Regulation of glucose transporter expression in human intestinal Caco-2 cells following exposure to an anthocyanin-rich berry extract

PLoS ONE

Volumn 8, Issue 11, 2013, Pages

  Alzaid, Fawaz ^a   Cheung, Hoi Man ^a   Preedy, Victor R ^a   Sharp, Paul A ^a  

^a KING'S COLLEGE LONDON   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ANTHOCYANINS; BIOLOGICAL TRANSPORT; CACO-2 CELLS; DOWN-REGULATION; DRUG EVALUATION, PRECLINICAL; FRAGARIA; FRUIT; GENE EXPRESSION; GLUCOSE; GLUCOSE TRANSPORTER TYPE 2; HUMANS; HYPOGLYCEMIC AGENTS; PLANT EXTRACTS; SAMBUCUS; SODIUM-GLUCOSE TRANSPORTER 1; VACCINIUM;

EID: 84893593461     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0078932     Document Type: Article

References (32)

1. Debnam ES, Levin RJ (1975) An experimental method of identifying and quantifying the active transfer electrogenic component from the diffusive component during sugar absorption measured in vivo. J Physiol. 246: 181-96.
2. Kellett GL (2001) The facilitated component of intestinal glucose absorption. J Physiol. 531: 585-95.
3. Puupponen-Pimiä R, Nohynek L, Alakomi HL, Oksman-Caldentey KM (2005) The action of berry phenolics against human intestinal pathogens. Biofactors. 23: 243-251. (Pubitemid 43264775)
4. McDougall GJ, Shpiro F, Dobson P, Smith P, Blake A, et al. (2005) Different polyphenolic components of soft fruits inhibit alpha-amylase and alpha-glucosidase. J Agric Food Chem 53: 2760-2766. (Pubitemid 40471760)
5. Törrönen R, Sarkkinen E, Tapola N, Hautaniemi E, Kilpi K, et al. (2010) Berries modify the postprandial plasma glucose response to sucrose in healthy subjects. Br J Nutr. 103: 1094-1097.
6. Johnston K, Sharp P, Clifford M, Morgan L (2005) Dietary polyphenols decrease glucose uptake by human intestinal Caco-2 cells. FEBS Lett. 579: 1653-1657. (Pubitemid 40341538)
7. Kwon O, Eck P, Chen S, Corpe CP, Lee JH, et al. (2007) Inhibition of the intestinal glucose transporter GLUT2 by flavonoids. FASEB J. 21: 366-377. (Pubitemid 46213484)
8. Manzano S, Williamson G (2010) Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol Nutr Food Res. 54: 1773-1780.
9. Chantret I, Rodolosse A, Barbat A, Dussaulx E, Brot-Laroche E, et al. (1994) Differential expression of sucrase-isomaltase in clones isolated from early and late passages of the cell line Caco-2: evidence for glucose-dependent negative regulation. J Cell Sci. 107: 213-225. (Pubitemid 24039048)
10. Mahraoui L, Rodolosse A, Barbat A, Dussaulx E, Zweibaum A, et al. (1994) Presence and differential expression of SGLT1, GLUT1, GLUT2, GLUT3 and GLUT5 hexose-transporter mRNAs in Caco-2 cell clones in relation to cell growth and glucose consumption. Biochem J. 298: 629-633. (Pubitemid 24085188)
11. Chaston T, Chung B, Mascarenhas M, Marks J, Patel B, et al. (2008) Evidence for differential effects of hepcidin in macrophages and intestinal epithelial cells. Gut. 57: 374-382. (Pubitemid 351288105)
12. Faria A, Pestana D, Azevedo J, Martel F, de Freitas V, et al. (2009) Absorption of anthocyanins through intestinal epithelial cells - Putative involvement of GLUT2. Mol Nutr Food Res. 53: 1430-1437.
13. Williamson G (2013) Possible effects of dietary polyphenols on sugar absorption and digestion. Mol Nutr Food Res. 57: 48-57.
14. Kellett GL, Brot-Laroche E, Mace OJ, Leturque A (2008) Sugar absorption in the intestine: the role of GLUT2. Annu Rev Nutr. 28: 35-54.
15. Corpe CP, Basaleh MM, Affleck J, Gould G, Jess TJ, et al. (1996) The regulation of GLUT5 and GLUT2 activity in the adaptation of intestinal brush-border fructose transport in diabetes. Pflugers Arch. 432: 192-201. (Pubitemid 26226101)
