-
1
-
-
79955563790
-
Organic synthesis toward small-molecule probes and drugs
-
Schreiber, S.L. Organic synthesis toward small-molecule probes and drugs. Proc. Nat. Acad. Sci. U.S.A., 2011, 108, 6699-6702.
-
(2011)
Proc. Nat. Acad. Sci. U.S.A.
, vol.108
, pp. 6699-6702
-
-
Schreiber, S.L.1
-
2
-
-
11144298973
-
Exploring biology with small organic molecules
-
Stockwell, B.R. Exploring biology with small organic molecules. Nature, 2004, 432(7019), 846-854.
-
(2004)
Nature
, vol.432
, Issue.7019
, pp. 846-854
-
-
Stockwell, B.R.1
-
3
-
-
79960937702
-
Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition
-
Ray, R.S.; Corcoran, A. E.; Brus, R.D.; Kim, J.C.; Richerson, G.B.; Nattie, E.; Dymecki, S.M. Impaired respiratory and body temperature control upon acute serotonergic neuron inhibition. Science, 2011, 333, 637-642.
-
(2011)
Science
, vol.333
, pp. 637-642
-
-
Ray, R.S.1
Corcoran, A.E.2
Brus, R.D.3
Kim, J.C.4
Richerson, G.B.5
Nattie, E.6
Dymecki, S.M.7
-
4
-
-
77952477596
-
Privileged scaffolds for library design and drug discovery
-
Welsch, M.E.; Snyder, S.A.; Stockwell, B.R. Privileged scaffolds for library design and drug discovery. Curr. Opin. Chem. Biol., 2010, 14(3), 347-361.
-
(2010)
Curr. Opin. Chem. Biol.
, vol.14
, Issue.3
, pp. 347-361
-
-
Welsch, M.E.1
Snyder, S.A.2
Stockwell, B.R.3
-
5
-
-
4243159924
-
Privileged structures: Applications in drug discovery
-
DeSimone, R.W.; Currie, K.S.; Mitchell, S. A.; Darrow, J.W.; Pippin, D.A. Privileged structures: Applications in drug discovery. Comb. Chem. High Throughput Screen., 2004, 7(3), 473-493.
-
(2004)
Comb. Chem. High Throughput Screen.
, vol.7
, Issue.3
, pp. 473-493
-
-
DeSimone, R.W.1
Currie, K.S.2
Mitchell, S.A.3
Darrow, J.W.4
Pippin, D.A.5
-
6
-
-
84872701305
-
Generation of molecular shape diversity. From privileged scaffolds to diverted total synthesis
-
Dai, W.-M. Generation of molecular shape diversity. from privileged scaffolds to diverted total synthesis. Diver.-Orient. Synth., 2012, 1, 11-20.
-
(2012)
Diver.-Orient. Synth.
, vol.1
, pp. 11-20
-
-
Dai, W.-M.1
-
7
-
-
25644454404
-
Pharmaceuticals: A new grammar for drug discovery
-
Fishman, M.C.; Porter, J.A. Pharmaceuticals: A new grammar for drug discovery. Nature, 2005, 437(7058), 491-493.
-
(2005)
Nature
, vol.437
, Issue.7058
, pp. 491-493
-
-
Fishman, M.C.1
Porter, J.A.2
-
8
-
-
0037785175
-
Chemistry challenges in lead optimization: Silicon isosteres in drug discovery
-
Showell, G.A.; Mills, J.S. Chemistry challenges in lead optimization: silicon isosteres in drug discovery. Drug Discov. Today, 2003, 8(12), 551-556.
-
(2003)
Drug Discov. Today
, vol.8
, Issue.12
, pp. 551-556
-
-
Showell, G.A.1
Mills, J.S.2
-
9
-
-
44949231073
-
Peptidomimetics, a synthetic tool of drug discovery
-
Vagner, J.; Qu, H.; Hruby, V.J. Peptidomimetics, a synthetic tool of drug discovery. Curr. Opin. Chem. Biol., 2008 12(3), 292- 296.
-
(2008)
Curr. Opin. Chem. Biol.
, vol.12
, Issue.3
, pp. 292-296
-
-
Vagner, J.1
Qu, H.2
Hruby, V.J.3
-
10
-
-
79955419410
-
Synopsis of some recent tactical application of bioisosteres in drug design
-
Meanwel, N.A. Synopsis of some recent tactical application of bioisosteres in drug design. J. Med. Chem., 2011, 54(8), 2529-2591.
-
(2011)
J. Med. Chem.
, vol.54
, Issue.8
, pp. 2529-2591
-
-
Meanwel, N.A.1
-
11
-
-
33646125891
-
Lessons from the drug discovery of lapatinib, a dual ErbB1/2 tyrosine kinase inhibitor
-
Lackey, K.E. Lessons from the drug discovery of lapatinib, a dual ErbB1/2 tyrosine kinase inhibitor. Curr. Top. Med. Chem., 2006, 6(5), 435-460.
-
(2006)
Curr. Top. Med. Chem.
, vol.6
, Issue.5
, pp. 435-460
-
-
Lackey, K.E.1
-
12
-
-
35448937282
-
The discovery of the factor Xa inhibitor otamixaban: From lead identification to clinical development
-
Guertin, K.R.; Choi, Y-M. The discovery of the factor Xa inhibitor otamixaban: from lead identification to clinical development. Curr. Med. Chem., 2007, 14(23), 2471-2481.
-
(2007)
Curr. Med. Chem.
, vol.14
, Issue.23
, pp. 2471-2481
-
-
Guertin, K.R.1
Choi, Y.-M.2
-
13
-
-
8544243974
-
The metabolism of nicotinamide-N-oxide
-
Chaykin, S.; Bloch, K. The metabolism of nicotinamide-N-oxide. Biochim. Biophys. Acta, 1959, 31(1), 1213-1216.
-
(1959)
Biochim. Biophys. Acta
, vol.31
, Issue.1
, pp. 1213-1216
-
-
Chaykin, S.1
Bloch, K.2
-
14
-
-
84868518284
-
Genotoxicity evaluation of mequindox in different short-term tests
-
Ihsan, A.; Wang, X.; Tu H-G.; Zhang, W.; Dai, M-H.; Peng, D-P.; Wang, Yu-L.; Huang, L-L.; Chen, D.-M.; Mannan, S.; Tao, Y-F.; Liu, Z-L.; Yuan, Z-H. Genotoxicity evaluation of mequindox in different short-term tests. Food Chem. Toxicol., 2013, 51, 330-336.
-
(2013)
Food Chem. Toxicol.
, vol.51
, pp. 330-336
-
-
Tu, H.-G.1
Ihsan, A.2
Wang, X.3
Zhang, W.4
Dai, M.-H.5
Peng, D.-P.6
Wang, Y.-L.7
Huang, L.-L.8
Chen, D.-M.9
Mannan, S.10
Tao, Y.-F.11
Liu, Z.-L.12
Yuan, Z.-H.13
-
15
-
-
33646755473
-
Discovery and development of smallmolecule chemokine coreceptor CCR5 antagonists
-
Palani, A.; Tagat, J.R. Discovery and development of smallmolecule chemokine coreceptor CCR5 antagonists. J. Med. Chem., 2006, 49, 2851-2856.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 2851-2856
-
-
Palani, A.1
Tagat, J.R.2
-
16
-
-
0141889021
-
Generation of predictive pharmacophore models for CCR5 antagonists: Study with piperidine- and piperazine-based compounds as a new class of HIV-1 entry inhibitors
-
Debnath, A.K. Generation of predictive pharmacophore models for CCR5 antagonists: Study with piperidine- and piperazine-based compounds as a new class of HIV-1 entry inhibitors. J. Med. Chem., 2003, 46, 4501-4515.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4501-4515
-
-
Debnath, A.K.1
-
17
-
-
0035846070
-
Piperazine-based CCR5 antagonists as HIV-1 Inhibitors. II. Discovery of 1- [(2, 4-dimethyl-3-pyridinyl)carbonyl]-4-methyl-4- [3(S)- methyl-4- [1(S)- [4-(trifluorome-thyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist
-
Tagat, J.R.; Steensm, R.W.; McCombie, S.W.; Dennis, V.; Nazaren, D.V.; Lin, S-L.; Neustadt, B.R.; Cox, K.; Xu, S.; Wojcik, L.; Murray, M.G.; Vantuno, N.; Baroudy, B.M.; Strizki, J.M. Piperazine-based CCR5 antagonists as HIV-1 Inhibitors. II. Discovery of 1- [(2, 4-dimethyl-3-pyridinyl)carbonyl]-4-methyl-4- [3(S)- methyl-4- [1(S)- [4-(trifluorome-thyl)phenyl]ethyl]-1-piperazinyl]- piperidine N1-oxide (Sch-350634), an orally bioavailable, potent CCR5 antagonist. J. Med. Chem., 2001, 44, 3343-3346.
