Anthocyanins are bioavailable in humans following an acute dose of cranberry juice

Journal of Nutrition

Volumn 140, Issue 6, 2010, Pages 1099-1104

  Milbury, Paul E ^a   Vita, Joseph A ^c   Blumberg, Jeffrey B ^b  

^a TUFTS UNIVERSITY   (United States)

^b TUFTS UNIVERSITY   (United States)

^c BOSTON UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHOCYANIN; GLUCOSIDE; POLYPHENOL;

ADULT; AGED; AREA UNDER THE CURVE; ARTICLE; BIOAVAILABILITY; BLOOD SAMPLING; CLINICAL ARTICLE; CONTROLLED STUDY; CORONARY ARTERY DISEASE; CRANBERRY JUICE; FEMALE; FOOD INTAKE; GENE EXPRESSION; HUMAN; MALE; OXIDATION REDUCTION POTENTIAL; SIGNAL TRANSDUCTION; URINALYSIS;

AGED; ANTHOCYANINS; BEVERAGES; FEMALE; HUMANS; MALE; MIDDLE AGED; VACCINIUM MACROCARPON;

VACCINIUM MACROCARPON;

EID: 77952633189     PISSN: 00223166     EISSN: 15416100     Source Type: Journal    
DOI: 10.3945/jn.109.117168     Document Type: Article

References (39)

