparticles loaded with siRNA
    • Jensen, DK, Jensen, LB, Koocheki, S, Bengtson, L, Cun, D, Nielsen, HM et al. (2012). Design of an inhalable dry powder formulation of DOTAP-modifed PLGA nanoparticles loaded with siRNA. J Control Release 157: 141-148.
    • (2012) J Control Release , vol.157 , pp. 141-148
    • Jensen, D.K.1    Jensen, L.B.2    Koocheki, S.3    Bengtson, L.4    Cun, D.5    Nielsen, H.M.6
  • 14
    • 66249123291 scopus 로고    scopus 로고
    • Hyaluronic acid-modifed DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells
    • Taetz, S, Bochot, A, Surace, C, Arpicco, S, Renoir, JM, Schaefer, UF et al. (2009). Hyaluronic acid-modifed DOTAP/DOPE liposomes for the targeted delivery of anti-telomerase siRNA to CD44-expressing lung cancer cells. Oligonucleotides 19: 103-116.
    • (2009) Oligonucleotides , vol.19 , pp. 103-116
    • Taetz, S.1    Bochot, A.2    Surace, C.3    Arpicco, S.4    Renoir, J.M.5    Schaefer, U.F.6
  • 15
    • 79959915264 scopus 로고    scopus 로고
    • Receptor-targeted liposome-peptide nanocomplexes for siRNA delivery
    • Tagalakis, AD, He, L, Saraiva, L, Gustafsson, KT and Hart, SL (2011). Receptor-targeted liposome-peptide nanocomplexes for siRNA delivery. Biomaterials 32: 6302-6315.
    • (2011) Biomaterials , vol.32 , pp. 6302-6315
    • Tagalakis, A.D.1    He, L.2    Saraiva, L.3    Gustafsson, K.T.4    Hart, S.L.5
  • 16
  • 17
    • 0032552426 scopus 로고    scopus 로고
    • Biodistribution and gene expression of lipid/plasmid complexes after systemic administration
    • Mahato, RI, Anwer, K, Tagliaferri, F, Meaney, C, Leonard, P, Wadhwa, MS et al. (1998). Biodistribution and gene expression of lipid/plasmid complexes after systemic administration. Hum Gene Ther 9: 2083-2099.
    • (1998) Hum Gene Ther , vol.9 , pp. 2083-2099
    • Mahato, R.I.1    Anwer, K.2    Tagliaferri, F.3    Meaney, C.4    Leonard, P.5    Wadhwa, M.S.6
  • 18
    • 80155150303 scopus 로고    scopus 로고
    • Personalized medicine in lung cancer: What we need to know
    • Mok, TS (2011). Personalized medicine in lung cancer: what we need to know. Nat Rev Clin Oncol 8: 661-668.
    • (2011) Nat Rev Clin Oncol , vol.8 , pp. 661-668
    • Mok, T.S.1
  • 19
    • 33845612190 scopus 로고    scopus 로고
    • Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo
    • Writer, M, Hurley, CA, Sarkar, S, Copeman, DM, Wong, JB, Odlyha, M et al. (2006). Analysis and optimization of the cationic lipid component of a lipid/peptide vector formulation for enhanced transfection in vitro and in vivo. J Liposome Res 16: 373-389.
    • (2006) J Liposome Res , vol.16 , pp. 373-389
    • Writer, M.1    Hurley, C.A.2    Sarkar, S.3    Copeman, D.M.4    Wong, J.B.5    Odlyha, M.6
  • 20
    • 77951498926 scopus 로고    scopus 로고
    • DC-Chol/DOPE cationic liposomes: A comparative study of the infuence factors on plasmid pDNA and siRNA gene delivery
    • Zhang, Y, Li, H, Sun, J, Gao, J, Liu, W, Li, B et al. (2010). DC-Chol/DOPE cationic liposomes: a comparative study of the infuence factors on plasmid pDNA and siRNA gene delivery. Int J Pharm 390: 198-207.