-
(2001)
J. Med. Chem.
, vol.44
, pp. 3343-3346
-
-
Tagat, J.R.1
Steensm, R.W.2
McCombie, S.W.3
Dennis, V.4
Nazaren, D.V.5
Lin, S.-L.6
Neustadt, B.R.7
Cox, K.8
Xu, S.9
Wojcik, L.10
Murray, M.G.11
Vantuno, N.12
Baroudy, B.M.13
Strizki, J.M.14
-
18
-
-
0034830902
-
Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1, 4-di-N-oxide
-
Ganley, B.; Chowdhury, G.; Bhansali, J.; Daniels, J.S.; Gates, K.S. Redox-activated, hypoxia-selective DNA cleavage by quinoxaline 1, 4-di-N-oxide. Bioorg. Med. Chem., 2001, 9, 2395-2401.
-
(2001)
Bioorg. Med. Chem.
, vol.9
, pp. 2395-2401
-
-
Ganley, B.1
Chowdhury, G.2
Bhansali, J.3
Daniels, J.S.4
Gates, K.S.5
-
19
-
-
33847344577
-
Synthesis and antimalarial activity of new isotebuquine analogues
-
Miroshnikova, O.V.; Hudson, T.H.; Gerena, L.; Kyle, D.E.; Lin, A.J. Synthesis and antimalarial activity of new isotebuquine analogues. J. Med. Chem., 2007, 50, 889-896.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 889-896
-
-
Miroshnikova, O.V.1
Hudson, T.H.2
Gerena, L.3
Kyle, D.E.4
Lin, A.J.5
-
20
-
-
84868125592
-
Antibacterial, antifungal and antileishmanial activities of indolone-N-oxide derivatives
-
Ibrahim, H.; Furiga, A.; Najahi, E.; Pigasse Henocq, C.; Nallet, J.P.; Roques, C.; Aubouy, A.; Sauvain, M.; Constant, P.; Daffe, M.; Nepveu, F. Antibacterial, antifungal and antileishmanial activities of indolone-N-oxide derivatives. J. Antibiot., 2012, 65(10), 499- 504.
-
(2012)
J. Antibiot.
, vol.65
, Issue.10
, pp. 499-504
-
-
Ibrahim, H.1
Furiga, A.2
Najahi, E.3
Pigasse Henocq, C.4
Nallet, J.P.5
Roques, C.6
Aubouy, A.7
Sauvain, M.8
Constant, P.9
Daffe, M.10
Nepveu, F.11
-
21
-
-
0033931470
-
Synthesis and herbicidal activity of N-oxide derivatives
-
Cerecetto, H.; Dias, E.; Di Maio, R.; Gonzalez, M.; Pacce, S.; Saenz, P.; Seoane, G. Synthesis and herbicidal activity of N-oxide derivatives. J. Agric. Food Chem., 2000, 48, 2995-3002.
-
(2000)
J. Agric. Food Chem.
, vol.48
, pp. 2995-3002
-
-
Cerecetto, H.1
Dias, E.2
Di Maio, R.3
Gonzalez, M.4
Pacce, S.5
Saenz, P.6
Seoane, G.7
-
22
-
-
1542507111
-
Minoxidil: Mechanisms of action on hair growth
-
Messenger, A.G.; Rundegren, J. Minoxidil: mechanisms of action on hair growth. Br. J. Dermatol., 2004, 150, 186-194.
-
(2004)
Br. J. Dermatol.
, vol.150
, pp. 186-194
-
-
Messenger, A.G.1
Rundegren, J.2
-
23
-
-
80051787124
-
Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil
-
Padois, K.; Cantien, C.; Bertholle, V. Solid lipid nanoparticles suspension versus commercial solutions for dermal delivery of minoxidil. Int. J. Pharm., 2011, 416, 300-304.
-
(2011)
Int. J. Pharm.
, vol.416
, pp. 300-304
-
-
Padois, K.1
Cantien, C.2
Bertholle, V.3
-
24
-
-
0028915434
-
Nitric oxide as a neurotransmitter in peripheral nerves: Nature of transmitter and mechanism of transmission
-
Rand, M.J.; Li, C.G. Nitric oxide as a neurotransmitter in peripheral nerves: nature of transmitter and mechanism of transmission. Ann. Rev. Physiol., 1995, 57, 659-682.
-
(1995)
Ann. Rev. Physiol.
, vol.57
, pp. 659-682
-
-
Rand, M.J.1
Li, C.G.2
-
25
-
-
0025317146
-
Nitric oxide as an inhibitory non-adrenergic noncholinergic neurotransmitter
-
Bult, H.; Boeckxstaens, G.E.; Pelckmans, P.A.; Jordaens, F.H.; Van Maercke, Y.M.; Herman, A.G. Nitric oxide as an inhibitory non-adrenergic noncholinergic neurotransmitter. Nature, 1990, 345, 346-347.
-
(1990)
Nature
, vol.345
, pp. 346-347
-
-
Bult, H.1
Boeckxstaens, G.E.2
Pelckmans, P.A.3
Jordaens, F.H.4
Van Maercke, Y.M.5
Herman, A.G.6
-
26
-
-
0035675210
-
Minoxidil- induced hair growth is mediated by adenosine in cultured dermal papilla cells: Possible involvement of sulfonylurea receptor 2B as a target of minoxidil
-
Li, M.; Marubayashi, A.; Nakaya, Y.; Fukui, K.; Arase, S. Minoxidil- induced hair growth is mediated by adenosine in cultured dermal papilla cells: possible involvement of sulfonylurea receptor 2B as a target of minoxidil. J. Invest. Dermatol., 2001, 117, 1594- 1600.
-
(2001)
J. Invest. Dermatol.
, vol.117
, pp. 1594-1600
-
-
Li, M.1
Marubayashi, A.2
Nakaya, Y.3
Fukui, K.4
Arase, S.5
-
27
-
-
0019977745
-
Sulfation of minoxidil by liver sulfotransferase
-
Johnson, G.A.; Barsuhn, K.J.; McCall, J.M. Sulfation of minoxidil by liver sulfotransferase. Biochem. Pharmacol., 1982, 31, 2949-2954.
-
(1982)
Biochem. Pharmacol.
, vol.31
, pp. 2949-2954
-
-
Johnson, G.A.1
Barsuhn, K.J.2
McCall, J.M.3
-
28
-
-
16844378485
-
Novel and established potassium channel openers stimulate hair growth in vitro: Implications for their modes of action in hair follicles
-
Davies, G.C.; Thornton, M.J.; Jenner, T.J.; Chen, Y.J.; Hansen, J.B.; Carr, R.D.; Randall, V.A. Novel and established potassium channel openers stimulate hair growth in vitro: implications for their modes of action in hair follicles. J. Invest. Dermatol., 2005, 124(4), 686-694.
-
(2005)
J. Invest. Dermatol.
, vol.124
, Issue.4
, pp. 686-694
-
-
Davies, G.C.1
Thornton, M.J.2
Jenner, T.J.3
Chen, Y.J.4
Hansen, J.B.5
Carr, R.D.6
Randall, V.A.7
-
29
-
-
10344226299
-
A double-blind, placebo-controlled trial of VX- 745, an oral p38 mitogen activated protein kinase (MAPK) inhibitor, in patients with rheumatoid arthritis (RA)
-
Present at EULAR 2002. Stockholm, Sweden
-
Weisman, M.; Furst, D.; Schiff, M.; Kauffman, R.; Merica, E.; Martin-Munley, S. A double-blind, placebo-controlled trial of VX- 745, an oral p38 mitogen activated protein kinase (MAPK) inhibitor, in patients with rheumatoid arthritis (RA). Present at EULAR 2002. Stockholm, Sweden. Abstract FRI0018. Ann. Rheum. Dis., 2002, 61, (Suppl. 2), 166.
-
(2002)
Ann. Rheum. Dis.
