-
1
-
-
36849082952
-
Tirapazamine plus cisplatin and irradiation in a mouse model: improved tumor control at the cost of increased toxicity
-
Adam M, Bayer C, Henke J, Grosu A, Molls M, Nieder C (2008) Tirapazamine plus cisplatin and irradiation in a mouse model: improved tumor control at the cost of increased toxicity. J Cancer Res Clin Oncol 134: 137-146.
-
(2008)
J Cancer Res Clin Oncol
, vol.134
, pp. 137-146
-
-
Adam, M.1
Bayer, C.2
Henke, J.3
Grosu, A.4
Molls, M.5
Nieder, C.6
-
2
-
-
38949199064
-
Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects
-
Aigner B, Rathkolb B, Herbach N, Hrabé de Angelis M, Wanke R, Wolf E (2008) Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am J Physiol Endocrinol Metab 294: E232-E240.
-
(2008)
Am J Physiol Endocrinol Metab
, vol.294
-
-
Aigner, B.1
Rathkolb, B.2
Herbach, N.3
Hrabé de Angelis, M.4
Wanke, R.5
Wolf, E.6
-
3
-
-
84872013355
-
Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant
-
doi:10.1126/scitranslmed.3004853
-
Al-Mashhadi RH, Sørensen CB, Kragh PM, Christoffersen C, Mortensen MB, Tolbod LP et al (2013) Familial hypercholesterolemia and atherosclerosis in cloned minipigs created by DNA transposition of a human PCSK9 gain-of-function mutant. Sci Transl Med 5: 166ra1. doi: 10. 1126/scitranslmed. 3004853.
-
(2013)
Sci Transl Med
, vol.5
-
-
Al-Mashhadi, R.H.1
Sørensen, C.B.2
Kragh, P.M.3
Christoffersen, C.4
Mortensen, M.B.5
Tolbod, L.P.6
-
4
-
-
33748757657
-
Neutralization of antifactor VIII inhibitors by recombinant porcine factor VIII
-
Barrow RT, Lollar P (2006) Neutralization of antifactor VIII inhibitors by recombinant porcine factor VIII. J Thromb Haemost 4: 2223-2229.
-
(2006)
J Thromb Haemost
, vol.4
, pp. 2223-2229
-
-
Barrow, R.T.1
Lollar, P.2
-
5
-
-
84885468845
-
A transgenic minipig model of Huntington's disease
-
Baxa M, Hruska-Plochan M, Juhas S, Vodicka P, Pavlok A, Juhasova J et al (2013) A transgenic minipig model of Huntington's disease. J Huntingtons Dis 2: 47-68.
-
(2013)
J Huntingtons Dis
, vol.2
, pp. 47-68
-
-
Baxa, M.1
Hruska-Plochan, M.2
Juhas, S.3
Vodicka, P.4
Pavlok, A.5
Juhasova, J.6
-
6
-
-
84864277891
-
Mouse models of SMA: tools for disease characterization and therapeutic development
-
Bebee TW, Dominguez CE, Chandler DS (2012) Mouse models of SMA: tools for disease characterization and therapeutic development. Hum Genet 131: 1277-1293.
-
(2012)
Hum Genet
, vol.131
, pp. 1277-1293
-
-
Bebee, T.W.1
Dominguez, C.E.2
Chandler, D.S.3
-
7
-
-
0033976813
-
Peroxisome proliferator-activated receptor (PPAR)-gamma expression in human vascular smooth muscle cells: inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)-gamma activator troglitazone
-
Benson S, Wu J, Padmanabhan S, Kurtz TW, Pershadsingh HA (2000) Peroxisome proliferator-activated receptor (PPAR)-gamma expression in human vascular smooth muscle cells: inhibition of growth, migration, and c-fos expression by the peroxisome proliferator-activated receptor (PPAR)-gamma activator troglitazone. Am J Hypertens 13: 74-82.
-
(2000)
Am J Hypertens
, vol.13
, pp. 74-82
-
-
Benson, S.1
Wu, J.2
Padmanabhan, S.3
Kurtz, T.W.4
Pershadsingh, H.A.5
-
8
-
-
77957583441
-
Atherosclerotic lesions in mouse and man: is it the same disease?
-
Bentzon JF, Falk E (2010) Atherosclerotic lesions in mouse and man: is it the same disease? Curr Opin Lipidol 21: 434-440.
-
(2010)
Curr Opin Lipidol
, vol.21
, pp. 434-440
-
-
Bentzon, J.F.1
Falk, E.2
-
9
-
-
0029011723
-
Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A
-
Bi L, Lawler AM, Antonarakis SE, High KA, Gearhart JD, Kazazian HH Jr (1995) Targeted disruption of the mouse factor VIII gene produces a model of haemophilia A. Nat Genet 10: 119-121.
-
(1995)
Nat Genet
, vol.10
, pp. 119-121
-
-
Bi, L.1
Lawler, A.M.2
Antonarakis, S.E.3
High, K.A.4
Gearhart, J.D.5
Kazazian Jr., H.H.6
-
10
-
-
0037370137
-
Pathology of mouse models of intestinal cancer: consensus report and recommendations
-
Boivin GP, Washington K, Yang K, Ward JM, Pretlow TP, Russell R et al (2003) Pathology of mouse models of intestinal cancer: consensus report and recommendations. Gastroenterology 124: 762-777.
-
(2003)
Gastroenterology
, vol.124
, pp. 762-777
-
-
Boivin, G.P.1
Washington, K.2
Yang, K.3
Ward, J.M.4
Pretlow, T.P.5
Russell, R.6
-
11
-
-
78549239179
-
Murine models of acute and chronic lung infection with cystic fibrosis pathogens
-
Bragonzi A (2010) Murine models of acute and chronic lung infection with cystic fibrosis pathogens. Int J Med Microbiol 300: 584-593.
-
(2010)
Int J Med Microbiol
, vol.300
, pp. 584-593
-
-
Bragonzi, A.1
-
12
-
-
84867911474
-
Efficient TALEN-mediated gene knockout in livestock
-
Carlson DF, Tan W, Lillico SG, Stverakova D, Proudfoot C, Christian M et al (2012) Efficient TALEN-mediated gene knockout in livestock. Proc Natl Acad Sci U S A 109: 17382-17387.
-
(2012)
Proc Natl Acad Sci U S A
, vol.109
, pp. 17382-17387
-
-
Carlson, D.F.1
Tan, W.2
Lillico, S.G.3
Stverakova, D.4
Proudfoot, C.5
Christian, M.6
-
13
-
-
4043134745
-
Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity
-
Cohn JS, Patterson BW, Uffelman KD, Davignon J, Steiner G (2004) Rate of production of plasma and very-low-density lipoprotein (VLDL) apolipoprotein C-III is strongly related to the concentration and level of production of VLDL triglyceride in male subjects with different body weights and levels of insulin sensitivity. J Clin Endocrinol Metab 89: 3949-3955.
-
(2004)
J Clin Endocrinol Metab
, vol.89
, pp. 3949-3955
-
-
Cohn, J.S.1
Patterson, B.W.2
Uffelman, K.D.3
Davignon, J.4
Steiner, G.5
-
15
-
-
26844507866
-
Age and manifestation related symptoms in familial adenomatous polyposis
-
Croner RS, Brueckl WM, Reingruber B, Hohenberger W, Guenther K (2005) Age and manifestation related symptoms in familial adenomatous polyposis. BMC Cancer 5: 24.
-
(2005)
BMC Cancer
, vol.5
, pp. 24
-
-
Croner, R.S.1
Brueckl, W.M.2
Reingruber, B.3
Hohenberger, W.4
Guenther, K.5
-
16
-
-
0037231480
-
Human and porcine early kidney precursors as a new source for transplantation
-
Dekel B, Burakova T, Arditti FD, Reich-Zeliger S, Milstein O, Aviel-Ronen S et al (2003) Human and porcine early kidney precursors as a new source for transplantation. Nat Med 9: 53-60.
