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Volumn 16, Issue 9, 2015, Pages 21555-21574

Anthocyanin absorption and metabolism by human intestinal Caco-2 cells—A review

Author keywords

Anthocyanins; Caco 2 cells; Intestinal absorption; Metabolism

Indexed keywords

ANTHOCYANIN; CYTOCHROME P450 1A; GLUCURONOSYLTRANSFERASE; GLUTATHIONE TRANSFERASE; INTERLEUKIN 8; PHLORETIN; PHLORIZIN; REACTIVE OXYGEN METABOLITE; SODIUM GLUCOSE COTRANSPORTER 1; SULFOTRANSFERASE;

EID: 84941236478     PISSN: 16616596     EISSN: 14220067     Source Type: Journal    
DOI: 10.3390/ijms160921555     Document Type: Review
Times cited : (190)

References (91)
  • 1
    • 33749241899 scopus 로고    scopus 로고
    • Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities
    • Prior, R.L.; Wu, X. Anthocyanins: Structural characteristics that result in unique metabolic patterns and biological activities. Free Radic. Res. 2006, 40, 1014–1028.
    • (2006) Free Radic. Res , vol.40 , pp. 1014-1028
    • Prior, R.L.1    Wu, X.2
  • 2
    • 79957867318 scopus 로고    scopus 로고
    • Anthocyanins: Natural colorants with health-promoting properties
    • He, J.; Giusti, M.M. Anthocyanins: Natural colorants with health-promoting properties. Annu. Rev. Food Sci. Technol. 2010, 1, 163–187.
    • (2010) Annu. Rev. Food Sci. Technol , vol.1 , pp. 163-187
    • He, J.1    Giusti, M.M.2
  • 4
    • 84879669696 scopus 로고    scopus 로고
    • Antioxidant activity and polyphenol composition of black mulberry (Morus nigra L.) products
    • Kamiloglu, S.; Serali, O.; Unal, N.; Capanoglu, E. Antioxidant activity and polyphenol composition of black mulberry (Morus nigra L.) products. J. Berry Res. 2013, 3, 41–51.
    • (2013) J. Berry Res , vol.3 , pp. 41-51
    • Kamiloglu, S.1    Serali, O.2    Unal, N.3    Capanoglu, E.4
  • 5
    • 84900300678 scopus 로고    scopus 로고
    • Strawberry and human health: Effects beyond antioxidant activity
    • Giampieri, F.; Alvarez-Suarez, J.M.; Battino, M. Strawberry and human health: Effects beyond antioxidant activity. J. Agric. Food Chem. 2014, 62, 3867–3876.
    • (2014) J. Agric. Food Chem , vol.62 , pp. 3867-3876
    • Giampieri, F.1    Alvarez-Suarez, J.M.2    Battino, M.3
  • 6
    • 84922184674 scopus 로고    scopus 로고
    • Improved color and anthocyanin retention in strawberry puree by oxygen exclusion
    • Howard, L.R; Brownmiller, C.; Prior, R.L. Improved color and anthocyanin retention in strawberry puree by oxygen exclusion. J. Berry Res. 2014, 4, 107–116.
    • (2014) J. Berry Res , vol.4 , pp. 107-116
    • Howard, L.R.1    Brownmiller, C.2    Prior, R.L.3
  • 7
    • 34447540210 scopus 로고    scopus 로고
    • The bioavailability and absorption of anthocyanins: Towards a better understanding
    • McGhie, T.K.; Walton, M.C. The bioavailability and absorption of anthocyanins: Towards a better understanding. Mol. Nutr. Food Res. 2007, 51, 702–713.
    • (2007) Mol. Nutr. Food Res , vol.51 , pp. 702-713
    • McGhie, T.K.1    Walton, M.C.2
  • 8
    • 84879962114 scopus 로고    scopus 로고
    • Anthocyanins in cardiovascular disease
    • Wallace, T.C. Anthocyanins in cardiovascular disease. Adv. Nutr. 2011, 2, 1–7.
    • (2011) Adv. Nutr , vol.2 , pp. 1-7
    • Wallace, T.C.1
  • 9
    • 77953156613 scopus 로고    scopus 로고
    • Anthocyanins; Winefield, C., Kevin Davies, K., etc., Eds.; Springer: New York, NY, USA
    • Mateus, N.; de Freitas, V. Anthocyanins as Food Colorants. In Anthocyanins; Winefield, C., Kevin Davies, K., etc., Eds.; Springer: New York, NY, USA, 2009; pp. 284–304.
    • (2009) Anthocyanins as Food Colorants , pp. 284-304
    • Mateus, N.1    De Freitas, V.2
  • 11
    • 84889830728 scopus 로고    scopus 로고
    • Investigating the transport dynamics of anthocyanins from unprocessed fruit and processed fruit juice from sour cherry (Prunus cerasus L.) across intestinal epithelial cells
    • Toydemir, G.; Boyacioglu, D.; Capanoglu, E.; van der Meer, I.M.; Tomassen, M.M.; Hall, R.D.; Mes, J.J.; Beekwilder, J. Investigating the transport dynamics of anthocyanins from unprocessed fruit and processed fruit juice from sour cherry (Prunus cerasus L.) across intestinal epithelial cells. J. Agric. Food Chem. 2013, 61, 11434–11441.