, vol.61
, pp. 166
-
-
Weisman, M.1
Furst, D.2
Schiff, M.3
Kauffman, R.4
Merica, E.5
Martin-Munley, S.6
-
30
-
-
0037434510
-
Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors, Development of an orally bioavailable series containing P1 and P3 pyridines
-
Burgey, C.S.; Robinson, K.A.; Lyle, T.A.; Sanderson, P.E.J.; Lewis, S.D.; Lucas, B.J.; Krueger, J.A.; Singh, R.; Miller-Stein, C.; White, R.B.; Wong, B.; Lyle, E.A.; Williams, P.D.; Coburn, C.A.; Dorsey, B.D.; Barrow, J.C.; Stranieri, M.T.; Holahan, M.A.; Sitko, G.R.; Cook, J.J.; McMasters, D.R.; McDonough, C.M.; Sanders, W.M.; Wallace, A.A.; Clayton, F.C.; Bohn, D.; Leonard, Y.M. Jr.; Detwiler, T.J. Jr.; Lynch, J.J. Jr.; Yan, Y.; Chen, Z.; Kuo, L.; Gardell, S.J.; Shafer, J.A.; Vacca, J.P. Metabolism-directed optimization of 3-aminopyrazinone acetamide thrombin inhibitors. Development of an orally bioavailable series containing P1 and P3 pyridines. J. Med. Chem., 2003, 46, 461-473.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 461-473
-
-
Burgey, C.S.1
Robinson, K.A.2
Lyle, T.A.3
Sanderson, P.E.J.4
Lewis, S.D.5
Lucas, B.J.6
Krueger, J.A.7
Singh, R.8
Miller-Stein, C.9
White, R.B.10
Wong, B.11
Lyle, E.A.12
Williams, P.D.13
Coburn, C.A.14
Dorsey, B.D.15
Barrow, J.C.16
Stranieri, M.T.17
Holahan, M.A.18
Sitko, G.R.19
Cook, J.J.20
McMasters, D.R.21
McDonough, C.M.22
Sanders, W.M.23
Wallace, A.A.24
Clayton, F.C.25
Bohn, D.26
Leonard, Y.M.27
Detwiler, T.J.28
Lynch, J.J.29
Yan, Y.30
Chen, Z.31
Kuo, L.32
Gardell, S.J.33
Shafer, J.A.34
Vacca, J.P.35
more..
-
31
-
-
0037460188
-
Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: The role of redox equilibria
-
Anderson, R.F.; Shinde, S.S.; Hay, M.P.; Gamage, S.A.; Denny, W.A. Potentiation of the cytotoxicity of the anticancer agent tirapazamine by benzotriazine N-oxides: The role of redox equilibria. J. Am. Chem. Soc., 2003, 125, 748-756.
-
(2003)
J. Am. Chem. Soc.
, vol.125
, pp. 748-756
-
-
Anderson, R.F.1
Shinde, S.S.2
Hay, M.P.3
Gamage, S.A.4
Denny, W.A.5
-
32
-
-
3042544368
-
Oxidation of 2- deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1, 2, 4- benzotriazine 1, 4-dioxides
-
Shinde, S.S.; Anderson, R.F.; Hay, M.P.; Gamage, S.A.; Denny, W.A. Oxidation of 2- deoxyribose by benzotriazinyl radicals of antitumor 3-amino-1, 2, 4- benzotriazine 1, 4-dioxides. J. Am. Chem. Soc., 2004, 126, 7853- 7864.
-
(2004)
J. Am. Chem. Soc.
, vol.126
, pp. 7853-7864
-
-
Shinde, S.S.1
Anderson, R.F.2
Hay, M.P.3
Gamage, S.A.4
Denny, W.A.5
-
33
-
-
0026802366
-
Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation
-
Wang, J.; Biedermann, K.A.; Brown, J.M. Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation. Cancer Res., 1992, 52, 4473-4477.
-
(1992)
Cancer Res
, vol.52
, pp. 4473-4477
-
-
Wang, J.1
Biedermann, K.A.2
Brown, J.M.3
-
34
-
-
0030009223
-
Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro
-
Siim, B.G.; van Zijl, P.L.; Brown, J.M. Tirapazamine-induced DNA damage measured using the comet assay correlates with cytotoxicity towards hypoxic tumour cells in vitro. Br. J. Cancer, 1996, 73, 952-960.
-
(1996)
Br. J. Cancer
, vol.73
, pp. 952-960
-
-
Siim, B.G.1
Van Zijl, P.L.2
Brown, J.M.3
-
35
-
-
0030871773
-
Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: Relationship to tumor hypoxia
-
Siim, B.G.; Menke, D.R.; Dorie, M.J.; Brown, J.M. Tirapazamine-induced cytotoxicity and DNA damage in transplanted tumors: relationship to tumor hypoxia. Cancer Res., 1997, 57, 2922-2928.
-
(1997)
Cancer Res
, vol.57
, pp. 2922-2928
-
-
Siim, B.G.1
Menke, D.R.2
Dorie, M.J.3
Brown, J.M.4
-
37
-
-
39149094633
-
Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation
-
Evans, J.W.; Chernikova, S.B.; Kachnic, L.A.; Banath, J.P.; Sordet, O.; Delahoussaye, Y.M.; Treszezamsky, A.; Chon, B.H.; Feng, Z.; Gu, Y.; Wilson, W.R.; Pommier, Y.; Olive, P.L.; Powell, S.N.; Brown, J.M. Repair of DNA and chromosome breaks in cells exposed to SR 4233 under hypoxia or to ionizing radiation. Cancer Res., 2008, 68, 257-265.
-
(2008)
Cancer Res
, vol.68
, pp. 257-265
-
-
Evans, J.W.1
Chernikova, S.B.2
Kachnic, L.A.3
Banath, J.P.4
Sordet, O.5
Delahoussaye, Y.M.6
Treszezamsky, A.7
Chon, B.H.8
Feng, Z.9
Gu, Y.10
Wilson, W.R.11
Pommier, Y.12
Olive, P.L.13
Powell, S.N.14
Brown, J.M.15
-
38
-
-
0029959898
-
DNA cleavage by the antitumor agent 3-amino-1, 2, 4-benzotriazine 1, 4-dioxide (SR4233): Evidence for involvement of hydroxyl radical
-
Daniels, J.S.; Gates, K.S. DNA cleavage by the antitumor agent 3-amino-1, 2, 4-benzotriazine 1, 4-dioxide (SR4233): Evidence for involvement of hydroxyl radical. J. Am. Chem. Soc., 1996, 118, 3380-3385.
-
(1996)
J. Am. Chem. Soc.
, vol.118
, pp. 3380-3385
-
-
Daniels, J.S.1
Gates, K.S.2
-
39
-
-
0037009278
-
Oxidative DNA base damage by the antitumor agent 3-amino-1, 2, 4- benzotriazine 1, 4-dioxide (Tirapazamine)
-
Kotandeniya, D.; Ganley, B.; Gates, K. Oxidative DNA base damage by the antitumor agent 3-amino-1, 2, 4- benzotriazine 1, 4-dioxide (Tirapazamine). Bioorg. Med. Chem. Lett., 2002, 12, 2325-2329.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 2325-2329
-
-
Kotandeniya, D.1
Ganley, B.2
Gates, K.3
-
40
-
-
0042348003
-
A mass spectrometry study of tirapazamine and its metabolites: Insights into the mechanism of metabolic transformations and characterization of reaction intermediates
-
Zagorevskii, D.; Song, M.; Breneman, C.; Yuan, Y.; Fuchs, T.; Gates, K.S.; Greenlief, C.M. A mass spectrometry study of tirapazamine and its metabolites: insights into the mechanism of metabolic transformations and characterization of reaction intermediates. J. Am. Soc. Mass Spectrom., 2003, 14, 881-892.
-
(2003)
J. Am. Soc. Mass Spectrom.
, vol.14
, pp. 881-892
-
-
Zagorevskii, D.1
Song, M.2
Breneman, C.3
Yuan, Y.4
Fuchs, T.5
Gates, K.S.6
Greenlief, C.M.7
-
41
-
-
84859796244
-
Furoxans (1, 2, 5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents
-
Schiefer, I.T.; VandeVrede, L.; Fa', M.; Arancio, O.; Thatcher, G.R.J. Furoxans (1, 2, 5-oxadiazole-N-oxides) as novel NO mimetic neuroprotective and procognitive agents J. Med. Chem., 2012, 55, 3076-3087.
-
(2012)
J. Med. Chem.
, vol.55
, pp. 3076-3087
-
-
Schiefer, I.T.1
VandeVrede, L.2
Fa, M.3
Arancio, O.4
Thatcher, G.R.J.5
-
42
-
-
33745625064
-
NO chimeras as therapeutic agents in Alzheimer's disease
-
Thatcher, G.R.J.; Bennett, B.M.; Reynolds, J.N. NO chimeras as therapeutic agents in Alzheimer's disease. Curr. Alzheimer Res., 2006, 3, 237-245.