    • (2010) Int J Pharm , vol.390 , pp. 198-207
    • Zhang, Y.1    Li, H.2    Sun, J.3    Gao, J.4    Liu, W.5    Li, B.6
  • 21
    • 0032820002 scopus 로고    scopus 로고
    • O-ethylphosphatidylcholine: A metabolizable cationic phospholipid which is a serum-compatible DNA transfection agent
    • MacDonald, RC, Rakhmanova, VA, Choi, KL, Rosenzweig, HS and Lahiri, MK (1999). O-ethylphosphatidylcholine: A metabolizable cationic phospholipid which is a serum-compatible DNA transfection agent. J Pharm Sci 88: 896-904.
    • (1999) J Pharm Sci , vol.88 , pp. 896-904
    • MacDonald, R.C.1    Rakhmanova, V.A.2    Choi, K.L.3    Rosenzweig, H.S.4    Lahiri, M.K.5
  • 22
    • 34548185242 scopus 로고    scopus 로고
    • Synergistic effect between components of mixtures of cationic amphipaths in transfection of primary endothelial cells
    • Wang, L and MacDonald, RC (2007). Synergistic effect between components of mixtures of cationic amphipaths in transfection of primary endothelial cells. Mol Pharm 4: 615-623.
    • (2007) Mol Pharm , vol.4 , pp. 615-623
    • Wang, L.1    MacDonald, R.C.2
  • 23
    • 78549278716 scopus 로고    scopus 로고
    • Tocopheryl oligochitosan-based self assembling oligomersomes for siRNA delivery
    • Noh, SM, Han, SE, Shim, G, Lee, KE, Kim, CW, Han, SS et al. (2011). Tocopheryl oligochitosan-based self assembling oligomersomes for siRNA delivery. Biomaterials 32: 849-857.
    • (2011) Biomaterials , vol.32 , pp. 849-857
    • Noh, S.M.1    Han, S.E.2    Shim, G.3    Lee, K.E.4    Kim, C.W.5    Han, S.S.6
  • 24
    • 34547161854 scopus 로고    scopus 로고
    • In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments
    • Bae, Y, Nishiyama, N and Kataoka, K (2007). In vivo antitumor activity of the folate-conjugated pH-sensitive polymeric micelle selectively releasing adriamycin in the intracellular acidic compartments. Bioconjug Chem 18: 1131-1139.
    • (2007) Bioconjug Chem , vol.18 , pp. 1131-1139
    • Bae, Y.1    Nishiyama, N.2    Kataoka, K.3
  • 25
    • 19444372923 scopus 로고    scopus 로고
    • A two-stage poly(ethylenimine)-mediated cytotoxicity: Implications for gene transfer/therapy
    • Moghimi, SM, Symonds, P, Murray, JC, Hunter, AC, Debska, G and Szewczyk, A (2005). A two-stage poly(ethylenimine)-mediated cytotoxicity: implications for gene transfer/therapy. Mol Ther 11: 990-995.
    • (2005) Mol Ther , vol.11 , pp. 990-995
    • Moghimi, S.M.1    Symonds, P.2    Murray, J.C.3    Hunter, A.C.4    Debska, G.5    Szewczyk, A.6
  • 26
    • 77953809654 scopus 로고    scopus 로고
    • Cationic carriers of genetic material and cell death: A mitochondrial tale
    • Hunter, AC and Moghimi, SM (2010). Cationic carriers of genetic material and cell death: a mitochondrial tale. Biochim Biophys Acta 1797: 1203-1209.
    • (2010) Biochim Biophys Acta , vol.1797 , pp. 1203-1209
    • Hunter, A.C.1    Moghimi, S.M.2
  • 27
    • 81355138363 scopus 로고    scopus 로고
    • Cationic phospholiposomes: Effcient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells
    • Wang, L and MacDonald, RC (2011). Cationic phospholiposomes: effcient delivery vehicles of anticancer derivatives of ATP to multiple myeloma cells. J Liposome Res 21: 306-314.
    • (2011) J Liposome Res , vol.21 , pp. 306-314
    • Wang, L.1    MacDonald, R.C.2
  • 28
    • 25144453314 scopus 로고    scopus 로고
    • Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells
    • Song, L, Coppola, D, Livingston, S, Cress, D and Haura, EB (2005). Mcl-1 regulates survival and sensitivity to diverse apoptotic stimuli in human non-small cell lung cancer cells. Cancer Biol Ther 4: 267-276.