-
(2003)
Nat Med
, vol.9
, pp. 53-60
-
-
Dekel, B.1
Burakova, T.2
Arditti, F.D.3
Reich-Zeliger, S.4
Milstein, O.5
Aviel-Ronen, S.6
-
17
-
-
0033396451
-
Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet
-
Dixon JL, Stoops JD, Parker JL, Laughlin MH, Weisman GA, Sturek M (1999) Dyslipidemia and vascular dysfunction in diabetic pigs fed an atherogenic diet. Arterioscler Thromb Vasc Biol 19: 2981-2992.
-
(1999)
Arterioscler Thromb Vasc Biol
, vol.19
, pp. 2981-2992
-
-
Dixon, J.L.1
Stoops, J.D.2
Parker, J.L.3
Laughlin, M.H.4
Weisman, G.A.5
Sturek, M.6
-
18
-
-
0033119609
-
Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14
-
Edwards AO, Miedziak A, Vrabec T, Verhoeven J, Acott TS, Weleber RG et al (1999) Autosomal dominant Stargardt-like macular dystrophy: I. Clinical characterization, longitudinal follow-up, and evidence for a common ancestry in families linked to chromosome 6q14. Am J Ophthalmol 127: 426-435.
-
(1999)
Am J Ophthalmol
, vol.127
, pp. 426-435
-
-
Edwards, A.O.1
Miedziak, A.2
Vrabec, T.3
Verhoeven, J.4
Acott, T.S.5
Weleber, R.G.6
-
19
-
-
0030888122
-
Naturally occurring primary deficiencies of the immune system
-
Fischer A, Cavazzana-Calvo M, De Saint Basile G, DeVillartay JP, Di Santo JP, Hivroz C et al (1997) Naturally occurring primary deficiencies of the immune system. Annu Rev Immunol 15: 93-124.
-
(1997)
Annu Rev Immunol
, vol.15
, pp. 93-124
-
-
Fischer, A.1
Cavazzana-Calvo, M.2
De Saint Basile, G.3
DeVillartay, J.P.4
Di Santo, J.P.5
Hivroz, C.6
-
20
-
-
79958695683
-
Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases
-
doi:10.1371/journal.pone.0021045
-
Flisikowska T, Thorey IS, Offner S, Ros F, Lifke V, Zeitler B et al (2011) Efficient immunoglobulin gene disruption and targeted replacement in rabbit using zinc finger nucleases. PLoS One 6: e21045. doi: 10. 1371/journal. pone. 0021045.
-
(2011)
PLoS One
, vol.6
-
-
Flisikowska, T.1
Thorey, I.S.2
Offner, S.3
Ros, F.4
Lifke, V.5
Zeitler, B.6
-
21
-
-
84867185165
-
A porcine model of familial adenomatous polyposis
-
Flisikowska T, Merkl C, Landmann M, Eser S, Rezaei N, Cui X et al (2012) A porcine model of familial adenomatous polyposis. Gastroenterology 143: 1173-1175. e7.
-
(2012)
Gastroenterology
, vol.143
, pp. 1173-1175
-
-
Flisikowska, T.1
Merkl, C.2
Landmann, M.3
Eser, S.4
Rezaei, N.5
Cui, X.6
-
22
-
-
0034902674
-
Disease model: familial adenomatous polyposis
-
Fodde R, Smits R (2001) Disease model: familial adenomatous polyposis. Trends Mol Med 7: 369-373.
-
(2001)
Trends Mol Med
, vol.7
, pp. 369-373
-
-
Fodde, R.1
Smits, R.2
-
23
-
-
34548217651
-
Maximizing mouse cancer models
-
Frese KK, Tuveson DA (2007) Maximizing mouse cancer models. Nat Rev Cancer 7: 645-658.
-
(2007)
Nat Rev Cancer
, vol.7
, pp. 645-658
-
-
Frese, K.K.1
Tuveson, D.A.2
-
24
-
-
1542515338
-
A census of human cancer genes
-
Futreal PA, Coin L, Marshall M, Down T, Hubbard T, Wooster R et al (2004) A census of human cancer genes. Nat Rev Cancer 4: 177-183.
-
(2004)
Nat Rev Cancer
, vol.4
, pp. 177-183
-
-
Futreal, P.A.1
Coin, L.2
Marshall, M.3
Down, T.4
Hubbard, T.5
Wooster, R.6
-
25
-
-
0027682599
-
Autosomal dominant polycystic kidney disease
-
Gabow PA (1993) Autosomal dominant polycystic kidney disease. Am J Kidney Dis 22: 511-512.
-
(1993)
Am J Kidney Dis
, vol.22
, pp. 511-512
-
-
Gabow, P.A.1
-
26
-
-
0028985574
-
Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein
-
Games D, Adams D, Alessandrini R, Barbour R, Berthelette P, Blackwell C et al (1995) Alzheimer-type neuropathology in transgenic mice overexpressing V717F beta-amyloid precursor protein. Nature 373: 523-527.
-
(1995)
Nature
, vol.373
, pp. 523-527
-
-
Games, D.1
Adams, D.2
Alessandrini, R.3
Barbour, R.4
Berthelette, P.5
Blackwell, C.6
-
27
-
-
54849146500
-
Clinical practice. Autosomal dominant polycystic kidney disease
-
Grantham JJ (2008) Clinical practice. Autosomal dominant polycystic kidney disease. N Engl J Med 359: 1477-1485.
-
(2008)
N Engl J Med
, vol.359
, pp. 1477-1485
-
-
Grantham, J.J.1
-
28
-
-
84869003221
-
Analyses of pig genomes provide insight into porcine demography and evolution
-
Groenen MA, Archibald AL, Uenishi H, Tuggle CK, Takeuchi Y, Rothschild MF et al (2012) Analyses of pig genomes provide insight into porcine demography and evolution. Nature 491: 393-398.
-
(2012)
Nature
, vol.491
, pp. 393-398
-
-
Groenen, M.A.1
Archibald, A.L.2
Uenishi, H.3
Tuggle, C.K.4
Takeuchi, Y.5
Rothschild, M.F.6
-
30
-
-
0021028244
-
A polymorphic DNA marker genetically linked to Huntington's disease
-
Gusella JF, Wexler NS, Conneally PM, Naylor SL, Anderson MA, Tanzi RE et al (1983) A polymorphic DNA marker genetically linked to Huntington's disease. Nature 306: 234-238.
-
(1983)
Nature
, vol.306
, pp. 234-238
-
-
Gusella, J.F.1
Wexler, N.S.2
Conneally, P.M.3
Naylor, S.L.4
Anderson, M.A.5
Tanzi, R.E.6
-
31
-
-
33751537273
-
Production of endothelial nitric oxide synthase (eNOS) over-expressing piglets
-
Hao YH, Yong HY, Murphy CN, Wax D, Samuel M, Rieke A et al (2006) Production of endothelial nitric oxide synthase (eNOS) over-expressing piglets. Transgenic Res 15: 739-750.
-
(2006)
Transgenic Res
, vol.15
, pp. 739-750
-
-
Hao, Y.H.1
Yong, H.Y.2
Murphy, C.N.3
Wax, D.4
Samuel, M.5
Rieke, A.6
-
32
-
-
0037135111
-
The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics
-
Hardy J, Selkoe DJ (2002) The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356.
