-
1
-
-
9444230573
-
Designing transcription factor architectures for drug discovery
-
Blancafort,P., Segal,D.J. and Barbas,C.F., 3rd. (2004) Designing transcription factor architectures for drug discovery. Mol. Pharmacol., 66, 1361-1371.
-
(2004)
Mol. Pharmacol.
, vol.66
, pp. 1361-1371
-
-
Blancafort, P.1
Segal, D.J.2
Barbas III, C.F.3
-
2
-
-
27744530147
-
Zinc finger nucleases: Custom-designed molecular scissors for genome engineering of plant and mammalian cells
-
Durai,S., Mani,M., Kandavelou,K., Wu,J., Porteus,M.H. and Chandrasegaran,S. (2005) Zinc finger nucleases: custom-designed molecular scissors for genome engineering of plant and mammalian cells. Nucleic Acids Res., 33, 5978-5990.
-
(2005)
Nucleic Acids Res.
, vol.33
, pp. 5978-5990
-
-
Durai, S.1
Mani, M.2
Kandavelou, K.3
Wu, J.4
Porteus, M.H.5
Chandrasegaran, S.6
-
3
-
-
0036168937
-
Engineering polydactyl zinc-finger transcription factors
-
Beerli,R.R. and Barbas,C.F.,III (2002) Engineering polydactyl zinc-finger transcription factors. Nat. Biotechnol., 20, 135-141.
-
(2002)
Nat. Biotechnol.
, vol.20
, pp. 135-141
-
-
Beerli, R.R.1
Barbas III, C.F.2
-
4
-
-
0032981699
-
Toward controlling gene expression at will: Selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences
-
Segal,D.J., Dreier,B., Beerli,R.R. and Barbas,C.F.,III (1999) Toward controlling gene expression at will: selection and design of zinc finger domains recognizing each of the 5′-GNN-3′ DNA target sequences. Proc. Natl Acad Sci. USA, 96, 2758-2763.
-
(1999)
Proc. Natl Acad Sci. USA
, vol.96
, pp. 2758-2763
-
-
Segal, D.J.1
Dreier, B.2
Beerli, R.R.3
Barbas III, C.F.4
-
5
-
-
0034602243
-
Insights into the molecular recognition of the 5′-GNN-3′ family of DNA sequences by zinc finger domains
-
Dreier,B., Segal,D.J. and Barbas,C.F.,III (2000) Insights into the molecular recognition of the 5′-GNN-3′ family of DNA sequences by zinc finger domains. J. Mol. Biol., 303, 489-502.
-
(2000)
J. Mol. Biol.
, vol.303
, pp. 489-502
-
-
Dreier, B.1
Segal, D.J.2
Barbas III, C.F.3
-
6
-
-
0035800769
-
Development of zinc finger domains for recognition of the 5′-ANN-3′ family of DNA sequences and their use in the construction of artificial transcription factors
-
Dreier,B., Beerli,R.R., Segal,D.J., Flippin,J.D. and Barbas,C.F.,III (2001) Development of zinc finger domains for recognition of the 5′-ANN-3′ family of DNA sequences and their use in the construction of artificial transcription factors. J. Biol. Chem., 276, 29466-29478.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 29466-29478
-
-
Dreier, B.1
Beerli, R.R.2
Segal, D.J.3
Flippin, J.D.4
Barbas III, C.F.5
-
7
-
-
0037338381
-
Scanning the human genome with combinatorial transcription factor libraries
-
Blancafort,P., Magnenat,L. and Barbas,C.F.,III (2003) Scanning the human genome with combinatorial transcription factor libraries. Nat. Biotechnol., 21, 269-274.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 269-274
-
-
Blancafort, P.1
Magnenat, L.2
Barbas III, C.F.3
-
8
-
-
27444444925
-
Development of zinc finger domains for recognition of the 5′-CNN-3′ family DNA sequences and their use in the construction of artificial transcription factors
-
Dreier,B., Fuller,R.P., Segal,D.J., Lund,C.V., Blancafort,P., Huber,A., Koksch,B. and Barbas,C.F.,III (2005) Development of zinc finger domains for recognition of the 5′-CNN-3′ family DNA sequences and their use in the construction of artificial transcription factors. J. Biol. Chem., 280, 35588-35597.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 35588-35597
-
-
Dreier, B.1
Fuller, R.P.2
Segal, D.J.3
Lund, C.V.4
Blancafort, P.5
Huber, A.6
Koksch, B.7
Barbas III, C.F.8
-
9
-
-
0037040240
-
Validated zinc finger protein designs for all 16 GNN DNA triplet targets
-
Liu,Q., Xia,Z., Zhong,X. and Case,C.C. (2002) Validated zinc finger protein designs for all 16 GNN DNA triplet targets. J. Biol. Chem., 277, 3850-3856.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 3850-3856
-
-
Liu, Q.1
Xia, Z.2
Zhong, X.3
Case, C.C.4
-
10
-
-
0037335514
-
Human zinc fingers as building blocks in the construction of artificial transcription factors
-
Bae,K.H., Kwon,Y.D., Shin,H.C., Hwang,M.S., Ryu,E.H., Park,K.S., Yang,H.Y., Lee,D.K., Lee,Y., Park,J. et al. (2003) Human zinc fingers as building blocks in the construction of artificial transcription factors. Nat. Biotechnol., 21, 275-280.