-
(2006)
Curr. Alzheimer Res.
, vol.3
, pp. 237-245
-
-
Thatcher, G.R.J.1
Bennett, B.M.2
Reynolds, J.N.3
-
43
-
-
8844265397
-
Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants
-
Cena, C.; Boschi, D.; Tron, G.C.; Chegaev, K.; Lazzarato, L.; Di Stilo, A.; Aragno, M.; Fruttero, R.; Gasco, A. Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants. Bioorg. Med. Chem. Lett., 2004, 14, 5971-5974.
-
(2004)
Bioorg. Med. Chem. Lett.
, vol.14
, pp. 5971-5974
-
-
Cena, C.1
Boschi, D.2
Tron, G.C.3
Chegaev, K.4
Lazzarato, L.5
Di Stilo, A.6
Aragno, M.7
Fruttero, R.8
Gasco, A.9
-
44
-
-
0024099850
-
The history of the development of minoxidil
-
Zins, G.R. The history of the development of minoxidil. Clin. Dermatol., 1988, 6, 132-147.
-
(1988)
Clin. Dermatol.
, vol.6
, pp. 132-147
-
-
Zins, G.R.1
-
45
-
-
0025202686
-
Minoxidil sulfate is the active metabolite that stimulates hair follicles
-
Buhl, A.E.; Waldon, D.J.; Baker, C.A.; Johnson, G.A. Minoxidil sulfate is the active metabolite that stimulates hair follicles. J. Invest. Dermatol., 1990, 95, 553-557.
-
(1990)
J. Invest. Dermatol.
, vol.95
, pp. 553-557
-
-
Buhl, A.E.1
Waldon, D.J.2
Baker, C.A.3
Johnson, G.A.4
-
46
-
-
0027371858
-
Potassium channel openers stimulate DNA synthesis in mouse epidermal keratinocyte and whole hair follicle cultures
-
Harmon, C.S.; Ducote, L.D. Potassium channel openers stimulate DNA synthesis in mouse epidermal keratinocyte and whole hair follicle cultures. J. Skin Pharmacol., 1993, 6, 170-178.
-
(1993)
J. Skin Pharmacol.
, vol.6
, pp. 170-178
-
-
Harmon, C.S.1
Ducote, L.D.2
-
47
-
-
0019977745
-
Sulfation of minoxidil by liver sulfotransferase
-
Johnson, G. A.; Barsuhn, K.J.; McCall, J.M. Sulfation of minoxidil by liver sulfotransferase. Biochem. Pharmacol., 1982, 31, 2949-2954.
-
(1982)
Biochem. Pharmacol.
, vol.31
, pp. 2949-2954
-
-
Johnson, G.A.1
Barsuhn, K.J.2
McCall, J.M.3
-
48
-
-
0024603159
-
The pharmacokinetics of 2.5- to 10-mg oral doses of minoxidil in healthy volunteers
-
Fleishaker, J.C.; Andreadis, N.A.; Welshma, I.R.; Wright, C.E. The pharmacokinetics of 2.5- to 10-mg oral doses of minoxidil in healthy volunteers. J. Clin. Pharmacol., 1989, 29, 162-167.
-
(1989)
J. Clin. Pharmacol.
, vol.29
, pp. 162-167
-
-
Fleishaker, J.C.1
Andreadis, N.A.2
Welshma, I.R.3
Wright, C.E.4
-
49
-
-
0016753713
-
Metabolism of minoxidil, a new hypotensive agent I: Absorption, distribution, and excretion following administration to rats, dogs, and monkeys
-
Thoma, R.C.; Harpootlian, H. Metabolism of minoxidil, a new hypotensive agent I: Absorption, distribution, and excretion following administration to rats, dogs, and monkeys. J. Pharm. Sci., 1975, 64, 1366-1371.
-
(1975)
J. Pharm. Sci.
, vol.64
, pp. 1366-1371
-
-
Thoma, R.C.1
Harpootlian, H.2
-
50
-
-
0019977745
-
Sulfation of minoxidil by liver sulfotransferase
-
Johnson, G.A.; Barsuhn, K.J.; McCall, J.M. Sulfation of minoxidil by liver sulfotransferase. Biochem. Pharmacol., 1982, 31, 2949-2954.
-
(1982)
Biochem. Pharmacol.
, vol.31
, pp. 2949-2954
-
-
Johnson, G.A.1
Barsuhn, K.J.2
McCall, J.M.3
-
51
-
-
0027476273
-
Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil
-
Meisheri, K.D.; Johnson, G.A.; Puddington, L. Enzymatic and non-enzymatic sulfation mechanisms in the biological actions of minoxidil. Biochem. Pharmacol., 1993, 45, 271-279.
-
(1993)
Biochem. Pharmacol.
, vol.45
, pp. 271-279
-
-
Meisheri, K.D.1
Johnson, G.A.2
Puddington, L.3
-
52
-
-
0025193236
-
Sulfation of minoxidil by human liver phenol sulfotransferase
-
Falany, C.N.; Kerl, E.A. Sulfation of minoxidil by human liver phenol sulfotransferase. Biochem. Pharmacol., 1990, 40, 1027- 1032.
-
(1990)
Biochem. Pharmacol.
, vol.40
, pp. 1027-1032
-
-
Falany, C.N.1
Kerl, E.A.2
-
53
-
-
0023544369
-
Sulfation of minoxidil by human platelet sulfotransferase
-
Johnson, G.A.; Baker, C.A. Sulfation of minoxidil by human platelet sulfotransferase. Clin. Chim. Acta, 1987, 169, 217-227.
-
(1987)
Clin. Chim. Acta
, vol.169
, pp. 217-227
-
-
Johnson, G.A.1
Baker, C.A.2
-
54
-
-
0026589846
-
Minoxidil sulfotransferase, a marker of human keratinocyte differentiation
-
Johnson, G.A.; Baker, C.A.; Knight, K.A. Minoxidil sulfotransferase, a marker of human keratinocyte differentiation. J. Invest. Dermatol., 1992, 98, 730-733.
-
(1992)
J. Invest. Dermatol.
, vol.98
, pp. 730-733
-
-
Johnson, G.A.1
Baker, C.A.2
Knight, K.A.3
-
55
-
-
0032549060
-
Sulfation of minoxidil by multiple human cytosolic sulfotransferases
-
Anderson, R.; Kudlacek, P.E.; Clemens, D.L. Sulfation of minoxidil by multiple human cytosolic sulfotransferases. Chem. Biol. Interact., 1998, 109, 53-67.
-
(1998)
Chem. Biol. Interact.
, vol.109
, pp. 53-67
-
-
Anderson, R.1
Kudlacek, P.E.2
Clemens, D.L.3
-
56
-
-
0032806517
-
Molecular biology of the human cytosolic sulfotransferase gene superfamily implicated in the bioactivation of minoxidil and cholesterol in skin
-
Dooley, T.P. Molecular biology of the human cytosolic sulfotransferase gene superfamily implicated in the bioactivation of minoxidil and cholesterol in skin. Exp. Dermatol., 1999, 8, 328-329.
-
(1999)
Exp. Dermatol.
, vol.8
, pp. 328-329
-
-
Dooley, T.P.1
-
57
-
-
1542698602
-
Minoxidil sulfotransferase activity influences the efficacy of rogaine topical solution (TS): Enzyme studies using scalp and platelets
-
Buhl, A.E.; Baker, C.A.; Dietz, A.J. Minoxidil sulfotransferase activity influences the efficacy of rogaine topical solution (TS): enzyme studies using scalp and platelets. J. Invest. Dermatol., 1994, 102, 534.
-
(1994)
J. Invest. Dermatol.
, vol.102
, pp. 534
-
-
Buhl, A.E.1
Baker, C.A.2
Dietz, A.J.3
-
58
-
-
0031596645
-
A view of sur/KIR6.X, KATP channels
-
Babenko, A.P.; Aguilar-Bryan, L.; Bryan, J. A view of sur/KIR6.X, KATP channels. Annu. Rev. Physiol., 1998, 60, 667- 687.
-
(1998)
Annu. Rev. Physiol.
, vol.60
, pp. 667-687
-
-
Babenko, A.P.1
Aguilar-Bryan, L.2
Bryan, J.3
-
60
-
-
0016866197
-
New approach to triaminopyrimidine N-oxides
-
McCall, J.M.; TenBrink, R.E.; Ursprung, J.J. New approach to triaminopyrimidine N-oxides. J. Org. Chem., 1975, 40(22), 3304- 3306.