-
(2002)
Science
, vol.297
, pp. 353-356
-
-
Hardy, J.1
Selkoe, D.J.2
-
33
-
-
0035813206
-
Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor
-
Hasty AH, Shimano H, Osuga J, Namatame I, Takahashi A, Yahagi N et al (2001) Severe hypercholesterolemia, hypertriglyceridemia, and atherosclerosis in mice lacking both leptin and the low density lipoprotein receptor. J Biol Chem 276: 37402-37408.
-
(2001)
J Biol Chem
, vol.276
, pp. 37402-37408
-
-
Hasty, A.H.1
Shimano, H.2
Osuga, J.3
Namatame, I.4
Takahashi, A.5
Yahagi, N.6
-
34
-
-
79961079857
-
Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases
-
Hauschild J, Petersen B, Santiago Y, Queisser AL, Carnwath JW, Lucas-Hahn A et al (2011) Efficient generation of a biallelic knockout in pigs using zinc-finger nucleases. Proc Natl Acad Sci U S A 108: 12013-12017.
-
(2011)
Proc Natl Acad Sci U S A
, vol.108
, pp. 12013-12017
-
-
Hauschild, J.1
Petersen, B.2
Santiago, Y.3
Queisser, A.L.4
Carnwath, J.W.5
Lucas-Hahn, A.6
-
35
-
-
84880512114
-
Construction of a transgenic pig model overexpressing polycystic kidney disease 2 (PKD2) gene
-
He J, Ye J, Li Q, Feng Y, Bai X, Chen X et al (2013) Construction of a transgenic pig model overexpressing polycystic kidney disease 2 (PKD2) gene. Transgenic Res 22: 861-867.
-
(2013)
Transgenic Res
, vol.22
, pp. 861-867
-
-
He, J.1
Ye, J.2
Li, Q.3
Feng, Y.4
Bai, X.5
Chen, X.6
-
36
-
-
19344362405
-
Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice
-
Hingorani SR, Wang L, Multani AS, Combs C, Deramaudt TB, Hruban RH et al (2005) Trp53R172H and KrasG12D cooperate to promote chromosomal instability and widely metastatic pancreatic ductal adenocarcinoma in mice. Cancer Cell 7: 469-483.
-
(2005)
Cancer Cell
, vol.7
, pp. 469-483
-
-
Hingorani, S.R.1
Wang, L.2
Multani, A.S.3
Combs, C.4
Deramaudt, T.B.5
Hruban, R.H.6
-
37
-
-
0023614188
-
Dystrophin: the protein product of the Duchenne muscular dystrophy locus
-
Hoffman EP, Brown RH Jr, Kunkel LM (1987) Dystrophin: the protein product of the Duchenne muscular dystrophy locus. Cell 51: 919-928.
-
(1987)
Cell
, vol.51
, pp. 919-928
-
-
Hoffman, E.P.1
Brown Jr., R.H.2
Kunkel, L.M.3
-
38
-
-
0029742199
-
Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice
-
Hsiao K, Chapman P, Nilsen S, Eckman C, Harigaya Y, Younkin S et al (1996) Correlative memory deficits, Abeta elevation, and amyloid plaques in transgenic mice. Science 274: 99-102.
-
(1996)
Science
, vol.274
, pp. 99-102
-
-
Hsiao, K.1
Chapman, P.2
Nilsen, S.3
Eckman, C.4
Harigaya, Y.5
Younkin, S.6
-
39
-
-
0033987669
-
A mouse model for spinal muscular atrophy
-
Hsieh-Li HM, Chang JG, Jong YJ, Wu MH, Wang NM, Tsai CH et al (2000) A mouse model for spinal muscular atrophy. Nat Genet 24: 66-70.
-
(2000)
Nat Genet
, vol.24
, pp. 66-70
-
-
Hsieh-Li, H.M.1
Chang, J.G.2
Jong, Y.J.3
Wu, M.H.4
Wang, N.M.5
Tsai, C.H.6
-
40
-
-
0031045876
-
Retinopathy induced in mice by targeted disruption of the rhodopsin gene
-
Humphries MM, Rancourt D, Farrar GJ, Kenna P, Hazel M, Bush RA et al (1997) Retinopathy induced in mice by targeted disruption of the rhodopsin gene. Nat Genet 15: 216-219.
-
(1997)
Nat Genet
, vol.15
, pp. 216-219
-
-
Humphries, M.M.1
Rancourt, D.2
Farrar, G.J.3
Kenna, P.4
Hazel, M.5
Bush, R.A.6
-
41
-
-
0027258140
-
Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery
-
Ishibashi S, Brown MS, Goldstein JL, Gerard RD, Hammer RE, Herz J (1993) Hypercholesterolemia in low density lipoprotein receptor knockout mice and its reversal by adenovirus-mediated gene delivery. J Clin Invest 92: 883-893.
-
(1993)
J Clin Invest
, vol.92
, pp. 883-893
-
-
Ishibashi, S.1
Brown, M.S.2
Goldstein, J.L.3
Gerard, R.D.4
Hammer, R.E.5
Herz, J.6
-
42
-
-
77952526316
-
An ovine transgenic Huntington's disease model
-
Jacobsen JC, Bawden CS, Rudiger SR, McLaughlan CJ, Reid SJ, Waldvogel HJ et al (2010) An ovine transgenic Huntington's disease model. Hum Mol Genet 19: 1873-1882.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 1873-1882
-
-
Jacobsen, J.C.1
Bawden, C.S.2
Rudiger, S.R.3
McLaughlan, C.J.4
Reid, S.J.5
Waldvogel, H.J.6
-
43
-
-
0031888958
-
PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines
-
Jiang C, Ting AT, Seed B (1998) PPAR-gamma agonists inhibit production of monocyte inflammatory cytokines. Nature 391: 82-86.
-
(1998)
Nature
, vol.391
, pp. 82-86
-
-
Jiang, C.1
Ting, A.T.2
Seed, B.3
-
44
-
-
84870321013
-
Porcine model of hemophilia A
-
doi:10.1371/journal.pone.0049450
-
Kashiwakura Y, Mimuro J, Onishi A, Iwamoto M, Madoiwa S, Fuchimoto D et al (2012) Porcine model of hemophilia A. PLoS One 7(11): e49450. doi: 10. 1371/journal. pone. 0049450.
-
(2012)
PLoS One
, vol.7
, Issue.11
-
-
Kashiwakura, Y.1
Mimuro, J.2
Onishi, A.3
Iwamoto, M.4
Madoiwa, S.5
Fuchimoto, D.6
-
45
-
-
0027767585
-
Autosomal dominant polycystic kidney disease: localization of the second gene to chromosome 4q13-q23
-
Kimberling WJ, Kumar S, Gabow PA, Kenyon JB, Connolly CJ, Somlo S (1993) Autosomal dominant polycystic kidney disease: localization of the second gene to chromosome 4q13-q23. Genomics 18: 467-472.
-
(1993)
Genomics
, vol.18
, pp. 467-472
-
-
Kimberling, W.J.1
Kumar, S.2
Gabow, P.A.3
Kenyon, J.B.4
Connolly, C.J.5
Somlo, S.6
-
46
-
-
84885723361
-
Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle
-
Klymiuk N, Blutke A, Graf A, Krause S, Burkhardt K, Wuensch A et al (2013) Dystrophin-deficient pigs provide new insights into the hierarchy of physiological derangements of dystrophic muscle. Hum Mol Genet 22: 4368-4382.
-
(2013)
Hum Mol Genet
, vol.22
, pp. 4368-4382
-
-
Klymiuk, N.1
Blutke, A.2
Graf, A.3
Krause, S.4
Burkhardt, K.5
Wuensch, A.6
-
48
-
-
0024466501
-
The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion
-
Koenig M, Beggs AH, Moyer M, Scherpf S, Heindrich K, Bettecken T et al (1989) The molecular basis for Duchenne versus Becker muscular dystrophy: correlation of severity with type of deletion. Am J Hum Genet 45: 498-506.