1. Ruel G, Couillard C. Evidences of the cardioprotective potential of fruits: the case of cranberries. Mol Nutr Food Res. 2007;51:692-701. (Pubitemid 47083680)
2. Neto CC, Amoroso JW, Liberty AM. Anticancer activities of cranberry phytochemicals: an update. Mol Nutr Food Res. 2008;52 Suppl 1: S18-27.
3. Willis LM, Shukitt-Hale B, Joseph JA. Recent advances in berry supplementation and age-related cognitive decline. Curr Opin Clin Nutr Metab Care. 2009;12:91-94
4. Szajdek A, Borowska EJ. Bioactive compounds and health-promoting properties of berry fruits: a review. Plant Foods Hum Nutr. 2008;63:147-156
5. Prior RL, Lazarus S, Cao G, Muccitelli H, Hammerstone JF. Identification of procyanidins and anthocyanins in blueberries and cranberries (Vaccinium Spp.) using high-performance liquid chromatography-mass spectrometry. J Agric Food Chem. 2001;49:1270-1276 (Pubitemid 32884947)
6. Vvedenskaya IO, Rosen RT, Guido JE, Russell DJ, Mills KA, Vorsa N. Characterization of flavonols in cranberry (Vaccinium macropon) powder. J Agric Food Chem. 2004;52:188-195
7. Kalt W, Blumberg JB, McDonald JE, Vinqvist-Tymchuk MR, Fillmore SA, Graf BA, O'Leary JM,Milbury PE. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J Agric Food Chem. 2008;56:705-712
8. Karlsen A, Retterstøl L, Laake P, Paur I, Kjølsrud- Bøhn S, Sandvik L, Blomhoff R. Anthocyanins inhibit nuclear factor-kappaB activation in monocytes and reduce plasma concentrations of pro-inflammatory mediators in healthy adults. J Nutr. 2007;137:1951-1954 (Pubitemid 47292744)
9. DeFuria J, Bennett G, Strissel KJ, Perfield JW II, Milbury PE, Greenberg AS, Obin MS. Dietary blueberry attenuates whole-body insulin resistance in high fat-fed mice by reducing adipocyte death and its inflammatory sequelae. J Nutr. 2009;139:1510-1516
10. Leahy M, Speroni J, Starr M. Latest developments in cranberry health research. Pharm Biol. 2002;40:50-54 (Pubitemid 34497350)
11. Porter ML, Krueger CG, Wiebe DA, Cunningham DG, Reed JD. Cranberry proanthocyanins associate with low-density lipoprotein and inhibit in vitro Cu2+induced oxidation. J Sci Food Agric. 2001;81:1306-1313
12. Cunningham DG, Vannozzi SA, Turk R, Roderick R, O'Shea E, Brilliant K. Cranberry phytochemicals and their health benefits. In: Shahidi F, Weerasinghe DK, ed. Nutraceutical Beverages: Chemistry, Nutrition, and Health Effects, ACS Symposium Series 871. Washington (DC): American Chemical Society; 2004. p. 35-51.
13. Milbury PE, Cao G, Prior RL, Blumberg J. Bioavailablility of elderberry anthocyanins. Mech Ageing Dev. 2002;123:997-1006.
14. Stoner GD, Sardo C, Apseloff G, Mullet D,WargoW, Pound V, Singh A, Sanders J, Aziz R, et al. harmacokinetics of anthocyanins and ellagic acid in healthy volunteers fed freeze-dried black raspberries for 7 days. J Clin Pharmacol. 2005;45:1153-1164
15. Kay CD, Mazza G, Holub BJ, Wang J. Anthocyanin metabolites in human urine and serum. Br J Nutr. 2004;91:933-942 (Pubitemid 38931457)
16. Kay CD, Mazza G, Holub BJ. Anthocyanins exist in the circulation primarily as metabolites in adult men. J Nutr. 2005;135:2582-2588 (Pubitemid 43156599)
17. Zhang K, Zu Y. GC-MS determination of flavonoids and phenolic and benzoic acids in human plasma after consumption of cranberry juice. J Agric Food Chem. 2004;52:222-227
18. Duthie SJ, Jenkinson AM, Crozier A, Mullen W, Pirie L, Kyle J, Yap LS, Christen P, Duthie GG. The effects of cranberry juice consumption on antioxidant status and biomarkers relating to heart disease and cancer in healthy human volunteers. Eur J Nutr. 2006;45:113-122 (Pubitemid 43345204)
19. Singleton VL, Rossi JA. Colorimetry of total phenolics with phosphomolybdic-phosphotungstic acid reagents. Am J Enol Vitic. 1965;16:144-158
20. Milbury PE, Graf B, Curran-Celentano JM, Blumberg JB. Bilberry (Vaccinium myrtillus) anthocyanins modulate heme oxygenase-1 and glutathione S-transferase-pi expression in ARPE-19 cells. Invest Ophthalmol Vis Sci. 2007;48:2343-2349 (Pubitemid 351261315)
21. Wulf LW, Nagel CW. High-pressure liquid chromatographic separation of anthocyanins of Vitis vinifera. Am J Enol Vitic. 1978;29:42-49
22. Usansky JI, Desai A, Tang-Liu D. Pharmacokinetic and pharmacodynamic resources [cited 2010 Feb 3]. Available from: http://www.boomer.org/pkin.
23. Wu X, Cao G, Prior RL. Absorption and metabolism of anthocyanins in elderly women after consumption of elderberry or blueberry. J Nutr. 2002;132:1865-1871 (Pubitemid 34742869)
24. Wu X, Pittman HE III, Prior RL. Pelargonidin is absorbed and metabolized differently than cyanidin after marionberry consumption in pigs. J Nutr. 2004;134:2603-2610 (Pubitemid 39315260)
25. Manach C, Williamson G, Morand C, Scalbert A, Remesy C. Bioavailability and bioefficacy of polyphenols in humans. I. Review of 97 bioavailability studies. Am J Clin Nutr. 2005;81 Suppl 1:S230-42.
26. Ito H, Gonthiera MP, Manach C, Morand C, Mennen L, Remesy C, Scalbert A. High-throughput profiling of dietary polyphenols and their metabolites by HPLC-ESIMS-MS in human urine. Biofactors. 2004;22:241-243 (Pubitemid 40921795)
27. Felgines C, Texier O, Besson C, Lyan B, Lamaison JL, Scalbert A. Strawberry pelargonidin glycosides are excreted in urine as intact glycosides and glucuronidated pelargonidin derivatives in rats. Br J Nutr. 2007;98:1126-1131 (Pubitemid 350193780)
28. Ohnishi R, Ito H, Kasajima N, Kaneda M, Kariyama R, Kumon H, Hatano T, Yoshida T. Urinary excretion of anthocyanins in humans after cranberry juice ingestion. Biosci Biotechnol Biochem. 2006;70:1681-1687 (Pubitemid 44124927)
29. Charron CS, Clevidence BA, Britz SJ, Novotny JA. Effect of dose size on bioavailability of acylated and nonacylated anthocyanins from red cabbage (Brassica oleracea L. Var. capitata). J Agric Food Chem. 2007;55:5354-5362
30. Bitsch I, Janssen M, Netzel M, Strass G, Frank T. Bioavailability of anthocyanidin-3-glycosides following consumption of elderberry extract and blackcurrant juice. Int J Clin Pharmacol Ther. 2004;42:293-300. (Pubitemid 38679019)
31. Netzel M, Strass G, Janssen M, Bitsch I, Bitsch R. Bioactive anthocyanins detected in human urine after ingestion of blackcurrant juice. J Environ Pathol Toxicol Oncol. 2001;20:89-95. (Pubitemid 32441337)
32. Mulleder U, Murkovic M, Pfannhauser W. Urinary excretion of cyanidin glycosides. J Biochem Biophys Methods. 2002;53:61-66
33. Felgines C, Talavéra S, Gonthier MP, Texier O, Scalbert A, Lamaison JL, Rémésy C. Strawberry anthocyanins are recovered in urine as glucuro- and sulfoconjugates in humans. J Nutr. 2003;133:1296-1301 (Pubitemid 36548697)
34. Carkeet C, Clevidence BA, Novotny JA. Anthocyanin excretion by humans increases linearly with increasing strawberry dose. J Nutr. 2008;138:897-902. (Pubitemid 351571589)
35. Mazza G, Kay CD. Bioactivity, absorption, and metabolism of anthocyanins. In: Daayf F, Lattanzio V, editors. Recent advances in polyphenols research. Hoboken (NJ): Blackwell Publishing; 2008. p. 228-262
36. Lampe JW, Chang JL. Interindividual differences in phytochemical metabolism and disposition. Semin Cancer Biol. 2007;17:347-353
37. Kalea AZ, Clark K, Schuschke DA, Klimis-Zacas DJ. Vascular reactivity is affected by dietary consumption of wild blueberries in the Sprague-Dawley rat. J Med Food. 2009;12:21-28
38. Ruel G, Pomerleau S, Couture P, Lemieux S, Lamarche B, Couillard C. Favourable impact of low-calorie cranberry juice consumption on plasma HDL-cholesterol concentrations in men. Br J Nutr. 2006;96:357-364 (Pubitemid 46470104)
39. Ruel G, Pomerleau S, Couture P, Lemieux S, Lamarche B, Couillard C. Low-calorie cranberry juice supplementation reduces plasma oxidized LDL and cell adhesion molecule concentrations in men. Br J Nutr. 2008;99:352-359