-
(2003)
Nat. Biotechnol.
, vol.21
, pp. 275-280
-
-
Bae, K.H.1
Kwon, Y.D.2
Shin, H.C.3
Hwang, M.S.4
Ryu, E.H.5
Park, K.S.6
Yang, H.Y.7
Lee, D.K.8
Lee, Y.9
Park, J.10
-
11
-
-
29344435487
-
Gene therapy. Putting the fingers on gene repair
-
Kaiser,J. (2005) Gene therapy. Putting the fingers on gene repair. Science, 310, 1894-1896.
-
(2005)
Science
, vol.310
, pp. 1894-1896
-
-
Kaiser, J.1
-
12
-
-
20444457963
-
Gene therapy: The moving finger
-
High,K.A. (2005) Gene therapy: the moving finger. Nature, 435, 577-579.
-
(2005)
Nature
, vol.435
, pp. 577-579
-
-
High, K.A.1
-
13
-
-
0000933784
-
A consensus zinc finger peptide: Design, high-affinity metal binding, a pH-dependent structure, and a His to Cys sequence variant
-
Krizek,B.A., Amann,B.T., Kilfoil,V.J., Merkle,D.L. and Berg,J.M. (1991) A consensus zinc finger peptide: design, high-affinity metal binding, a pH-dependent structure, and a His to Cys sequence variant. J. Am. Chem. Soc., 113, 4518-4523.
-
(1991)
J. Am. Chem. Soc.
, vol.113
, pp. 4518-4523
-
-
Krizek, B.A.1
Amann, B.T.2
Kilfoil, V.J.3
Merkle, D.L.4
Berg, J.M.5
-
14
-
-
0029240283
-
A direct comparison of the properties of natural and designed zinc-finger proteins
-
Shi,Y. and Berg,J.M. (1995) A direct comparison of the properties of natural and designed zinc-finger proteins. Chem. Biol., 2, 83-89.
-
(1995)
Chem. Biol.
, vol.2
, pp. 83-89
-
-
Shi, Y.1
Berg, J.M.2
-
15
-
-
0344839044
-
Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins
-
Segal,D.J., Beerli,R.R., Blancafort,P., Dreier,B., Effertz,K., Huber,A., Koksch,B., Lund,C.V., Magnenat,L., Valente,D. et al. (2003) Evaluation of a modular strategy for the construction of novel polydactyl zinc finger DNA-binding proteins. Biochemistry, 42, 2137-2148.
-
(2003)
Biochemistry
, vol.42
, pp. 2137-2148
-
-
Segal, D.J.1
Beerli, R.R.2
Blancafort, P.3
Dreier, B.4
Effertz, K.5
Huber, A.6
Koksch, B.7
Lund, C.V.8
Magnenat, L.9
Valente, D.10
-
16
-
-
0032437591
-
Toward controlling gene expression at will: Specific regulation of the erbB-2/HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks
-
Beerli,R.R., Segal,D.J., Dreier,B. and Barbas,C.F.,III (1998) Toward controlling gene expression at will: specific regulation of the erbB-2/ HER-2 promoter by using polydactyl zinc finger proteins constructed from modular building blocks. Proc. Natl Acad Sci. USA, 95, 14628-14633.
-
(1998)
Proc. Natl Acad Sci. USA
, vol.95
, pp. 14628-14633
-
-
Beerli, R.R.1
Segal, D.J.2
Dreier, B.3
Barbas III, C.F.4
-
18
-
-
0035712253
-
Custom DNA-binding proteins come of age: Polydactyl zinc-finger proteins
-
Segal,D.J. and Barbas,C.F.,III (2001) Custom DNA-binding proteins come of age: polydactyl zinc-finger proteins. Curr. Opin. Biotechnol., 12, 632-637.