-
(1989)
Am J Hum Genet
, vol.45
, pp. 498-506
-
-
Koenig, M.1
Beggs, A.H.2
Moyer, M.3
Scherpf, S.4
Heindrich, K.5
Bettecken, T.6
-
49
-
-
69449096843
-
Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw
-
Kragh PM, Nielsen AL, Li J, Du Y, Lin L, Schmidt M et al (2009) Hemizygous minipigs produced by random gene insertion and handmade cloning express the Alzheimer's disease-causing dominant mutation APPsw. Transgenic Res 18: 545-558.
-
(2009)
Transgenic Res
, vol.18
, pp. 545-558
-
-
Kragh, P.M.1
Nielsen, A.L.2
Li, J.3
Du, Y.4
Lin, L.5
Schmidt, M.6
-
50
-
-
0029805189
-
Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD)
-
Lanoix J, D'Agati V, Szabolcs M, Trudel M (1996) Dysregulation of cellular proliferation and apoptosis mediates human autosomal dominant polycystic kidney disease (ADPKD). Oncogene 13: 1153-1160.
-
(1996)
Oncogene
, vol.13
, pp. 1153-1160
-
-
Lanoix, J.1
D'Agati, V.2
Szabolcs, M.3
Trudel, M.4
-
51
-
-
11144296836
-
Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase
-
Lauer N, Suvorava T, Rüther U, Jacob R, Meyer W, Harrison DG et al (2005) Critical involvement of hydrogen peroxide in exercise-induced up-regulation of endothelial NO synthase. Cardiovasc Res 65: 254-262.
-
(2005)
Cardiovasc Res
, vol.65
, pp. 254-262
-
-
Lauer, N.1
Suvorava, T.2
Rüther, U.3
Jacob, R.4
Meyer, W.5
Harrison, D.G.6
-
52
-
-
0030828519
-
The SCID mouse mutant: definition and potential use as a model for immune and hematological disorders
-
Leblond V, Autran B, Cesbron JY (1997) The SCID mouse mutant: definition and potential use as a model for immune and hematological disorders. Hematol Cell Ther 39: 213-221.
-
(1997)
Hematol Cell Ther
, vol.39
, pp. 213-221
-
-
Leblond, V.1
Autran, B.2
Cesbron, J.Y.3
-
53
-
-
0029924265
-
The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling
-
Leonard WJ (1996) The molecular basis of X-linked severe combined immunodeficiency: defective cytokine receptor signaling. Annu Rev Med 47: 229-239.
-
(1996)
Annu Rev Med
, vol.47
, pp. 229-239
-
-
Leonard, W.J.1
-
54
-
-
84867171118
-
Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs
-
doi:10.1371/journal.pone.0043323
-
Leuchs S, Saalfrank A, Merkl C, Flisikowska T, Edlinger M, Durkovic M et al (2012) Inactivation and inducible oncogenic mutation of p53 in gene targeted pigs. PLoS One 7: e43323. doi: 10. 1371/journal. pone. 0043323.
-
(2012)
PLoS One
, vol.7
-
-
Leuchs, S.1
Saalfrank, A.2
Merkl, C.3
Flisikowska, T.4
Edlinger, M.5
Durkovic, M.6
-
55
-
-
84863100006
-
Influence of species differences on the neuropathology of transgenic Huntington's disease animal models
-
Li XJ, Li S (2012) Influence of species differences on the neuropathology of transgenic Huntington's disease animal models. J Genet Genomics 39: 239-245.
-
(2012)
J Genet Genomics
, vol.39
, pp. 239-245
-
-
Li, X.J.1
Li, S.2
-
56
-
-
0030475229
-
Transgenic mice carrying the dominant rhodopsin mutation P347S: evidence for defective vectorial transport of rhodopsin to the outer segments
-
Li T, Snyder WK, Olsson JE, Dryja TP (1996) Transgenic mice carrying the dominant rhodopsin mutation P347S: evidence for defective vectorial transport of rhodopsin to the outer segments. Proc Natl Acad Sci U S A 93: 14176-14181.
-
(1996)
Proc Natl Acad Sci U S A
, vol.93
, pp. 14176-14181
-
-
Li, T.1
Snyder, W.K.2
Olsson, J.E.3
Dryja, T.P.4
-
57
-
-
0033033434
-
A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy
-
Lorson CL, Hahnen E, Androphy EJ, Wirth B (1999) A single nucleotide in the SMN gene regulates splicing and is responsible for spinal muscular atrophy. Proc Natl Acad Sci U S A 96: 6307-6311.
-
(1999)
Proc Natl Acad Sci U S A
, vol.96
, pp. 6307-6311
-
-
Lorson, C.L.1
Hahnen, E.2
Androphy, E.J.3
Wirth, B.4
-
58
-
-
80855144747
-
Disruption of the Survival Motor Neuron (SMN) gene in pigs using ssDNA
-
Lorson MA, Spate LD, Samuel MS, Murphy CN, Lorson CL, Prather RS et al (2011) Disruption of the Survival Motor Neuron (SMN) gene in pigs using ssDNA. Transgenic Res 20: 1293-1304.
-
(2011)
Transgenic Res
, vol.20
, pp. 1293-1304
-
-
Lorson, M.A.1
Spate, L.D.2
Samuel, M.S.3
Murphy, C.N.4
Lorson, C.L.5
Prather, R.S.6
-
59
-
-
0031252295
-
Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation
-
Lu W, Peissel B, Babakhanlou H, Pavlova A, Geng L, Fan X et al (1997) Perinatal lethality with kidney and pancreas defects in mice with a targetted Pkd1 mutation. Nat Genet 17: 179-181.
-
(1997)
Nat Genet
, vol.17
, pp. 179-181
-
-
Lu, W.1
Peissel, B.2
Babakhanlou, H.3
Pavlova, A.4
Geng, L.5
Fan, X.6
-
60
-
-
80053903736
-
Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair
-
Lu H, Huang D, Ransohoff RM, Zhou L (2011) Acute skeletal muscle injury: CCL2 expression by both monocytes and injured muscle is required for repair. FASEB J 25: 3344-3355.
-
(2011)
FASEB J
, vol.25
, pp. 3344-3355
-
-
Lu, H.1
Huang, D.2
Ransohoff, R.M.3
Zhou, L.4
-
61
-
-
80052849451
-
High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer
-
Luo Y, Li J, Liu Y, Lin L, Du Y, Li S et al (2011) High efficiency of BRCA1 knockout using rAAV-mediated gene targeting: developing a pig model for breast cancer. Transgenic Res 20: 975-988.
-
(2011)
Transgenic Res
, vol.20
, pp. 975-988
-
-
Luo, Y.1
Li, J.2
Liu, Y.3
Lin, L.4
Du, Y.5
Li, S.6
-
62
-
-
0035822038
-
The hemophilias-from royal genes to gene therapy
-
Mannucci PM, Tuddenham EG (2001) The hemophilias-from royal genes to gene therapy. N Engl J Med 344: 1773-1779.
-
(2001)
N Engl J Med
, vol.344
, pp. 1773-1779
-
-
Mannucci, P.M.1
Tuddenham, E.G.2
-
63
-
-
33845473315
-
Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction
-
Martignoni M, Groothuis GM, de Kanter R (2006) Species differences between mouse, rat, dog, monkey and human CYP-mediated drug metabolism, inhibition and induction. Expert Opin Drug Metab Toxicol 2: 875-894.