    • (2013) J. Agric. Food Chem. , vol.61 , pp. 11434-11441
    • Toydemir, G.1    Boyacioglu, D.2    Capanoglu, E.3    Van Der Meer, I.M.4    Tomassen, M.M.5    Hall, R.D.6    Mes, J.J.7    Beekwilder, J.8
  • 12
    • 84992728357 scopus 로고    scopus 로고
    • Bioavailability of anthocyanins
    • Phenolics and Terpenes; Ramawat, K.G., Merillon, J.M., Eds.; Springer: Berlin-Heidelberg, Germany
    • Faria, A.; Fernandes, I.; Mateus, N.; Calhau, C. Bioavailability of anthocyanins. In Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids, Phenolics and Terpenes; Ramawat, K.G., Merillon, J.M., Eds.; Springer: Berlin-Heidelberg, Germany, 2013; pp. 2465–2487.
    • (2013) Natural Products: Phytochemistry, Botany and Metabolism of Alkaloids , pp. 2465-2487
    • Faria, A.1    Fernandes, I.2    Mateus, N.3    Calhau, C.4
  • 14
    • 79551573834 scopus 로고    scopus 로고
    • A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables
    • Ignat, I.; Volf, I.; Popa, V.I. A critical review of methods for characterisation of polyphenolic compounds in fruits and vegetables. Food Chem. 2011, 126, 1821–1835.
    • (2011) Food Chem , vol.126 , pp. 1821-1835
    • Ignat, I.1    Volf, I.2    Popa, V.I.3
  • 15
    • 33745512076 scopus 로고    scopus 로고
    • Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption
    • Wu, X.; Beecher, G.R.; Holden, J.M.; Haytowitz, D.B.; Gebhardt, S.E.; Prior, R.L. Concentrations of anthocyanins in common foods in the United States and estimation of normal consumption. J. Agric. Food Chem. 2006, 54, 4069–4075.
    • (2006) J. Agric. Food Chem. , vol.54 , pp. 4069-4075
    • Wu, X.1    Beecher, G.R.2    Holden, J.M.3    Haytowitz, D.B.4    Gebhardt, S.E.5    Prior, R.L.6
  • 16
    • 84908569749 scopus 로고    scopus 로고
    • Bioavailability of anthocyanins
    • Fang, J. Bioavailability of anthocyanins. Drug Metab. Rev. 2014, 46, 508–520.
    • (2014) Drug Metab. Rev , vol.46 , pp. 508-520
    • Fang, J.1
  • 20
    • 84855315675 scopus 로고    scopus 로고
    • Dietary anthocyanin-rich plants: Biochemical basis and recent progress in health benefits studies
    • Tsuda, T. Dietary anthocyanin-rich plants: Biochemical basis and recent progress in health benefits studies. Mol. Nutr. Food Res. 2012, 56, 159–170.
    • (2012) Mol. Nutr. Food Res , vol.56 , pp. 159-170
    • Tsuda, T.1
  • 22
    • 33847784843 scopus 로고    scopus 로고
    • Food microstructure affects the bioavailability of several nutrients
    • Parada, J.; Aguilera, J.M. Food microstructure affects the bioavailability of several nutrients. J. Food Sci. 2007, 72, R21–R32.
    • (2007) J. Food Sci , vol.72 , pp. R21-R32
    • Parada, J.1    Aguilera, J.M.2
  • 23
  • 24
    • 0034737452 scopus 로고    scopus 로고
    • Transport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 cells
    • Manna, C.; Galletti, P.; Maisto, G.; Cucciolla, V.; D’Angelo, S.; Zappia, V. Transport mechanism and metabolism of olive oil hydroxytyrosol in Caco-2 cells. FEBS Lett. 2000, 470, 341–344.
    • (2000) FEBS Lett , vol.470 , pp. 341-344
    • Manna, C.1    Galletti, P.2    Maisto, G.3    Cucciolla, V.4    D’Angelo, S.5    Zappia, V.6
  • 25
    • 0035663005 scopus 로고    scopus 로고
    • Scalbert, A. Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells
    • Deprez, S.; Mila, I.; Huneau, J.F.; Tome, D.; Scalbert, A. Transport of proanthocyanidin dimer, trimer, and polymer across monolayers of human intestinal epithelial Caco-2 cells. Antioxid. Redox Signal. 2001, 3, 957–967.
    • (2001) Antioxid. Redox Signal , vol.3 , pp. 957-967
    • Deprez, S.1    Mila, I.2    Huneau, J.F.3    Tome, D.4
  • 26
    • 2342513567 scopus 로고    scopus 로고
    • Transepithelial transport of chlorogenic acid, caffeic acid, and their colonic metabolites in intestinal Caco-2 cell monolayers
    • Konishi, Y.; Kobayashi, S. Transepithelial transport of chlorogenic acid, caffeic acid, and their colonic metabolites in intestinal Caco-2 cell monolayers. J. Agric. Food Chem. 2004, 52, 2518–2526.
    • (2004) J. Agric. Food Chem. , vol.52 , pp. 2518-2526
    • Konishi, Y.1    Kobayashi, S.2
  • 27
    • 78649820061 scopus 로고    scopus 로고
    • Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells
    • Manzano, S.; Williamson, G. Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol. Nutr. Food Res. 2010, 54, 1773–1780.