-
(1975)
J. Org. Chem.
, vol.40
, Issue.22
, pp. 3304-3306
-
-
McCall, J.M.1
TenBrink, R.E.2
Ursprung, J.J.3
-
63
-
-
0020626572
-
Enhancement of GABA binding by benzodiazepines and related anxiolytics
-
Skerritt, J.H.; Johnston, G.A. Enhancement of GABA binding by benzodiazepines and related anxiolytics. Eur. J. Pharmacol., 1983, 89, 193-198.
-
(1983)
Eur. J. Pharmacol.
, vol.89
, pp. 193-198
-
-
Skerritt, J.H.1
Johnston, G.A.2
-
64
-
-
33750576990
-
The role of serendipity in drug discovery
-
Ban, T.A. The role of serendipity in drug discovery. Dialogues Clin. Neurosci., 2006, 8, 335-344.
-
(2006)
Dialogues Clin. Neurosci.
, vol.8
, pp. 335-344
-
-
Ban, T.A.1
-
65
-
-
0010732837
-
Quinazolines and 1, 4- benzodiazepines, XIV. Synthesis and transformation of 5-phenyl- 1, 4-benzodiazepine-2-thiones
-
Sternbach, L.; Stempe, R.A.; Rachlin, A. Quinazolines and 1, 4- benzodiazepines. XIV. Synthesis and transformation of 5-phenyl- 1, 4-benzodiazepine-2-thiones. J. Org. Chem., 1964, 29, 3744-3744.
-
(1964)
J. Org. Chem.
, vol.29
, pp. 3744-3744
-
-
Sternbach, L.1
Stempe, R.A.2
Rachlin, A.3
-
66
-
-
0018118258
-
Benzodiazepines: A summary of pharmacokinetic properties
-
Greenblatt, D.J.; Shader, R.I.; MacLeod, S.M.; Sellers, E.M. Benzodiazepines: A summary of pharmacokinetic properties. Clin. Pharmacokinet., 1978, 3, 381-394.
-
(1978)
Clin. Pharmacokinet.
, vol.3
, pp. 381-394
-
-
Greenblatt, D.J.1
Shader, R.I.2
MacLeod, S.M.3
Sellers, E.M.4
-
67
-
-
33749341551
-
Mechanism of action of benzodiazepines on GABAA receptors
-
Campo-Soria, C.; Chang, Y.; Weiss, D.S. Mechanism of action of benzodiazepines on GABAA receptors. Br. J. Pharmacol., 2006, 148, 984-990.
-
(2006)
Br. J. Pharmacol.
, vol.148
, pp. 984-990
-
-
Campo-Soria, C.1
Chang, Y.2
Weiss, D.S.3
-
68
-
-
1642288469
-
Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding
-
Derry, J.M.; Dunn, S.M.; Davies, M. Identification of a residue in the gamma-aminobutyric acid type A receptor alpha subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding. J. Neurochem., 2004, 88, 1431-1438.
-
(2004)
J. Neurochem.
, vol.88
, pp. 1431-1438
-
-
Derry, J.M.1
Dunn, S.M.2
Davies, M.3
-
69
-
-
84862757100
-
Selective modulation of different GABAA receptor isoforms by diazepam and etomidate in hippocampal neurons
-
Seymour, V.A.; Curmi, J.P.; Howitt, S.M.; Casarotto, M.G.; Laver, D.R.; Tierney, M.L. Selective modulation of different GABAA receptor isoforms by diazepam and etomidate in hippocampal neurons. Int. J. Biochem. Cell Biol., 2012, 44, 1491-1500.
-
(2012)
Int. J. Biochem. Cell Biol.
, vol.44
, pp. 1491-1500
-
-
Seymour, V.A.1
Curmi, J.P.2
Howitt, S.M.3
Casarotto, M.G.4
Laver, D.R.5
Tierney, M.L.6
-
70
-
-
70450182120
-
Role of GABAA receptors in cognition
-
Mohler, H. Role of GABAA receptors in cognition. Biochem. Soc. Trans., 2009, 37, 1328-1333.
-
(2009)
Biochem. Soc. Trans.
, vol.37
, pp. 1328-1333
-
-
Mohler, H.1
-
71
-
-
0036676629
-
Mapping of the benzodiazepine recognition site on GABAA receptors
-
Sigel E. Mapping of the benzodiazepine recognition site on GABAA receptors. Curr. Top. Med. Chem., 2002, 2, 833-839.
-
(2002)
Curr. Top. Med. Chem.
, vol.2
, pp. 833-839
-
-
Sigel, E.1
-
72
-
-
42349109493
-
GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition
-
Jacob, T.C.; Moss, S.J.; Jurd, R. GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition. Nat. Rev. Neurosci., 2008, 9, 331-343.
-
(2008)
Nat. Rev. Neurosci.
, vol.9
, pp. 331-343
-
-
Jacob, T.C.1
Moss, S.J.2
Jurd, R.3
-
73
-
-
16444387677
-
GABAA receptor structure-function studies: A reexamination in light of new acetylcholine receptor structures
-
Akabas, M.H. GABAA receptor structure-function studies: A reexamination in light of new acetylcholine receptor structures. Int. Rev. Neurobiol., 2004, 62, 1-43.
-
(2004)
Int. Rev. Neurobiol.
, vol.62
, pp. 1-43
-
-
Akabas, M.H.1
-
74
-
-
41549125604
-
Structural mechanisms underlying benzodiazepine modulation of the GABAA receptor
-
Hanson, S.M.; Czajkowski, C. Structural mechanisms underlying benzodiazepine modulation of the GABAA receptor. J. Neurosci., 2008, 28(13), 3490-3499.
-
(2008)
J. Neurosci.
, vol.28
, Issue.13
, pp. 3490-3499
-
-
Hanson, S.M.1
Czajkowski, C.2
-
75
-
-
0344094878
-
Quinazolines and 1, 4-benzodiazepines. XVIII. The acetylation of chlordiazepoxide and its transformation into 6-chloro-4-phenyl-2- quinazoline-carboxaldehyde
-
Sternbach, L.H.; Reeder, E.; Stempel, A.; Rachlin, A. Quinazolines and 1, 4-benzodiazepines. XVIII. The acetylation of chlordiazepoxide and its transformation into 6-chloro-4-phenyl-2- quinazoline-carboxaldehyde. J. Org. Chem., 1964, 29, 332-336.
-
(1964)
J. Org. Chem.
, vol.29
, pp. 332-336
-
-
Sternbach, L.H.1
Reeder, E.2
Stempel, A.3
Rachlin, A.4
-
76
-
-
33947489281
-
Additions and corrections - quinazolines and 1, 4-benzodiazepines. XVIII. The acetylation of chlordiazepoxide and its transformation into 6- chloro-4-phenyl-2-quinazolinecarboxaldehyde
-
Sternbach, L.H.; Reeder, E.; Stempel, A.; Rachlin, A. Additions and corrections - quinazolines and 1, 4-benzodiazepines. XVIII. The acetylation of chlordiazepoxide and its transformation into 6- chloro-4-phenyl-2-quinazolinecarboxaldehyde. J. Org. Chem., 1964, 29, 3744-3744.
-
(1964)
J. Org. Chem.
, vol.29
, pp. 3744-3744
-
-
Sternbach, L.H.1
Reeder, E.2
Stempel, A.3
Rachlin, A.4
-
77
-
-
33845676166
-
Drug evaluation: The directly activated factor Xa inhibitor otamixaban
-
Nutescu, E.A.; Pater, K. Drug evaluation: The directly activated factor Xa inhibitor otamixaban. IDrugs, 2006, 9, 854-865.
-
(2006)
IDrugs
, vol.9
, pp. 854-865
-
-
Nutescu, E.A.1
Pater, K.2
-
78
-
-
33845536606
-
Direct and rapid inhibition of factor Xa by otamixaban: A pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease
-
Hinder, M.; Frick, A.; Jordaan, P.; Hesse, G.; Gebauer, A.; Maas, J.; Paccaly, A. Direct and rapid inhibition of factor Xa by otamixaban: A pharmacokinetic and pharmacodynamic investigation in patients with coronary artery disease. Clin. Pharmacol. Ther., 2006, 80, 691-702.
-
(2006)
Clin. Pharmacol. Ther.