-
(2006)
Expert Opin Drug Metab Toxicol
, vol.2
, pp. 875-894
-
-
Martignoni, M.1
Groothuis, G.M.2
de Kanter, R.3
-
64
-
-
77749273530
-
Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases
-
doi:10.1371/journal.pone.0008870
-
Mashimo T, Takizawa A, Voigt B, Yoshimi K, Hiai H, Kuramoto T et al (2010) Generation of knockout rats with X-linked severe combined immunodeficiency (X-SCID) using zinc-finger nucleases. PLoS One 5: e8870. doi: 10. 1371/journal. pone. 0008870.
-
(2010)
PLoS One
, vol.5
-
-
Mashimo, T.1
Takizawa, A.2
Voigt, B.3
Yoshimi, K.4
Hiai, H.5
Kuramoto, T.6
-
65
-
-
84866924344
-
Generation and characterization of severe combined immunodeficiency rats
-
Mashimo T, Takizawa A, Kobayashi J, Kunihiro Y, Yoshimi K, Ishida S et al (2012) Generation and characterization of severe combined immunodeficiency rats. Cell Rep 2: 685-694.
-
(2012)
Cell Rep
, vol.2
, pp. 685-694
-
-
Mashimo, T.1
Takizawa, A.2
Kobayashi, J.3
Kunihiro, Y.4
Yoshimi, K.5
Ishida, S.6
-
66
-
-
77956494168
-
Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2 Delta N
-
McCalla-Martin AC, Chen X, Linder KE, Estrada JL, Piedrahita JA (2010) Varying phenotypes in swine versus murine transgenic models constitutively expressing the same human Sonic hedgehog transcriptional activator, K5-HGLI2 Delta N. Transgenic Res 19: 869-887.
-
(2010)
Transgenic Res
, vol.19
, pp. 869-887
-
-
McCalla-Martin, A.C.1
Chen, X.2
Linder, K.E.3
Estrada, J.L.4
Piedrahita, J.A.5
-
67
-
-
0034729804
-
Production of gene-targeted sheep by nuclear transfer from cultured somatic cells
-
McCreath KJ, Howcroft J, Campbell KH, Colman A, Schnieke AE, Kind AJ (2000) Production of gene-targeted sheep by nuclear transfer from cultured somatic cells. Nature 405: 1066-1069.
-
(2000)
Nature
, vol.405
, pp. 1066-1069
-
-
McCreath, K.J.1
Howcroft, J.2
Campbell, K.H.3
Colman, A.4
Schnieke, A.E.5
Kind, A.J.6
-
68
-
-
0030825813
-
p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding
-
Midgley CA, Lane DP (1997) p53 protein stability in tumour cells is not determined by mutation but is dependent on Mdm2 binding. Oncogene 15: 1179-1189.
-
(1997)
Oncogene
, vol.15
, pp. 1179-1189
-
-
Midgley, C.A.1
Lane, D.P.2
-
69
-
-
15844385078
-
PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein
-
Mochizuki T, Wu G, Hayashi T, Xenophontos SL, Veldhuisen B, Saris JJ et al (1996) PKD2, a gene for polycystic kidney disease that encodes an integral membrane protein. Science 272: 1339-1342.
-
(1996)
Science
, vol.272
, pp. 1339-1342
-
-
Mochizuki, T.1
Wu, G.2
Hayashi, T.3
Xenophontos, S.L.4
Veldhuisen, B.5
Saris, J.J.6
-
70
-
-
0032799998
-
A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2
-
Monani UR, Lorson CL, Parsons DW, Prior TW, Androphy EJ, Burghes AH et al (1999) A single nucleotide difference that alters splicing patterns distinguishes the SMA gene SMN1 from the copy gene SMN2. Hum Mol Genet 8: 1177-1183.
-
(1999)
Hum Mol Genet
, vol.8
, pp. 1177-1183
-
-
Monani, U.R.1
Lorson, C.L.2
Parsons, D.W.3
Prior, T.W.4
Androphy, E.J.5
Burghes, A.H.6
-
71
-
-
0027405692
-
Use of porcine factor VIII in the treatment of patients with acquired hemophilia
-
Morrison AE, Ludlam CA, Kessler C (1993) Use of porcine factor VIII in the treatment of patients with acquired hemophilia. Blood 81: 1513-1520.
-
(1993)
Blood
, vol.81
, pp. 1513-1520
-
-
Morrison, A.E.1
Ludlam, C.A.2
Kessler, C.3
-
72
-
-
70449368195
-
The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis
-
Mousavi SA, Berge KE, Leren TP (2009) The unique role of proprotein convertase subtilisin/kexin 9 in cholesterol homeostasis. J Intern Med 266: 507-519.
-
(2009)
J Intern Med
, vol.266
, pp. 507-519
-
-
Mousavi, S.A.1
Berge, K.E.2
Leren, T.P.3
-
73
-
-
84875193432
-
RNA guides genome engineering
-
Mussolino C, Cathomen T (2013) RNA guides genome engineering. Nat Biotechnol 31: 208-209.
-
(2013)
Nat Biotechnol
, vol.31
, pp. 208-209
-
-
Mussolino, C.1
Cathomen, T.2
-
74
-
-
79952210574
-
Mammalian models of Duchenne Muscular Dystrophy: pathological characteristics and therapeutic applications
-
doi:10.1155/2011/184393
-
Nakamura A, Takeda S (2011) Mammalian models of Duchenne Muscular Dystrophy: pathological characteristics and therapeutic applications. J Biomed Biotechnol 2011: 184393. doi: 10. 1155/2011/184393.
-
(2011)
J Biomed Biotechnol
, vol.2011
, pp. 184393
-
-
Nakamura, A.1
Takeda, S.2
-
75
-
-
5644221730
-
Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes
-
Nauck MA, El-Ouaghlidi A, Gabrys B, Hücking K, Holst JJ, Deacon CF et al (2004) Secretion of incretin hormones (GIP and GLP-1) and incretin effect after oral glucose in first-degree relatives of patients with type 2 diabetes. Regul Pept 122: 209-217.
-
(2004)
Regul Pept
, vol.122
, pp. 209-217
-
-
Nauck, M.A.1
El-Ouaghlidi, A.2
Gabrys, B.3
Hücking, K.4
Holst, J.J.5
Deacon, C.F.6
-
76
-
-
34250212715
-
Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes
-
Nissen SE, Wolski K (2007) Effect of rosiglitazone on the risk of myocardial infarction and death from cardiovascular causes. N Engl J Med 356: 2457-2471.
-
(2007)
N Engl J Med
, vol.356
, pp. 2457-2471
-
-
Nissen, S.E.1
Wolski, K.2
-
77
-
-
58749098444
-
Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans
-
Noguchi M, Yi H, Rosenblatt HM, Filipovich AH, Adelstein S, Modi WS et al (2008) Interleukin-2 receptor gamma chain mutation results in X-linked severe combined immunodeficiency in humans. J Immunol 181: 5817-5827.
-
(2008)
J Immunol
, vol.181
, pp. 5817-5827
-
-
Noguchi, M.1
Yi, H.2
Rosenblatt, H.M.3
Filipovich, A.H.4
Adelstein, S.5
Modi, W.S.6
-
78
-
-
0026463972
-
Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa
-
Olsson JE, Gordon JW, Pawlyk BS, Roof D, Hayes A, Molday RS et al (1992) Transgenic mice with a rhodopsin mutation (Pro23His): a mouse model of autosomal dominant retinitis pigmentosa. Neuron 9: 815-830.
-
(1992)
Neuron
, vol.9
, pp. 815-830
-
-
Olsson, J.E.1
Gordon, J.W.2
Pawlyk, B.S.3
Roof, D.4
Hayes, A.5
Molday, R.S.6
-
79
-
-
77950498540
-
The challenge of multiple comorbidity for the US health care system
-
Parekh AK, Barton MB (2010) The challenge of multiple comorbidity for the US health care system. JAMA 303: 1303-1304.