    • (2010) Mol. Nutr. Food Res , vol.54 , pp. 1773-1780
    • Manzano, S.1    Williamson, G.2
  • 28
    • 33746878757 scopus 로고    scopus 로고
    • Absorption of anthocyanins from blueberry extracts by Caco-2 human intestinal cell monolayers
    • Yi, W.; Akoh, C.C.; Fischer, J.; Krewer, G. Absorption of anthocyanins from blueberry extracts by Caco-2 human intestinal cell monolayers. J. Agric. Food Chem. 2006, 54, 5651–5658.
    • (2006) J. Agric. Food Chem , vol.54 , pp. 5651-5658
    • Yi, W.1    Akoh, C.C.2    Fischer, J.3    Krewer, G.4
  • 29
    • 84896535550 scopus 로고    scopus 로고
    • Encapsulation of anthocyanin molecules within a ferritin nanocage increases their stability and cell uptake efficiency
    • Zhang, T.; Lv, C.; Chen, L.; Bai, G.; Zhao, G.; Xu, C. Encapsulation of anthocyanin molecules within a ferritin nanocage increases their stability and cell uptake efficiency. Food Res. Int. 2014, 62, 183–192.
    • (2014) Food Res. Int , vol.62 , pp. 183-192
    • Zhang, T.1    Lv, C.2    Chen, L.3    Bai, G.4    Zhao, G.5    Xu, C.6
  • 31
    • 84924261719 scopus 로고    scopus 로고
    • Effect of apple, baobab, red-chicory, and pear extracts on cellular energy expenditure and morphology of a Caco-2 cells using transepithelial electrical resistance (TEER) and scanning electron microscopy (SEM)
    • Finotti, E.; Gezzi, R.; Nobili, F.; Garaguso, I.; Friedman, M. Effect of apple, baobab, red-chicory, and pear extracts on cellular energy expenditure and morphology of a Caco-2 cells using transepithelial electrical resistance (TEER) and scanning electron microscopy (SEM). RSC Adv. 2015, 5, 22490–22498.
    • (2015) RSC Adv , vol.5 , pp. 22490-22498
    • Finotti, E.1    Gezzi, R.2    Nobili, F.3    Garaguso, I.4    Friedman, M.5
  • 32
    • 79951944523 scopus 로고    scopus 로고
    • Organic acid bioavailability from banana and sweet potato using an in vitro digestion and Caco-2 cell model
    • Sabboh-Jourdan, H.; Valla, F.; Epriliati, I.; Gidley, M.J. Organic acid bioavailability from banana and sweet potato using an in vitro digestion and Caco-2 cell model. Eur. J. Nutr. 2011, 50, 31–40.
    • (2011) Eur. J. Nutr , vol.50 , pp. 31-40
    • Sabboh-Jourdan, H.1    Valla, F.2    Epriliati, I.3    Gidley, M.J.4
  • 33
    • 20044371666 scopus 로고    scopus 로고
    • The Caco-2 cell line as a model of the intestinal barrier: Influence of cell and culture-related factors on Caco-2 cell functional characteristics
    • Sambuy, Y.; de Angelis, I.; Ranaldi, G.; Scarino, M.L.; Stammati, A.; Zucco, F. The Caco-2 cell line as a model of the intestinal barrier: Influence of cell and culture-related factors on Caco-2 cell functional characteristics. Cell Biol. Toxicol. 2005, 21, 1–26.
    • (2005) Cell Biol. Toxicol , vol.21 , pp. 1-26
    • Sambuy, Y.1    De Angelis, I.2    Ranaldi, G.3    Scarino, M.L.4    Stammati, A.5    Zucco, F.6
  • 34
    • 67651166650 scopus 로고    scopus 로고
    • Absorption, conjugation and efflux of the flavonoids, kaempferol and galangin, using the intestinal CaCo-2/TC7 cell model
    • Barrington, R.; Williamson, G.; Bennett, R.N.; Davis, B.D.; Brodbelt, J.S.; Kroon, P.A. Absorption, conjugation and efflux of the flavonoids, kaempferol and galangin, using the intestinal CaCo-2/TC7 cell model. J. Funct. Foods 2009, 1, 74–87.
    • (2009) J. Funct. Foods , vol.1 , pp. 74-87
    • Barrington, R.1    Williamson, G.2    Bennett, R.N.3    Davis, B.D.4    Brodbelt, J.S.5    Kroon, P.A.6
  • 35
    • 78149303197 scopus 로고    scopus 로고
    • Transepithelial transport and metabolism of new lipophilic ether derivatives of hydroxytyrosol by enterocyte-like Caco-2/TC7 cells
    • Pereira-Caro, G.; Mateos, R.; Saha, S.; Madrona, A.; Espartero, J.L.; Bravo, L.; Kroon, P.A. Transepithelial transport and metabolism of new lipophilic ether derivatives of hydroxytyrosol by enterocyte-like Caco-2/TC7 cells. J. Agric. Food Chem. 2010, 58, 11501–11509.