, vol.80
, pp. 691-702
-
-
Hinder, M.1
Frick, A.2
Jordaan, P.3
Hesse, G.4
Gebauer, A.5
Maas, J.6
Paccaly, A.7
-
79
-
-
33644973993
-
Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro
-
Gould, W.R.; McClanahan, T.B.; Welch, K.M.; Baxi, S.M.; Saiya-Cork, K.; Chi, L.; Johnson, T.R.; Leadley, R.J. Inhibitors of blood coagulation factors Xa and IIa synergize to reduce thrombus weight and thrombin generation in vivo and in vitro. J. Thromb. Haemost., 2006, 4, 834-841.
-
(2006)
J. Thromb. Haemost.
, vol.4
, pp. 834-841
-
-
Gould, W.R.1
McClanahan, T.B.2
Welch, K.M.3
Baxi, S.M.4
Saiya-Cork, K.5
Chi, L.6
Johnson, T.R.7
Leadley, R.J.8
-
81
-
-
0041767435
-
Endothelial cell functions
-
Michiels, C. Endothelial cell functions. J. Cell Physiol., 2003, 196, 430-443.
-
(2003)
J. Cell Physiol.
, vol.196
, pp. 430-443
-
-
Michiels, C.1
-
82
-
-
0022764019
-
11- Dehydrothromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation
-
Catella, F.; Healy, D.; Lawson, J.A.; FitzGerald, G.A. 11- Dehydrothromboxane B2: A quantitative index of thromboxane A2 formation in the human circulation. Proc. Nat. Acad. Sci. USA, 1986, 83, 5861-5865.
-
(1986)
Proc. Nat. Acad. Sci. USA
, vol.83
, pp. 5861-5865
-
-
Catella, F.1
Healy, D.2
Lawson, J.A.3
FitzGerald, G.A.4
-
83
-
-
32844458881
-
Tissue factor initiated blood coagulation
-
Gomez, K.; McVey, J.H.; Tissue factor initiated blood coagulation. Front. Biosci., 2006, 11, 1349-1359.
-
(2006)
Front. Biosci.
, vol.11
, pp. 1349-1359
-
-
Gomez, K.1
McVey, J.H.2
-
84
-
-
0034758293
-
Structure and biology of tissue factor pathway inhibitor
-
Bajaj, M.S.; Birktoft, J.J.; Steer, S.A.; Bajaj, S.P. Structure and biology of tissue factor pathway inhibitor. Thromb. Haemost., 2001, 86, 959-972.
-
(2001)
Thromb. Haemost.
, vol.86
, pp. 959-972
-
-
Bajaj, M.S.1
Birktoft, J.J.2
Steer, S.A.3
Bajaj, S.P.4
-
85
-
-
0018622772
-
The contribution of bovine Factor V and Factor Va to the activity of prothrombinase
-
Nesheim, M.E.; Taswell, J.B.; Mann, K.G. The contribution of bovine Factor V and Factor Va to the activity of prothrombinase. J. Biol. Chem., 1979, 254, 10952-10962.
-
(1979)
J. Biol. Chem.
, vol.254
, pp. 10952-10962
-
-
Nesheim, M.E.1
Taswell, J.B.2
Mann, K.G.3
-
86
-
-
0021225352
-
Kinetic studies of prothrombin activation: Effect of factor Va and phospholipids on the formation of the enzyme-substrate complex
-
van Rijn, J.L.; Govers- Riemslag, J.W.; Zwaal, R.F.; Rosing, J. Kinetic studies of prothrombin activation: effect of factor Va and phospholipids on the formation of the enzyme-substrate complex. Biochemistry, 1984, 23, 4557-4564.
-
(1984)
Biochemistry
, vol.23
, pp. 4557-4564
-
-
Van Rijn, J.L.1
Govers-Riemslag, J.W.2
Zwaal, R.F.3
Rosing, J.4
-
87
-
-
28344448202
-
Fibrinogen and fibrin structure and functions
-
Mosesson, M.W. Fibrinogen and fibrin structure and functions. J. Thromb. Haemost., 2005, 3, 1894-1904.
-
(2005)
J. Thromb. Haemost.
, vol.3
, pp. 1894-1904
-
-
Mosesson, M.W.1
-
88
-
-
1642336686
-
On the solubility of fibrin clots
-
Laki, K.; Lorand, L. On the solubility of fibrin clots. Science, 1948, 108(2802), 280.
-
(1948)
Science
, vol.108
, Issue.2802
, pp. 280
-
-
Laki, K.1
Lorand, L.2
-
89
-
-
0036682920
-
Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms
-
Ariens, R.A.S.; Lai, T.S.; Weisel, J.W.; Greenberg, C.S.; Grant, P.G. Role of factor XIII in fibrin clot formation and effects of genetic polymorphisms. Blood, 2002, 100, 743-754.
-
(2002)
Blood
, vol.100
, pp. 743-754
-
-
Ariens, R.A.S.1
Lai, T.S.2
Weisel, J.W.3
Greenberg, C.S.4
Grant, P.G.5
-
90
-
-
18444386848
-
Molecular mechanisms of fibrinolysis
-
Cesarman-Maus, G.; Hajjar, K.A. Molecular mechanisms of fibrinolysis. Br. J. Haematol., 2005, 129, 307-321.
-
(2005)
Br. J. Haematol.
, vol.129
, pp. 307-321
-
-
Cesarman-Maus, G.1
Hajjar, K.A.2
-
91
-
-
74849105708
-
Limitations of current therapies to prevent thrombosis: A need for novel strategies
-
Fabre, J.E.; Gurney, M.E. Limitations of current therapies to prevent thrombosis: A need for novel strategies. Mol. Biosyst., 2010, 6, 305-315.
-
(2010)
Mol. Biosyst.
, vol.6
, pp. 305-315
-
-
Fabre, J.E.1
Gurney, M.E.2
-
92
-
-
0024987599
-
Monocyclic b-lactam inhibitors of human leukocyte elastase
-
Firestone, R.A.; Barker, P.L.; Pisano, J.M.; Asher, B.M.; Dahlgren, M.E. Monocyclic b-lactam inhibitors of human leukocyte elastase. Tetrahedron, 1990, 46(7), 2255-2262.
-
(1990)
Tetrahedron
, vol.46
, Issue.7
, pp. 2255-2262
-
-
Firestone, R.A.1
Barker, P.L.2
Pisano, J.M.3
Asher, B.M.4
Dahlgren, M.E.5
-
93
-
-
0026725323
-
Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives
-
Knight, W.B.; Maycock, A.L.; Green, B.G.; Asher, B.M.; Gale, P.; Weston, H.; Finke, P.E.; Hagmann, W.K.; Shah, S.K.; Doherty, J.B. Mechanism of inhibition of human leukocyte elastase by two cephalosporin derivatives. Biochemistry, 1992, 31(21), 4980-4986.
-
(1992)
Biochemistry
, vol.31
, Issue.21
, pp. 4980-4986
-
-
Knight, W.B.1
Maycock, A.L.2
Green, B.G.3
Asher, B.M.4
Gale, P.5
Weston, H.6
Finke, P.E.7
Hagmann, W.K.8
Shah, S.K.9
Doherty, J.B.10
-
94
-
-
15444348427
-
Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa
-
Klein, S.I.; Czekaj, M.; Gardner, C.J.; Guertin, K.R.; Cheney, D.L.; Spada, A.P.; Bolton, S.A.; Brown, K.; Colussi, D.; Heran, C.L.; Morgan, S.R.; Leadley, R.J.; Dunwiddie, C.T.; Perrone, M.H.; Chu, V. Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa. J. Med. Chem., 1998, 41, 437-450.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 437-450
-
-
Klein, S.I.1
Czekaj, M.2
Gardner, C.J.3
Guertin, K.R.4
Cheney, D.L.5
Spada, A.P.6
Bolton, S.A.7
Brown, K.8
Colussi, D.9
Heran, C.L.10
Morgan, S.R.11
Leadley, R.J.12
Dunwiddie, C.T.13
Perrone, M.H.14
Chu, V.15
-
95
-
-
0037124199
-
Optimization of the b-aminoester class of factor Xa inhibitors. Part 1: P(4) and side-chain modifications for improved in vitro potency
-
Czekaj, M.; Klein, S.; Guertin, K.; Gardner, C.; Zulli, A.; Pauls, H.; Spada, A.; Cheney, D.; Brown, K.; Colussi, D.; Chu, V.; Leadley, R.; Dunwiddie, C. Optimization of the b-aminoester class of factor Xa inhibitors. Part 1: P(4) and side-chain modifications for improved in vitro potency. Bioorg. Med. Chem. Lett., 2002, 12, 1667- 1670.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1667-1670
-
-
Czekaj, M.1
Klein, S.2
Guertin, K.3
Gardner, C.4
Zulli, A.5
Pauls, H.6
Spada, A.7
Cheney, D.8
Brown, K.9
Colussi, D.10
Chu, V.11
Leadley, R.12
Dunwiddie, C.13
-
96
-
-
0037124202
-
Optimization of the β-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent in vivo anticoagulant activity
-
Guertin, K.R.; Gardner, C.J.; Klein, S.I.; Zulli, A.L.; Czekaj, M.; Gong, Y.; Spada, A.P.; Cheney, D.L.; Maignan, S.; Guilloteau, J.- P.; Brown, K.D.; Colussi, D.J.; Chu, V.; Heran, C.L.; Morgan, S.R.; Bentley, R.G.; Dunwiddie, C.T.; Leadley, R.J.; Pauls, H.W. Optimization of the β-aminoester class of factor Xa inhibitors. Part 2: Identification of FXV673 as a potent and selective inhibitor with excellent in vivo anticoagulant activity. Bioorg. Med. Chem. Lett., 2002, 12, 1671-1674.