-
(2010)
Jama
, vol.303
, pp. 1303-1304
-
-
Parekh, A.K.1
Barton, M.B.2
-
80
-
-
0030851707
-
Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa
-
Petters RM, Alexander CA, Wells KD, Collins EB, Sommer JR, Blanton MR et al (1997) Genetically engineered large animal model for studying cone photoreceptor survival and degeneration in retinitis pigmentosa. Nat Biotechnol 15: 965-970.
-
(1997)
Nat Biotechnol
, vol.15
, pp. 965-970
-
-
Petters, R.M.1
Alexander, C.A.2
Wells, K.D.3
Collins, E.B.4
Sommer, J.R.5
Blanton, M.R.6
-
81
-
-
0026802532
-
Multipoint mapping of adult onset polycystic kidney disease (PKD1) on chromosome 16
-
Pignatelli PM, Pound SE, Carothers AD, Macnicol AM, Allan PL, Watson ML et al (1992) Multipoint mapping of adult onset polycystic kidney disease (PKD1) on chromosome 16. J Med Genet 29: 638-641.
-
(1992)
J Med Genet
, vol.29
, pp. 638-641
-
-
Pignatelli, P.M.1
Pound, S.E.2
Carothers, A.D.3
Macnicol, A.M.4
Allan, P.L.5
Watson, M.L.6
-
82
-
-
20444376132
-
Transgenic and knockout mice in diabetes research: novel insights into pathophysiology, limitations, and perspectives
-
Plum L, Wunderlich FT, Baudler S, Krone W, Brüning JC (2005) Transgenic and knockout mice in diabetes research: novel insights into pathophysiology, limitations, and perspectives. Physiology (Bethesda) 20: 152-161.
-
(2005)
Physiology (Bethesda)
, vol.20
, pp. 152-161
-
-
Plum, L.1
Wunderlich, F.T.2
Baudler, S.3
Krone, W.4
Brüning, J.C.5
-
83
-
-
0026725757
-
Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells
-
Plump AS, Smith JD, Hayek T, Aalto-Setälä K, Walsh A, Verstuyft JG et al (1999) Severe hypercholesterolemia and atherosclerosis in apolipoprotein E-deficient mice created by homologous recombination in ES cells. Cell 71: 343-353.
-
(1999)
Cell
, vol.71
, pp. 343-353
-
-
Plump, A.S.1
Smith, J.D.2
Hayek, T.3
Aalto-Setälä, K.4
Walsh, A.5
Verstuyft, J.G.6
-
84
-
-
0034326865
-
A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype
-
Pritchard L, Sloane-Stanley JA, Sharpe JA, Aspinwall R, Lu W, Buckle V et al (2000) A human PKD1 transgene generates functional polycystin-1 in mice and is associated with a cystic phenotype. Hum Mol Genet 9: 2617-2627.
-
(2000)
Hum Mol Genet
, vol.9
, pp. 2617-2627
-
-
Pritchard, L.1
Sloane-Stanley, J.A.2
Sharpe, J.A.3
Aspinwall, R.4
Lu, W.5
Buckle, V.6
-
85
-
-
77951829073
-
Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function
-
Renner S, Fehlings C, Herbach N, Hofmann A, von Waldthausen DC, Kessler B et al (2010) Glucose intolerance and reduced proliferation of pancreatic beta-cells in transgenic pigs with impaired glucose-dependent insulinotropic polypeptide function. Diabetes 59: 1228-1238.
-
(2010)
Diabetes
, vol.59
, pp. 1228-1238
-
-
Renner, S.1
Fehlings, C.2
Herbach, N.3
Hofmann, A.4
von Waldthausen, D.C.5
Kessler, B.6
-
86
-
-
84864300391
-
Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced beta-cell mass
-
Renner S, Römisch-Margl W, Prehn C, Krebs S, Adamski J, Göke B et al (2012) Changing metabolic signatures of amino acids and lipids during the prediabetic period in a pig model with impaired incretin function and reduced beta-cell mass. Diabetes 61: 2166-2175.
-
(2012)
Diabetes
, vol.61
, pp. 2166-2175
-
-
Renner, S.1
Römisch-Margl, W.2
Prehn, C.3
Krebs, S.4
Adamski, J.5
Göke, B.6
-
87
-
-
84876517346
-
Permanent neonatal diabetes in INS(C94Y) transgenic pigs
-
Renner S, Braun-Reichhart C, Blutke A, Herbach N, Emrich D, Streckel E et al (2013) Permanent neonatal diabetes in INS(C94Y) transgenic pigs. Diabetes 62(5): 1505-1511.
-
(2013)
Diabetes
, vol.62
, Issue.5
, pp. 1505-1511
-
-
Renner, S.1
Braun-Reichhart, C.2
Blutke, A.3
Herbach, N.4
Emrich, D.5
Streckel, E.6
-
88
-
-
84874235716
-
CFTR-deficient pigs display peripheral nervous system defects at birth
-
Reznikov LR, Dong Q, Chen JH, Moninger TO, Park JM, Zhang Y et al (2013) CFTR-deficient pigs display peripheral nervous system defects at birth. Proc Natl Acad Sci U S A 110: 3083-3038.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 3038-3083
-
-
Reznikov, L.R.1
Dong, Q.2
Chen, J.H.3
Moninger, T.O.4
Park, J.M.5
Zhang, Y.6
-
89
-
-
0031886864
-
The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation
-
Ricote M, Li AC, Willson TM, Kelly CJ, Glass CK (1998) The peroxisome proliferator-activated receptor-gamma is a negative regulator of macrophage activation. Nature 391: 79-82.
-
(1998)
Nature
, vol.391
, pp. 79-82
-
-
Ricote, M.1
Li, A.C.2
Willson, T.M.3
Kelly, C.J.4
Glass, C.K.5
-
90
-
-
0024424270
-
Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA
-
Riordan JR, Rommens JM, Kerem B, Alon N, Rozmahel R, Grzelczak Z et al (1989) Identification of the cystic fibrosis gene: cloning and characterization of complementary DNA. Science 245: 1066-1073.
-
(1989)
Science
, vol.245
, pp. 1066-1073
-
-
Riordan, J.R.1
Rommens, J.M.2
Kerem, B.3
Alon, N.4
Rozmahel, R.5
Grzelczak, Z.6
-
91
-
-
41849148289
-
Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer
-
Rogers CS, Hao Y, Rokhlina T, Samuel M, Stoltz DA, Li Y et al (2008a) Production of CFTR-null and CFTR-DeltaF508 heterozygous pigs by adeno-associated virus-mediated gene targeting and somatic cell nuclear transfer. J Clin Invest 118: 1571-1577.
-
(2008)
J Clin Invest
, vol.118
, pp. 1571-1577
-
-
Rogers, C.S.1
Hao, Y.2
Rokhlina, T.3
Samuel, M.4
Stoltz, D.A.5
Li, Y.6
-
92
-
-
52949154301
-
Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs
-
Rogers CS, Stoltz DA, Meyerholz DK, Ostedgaard LS, Rokhlina T, Taft PJ et al (2008b) Disruption of the CFTR gene produces a model of cystic fibrosis in newborn pigs. Science 321: 1837-1841.
-
(2008)
Science
, vol.321
, pp. 1837-1841
-
-
Rogers, C.S.1
Stoltz, D.A.2
Meyerholz, D.K.3
Ostedgaard, L.S.4
Rokhlina, T.5
Taft, P.J.6
-
93
-
-
84858858553
-
Generation of an inbred miniature pig model of retinitis pigmentosa
-
Ross JW, Fernandez de Castro JP, Zhao J, Samuel M, Walters E, Rios C et al (2012) Generation of an inbred miniature pig model of retinitis pigmentosa. Invest Ophthalmol Vis Sci 53: 501-507.