    • (2010) J. Agric. Food Chem , vol.58 , pp. 11501-11509
    • Pereira-Caro, G.1    Mateos, R.2    Saha, S.3    Madrona, A.4    Espartero, J.L.5    Bravo, L.6    Kroon, P.A.7
  • 36
    • 70350573359 scopus 로고    scopus 로고
    • Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial Caco-2/TC7 cell line
    • Soler, A.; Romero, M.P.; Macià, A.; Saha, S.; Furniss, C.S.; Kroon, P.A.; Motilva, M.J. Digestion stability and evaluation of the metabolism and transport of olive oil phenols in the human small-intestinal epithelial Caco-2/TC7 cell line. Food Chem. 2010, 119, 703–714.
    • (2010) Food Chem , vol.119 , pp. 703-714
    • Soler, A.1    Romero, M.P.2    Macià, A.3    Saha, S.4    Furniss, C.S.5    Kroon, P.A.6    Motilva, M.J.7
  • 37
    • 14644398632 scopus 로고    scopus 로고
    • Cell culture-based models for intestinal permeability: A critique
    • Balimane, P.V.; Chong, S. Cell culture-based models for intestinal permeability: A critique. Drug Discov. Today 2005, 10, 335–343.
    • (2005) Drug Discov. Today , vol.10 , pp. 335-343
    • Balimane, P.V.1    Chong, S.2
  • 38
    • 0022002954 scopus 로고
    • Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose
    • Zweibaum, A.; Pinto, M.; Chevalier, G.; Dussaulx, E.; Triadou, N.; Lacroix, B.; Haffen, K.; Brun, J.L.; Rousset, M. Enterocytic differentiation of a subpopulation of the human colon tumor cell line HT-29 selected for growth in sugar-free medium and its inhibition by glucose. J. Cell. Physiol. 1985, 122, 21–29.
    • (1985) J. Cell. Physiol. , vol.122 , pp. 21-29
    • Zweibaum, A.1    Pinto, M.2    Chevalier, G.3    Dussaulx, E.4    Triadou, N.5    Lacroix, B.6    Haffen, K.7    Brun, J.L.8    Rousset, M.9
  • 39
    • 2342515521 scopus 로고    scopus 로고
    • Total cranberry extract versus its phytochemical constituents: Antiproliferative and synergistic effects against human tumor cell lines
    • Seeram, N.P.; Adams, L.S.; Hardy, M.L.; Heber, D. Total cranberry extract versus its phytochemical constituents: Antiproliferative and synergistic effects against human tumor cell lines. J. Agric. Food Chem. 2004, 52, 2512–2517.
    • (2004) J. Agric. Food Chem , vol.52 , pp. 2512-2517
    • Seeram, N.P.1    Adams, L.S.2    Hardy, M.L.3    Heber, D.4
  • 40
    • 16244422650 scopus 로고    scopus 로고
    • Synergistic antiproliferative action of the flavonols quercetin and kaempferol in cultured human cancer cell lines
    • Ackland, M.L.; van de Waarsenburg, S.; Jones, R. Synergistic antiproliferative action of the flavonols quercetin and kaempferol in cultured human cancer cell lines. In Vivo 2005, 19, 69–76.
    • (2005) In Vivo , vol.19 , pp. 69-76
    • Ackland, M.L.1    Van De Waarsenburg, S.2    Jones, R.3
  • 41
    • 47849094565 scopus 로고    scopus 로고
    • Absorption of black currant anthocyanins by monolayers of human intestinal epithelial Caco-2 cells mounted in ussing type chambers
    • Steinert, R.E.; Ditscheid, B.; Netzel, M.; Jahreis, G. Absorption of black currant anthocyanins by monolayers of human intestinal epithelial Caco-2 cells mounted in ussing type chambers. J. Agric. Food Chem. 2008, 56, 4995–5001.
    • (2008) J. Agric. Food Chem , vol.56 , pp. 4995-5001
    • Steinert, R.E.1    Ditscheid, B.2    Netzel, M.3    Jahreis, G.4
  • 43
    • 70449119975 scopus 로고    scopus 로고
    • In vitro absorption and antiproliferative activities of monomeric and polymeric anthocyanin fractions from açai fruit (Euterpe oleracea Mart.)
    • Pacheco-Palencia, L.A.; Mertens-Talcott, S.U.; Talcott, S.T. In vitro absorption and antiproliferative activities of monomeric and polymeric anthocyanin fractions from açai fruit (Euterpe oleracea Mart.). Food Chem. 2010, 119, 1071–1078.
    • (2010) Food Chem , vol.119 , pp. 1071-1078
    • Pacheco-Palencia, L.A.1    Mertens-Talcott, S.U.2    Talcott, S.T.3
  • 44
    • 84863962533 scopus 로고    scopus 로고
    • On the bioavailability of flavanols and anthocyanins: Flavanol—Anthocyanin dimers
    • Fernandes, I.; Nave, F.; Gonçalves, R.; de Freitas, V.; Mateus, N. On the bioavailability of flavanols and anthocyanins: Flavanol—Anthocyanin dimers. Food Chem. 2012, 135, 812–818.