16. Helliwell PA, Richardson M, Affleck J, Kellett GL (2000) Regulation of GLUT5, GLUT2 and intestinal brush-border fructose absorption by the extracellular signal-regulated kinase, p38 mitogen-activated kinase and phosphatidylinositol 3-kinase intracellular signalling pathways: implications for adaptation to diabetes. Biochem J. 350: 163-169.
17. Ait-Omar A, Monteiro-Sepulveda M, Poitou C, Le Gall M, Cotillard A, et al. (2011) GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice. Diabetes.60: 2598-2607.
18. Ferraris RP, Diamond JM (1993) Crypt/villus site of substrate-dependent regulation of mouse intestinal glucose transporters. Proc Natl Acad Sci U S A.90: 5868-5872. (Pubitemid 23176264)
19. Burant CF, Saxena M (1994) Rapid reversible substrate regulation of fructose transporter expression in rat small intestine and kidney. Am J Physiol. 267: G71- G79.
20. Gouyon F, Caillaud L, Carriere V, Klein C, Dalet V, et al. (2003) Simple-sugar meals target GLUT2 at enterocyte apical membranes to improve sugar absorption: a study in GLUT2-null mice. J Physiol. 552: 823-832. (Pubitemid 37428423)
21. Margolskee RF, Dyer J, Kokrashvili Z, Salmon KS, Ilegems E, et al. (2007) T1R3 and gustducin in gut sense sugars to regulate expression of Na+-glucose cotransporter 1. Proc Natl Acad Sci USA. 104: 15075-15080. (Pubitemid 47619595)
22. Oliveira DM, Freitas HS, Souza MF, Arçari DP, Ribeiro ML, et al. (2008) Yerba Maté (Ilex paraguariensis) aqueous extract decreases intestinal SGLT1 gene expression but does not affect other biochemical parameters in alloxan-diabetic Wistar rats. J Agric Food Chem. 56: 10527-10532.
23. Tobin V, Le Gall M, Fioramonti X, Stolarczyk E, Blazquez AG, et al. (2008) Insulin internalizes GLUT2 in the enterocytes of healthy but not insulin-resistant mice. Diabetes. 57: 555-562.
24. Khoursandi S, Scharlau D, Herter P, Kuhnen C, Martin D, et al. (2008) Different modes of sodium-D-glucose cotransporter-mediated D-glucose uptake regulation in Caco-2 cells. Am J Physiol 287: C1041-C1047. (Pubitemid 39238328)
25. Kellett GL, Helliwell PA (2000) The diffusive component of intestinal glucose absorption is mediated by the glucose-induced recruitment of GLUT2 to the brush-border membrane. Biochem J. 350: 155-162.
26. Williams M, Sharp P (2002) Regulation of jejunal glucose transporter expression by forskolin. Biochim et Biophys Acta 1559: 179-185. (Pubitemid 34164426)
27. Gorboulev V, Schürmann A, Vallon V, Kipp H, Jaschke A, et al. (2012) Na(+)-D-glucose cotransporter SGLT1 is pivotal for intestinal glucose absorption and glucose-dependent incretin secretion. Diabetes. 61: 187-196.
28. Morgan EL, Mace OJ, Affleck J, Kellett GL (2007) Apical GLUT2 and Cav1.3: regulation of rat intestinal glucose and calcium absorption. J Physiol. 580: 593-604. (Pubitemid 46564184)
29. Mace OJ, Affleck J, Patel N, Kellett GL (2007) Sweet taste receptors in rat small intestine stimulate glucose absorption through apical GLUT2. J Physiol. 582: 379-392. (Pubitemid 46993582)
30. Sharp PA, Debnam ES, Srai SK (1996) Rapid enhancement of brush border glucose uptake after exposure of rat jejunal mucosa to glucose. Gut. 39: 545-550. (Pubitemid 26376037)
31. Raybould HE (2008) Nutrient sensing in the gastrointestinal tract: possible role for nutrient transporters. J Physiol Biochem. 64: 349-356.
32. Le Gall M, Tobin V, Stolarczyk E, Dalet V, Leturque A, et al. (2007) Sugar sensing by enterocytes combines polarity, membrane bound detectors and sugar metabolism. J Cell Physiol. 213: 834-843. (Pubitemid 350058278)