-
(2012)
Invest Ophthalmol Vis Sci
, vol.53
, pp. 501-507
-
-
Ross, J.W.1
Fernandez de Castro, J.P.2
Zhao, J.3
Samuel, M.4
Walters, E.5
Rios, C.6
-
94
-
-
16044373524
-
Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease
-
Scheuner D, Eckman C, Jensen M, Song X, Citron M, Suzuki N et al (1996) Secreted amyloid beta-protein similar to that in the senile plaques of Alzheimer's disease is increased in vivo by the presenilin 1 and 2 and APP mutations linked to familial Alzheimer's disease. Nat Med 2: 864-870.
-
(1996)
Nat Med
, vol.2
, pp. 864-870
-
-
Scheuner, D.1
Eckman, C.2
Jensen, M.3
Song, X.4
Citron, M.5
Suzuki, N.6
-
95
-
-
2642705886
-
Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts
-
Schnieke AE, Kind AJ, Ritchie WA, Mycock K, Scott AR, Ritchie M et al (1997) Human factor IX transgenic sheep produced by transfer of nuclei from transfected fetal fibroblasts. Science 278: 2130-2133.
-
(1997)
Science
, vol.278
, pp. 2130-2133
-
-
Schnieke, A.E.1
Kind, A.J.2
Ritchie, W.A.3
Mycock, K.4
Scott, A.R.5
Ritchie, M.6
-
96
-
-
0030931720
-
Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos
-
Schrank B, Götz R, Gunnersen JM, Ure JM, Toyka KV, Smith AG et al (1997) Inactivation of the survival motor neuron gene, a candidate gene for human spinal muscular atrophy, leads to massive cell death in early mouse embryos. Proc Natl Acad Sci U S A 94: 9920-9925.
-
(1997)
Proc Natl Acad Sci U S A
, vol.94
, pp. 9920-9925
-
-
Schrank, B.1
Götz, R.2
Gunnersen, J.M.3
Ure, J.M.4
Toyka, K.V.5
Smith, A.G.6
-
97
-
-
84874457770
-
Genomic responses in mouse models poorly mimic human inflammatory diseases
-
Seok J, Warren HS, Cuenca AG, Mindrinos MN, Baker HV, Xu W et al (2013) Genomic responses in mouse models poorly mimic human inflammatory diseases. Proc Natl Acad Sci U S A 110: 3507-3512.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 3507-3512
-
-
Seok, J.1
Warren, H.S.2
Cuenca, A.G.3
Mindrinos, M.N.4
Baker, H.V.5
Xu, W.6
-
98
-
-
81555204465
-
Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration
-
Sommer JR, Estrada JL, Collins EB, Bedell M, Alexander CA, Yang Z et al (2011) Production of ELOVL4 transgenic pigs: a large animal model for Stargardt-like macular degeneration. Br J Ophthalmol 95: 1749-1754.
-
(2011)
Br J Ophthalmol
, vol.95
, pp. 1749-1754
-
-
Sommer, J.R.1
Estrada, J.L.2
Collins, E.B.3
Bedell, M.4
Alexander, C.A.5
Yang, Z.6
-
99
-
-
79957923056
-
Unexpected roles for PCSK9 in lipid metabolism
-
Soutar AK (2011) Unexpected roles for PCSK9 in lipid metabolism. Curr Opin Lipidol 22: 192-196.
-
(2011)
Curr Opin Lipidol
, vol.22
, pp. 192-196
-
-
Soutar, A.K.1
-
100
-
-
79959297748
-
Cardiomyopathy of Duchenne muscular dystrophy: current understanding and future directions
-
Spurney CF (2011) Cardiomyopathy of Duchenne muscular dystrophy: current understanding and future directions. Muscle Nerve 44: 8-19.
-
(2011)
Muscle Nerve
, vol.44
, pp. 8-19
-
-
Spurney, C.F.1
-
101
-
-
84878578719
-
Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs
-
Stoltz DA, Rokhlina T, Ernst SE, Pezzulo AA, Ostedgaard LS, Karp PH et al (2013) Intestinal CFTR expression alleviates meconium ileus in cystic fibrosis pigs. J Clin Invest 123: 2685-2693.
-
(2013)
J Clin Invest
, vol.123
, pp. 2685-2693
-
-
Stoltz, D.A.1
Rokhlina, T.2
Ernst, S.E.3
Pezzulo, A.A.4
Ostedgaard, L.S.5
Karp, P.H.6
-
102
-
-
84862560337
-
Il2rg gene-targeted severe combined immunodeficiency pigs
-
Suzuki S, Iwamoto M, Saito Y, Fuchimoto D, Sembon S, Suzuki M et al (2012) Il2rg gene-targeted severe combined immunodeficiency pigs. Cell Stem Cell 10: 753-758.
-
(2012)
Cell Stem Cell
, vol.10
, pp. 753-758
-
-
Suzuki, S.1
Iwamoto, M.2
Saito, Y.3
Fuchimoto, D.4
Sembon, S.5
Suzuki, M.6
-
103
-
-
67649873481
-
Renal injury is a third hit promoting rapid development of adult polycystic kidney disease
-
Takakura A, Contrino L, Zhou X, Bonventre JV, Sun Y, Humphreys BD et al (2009) Renal injury is a third hit promoting rapid development of adult polycystic kidney disease. Hum Mol Genet 18: 2523-2531.
-
(2009)
Hum Mol Genet
, vol.18
, pp. 2523-2531
-
-
Takakura, A.1
Contrino, L.2
Zhou, X.3
Bonventre, J.V.4
Sun, Y.5
Humphreys, B.D.6
-
104
-
-
0033872024
-
Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss
-
Takeuchi A, Irizarry MC, Duff K, Saido TC, Hsiao Ashe K, Hasegawa M et al (2000) Age-related amyloid beta deposition in transgenic mice overexpressing both Alzheimer mutant presenilin 1 and amyloid beta precursor protein Swedish mutant is not associated with global neuronal loss. Am J Pathol 157: 331-339.
-
(2000)
Am J Pathol
, vol.157
, pp. 331-339
-
-
Takeuchi, A.1
Irizarry, M.C.2
Duff, K.3
Saido, T.C.4
Hsiao Ashe, K.5
Hasegawa, M.6
-
105
-
-
84885358161
-
Efficient nonmeiotic allele introgression in livestock using custom endonucleases
-
Tan W, Carlson DF, Lancto CA, Garbe JR, Webster DA, Hackett PB et al (2013) Efficient nonmeiotic allele introgression in livestock using custom endonucleases. Proc Natl Acad Sci U S A 110: 16526-16531.
-
(2013)
Proc Natl Acad Sci U S A
, vol.110
, pp. 16526-16531
-
-
Tan, W.1
Carlson, D.F.2
Lancto, C.A.3
Garbe, J.R.4
Webster, D.A.5
Hackett, P.B.6
-
106
-
-
33847619217
-
Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response
-
Thomas S, Kotamraju S, Zielonka J, Harder DR, Kalyanaraman B (2007) Hydrogen peroxide induces nitric oxide and proteosome activity in endothelial cells: a bell-shaped signaling response. Free Radic Biol Med 42: 1049-1061.
-
(2007)
Free Radic Biol Med
, vol.42
, pp. 1049-1061
-
-
Thomas, S.1
Kotamraju, S.2
Zielonka, J.3
Harder, D.R.4
Kalyanaraman, B.5
-
107
-
-
77957742557
-
OBI-1, porcine recombinant Factor VIII for the potential treatment of patients with congenital hemophilia A and alloantibodies against human Factor VIII
-
Toschi V (2010) OBI-1, porcine recombinant Factor VIII for the potential treatment of patients with congenital hemophilia A and alloantibodies against human Factor VIII. Curr Opin Mol Ther 12: 617-625.