-
(2002)
Bioorg. Med. Chem. Lett.
, vol.12
, pp. 1671-1674
-
-
Guertin, K.R.1
Gardner, C.J.2
Klein, S.I.3
Zulli, A.L.4
Czekaj, M.5
Gong, Y.6
Spada, A.P.7
Cheney, D.L.8
Maignan, S.9
Guilloteau, J.-P.10
Brown, K.D.11
Colussi, D.J.12
Chu, V.13
Heran, C.L.14
Morgan, S.R.15
Bentley, R.G.16
Dunwiddie, C.T.17
Leadley, R.J.18
Pauls, H.W.19
-
97
-
-
85050579956
-
AstraZeneca, Sanofi cut programs
-
Jarvis, L.M. AstraZeneca, Sanofi cut programs. Chem. Eng. News, 2013, 91(23), 17.
-
(2013)
Chem. Eng. News
, vol.91
, Issue.23
, pp. 17
-
-
Jarvis, L.M.1
-
98
-
-
0035880858
-
Pharmacological characterization of a novel factor Xa inhibitor, FXV673
-
Chu, V.; Brown, K.; Colussi, D.; Gao, J.; Bostwick, J.; Kasiewski, C.; Bentley, R.; Morgan, S.; Guertin, K.; Pauls, H.W.; Gong, Y.; Zulli, A.; Perrone, M.H.; Dunwiddie, C.T.; Leadley, R.J. Pharmacological characterization of a novel factor Xa inhibitor, FXV673. Thromb. Res., 2001, 103, 309-324.
-
(2001)
Thromb. Res.
, vol.103
, pp. 309-324
-
-
Chu, V.1
Brown, K.2
Colussi, D.3
Gao, J.4
Bostwick, J.5
Kasiewski, C.6
Bentley, R.7
Morgan, S.8
Guertin, K.9
Pauls, H.W.10
Gong, Y.11
Zulli, A.12
Perrone, M.H.13
Dunwiddie, C.T.14
Leadley, R.J.15
-
99
-
-
0037330483
-
Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins
-
Singh, R.; Silva Elipe, M.V.; Pearson, P.G.; Arison, B.H.; Wong, B.K.; White, R.; Yu, X.; Burgey, C.S.; Lin, J.H.; Baillie, T.A. Metabolic activation of a pyrazinone-containing thrombin inhibitor. Evidence for novel biotransformation involving pyrazinone ring oxidation, rearrangement, and covalent binding to proteins. Chem. Res. Toxicol., 2003, 16, 198-207.
-
(2003)
Chem. Res. Toxicol.
, vol.16
, pp. 198-207
-
-
Singh, R.1
Silva Elipe, M.V.2
Pearson, P.G.3
Arison, B.H.4
Wong, B.K.5
White, R.6
Yu, X.7
Burgey, C.S.8
Lin, J.H.9
Baillie, T.A.10
-
100
-
-
10744228010
-
Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: Structures and mechanism using 13C-labels, mass spectrometry, and NMR
-
Subramanian, R.; Lin, C. C.; Ho, J.Z.; Pitzenberger, S.M.; Silva-Elipe, M.V.; Gibson, C.R.; Braun, M.P.; Yu, X.; Yergey, J.L.; Singh, R. Bioactivation of the 3-amino-6-chloropyrazinone ring in a thrombin inhibitor leads to novel dihydro-imidazole and imidazolidine derivatives: structures and mechanism using 13C-labels, mass spectrometry, and NMR. Drug Metab. Dispos., 2003, 31, 1437-14347.
-
(2003)
Drug Metab. Dispos.
, vol.31
, pp. 1437-14347
-
-
Subramanian, R.1
Lin, C.C.2
Ho, J.Z.3
Pitzenberger, S.M.4
Silva-Elipe, M.V.5
Gibson, C.R.6
Braun, M.P.7
Yu, X.8
Yergey, J.L.9
Singh, R.10
-
101
-
-
21144453843
-
P2 pyridine Noxide thrombin inhibitors: A novel peptidomimetic scaffold
-
Nantermet, P.G.; Burgey, C.S.; Robinson, K.A.; Pellicore, J.M.; Newton, C.L.; Deng, J.Z.; Selnick, H.G.; Lewis, S.D.; Lucas, B.J.; Krueger, J.A.; Miller-Stein, C.; White, R.B.; Wong, B.; McMasters, D.R.; Wallace, A.A.; Lynch, J.J.; Yan, Y.; Chen, Z.; Kuo, L.; Gardell, S.J.; Shafer, J.A.; Vacca, J.P.; Lyle, T.A. P2 pyridine Noxide thrombin inhibitors: A novel peptidomimetic scaffold. Bioorg. Med. Chem. Lett., 2005, 15, 2771-2775.
-
(2005)
Bioorg. Med. Chem. Lett.
, vol.15
, pp. 2771-2775
-
-
Nantermet, P.G.1
Burgey, C.S.2
Robinson, K.A.3
Pellicore, J.M.4
Newton, C.L.5
Deng, J.Z.6
Selnick, H.G.7
Lewis, S.D.8
Lucas, B.J.9
Krueger, J.A.10
Miller-Stein, C.11
White, R.B.12
Wong, B.13
McMasters, D.R.14
Wallace, A.A.15
Lynch, J.J.16
Yan, Y.17
Chen, Z.18
Kuo, L.19
Gardell, S.J.20
Shafer, J.A.21
Vacca, J.P.22
Lyle, T.A.23
more..
-
102
-
-
0028824368
-
Inhibition of thrombin by peptides containing lysyl-alpha-keto carbonyl derivatives
-
Lewis, S.D.; Ng, A.S.; Lyle, E.A.; Mellott, M.J.; Appelby, S.D.; Brady, S.F.; Stauffer, K.S.; Sisko, J.T.; Mao, S.-S.; Veber, D.F.; Nutt, R.F.; Lynch, J.J.; Cook, J.J.; Gardell, S.J.; Shafer, J.A. Inhibition of thrombin by peptides containing lysyl-alpha-keto carbonyl derivatives. Thromb. Haemostasis, 1995, 74, 1107-1112.
-
(1995)
Thromb. Haemostasis
, vol.74
, pp. 1107-1112
-
-
Lewis, S.D.1
Ng, A.S.2
Lyle, E.A.3
Mellott, M.J.4
Appelby, S.D.5
Brady, S.F.6
Stauffer, K.S.7
Sisko, J.T.8
Mao, S.-S.9
Veber, D.F.10
Nutt, R.F.11
Lynch, J.J.12
Cook, J.J.13
Gardell, S.J.14
Shafer, J.A.15
-
103
-
-
77952679476
-
Effect of storage conditions on prothrombin time, activated partial thromboplastin time and fibrinogen concentration on canine plasma samples
-
Piccione, G.; Casella, S.; Giannetto1, C; Giudice, E. Effect of storage conditions on prothrombin time, activated partial thromboplastin time and fibrinogen concentration on canine plasma samples. J. Vet. Sci., 2010, 11, 121-124.