-
(2001)
Curr. Opin. Biotechnol.
, vol.12
, pp. 632-637
-
-
Segal, D.J.1
Barbas III, C.F.2
-
19
-
-
0022422660
-
Nomenclature for incompletely specified bases in nucleic acid sequences: Recommendations 1984
-
Cornish-Bowden,A. (1985) Nomenclature for incompletely specified bases in nucleic acid sequences: recommendations 1984. Nucleic Acids Res., 13, 3021-3030.
-
(1985)
Nucleic Acids Res.
, vol.13
, pp. 3021-3030
-
-
Cornish-Bowden, A.1
-
20
-
-
0030032063
-
Hybrid restriction enzymes: Zinc finger fusions to Fok I cleavage domain
-
Kim,Y.G., Cha,J. and Chandrasegaran,S. (1996) Hybrid restriction enzymes: zinc finger fusions to Fok I cleavage domain. Proc. Natl Acad Sci. USA, 93, 1156-1160.
-
(1996)
Proc. Natl Acad Sci. USA
, vol.93
, pp. 1156-1160
-
-
Kim, Y.G.1
Cha, J.2
Chandrasegaran, S.3
-
21
-
-
0030801002
-
Gapped BLAST and PSI-BLAST: A new generation of protein database search programs
-
Altschul,S.F., Madden,T.L., Schaffer,A.A., Zhang,J., Zhang,Z., Miller,W. and Lipman,D.J. (1997) Gapped BLAST and PSI-BLAST: a new generation of protein database search programs. Nucleic Acids Res., 25, 3389-3402.
-
(1997)
Nucleic Acids Res.
, vol.25
, pp. 3389-3402
-
-
Altschul, S.F.1
Madden, T.L.2
Schaffer, A.A.3
Zhang, J.4
Zhang, Z.5
Miller, W.6
Lipman, D.J.7
-
22
-
-
2942744633
-
Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation
-
Lund,C.V., Blancafort,P., Popkov,M. and Barbas,C.F.,III (2004) Promoter-targeted phage display selections with preassembled synthetic zinc finger libraries for endogenous gene regulation. J. Mol. Biol., 340, 599-613.
-
(2004)
J. Mol. Biol.
, vol.340
, pp. 599-613
-
-
Lund, C.V.1
Blancafort, P.2
Popkov, M.3
Barbas III, C.F.4
-
23
-
-
2442536906
-
Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor
-
Segal,D.J., Goncalves,J., Eberhardy,S., Swan,C.H., Torbett,B.E., Li,X. and Barbas,C.F.,III (2004) Attenuation of HIV-1 replication in primary human cells with a designed zinc finger transcription factor. J. Biol. Chem., 279, 14509-14519.
-
(2004)
J. Biol. Chem.
, vol.279
, pp. 14509-14519
-
-
Segal, D.J.1
Goncalves, J.2
Eberhardy, S.3
Swan, C.H.4
Torbett, B.E.5
Li, X.6
Barbas III, C.F.7
-
24
-
-
0031576363
-
Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: Determinants of affinity and sequence specificity
-
Wuttke,D.S., Foster,M.P., Case,D.A., Gottesfeld,J.M. and Wright,P.E. (1997) Solution structure of the first three zinc fingers of TFIIIA bound to the cognate DNA sequence: determinants of affinity and sequence specificity. J. Mol. Biol., 273, 183-206.
-
(1997)
J. Mol. Biol.
, vol.273
, pp. 183-206
-
-
Wuttke, D.S.1
Foster, M.P.2
Case, D.A.3
Gottesfeld, J.M.4
Wright, P.E.5
-
25
-
-
0032539902
-
Getting a handhold on DNA: Design of poly-zinc finger proteins with femtomolar dissociation constants
-
Kim,J.-S. and Pabo,C.O. (1998) Getting a handhold on DNA: design of poly-zinc finger proteins with femtomolar dissociation constants. Proc. Natl Acad Sci. USA, 95, 2812-2817.
-
(1998)
Proc. Natl Acad Sci. USA
, vol.95
, pp. 2812-2817
-
-
Kim, J.-S.1
Pabo, C.O.2
-
26
-
-
28144458971
-
Effects of different zinc finger transcription factors on genomic targets
-
Neuteboom,L.W., Lindhout,B.I., Saman,I.L., Hooykaas,P.J. and van der Zaal,B.J. (2006) Effects of different zinc finger transcription factors on genomic targets. Biochem. Biophys. Res. Commun., 339, 263-270.