-
(2010)
Curr Opin Mol Ther
, vol.12
, pp. 617-625
-
-
Toschi, V.1
-
108
-
-
0035543870
-
Production of transgenic miniature pigs by pronuclear microinjection
-
Uchida M, Shimatsu Y, Onoe K, Matsuyama N, Niki R, Ikeda JE et al (2001) Production of transgenic miniature pigs by pronuclear microinjection. Transgenic Res 10: 577-582.
-
(2001)
Transgenic Res
, vol.10
, pp. 577-582
-
-
Uchida, M.1
Shimatsu, Y.2
Onoe, K.3
Matsuyama, N.4
Niki, R.5
Ikeda, J.E.6
-
109
-
-
70349981719
-
Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs
-
Umeyama K, Watanabe M, Saito H, Kurome M, Tohi S, Matsunari H et al (2009) Dominant-negative mutant hepatocyte nuclear factor 1alpha induces diabetes in transgenic-cloned pigs. Transgenic Res 18: 697-706.
-
(2009)
Transgenic Res
, vol.18
, pp. 697-706
-
-
Umeyama, K.1
Watanabe, M.2
Saito, H.3
Kurome, M.4
Tohi, S.5
Matsunari, H.6
-
111
-
-
83655161317
-
Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII
-
Wei J, Ouyang H, Wang Y, Pang D, Cong NX, Wang T et al (2012) Characterization of a hypertriglyceridemic transgenic miniature pig model expressing human apolipoprotein CIII. FEBS J 279: 91-99.
-
(2012)
FEBS J
, vol.279
, pp. 91-99
-
-
Wei, J.1
Ouyang, H.2
Wang, Y.3
Pang, D.4
Cong, N.X.5
Wang, T.6
-
112
-
-
80052846931
-
Vascular endothelium-specific overexpression of human catalase in cloned pigs
-
Whyte JJ, Samuel M, Mahan E, Padilla J, Simmons GH, Arce-Esquivel AA et al (2011) Vascular endothelium-specific overexpression of human catalase in cloned pigs. Transgenic Res 20: 989-1001.
-
(2011)
Transgenic Res
, vol.20
, pp. 989-1001
-
-
Whyte, J.J.1
Samuel, M.2
Mahan, E.3
Padilla, J.4
Simmons, G.H.5
Arce-Esquivel, A.A.6
-
113
-
-
10544249874
-
Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3)
-
Yamagata K, Oda N, Kaisaki PJ, Menzel S, Furuta H, Vaxillaire M et al (1996) Mutations in the hepatocyte nuclear factor-1alpha gene in maturity-onset diabetes of the young (MODY3). Nature 384: 455-458.
-
(1996)
Nature
, vol.384
, pp. 455-458
-
-
Yamagata, K.1
Oda, N.2
Kaisaki, P.J.3
Menzel, S.4
Furuta, H.5
Vaxillaire, M.6
-
114
-
-
0031848797
-
Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative
-
Yamagata K, Yang Q, Yamamoto K, Iwahashi H, Miyagawa J, Okita K et al (1998) Mutation P291fsinsC in the transcription factor hepatocyte nuclear factor-1alpha is dominant negative. Diabetes 47: 1231-1235.
-
(1998)
Diabetes
, vol.47
, pp. 1231-1235
-
-
Yamagata, K.1
Yang, Q.2
Yamamoto, K.3
Iwahashi, H.4
Miyagawa, J.5
Okita, K.6
-
115
-
-
53149104793
-
Production of transgenic pig carrying MMTV/v-Ha-ras
-
Yamakawa H, Nagai T, Harasawa R, Yamagami T, Takahashi J, Ishikawa KI et al (1999) Production of transgenic pig carrying MMTV/v-Ha-ras. J Reprod Dev 45: 111-118.
-
(1999)
J Reprod Dev
, vol.45
, pp. 111-118
-
-
Yamakawa, H.1
Nagai, T.2
Harasawa, R.3
Yamagami, T.4
Takahashi, J.5
Ishikawa, K.I.6
-
116
-
-
45149105779
-
Towards a transgenic model of Huntington's disease in a non-human primate
-
Yang SH, Cheng PH, Banta H, Piotrowska-Nitsche K, Yang JJ, Cheng EC et al (2008) Towards a transgenic model of Huntington's disease in a non-human primate. Nature 453: 921-924.
-
(2008)
Nature
, vol.453
, pp. 921-924
-
-
Yang, S.H.1
Cheng, P.H.2
Banta, H.3
Piotrowska-Nitsche, K.4
Yang, J.J.5
Cheng, E.C.6
-
117
-
-
77957732707
-
Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs
-
Yang D, Wang CE, Zhao B, Li W, Ouyang Z, Liu Z et al (2010) Expression of Huntington's disease protein results in apoptotic neurons in the brains of cloned transgenic pigs. Hum Mol Genet 19: 3983-3994.
-
(2010)
Hum Mol Genet
, vol.19
, pp. 3983-3994
-
-
Yang, D.1
Wang, C.E.2
Zhao, B.3
Li, W.4
Ouyang, Z.5
Liu, Z.6
-
118
-
-
85027921901
-
Generation of PPARgamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning
-
Yang D, Yang H, Li W, Zhao B, Ouyang Z, Liu Z et al (2011) Generation of PPARgamma mono-allelic knockout pigs via zinc-finger nucleases and nuclear transfer cloning. Cell Res 21: 979-982.
-
(2011)
Cell Res
, vol.21
, pp. 979-982
-
-
Yang, D.1
Yang, H.2
Li, W.3
Zhao, B.4
Ouyang, Z.5
Liu, Z.6
-
119
-
-
84891663513
-
Generation of c-Myc transgenic pigs for autosomal dominant polycystic kidney disease
-
Mar 30 [Epub ahead of print]
-
Ye J, He J, Li Q, Feng Y, Bai X, Chen X et al (2013) Generation of c-Myc transgenic pigs for autosomal dominant polycystic kidney disease. Transgenic Res, Mar 30 [Epub ahead of print].
-
(2013)
Transgenic Res
-
-
Ye, J.1
He, J.2
Li, Q.3
Feng, Y.4
Bai, X.5
Chen, X.6
-
120
-
-
0032572281
-
Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors
-
Zaidi A, Schmoeckel M, Bhatti F, Waterworth P, Tolan M, Cozzi E et al (1998) Life-supporting pig-to-primate renal xenotransplantation using genetically modified donors. Transplantation 65: 1584-1590.
-
(1998)
Transplantation
, vol.65
, pp. 1584-1590
-
-
Zaidi, A.1
Schmoeckel, M.2
Bhatti, F.3
Waterworth, P.4
Tolan, M.5
Cozzi, E.6
-
121
-
-
0026592806
-
Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E
-
Zhang SH, Reddick RL, Piedrahita JA, Maeda N (1992) Spontaneous hypercholesterolemia and arterial lesions in mice lacking apolipoprotein E. Science 258: 468-471.
-
(1992)
Science
, vol.258
, pp. 468-471
-
-
Zhang, S.H.1
Reddick, R.L.2
Piedrahita, J.A.3
Maeda, N.4
-
122
-
-
77955643169
-
Molecular mechanisms and potential therapeutical targets in Huntington's disease
-
Zuccato C, Valenza M, Cattaneo E (2010) Molecular mechanisms and potential therapeutical targets in Huntington's disease. Physiol Rev 90: 905-981.
-
(2010)
Physiol Rev
, vol.90
, pp. 905-981
-
-
Zuccato, C.1
Valenza, M.2
Cattaneo, E.3
|