    • (2005) Cancer Biol Ther , vol.4 , pp. 267-276
    • Song, L.1    Coppola, D.2    Livingston, S.3    Cress, D.4    Haura, E.B.5
  • 29
    • 70949089720 scopus 로고    scopus 로고
    • Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells
    • Simonin, K, Brotin, E, Dufort, S, Dutoit, S, Goux, D, N'diaye, M et al. (2009). Mcl-1 is an important determinant of the apoptotic response to the BH3-mimetic molecule HA14-1 in cisplatin-resistant ovarian carcinoma cells. Mol Cancer Ther 8: 3162-3170.
    • (2009) Mol Cancer Ther , vol.8 , pp. 3162-3170
    • Simonin, K.1    Brotin, E.2    Dufort, S.3    Dutoit, S.4    Goux N'Diaye D, M.5
  • 30
    • 84872675104 scopus 로고    scopus 로고
    • MiR-101 and Mcl-1 in non-small-cell lung cancer: Expression profle and clinical signifcance
    • Luo, L, Zhang, T, Liu, H, Lv, T, Yuan, D, Yao, Y et al. (2012). MiR-101 and Mcl-1 in non-small-cell lung cancer: expression profle and clinical signifcance. Med Oncol 29: 1681-1686.
    • (2012) Med Oncol , vol.29 , pp. 1681-1686
    • Luo, L.1    Zhang, T.2    Liu, H.3    Lv, T.4    Yuan, D.5    Yao, Y.6
  • 31
    • 81055149759 scopus 로고    scopus 로고
    • Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors
    • Zhou, W, Hu, J, Tang, H, Wang, D, Huang, X, He, C et al. (2011). Small interfering RNA targeting mcl-1 enhances proteasome inhibitor-induced apoptosis in various solid malignant tumors. BMC Cancer 11: 485.
    • (2011) BMC Cancer , vol.11 , pp. 485
    • Zhou, W.1    Hu, J.2    Tang, H.3    Wang, D.4    Huang, X.5    He, C.6
  • 32
    • 80052145802 scopus 로고    scopus 로고
    • Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug
    • Shim, G, Han, SE, Yu, YH, Lee, S, Lee, HY, Kim, K et al. (2011). Trilysinoyl oleylamide-based cationic liposomes for systemic co-delivery of siRNA and an anticancer drug. J Control Release 155: 60-66.
    • (2011) J Control Release , vol.155 , pp. 60-66
    • Shim, G.1    Han, S.E.2    Yu, Y.H.3    Lee, S.4    Lee, H.Y.5    Kim, K.6
  • 33
    • 84861681753 scopus 로고    scopus 로고
    • RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment
    • Yonenaga, N, Kenjo, E, Asai, T, Tsuruta, A, Shimizu, K, Dewa, T et al. (2012). RGD-based active targeting of novel polycation liposomes bearing siRNA for cancer treatment. J Control Release 160: 177-181.
    • (2012) J Control Release , vol.160 , pp. 177-181
    • Yonenaga, N.1    Kenjo, E.2    Asai, T.3    Tsuruta, A.4    Shimizu, K.5    Dewa, T.6
  • 34
    • 79959266354 scopus 로고    scopus 로고
    • M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis
    • Zhou, H, Roy, S, Cochran, E, Zouaoui, R, Chu, CL, Duffner, J et al. (2011). M402, a novel heparan sulfate mimetic, targets multiple pathways implicated in tumor progression and metastasis. PLoS ONE 6: e21106.
    • (2011) PLoS ONE , vol.6
    • Zhou, H.1    Roy, S.2    Cochran, E.3    Zouaoui, R.4    Chu, C.L.5    Duffner, J.6
  • 35
    • 63849114023 scopus 로고    scopus 로고
    • The utility of a nebulised intra-tracheal rat model of invasive pulmonary aspergillosis
    • Chandenier, J, Bernard, S, Montharu, J, Bailly, E, Fetissof, F, de Monte, M et al. (2009). The utility of a nebulised intra-tracheal rat model of invasive pulmonary aspergillosis. Mycoses 52: 239-245.