-
(2006)
Biochem. Biophys. Res. Commun.
, vol.339
, pp. 263-270
-
-
Neuteboom, L.W.1
Lindhout, B.I.2
Saman, I.L.3
Hooykaas, P.J.4
van der Zaal, B.J.5
-
27
-
-
0035815697
-
Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A
-
Liu,P.Q., Rebar,E.J., Zhang,L., Liu,Q., Jamieson,A.C., Liang,Y., Qi,H., Li,P.X., Chen,B., Mendel,M.C. et al. (2001) Regulation of an endogenous locus using a panel of designed zinc finger proteins targeted to accessible chromatin regions. Activation of vascular endothelial growth factor A. J. Biol. Chem., 276, 11323-11334.
-
(2001)
J. Biol. Chem.
, vol.276
, pp. 11323-11334
-
-
Liu, P.Q.1
Rebar, E.J.2
Zhang, L.3
Liu, Q.4
Jamieson, A.C.5
Liang, Y.6
Qi, H.7
Li, P.X.8
Chen, B.9
Mendel, M.C.10
-
28
-
-
0034652141
-
Positive and negative regulation of endogenous genes by designed transcription factors
-
Beerli,R.R., Dreier,B. and Barbas,C.F.,III (2000) Positive and negative regulation of endogenous genes by designed transcription factors. Proc. Natl Acad. Sci. USA, 97, 1495-1500.
-
(2000)
Proc. Natl Acad. Sci. USA
, vol.97
, pp. 1495-1500
-
-
Beerli, R.R.1
Dreier, B.2
Barbas III, C.F.3
-
29
-
-
0025245027
-
Suppression of signals required for activation of transcription factor NF-kappa B in cells constitutively expressing the HTLV-I Tax protein
-
Ruben,S.M. and Rosen,C.A. (1990) Suppression of signals required for activation of transcription factor NF-kappa B in cells constitutively expressing the HTLV-I Tax protein. New Biol., 2, 894-902.
-
(1990)
New Biol.
, vol.2
, pp. 894-902
-
-
Ruben, S.M.1
Rosen, C.A.2
-
30
-
-
0028183182
-
Krueppel-associated boxes are potent transcriptional repression domains
-
Margolin,J.F., Friedman,J.R., Meyer,W.K.-H., Vissing,H., Thiesen,H.-J. and Rauscher,F.J.,III. (1994) Krueppel-associated boxes are potent transcriptional repression domains. Proc. Natl Acad. Sci. USA, 91, 4509-4513.
-
(1994)
Proc. Natl Acad. Sci. USA
, vol.91
, pp. 4509-4513
-
-
Margolin, J.F.1
Friedman, J.R.2
Meyer, W.K.-H.3
Vissing, H.4
Thiesen, H.-J.5
Rauscher III, F.J.6
-
31
-
-
0029814513
-
Mad proteins contain a dominant transcription repression domain
-
Ayer,D.E., Laherty,C.D., Lawrence,Q.A., Armstrong,A.P. and Eisenman,R.N. (1996) Mad proteins contain a dominant transcription repression domain. Mol. Cell. Biol., 16, 5772-5781.
-
(1996)
Mol. Cell. Biol.
, vol.16
, pp. 5772-5781
-
-
Ayer, D.E.1
Laherty, C.D.2
Lawrence, Q.A.3
Armstrong, A.P.4
Eisenman, R.N.5
-
32
-
-
0029095176
-
ERF: An ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation
-
Sgouras,D.N., Athanasiou,M.A., Beal,G.J.,Jr, Fisher,R.J., Blair,D.G. and Mavrothalassitis,G.J. (1995) ERF: an ETS domain protein with strong transcriptional repressor activity, can suppress ets-associated tumorigenesis and is regulated by phosphorylation during cell cycle and mitogenic stimulation. EMBO J., 14, 4781-4793.
-
(1995)
EMBO J.
, vol.14
, pp. 4781-4793
-
-
Sgouras, D.N.1
Athanasiou, M.A.2
Beal Jr., G.J.3
Fisher, R.J.4
Blair, D.G.5
Mavrothalassitis, G.J.6
-
33
-
-
0032940072
-
Histone deacetylases: Transcriptional repression with SINers and NuRDs
-
Ayer,D.E. (1999) Histone deacetylases: transcriptional repression with SINers and NuRDs. Trends Cell Biol., 9, 193-198.
-
(1999)
Trends Cell Biol.
, vol.9
, pp. 193-198
-
-
Ayer, D.E.1
|