Gene knockout and knockin by zinc-finger nucleases: Current status and perspectives

Cellular and Molecular Life Sciences

Volumn 70, Issue 16, 2013, Pages 2969-2983

  Hauschild Quintern, J ^a   Petersen, B ^a   Cost, G J ^c   Niemann, H ^a,b  

^a FEDERAL RESEARCH INSTITUTE FOR ANIMAL HEALTH   (Germany)

^b HANNOVER MEDICAL SCHOOL   (Germany)

^c SANGAMO BIOSCIENCES INC   (United States)

Author keywords

Gene knockout; Homology directed repair; Targeting efficiency; Transgenic animals; Zinc finger nucleases

Indexed keywords

DNA; ZINC FINGER NUCLEASE;

AMINO ACID SEQUENCE; CHO CELL; COW (MAMMAL); DNA CLEAVAGE; DNA MODIFICATION; DNA REPAIR; DOMESTIC PIG; DOUBLE STRANDED DNA BREAK; DROSOPHILA; EMBRYONIC STEM CELL; EXPERIMENTAL MODEL; EXPERIMENTAL MOUSE; EXPERIMENTAL RABBIT; EXPERIMENTAL RAT; GENE INACTIVATION; GENE TARGETING; GENETIC ENGINEERING; GENOME ANALYSIS; HUMAN; MUTATIONAL ANALYSIS; NEMATODE; NONHUMAN; PLURIPOTENT STEM CELL; PROTEIN BINDING; PROTEIN DOMAIN; PROTEIN FUNCTION; REVIEW; STRUCTURE ACTIVITY RELATION; ZEBRA FISH;

ANIMALS; ENDONUCLEASES; GENE KNOCK-IN TECHNIQUES; GENE KNOCKOUT TECHNIQUES; HUMANS; ZINC FINGERS;

AMPHIBIA; ANIMALIA; HEXAPODA; MAMMALIA; NEMATODA;

EID: 84881147545     PISSN: 1420682X     EISSN: 14209071     Source Type: Journal    
DOI: 10.1007/s00018-012-1204-1     Document Type: Review

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