    • (2009) Mycoses , vol.52 , pp. 239-245
    • Chandenier, J.1    Bernard, S.2    Montharu, J.3    Bailly, E.4    Fetissof, F.5    De Monte, M.6
  • 36
    • 24744466699 scopus 로고    scopus 로고
    • Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque
    • Li, BJ, Tang, Q, Cheng, D, Qin, C, Xie, FY, Wei, Q et al. (2005). Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat Med 11: 944-951.
    • (2005) Nat Med , vol.11 , pp. 944-951
    • Li, B.J.1    Tang, Q.2    Cheng, D.3    Qin, C.4    Xie, F.Y.5    Wei, Q.6
  • 40
    • 24944577514 scopus 로고    scopus 로고
    • Cationic lipid saturation infuences intracellular delivery of encapsulated nucleic acids
    • Heyes, J, Palmer, L, Bremner, K and MacLachlan, I (2005). Cationic lipid saturation infuences intracellular delivery of encapsulated nucleic acids. J Control Release 107: 276-287.
    • (2005) J Control Release , vol.107 , pp. 276-287
    • Heyes, J.1    Palmer, L.2    Bremner, K.3    MacLachlan, I.4
  • 41
    • 80052552280 scopus 로고    scopus 로고
    • Effcient topical delivery of plasmid DNA to lung in vivo mediated by putative triggered, PEGylated pDNA nanoparticles
    • Aissaoui, A, Chami, M, Hussein, M and Miller, AD (2011). Effcient topical delivery of plasmid DNA to lung in vivo mediated by putative triggered, PEGylated pDNA nanoparticles. J Control Release 154: 275-284.
    • (2011) J Control Release , vol.154 , pp. 275-284
    • Aissaoui, A.1    Chami, M.2    Hussein, M.3    Miller, A.D.4
  • 42
    • 84870232413 scopus 로고    scopus 로고
    • The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine
    • Mochizuki, S, Kanegae, N, Nishina, K, Kamikawa, Y, Koiwai, K, Masunaga, H et al. (2013). The role of the helper lipid dioleoylphosphatidylethanolamine (DOPE) for DNA transfection cooperating with a cationic lipid bearing ethylenediamine. Biochim Biophys Acta 1828: 412-418.
    • (2013) Biochim Biophys Acta , vol.1828 , pp. 412-418
    • Mochizuki, S.1    Kanegae, N.2    Nishina, K.3    Kamikawa, Y.4    Koiwai, K.5    Masunaga, H.6
  • 43
    • 17644419268 scopus 로고    scopus 로고
    • Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection effciency
    • Zuhorn, IS, Bakowsky, U, Polushkin, E, Visser, WH, Stuart, MC, Engberts, JB et al. (2005). Nonbilayer phase of lipoplex-membrane mixture determines endosomal escape of genetic cargo and transfection effciency. Mol Ther 11: 801-810.
    • (2005) Mol Ther , vol.11 , pp. 801-810
    • Zuhorn, I.S.1    Bakowsky, U.2    Polushkin, E.3    Visser, W.H.4    Stuart, M.C.5    Engberts, J.B.6
  • 44
    • 84862163934 scopus 로고    scopus 로고
    • Lipid nanoparticles for hepatic delivery of small interfering RNA
    • Yu, B, Hsu, SH, Zhou, C, Wang, X, Terp, MC, Wu, Y et al. (2012). Lipid nanoparticles for hepatic delivery of small interfering RNA. Biomaterials 33: 5924-5934.
    • (2012) Biomaterials , vol.33 , pp. 5924-5934
    • Yu, B.1    Hsu, S.H.2    Zhou, C.3    Wang, X.4    Terp, M.C.5    Wu, Y.6
  • 45
    • 80054060205 scopus 로고    scopus 로고
    • Cationic drug-derived nanoparticles for multifunctional delivery of anticancer siRNA
    • Chang, RS, Suh, MS, Kim, S, Shim, G, Lee, S, Han, SS et al. (2011). Cationic drug-derived nanoparticles for multifunctional delivery of anticancer siRNA. Biomaterials 32: 9785-9795.
    • (2011) Biomaterials , vol.32 , pp. 9785-9795
    • Chang, R.S.1    Suh, M.S.2    Kim, S.3    Shim, G.4    Lee, S.5    Han, S.S.6


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