Targeted disruption of Tbc1d20 with zinc-finger nucleases causes cataracts and testicular abnormalities in mice

BMC Genetics

Volumn 15, Issue 1, 2014, Pages

  Park, Anna Kyunglim ^a   Liegel, Ryan P ^a   Ronchetti, Adam ^a   Ebert, Allison D ^a   Geurts, Aron ^a   Sidjanin, Duska J ^a  

^a MEDICAL COLLEGE OF WISCONSIN   (United States)

Author keywords

Blind sterile; Loss of function; Spermatogenesis; TBC1D20; Warburg Micro Syndrome; Zinc finger nuclease

Indexed keywords

ZINC FINGER NUCLEASE; DEOXYRIBONUCLEASE; RAB PROTEIN; TBC1D20 PROTEIN, MOUSE; ZINC FINGER PROTEIN;

AMINO TERMINAL SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CATARACT; CONTROLLED STUDY; DISEASE SEVERITY; FEMALE; GENE; GENE DELETION; GENE DISRUPTION; GENETIC VARIATION; HETEROZYGOTE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PHENOTYPIC VARIATION; PROTEIN EXPRESSION; TBC1D20 GENE; TESTIS DISEASE; ACROSOME; ANIMAL; C57BL MOUSE; CONGENITAL MALFORMATION; DBA MOUSE; DNA SEQUENCE; GENE EXPRESSION; GENE SILENCING; GENETIC ASSOCIATION; GENETIC ENGINEERING; GENETICS; HELA CELL LINE; HUMAN; METABOLISM; NUCLEOTIDE SEQUENCE; PHYSIOLOGY; TESTIS; TRANSGENIC MOUSE;

ACROSOME; ANIMALS; BASE SEQUENCE; CATARACT; ENDODEOXYRIBONUCLEASES; FEMALE; GENE EXPRESSION; GENE KNOCKDOWN TECHNIQUES; GENETIC ASSOCIATION STUDIES; GENETIC ENGINEERING; HELA CELLS; HUMANS; MALE; MICE, INBRED C57BL; MICE, INBRED DBA; MICE, TRANSGENIC; RAB1 GTP-BINDING PROTEINS; SEQUENCE ANALYSIS, DNA; TESTIS; ZINC FINGERS;

EID: 84964313193     PISSN: None     EISSN: 14712156     Source Type: Journal    
DOI: 10.1186/s12863-014-0135-2     Document Type: Article

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