Recent developments and clinical studies utilizing engineered zinc finger nuclease technology

Cellular and Molecular Life Sciences

Volumn 72, Issue 20, 2015, Pages 3819-3830

  Jo, Young Il ^a   Kim, Hyongbum ^b,c   Ramakrishna, Suresh ^d  

^a BRANDEIS UNIVERSITY   (United States)

^b Yonsei University College of Medicine   (South Korea)

^c Yonsei University   (South Korea)

^d Hanyang University   (South Korea)

Author keywords

Farm animals; Pre clinical trials; Programmable nucleases; Targeted genetic modifications; Therapeutic applications; ZFN architecture; ZFN delivery; ZFN modification

Indexed keywords

CHEMOKINE RECEPTOR CCR5; CHEMOKINE RECEPTOR CXCR4; INTERLEUKIN 2 RECEPTOR GAMMA; ZINC FINGER NUCLEASE; ZINC FINGER PROTEIN; DEOXYRIBONUCLEASE;

BIOTECHNOLOGY; CCR5 GENE; CRISPR CAS SYSTEM; CXCR4 GENE; DNA BINDING MOTIF; DNA MODIFICATION; DRUG SAFETY; ENZYME ACTIVITY; ENZYME ENGINEERING; ENZYME SPECIFICITY; ENZYME STABILITY; FARM ANIMAL; GENE INACTIVATION; GENE INSERTION; GENE TARGETING; HEMOPHILIA A; HEMOPHILIA B; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUNTER SYNDROME; HUNTINGTON CHOREA; HURLER SYNDROME; IL2RGAMMA GENE; LYSOSOME STORAGE DISEASE; NONHUMAN; NONVIRAL GENE DELIVERY SYSTEM; PATIENT SAFETY; PHASE 1 CLINICAL TRIAL (TOPIC); PHASE 2 CLINICAL TRIAL (TOPIC); PROTEIN CLEAVAGE; PROTEIN DOMAIN; REVIEW; SICKLE CELL ANEMIA; X LINKED SEVERE COMBINED IMMUNODEFICIENCY; ZFN GENE; ANIMAL; CHEMISTRY; CULTURE TECHNIQUE; DOMESTIC ANIMAL; GENE THERAPY; GENETIC ENGINEERING; GENETICS; PROCEDURES; TRENDS;

ANIMALS; ANIMALS, DOMESTIC; CELL CULTURE TECHNIQUES; DEOXYRIBONUCLEASES; GENETIC ENGINEERING; GENETIC THERAPY; ZINC FINGERS;

EID: 84942369794     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-015-1956-5     Document Type: Review

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