    • (2012) Food Chem , vol.135 , pp. 812-818
    • Fernandes, I.1    Nave, F.2    Gonçalves, R.3    De Freitas, V.4    Mateus, N.5
  • 45
    • 84908199194 scopus 로고    scopus 로고
    • The role of sodium-dependent glucose transporter 1 and glucose transporter 2 in the absorption of cyanidin-3-O-β-glucoside in Caco-2 cells
    • Zou, T.B.; Feng, D.; Song, G.; Li, H.W.; Tang, H.W.; Ling, W.H. The role of sodium-dependent glucose transporter 1 and glucose transporter 2 in the absorption of cyanidin-3-O-β-glucoside in Caco-2 cells. Nutrients 2014, 6, 4165–4177.
    • (2014) Nutrients , vol.6 , pp. 4165-4177
    • Zou, T.B.1    Feng, D.2    Song, G.3    Li, H.W.4    Tang, H.W.5    Ling, W.H.6
  • 46
    • 84916613616 scopus 로고    scopus 로고
    • Phospholipids and terpenes modulate Caco-2 transport of açaí anthocyanins
    • Cardona, J.A.; Mertens-Talcott, S.U.; Talcott, S.T. Phospholipids and terpenes modulate Caco-2 transport of açaí anthocyanins. Food Chem. 2015, 175, 267–272.
    • (2015) Food Chem , vol.175 , pp. 267-272
    • Cardona, J.A.1    Mertens-Talcott, S.U.2    Talcott, S.T.3
  • 47
    • 84906957620 scopus 로고    scopus 로고
    • Identification of bioaccessible and uptaken phenolic compounds from strawberry fruits in in vitro digestion/Caco-2 absorption model
    • Kosińska-Cagnazzo, A.; Diering, S.; Prim, D.; Andlauer, W. Identification of bioaccessible and uptaken phenolic compounds from strawberry fruits in in vitro digestion/Caco-2 absorption model. Food Chem. 2015, 170, 288–294.
    • (2015) Food Chem , vol.170 , pp. 288-294
    • Kosińska-Cagnazzo, A.1    Diering, S.2    Prim, D.3    Andlauer, W.4
  • 48
    • 84927646896 scopus 로고    scopus 로고
    • Inhibition of low-grade inflammation by anthocyanins from grape extract in an in vitro epithelial-endothelial co-culture model
    • Kuntz, S.; Asseburg, H.; Dold, S.; Römpp, A.; Fröhling, B.; Kunz, C.; Rudloff, S. Inhibition of low-grade inflammation by anthocyanins from grape extract in an in vitro epithelial-endothelial co-culture model. Food Funct. 2015, 6, 1136–1149.
    • (2015) Food Funct , vol.6 , pp. 1136-1149
    • Kuntz, S.1    Asseburg, H.2    Dold, S.3    Römpp, A.4    Fröhling, B.5    Kunz, C.6    Rudloff, S.7
  • 49
    • 84928613102 scopus 로고    scopus 로고
    • Uptake and bioavailability of anthocyanins and phenolic acids from grape/blueberry juice and smoothie in vitro and in vivo
    • Kuntz, S.; Rudloff, S.; Asseburg, H.; Borsch, C.; Fröhling, B.; Unger, F.; Dold, S.; Spengler, B.; Römpp, A.; Kunz, C. Uptake and bioavailability of anthocyanins and phenolic acids from grape/blueberry juice and smoothie in vitro and in vivo. Br. J. Nutr. 2015, 113, 1044–1055.
    • (2015) Br. J. Nutr , vol.113 , pp. 1044-1055
    • Kuntz, S.1    Rudloff, S.2    Asseburg, H.3    Borsch, C.4    Fröhling, B.5    Unger, F.6    Dold, S.7    Spengler, B.8    Römpp, A.9    Kunz, C.10
  • 51
    • 0037855692 scopus 로고    scopus 로고
    • Bioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juice
    • Frank, T.; Netzel, M.; Strass, G.; Bitsch, R.; Bitsch, I. Bioavailability of anthocyanidin-3-glucosides following consumption of red wine and red grape juice. Can. J. Physiol. Pharmacol. 2003, 81, 423–435.
    • (2003) Can. J. Physiol. Pharmacol. , vol.81 , pp. 423-435
    • Frank, T.1    Netzel, M.2    Strass, G.3    Bitsch, R.4    Bitsch, I.5
  • 52
    • 23844534408 scopus 로고    scopus 로고
    • Plasma and urine responses are lower for acylated vs. Nonacylated anthocyanins from raw and cooked purple carrots
    • Kurilich, A.C.; Clevidence, B.A.; Britz, S.J.; Simon, P.W.; Novotny, J.A. Plasma and urine responses are lower for acylated vs. nonacylated anthocyanins from raw and cooked purple carrots. J. Agric. Food Chem. 2005, 53, 6537–6542.
    • (2005) J. Agric. Food Chem , vol.53 , pp. 6537-6542
    • Kurilich, A.C.1    Clevidence, B.A.2    Britz, S.J.3    Simon, P.W.4    Novotny, J.A.5
  • 54
    • 77952633189 scopus 로고    scopus 로고
    • Anthocyanins are bioavailable in humans following an acute dose of cranberry juice
    • Milbury, P.E.; Vita, J.A.; Blumberg, J.B. Anthocyanins are bioavailable in humans following an acute dose of cranberry juice. J. Nutr. 2010, 140, 1099–1104.
    • (2010) J. Nutr , vol.140 , pp. 1099-1104
    • Milbury, P.E.1    Vita, J.A.2    Blumberg, J.B.3
  • 55
    • 58249119578 scopus 로고    scopus 로고
    • Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model
    • Tian, X.J.; Yang, X.W.; Yang, X.; Wang, K. Studies of intestinal permeability of 36 flavonoids using Caco-2 cell monolayer model. Int. J. Pharm. 2009, 367, 58–64.
    • (2009) Int. J. Pharm , vol.367 , pp. 58-64
    • Tian, X.J.1    Yang, X.W.2    Yang, X.3    Wang, K.4
  • 56
    • 0034788719 scopus 로고    scopus 로고
    • Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice
    • Bub, A.; Watzl, B.; Heeb, D.; Rechkemmer, G.; Briviba, K. Malvidin-3-glucoside bioavailability in humans after ingestion of red wine, dealcoholized red wine and red grape juice. Eur. J. Nutr. 2001, 40, 113–120.
    • (2001) Eur. J. Nutr , vol.40 , pp. 113-120
    • Bub, A.1    Watzl, B.2    Heeb, D.3    Rechkemmer, G.4    Briviba, K.5
  • 57
    • 0043022152 scopus 로고    scopus 로고
    • Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol
    • Andlauer, W.; Stumpf, C.; Frank, K.; Fürst, P. Absorption and metabolism of anthocyanin cyanidin-3-glucoside in the isolated rat small intestine is not influenced by ethanol. Eur. J. Nutr. 2003, 42, 217–223.
    • (2003) Eur. J. Nutr , vol.42 , pp. 217-223
    • Andlauer, W.1    Stumpf, C.2    Frank, K.3    Fürst, P.4
  • 59
    • 67649968264 scopus 로고    scopus 로고
    • The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products
    • Kay, C.D.; Kroon, P.A.; Cassidy, A. The bioactivity of dietary anthocyanins is likely to be mediated by their degradation products. Mol. Nutr. Food Res. 2009, 53, S92–S101.
    • (2009) Mol. Nutr. Food Res , vol.53 , pp. SS92-S101
    • Kay, C.D.1    Kroon, P.A.2    Cassidy, A.3
  • 60
    • 84893593461 scopus 로고    scopus 로고
    • Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract
    • Alzaid, F.; Cheung, H.M.; Preedy, V.R.; Sharp, P.A. Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract. PLoS ONE 2013, 8, e78932.
    • (2013) Plos ONE , vol.8
    • Alzaid, F.1    Cheung, H.M.2    Preedy, V.R.3    Sharp, P.A.4
  • 63
    • 84928793435 scopus 로고    scopus 로고
    • The Encapsulation of anthocyanins from berry-type fruits. Trends in foods
    • Robert, P.; Fredes, C. The Encapsulation of anthocyanins from berry-type fruits. Trends in foods. Molecules 2015, 20, 5875–5888.
    • (2015) Molecules , vol.20 , pp. 5875-5888
    • Robert, P.1    Fredes, C.2
  • 66
    • 84879232770 scopus 로고    scopus 로고
    • Antioxidant and antiproliferative properties of methylated metabolites of anthocyanins
    • Fernandes, I.; Marques, F.; de Freitas, V.; Mateus, N. Antioxidant and antiproliferative properties of methylated metabolites of anthocyanins. Food Chem. 2013, 141, 2923–2933.
    • (2013) Food Chem , vol.141 , pp. 2923-2933
    • Fernandes, I.1    Marques, F.2    De Freitas, V.3    Mateus, N.4
  • 67
    • 77952198157 scopus 로고    scopus 로고
    • Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells
    • Forester, S.C.; Waterhouse, A.L. Gut metabolites of anthocyanins, gallic acid, 3-O-methylgallic acid, and 2,4,6-trihydroxybenzaldehyde, inhibit cell proliferation of Caco-2 cells. J. Agric. Food Chem. 2010, 58, 5320–5327.
    • (2010) J. Agric. Food Chem. , vol.58 , pp. 5320-5327
    • Forester, S.C.1    Waterhouse, A.L.2
  • 69
    • 25444490122 scopus 로고    scopus 로고
    • Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis
    • Yi, W.; Fischer, J.; Krewer, G.; Akoh, C.C. Phenolic compounds from blueberries can inhibit colon cancer cell proliferation and induce apoptosis. J. Agric. Food Chem. 2005, 53, 7320–7329.
    • (2005) J. Agric. Food Chem , vol.53 , pp. 7320-7329
    • Yi, W.1    Fischer, J.2    Krewer, G.3    Akoh, C.C.4
  • 70
    • 33847629716 scopus 로고    scopus 로고
    • Up-regulation of tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 in human colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice
    • Bermúdez-Soto, M.J.; Larrosa, M.; Garcia-Cantalejo, J.M.; Espín, J.C.; Tomás-Barberan, F.A.; García-Conesa, M.T. Up-regulation of tumor suppressor carcinoembryonic antigen-related cell adhesion molecule 1 in human colon cancer Caco-2 cells following repetitive exposure to dietary levels of a polyphenol-rich chokeberry juice. J. Nutr. Biochem. 2007, 18, 259–271.
    • (2007) J. Nutr. Biochem , vol.18 , pp. 259-271
    • Bermúdez-Soto, M.J.1    Larrosa, M.2    Garcia-Cantalejo, J.M.3    Espín, J.C.4    Tomás-Barberan, F.A.5    García-Conesa, M.T.6
  • 71
    • 49049121422 scopus 로고    scopus 로고
    • Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds
    • Lea, M.A.; Ibeh, C.; Vizzotto, M.; Cisneros-Zevallos, L.; Byrne, D.H.; Okie, W.R.; Moyer, M.P. Inhibition of growth and induction of differentiation of colon cancer cells by peach and plum phenolic compounds. Anticancer Res. 2008, 28, 2067–2076.
    • (2008) Anticancer Res , vol.28 , pp. 2067-2076
    • Lea, M.A.1    Ibeh, C.2    Vizzotto, M.3    Cisneros-Zevallos, L.4    Byrne, D.H.5    Okie, W.R.6    Moyer, M.P.7
  • 72
    • 44349169060 scopus 로고    scopus 로고
    • Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro
    • McDougall, G.J.; Ross, H.A.; Ikeji, M.; Stewart, D. Berry extracts exert different antiproliferative effects against cervical and colon cancer cells grown in vitro. J. Agric. Food Chem. 2008, 56, 3016–3023.
    • (2008) J. Agric. Food Chem , vol.56 , pp. 3016-3023
    • McDougall, G.J.1    Ross, H.A.2    Ikeji, M.3    Stewart, D.4
  • 73
    • 77953885976 scopus 로고    scopus 로고
    • Bog bilberry (Vaccinium uliginosum L.) extract reduces cultured Hep-G2, Caco-2, and 3T3-L1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability
    • Liu, J.; Zhang, W.; Jing, H.; Popovich, D.G. Bog bilberry (Vaccinium uliginosum L.) extract reduces cultured Hep-G2, Caco-2, and 3T3-L1 cell viability, affects cell cycle progression, and has variable effects on membrane permeability. J. Food Sci. 2010, 75, H103–H107.
    • (2010) J. Food Sci , vol.75 , pp. H103-H107
    • Liu, J.1    Zhang, W.2    Jing, H.3    Popovich, D.G.4
  • 74
    • 79954996213 scopus 로고    scopus 로고
    • Effect of processing of black currant press-residue on polyphenol composition and cell proliferation
    • Holtung, L.; Grimmer, S.; Aaby, K. Effect of processing of black currant press-residue on polyphenol composition and cell proliferation. J. Agric. Food Chem. 2011, 59, 3632–3640.
    • (2011) J. Agric. Food Chem. , vol.59 , pp. 3632-3640
    • Holtung, L.1    Grimmer, S.2    Aaby, K.3
  • 75
    • 79958054540 scopus 로고    scopus 로고
    • Araçá (Psidium cattleianum Sabine) fruit extracts with antioxidant and antimicrobial activities and antiproliferative effect on human cancer cells
    • Medina, A.L.; Haas, L.I.R.; Chaves, F.C.; Salvador, M.; Zambiazi, R.C.; Da Silva, W.P.; Nora, L.; Rombaldi, C.V. Araçá (Psidium cattleianum Sabine) fruit extracts with antioxidant and antimicrobial activities and antiproliferative effect on human cancer cells. Food Chem. 2011, 128, 916–922.
    • (2011) Food Chem , vol.128 , pp. 916-922
    • Medina, A.L.1    Haas, L.2    Chaves, F.C.3    Salvador, M.4    Zambiazi, R.C.5    Da Silva, W.P.6    Nora, L.7    Rombaldi, C.V.8
  • 76
    • 80053641129 scopus 로고    scopus 로고
    • Inhibitory effect of antioxidant extracts from various potatoes on the proliferation of human colon and liver cancer cells
    • Wang, Q.; Chen, Q.; He, M.; Mir, P.; Su, J.; Yang, Q. Inhibitory effect of antioxidant extracts from various potatoes on the proliferation of human colon and liver cancer cells. Nutr. Cancer 2011, 63, 1044–1052.
    • (2011) Nutr. Cancer , vol.63 , pp. 1044-1052
    • Wang, Q.1    Chen, Q.2    He, M.3    Mir, P.4    Su, J.5    Yang, Q.6
  • 77
    • 84879787980 scopus 로고    scopus 로고
    • Extraction of phenolic compounds from bilberry (Vaccinium myrtillus L.) press residue: Effects on phenolic composition and cell proliferation
    • Aaby, K.; Grimmer, S.; Holtung, L. Extraction of phenolic compounds from bilberry (Vaccinium myrtillus L.) press residue: Effects on phenolic composition and cell proliferation. LWT-Food Sci. Technol. 2013, 54, 257–264.
    • (2013) Lwt-Food Sci. Technol , vol.54 , pp. 257-264
    • Aaby, K.1    Grimmer, S.2    Holtung, L.3
  • 78
    • 84929452970 scopus 로고    scopus 로고
    • Antioxidant activities and antiproliferative activity of Thai purple rice cooked by various methods on human colon cancer cells
    • Chatthongpisut, R.; Schwartz, S.J.; Yongsawatdigul, J. Antioxidant activities and antiproliferative activity of Thai purple rice cooked by various methods on human colon cancer cells. Food Chem. 2015, 188, 99–105.
    • (2015) Food Chem , vol.188 , pp. 99-105
    • Chatthongpisut, R.1    Schwartz, S.J.2    Yongsawatdigul, J.3
  • 81
    • 42149124475 scopus 로고    scopus 로고
    • Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells
    • Elisia, I.; Kitts, D.D. Anthocyanins inhibit peroxyl radical-induced apoptosis in Caco-2 cells. Mol. Cell. Biochem. 2008, 312, 139–145.
    • (2008) Mol. Cell. Biochem , vol.312 , pp. 139-145
    • Elisia, I.1    Kitts, D.D.2
  • 82
    • 84861576692 scopus 로고    scopus 로고
    • Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells
    • Bornsek, S.M.; Ziberna, L.; Polak, T.; Vanzo, A.; Ulrih, N.P.; Abram, V.; Tramer, F.; Passamonti, S. Bilberry and blueberry anthocyanins act as powerful intracellular antioxidants in mammalian cells. Food Chem. 2012, 134, 1878–1884.
    • (2012) Food Chem , vol.134 , pp. 1878-1884
    • Bornsek, S.M.1    Ziberna, L.2    Polak, T.3    Vanzo, A.4    Ulrih, N.P.5    Abram, V.6    Tramer, F.7    Passamonti, S.8
  • 84
    • 84904865532 scopus 로고    scopus 로고
    • Fractionation of an anthocyanin-rich bilberry extract and in vitro antioxidative activity testing
    • Juadjur, A.; Mohn, C.; Schantz, M.; Baum, M.; Winterhalter, P.; Richling, E. Fractionation of an anthocyanin-rich bilberry extract and in vitro antioxidative activity testing. Food Chem. 2015, 167, 418–424.
    • (2015) Food Chem , vol.167 , pp. 418-424
    • Juadjur, A.1    Mohn, C.2    Schantz, M.3    Baum, M.4    Winterhalter, P.5    Richling, E.6
  • 85
    • 84923320233 scopus 로고    scopus 로고
    • Effects of colored and noncolored phenolics of Echium plantagineum L. Bee pollen in Caco-2 cells under oxidative stress induced by tert-butyl hydroperoxide
    • Sousa, C.; Moita, E.; Valentão, P.; Fernandes, F.; Monteiro, P.; Andrade, P.B. Effects of colored and noncolored phenolics of Echium plantagineum L. bee pollen in Caco-2 cells under oxidative stress induced by tert-butyl hydroperoxide. J. Agric. Food Chem. 2015, 63, 2083–2091.
    • (2015) J. Agric. Food Chem. , vol.63 , pp. 2083-2091
    • Sousa, C.1    Moita, E.2    Valentão, P.3    Fernandes, F.4    Monteiro, P.5    Andrade, P.B.6
  • 87
    • 84930577323 scopus 로고    scopus 로고
    • Anti-inflammatory activities of Rubus fruit anthocyanins in inflamed human intestinal epithelial cells
    • Jung, H.; Lee, H.J.; Cho, H.; Hwang, K.T. Anti-inflammatory activities of Rubus fruit anthocyanins in inflamed human intestinal epithelial cells. J. Food Biochem. 2015, 39, 300–309.
    • (2015) J. Food Biochem , vol.39 , pp. 300-309
    • Jung, H.1    Lee, H.J.2    Cho, H.3    Hwang, K.T.4
  • 89
    • 84860538880 scopus 로고    scopus 로고
    • A new approach on the gastric absorption of anthocyanins
    • Fernandes, I.; de Freitas, V.; Reis, C.; Mateus, N. A new approach on the gastric absorption of anthocyanins. Food Funct. 2012, 3, 508–516.
    • (2012) Food Funct , vol.3 , pp. 508-516
    • Fernandes, I.1    De Freitas, V.2    Reis, C.3    Mateus, N.4
  • 90
    • 84900314648 scopus 로고    scopus 로고
    • Some anthocyanins could be efficiently absorbed across the gastrointestinal mucosa: Extensive presystemic metabolism reduces apparent bioavailability
    • Fang, J. Some anthocyanins could be efficiently absorbed across the gastrointestinal mucosa: Extensive presystemic metabolism reduces apparent bioavailability. J. Agric. Food Chem. 2014, 62, 3904–3911.
    • (2014) J. Agric. Food Chem , vol.62 , pp. 3904-3911
    • Fang, J.1
  • 91
    • 84936794876 scopus 로고    scopus 로고
    • Experimental and theoretical data on the mechanism by which red wine anthocyanins are transported through a human MKN-28 gastric cell model
    • Oliveira, H.; Fernandes, I.; Brás, N.F.; Faria, A.; de Freitas, V.; Calhau, C.; Mateus, N. Experimental and theoretical data on the mechanism by which red wine anthocyanins are transported through a human MKN-28 gastric cell model. J. Agric. Food Chem. 2015, doi:10.1021/acs.jafc.5b00412.
    • (2015) J. Agric. Food Chem
    • Oliveira, H.1    Fernandes, I.2    Brás, N.F.3    Faria, A.4    De Freitas, V.5    Calhau, C.6    Mateus, N.7


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