-
(2010)
J. Vet. Sci.
, vol.11
, pp. 121-124
-
-
Piccione, G.1
Casella, S.2
Giudice, E.3
-
104
-
-
15444357766
-
Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: Rapid structure-activity studies by solid-phase synthesis
-
Lumma, W.C.; Witherup, K. M.; Tucker, T. J.; Brady, S. F.; Sisko, J. T.; Naylor-Olsen, A. M.; Lewis, S. D.; Lucas, B. J.; Vacca, J. P. Design of novel, potent, noncovalent inhibitors of thrombin with nonbasic P-1 substructures: rapid structure-activity studies by solid-phase synthesis. J. Med. Chem., 1998, 41, 1011- 1013.
-
(1998)
J. Med. Chem.
, vol.41
, pp. 1011-1013
-
-
Lumma, W.C.1
Witherup, K.M.2
Tucker, T.J.3
Brady, S.F.4
Sisko, J.T.5
Naylor-Olsen, A.M.6
Lewis, S.D.7
Lucas, B.J.8
Vacca, J.P.9
-
105
-
-
0343443219
-
Potent noncovalent thrombin inhibitors that utilize the unique amino acid d-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy
-
Tucker, T.J.; Lumma, W.C.; Lewis, S.D.; Gardell, S.J.; Lucas, B.J.; Baskin, E.P.; Woltmann, R.; Lynch, J.J.; Lyle, E.A.; Appleby, S.D.; Chen, I.-W.; Dancheck, K.B.; Vacca, J.P. Potent noncovalent thrombin inhibitors that utilize the unique amino acid d-dicyclohexylalanine in the P3 position. Implications on oral bioavailability and antithrombotic efficacy. J. Med. Chem., 1997, 40, 1565-1569.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 1565-1569
-
-
Tucker, T.J.1
Lumma, W.C.2
Lewis, S.D.3
Gardell, S.J.4
Lucas, B.J.5
Baskin, E.P.6
Woltmann, R.7
Lynch, J.J.8
Lyle, E.A.9
Appleby, S.D.10
Chen, I.-W.11
Dancheck, K.B.12
Vacca, J.P.13
-
106
-
-
0033615307
-
HIV-1 drug resistance in newly infected individuals
-
Boden, D.; Hurley, A.; Zhang, L.; Cao, Y.; Guo, Y.; Jones, E.; Tsay, J.; Ip, J.; Farthing, C.; Limoli, K.; Parkin, N.; Markowitz, M. HIV-1 drug resistance in newly infected individuals. J. Am. Med. Assoc., 1999, 282, 1135-1141.
-
(1999)
J. Am. Med. Assoc.
, vol.282
, pp. 1135-1141
-
-
Boden, D.1
Hurley, A.2
Zhang, L.3
Cao, Y.4
Guo, Y.5
Jones, E.6
Tsay, J.7
Ip, J.8
Farthing, C.9
Limoli, K.10
Parkin, N.11
Markowitz, M.12
-
107
-
-
0032577581
-
Chemokine receptors: Keys to AIDS pathogenesis?
-
Littman, D.R. Chemokine receptors: keys to AIDS pathogenesis? Cell, 1998, 93, 677-680.
-
(1998)
Cell
, vol.93
, pp. 677-680
-
-
Littman, D.R.1
-
108
-
-
0035259780
-
Viral exploitation and subversion of the immune system through chemokine mimicry
-
Murphy, P.M. Viral exploitation and subversion of the immune system through chemokine mimicry. Nat. Immun., 2001, 2, 116-122.
-
(2001)
Nat. Immun.
, vol.2
, pp. 116-122
-
-
Murphy, P.M.1
-
109
-
-
0001027302
-
Chemokine receptors as HIV co-receptors: Targets for therapeutic intervention in AIDS
-
Hunt, S.W. III; LaRosa, G. J. Chemokine receptors as HIV co-receptors: Targets for therapeutic intervention in AIDS. Annu. Rep. Med. Chem., 1998, 33, 263-270.
-
(1998)
Annu. Rep. Med. Chem.
, vol.33
, pp. 263-270
-
-
Hunt, S.W.1
LaRosa, G.J.2
-
110
-
-
0033083950
-
Opportunities for novel therapeutic agents acting at chemokine receptors
-
Saunders, J.; Tarby, C.M. Opportunities for novel therapeutic agents acting at chemokine receptors. Drug Discov. Today, 1999, 4, 80-92.
-
(1999)
Drug Discov. Today
, vol.4
, pp. 80-92
-
-
Saunders, J.1
Tarby, C.M.2
-
112
-
-
0029417004
-
Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells
-
Cocchi, F.; DeVico, A.L.; Garzino-Demo, A.; Arya, S.K.; Gallo, R.C.; Lusso, P. Identification of RANTES, MIP-1 alpha, and MIP-1 beta as the major HIV-suppressive factors produced by CD8+ T cells. Science, 1995, 270, 1811-1815.
-
(1995)
Science
, vol.270
, pp. 1811-1815
-
-
Cocchi, F.1
DeVico, A.L.2
Garzino-Demo, A.3
Arya, S.K.4
Gallo, R.C.5
Lusso, P.6
-
113
-
-
0033057961
-
HIV-1 entry inhibitors: Evading the issue
-
Michael, N.L.; Moore, J.P. HIV-1 entry inhibitors: evading the issue. Nat. Med., 1999, 5(7), 740-743.
-
(1999)
Nat. Med.
, vol.5
, Issue.7
, pp. 740-743
-
-
Michael, N.L.1
Moore, J.P.2
-
114
-
-
0031041571
-
The role of viral phenotype and CCR- 5 gene defects in HIV-1 transmission and disease progression
-
Michael, N.L.; Chang, G.; Louie, L.G.; Mascola, J.R.; Dondero, D.; Birx, D. L.; Sheppard, H.W. The role of viral phenotype and CCR- 5 gene defects in HIV-1 transmission and disease progression. Nat. Med., 1997, 3(3), 338-340.
-
(1997)
Nat. Med.
, vol.3
, Issue.3
, pp. 338-340
-
-
Michael, N.L.1
Chang, G.2
Louie, L.G.3
Mascola, J.R.4
Dondero, D.5
Birx, D.L.6
Sheppard, H.W.7
-
115
-
-
0035860744
-
Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5
-
Maeda, K.; Yoshimura, K.; Shibayama, S.; Habashita, H.; Tada, H.; Sagawa, K.; Miyakawa, T.; Aoki, M.; Fukushima, D. Novel low molecular weight spirodiketopiperazine derivatives potently inhibit R5 HIV-1 infection through their antagonistic effects on CCR5. J. Biol. Chem., 2001, 276(37), 35194-35200.
-
(2001)
J. Biol. Chem.
, vol.276
, Issue.37
, pp. 35194-35200
-
-
Maeda, K.1
Yoshimura, K.2
Shibayama, S.3
Habashita, H.4
Tada, H.5
Sagawa, K.6
Miyakawa, T.7
Aoki, M.8
Fukushima, D.9
-
116
-
-
0034899714
-
Update on the development of HIV entry inhibitors
-
Mastrolorenzo, A.; Scozzafava, A.; Supuran, C.T. Update on the development of HIV entry inhibitors. Expert Opin. Ther. Pat., 2001, 11, 1245-1252.
-
(2001)
Expert Opin. Ther. Pat.
, vol.11
, pp. 1245-1252
-
-
Mastrolorenzo, A.1
Scozzafava, A.2
Supuran, C.T.3
-
117
-
-
0037019271
-
Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti- HIV activity
-
Palani, A.; Shapiro, S.; Josien, H.; Bara, T.; Clader, J.W.; Greenlee, W.J.; Cox, K.; Strizki, J.M.; Baroudy, B.M. Synthesis, SAR, and biological evaluation of oximino-piperidino-piperidine amides. 1. Orally bioavailable CCR5 receptor antagonists with potent anti- HIV activity. J. Med. Chem., 2002, 45, 3143-3160.
-
(2002)
J. Med. Chem.
, vol.45
, pp. 3143-3160
-
-
Palani, A.1
Shapiro, S.2
Josien, H.3
Bara, T.4
Clader, J.W.5
Greenlee, W.J.6
Cox, K.7
Strizki, J.M.8
Baroudy, B.M.9
-
118
-
-
0035921055
-
Piperazinebased CCR5 antagonists as HIV-1 inhibitors I: 2(S)-methyl piperazine as a key pharmacophore element
-
Tagat, J.R.; McCombie, S.W.; Steensma, R.W.; Lin, S.-I.; Nazareno, D.V.; Baroudy, B.; Vantuno, N.; Xu, S.; Liu, J. Piperazinebased CCR5 antagonists as HIV-1 inhibitors I: 2(S)-methyl piperazine as a key pharmacophore element. Bioorg. Med. Chem. Lett., 2001, 11, 2143-2146.
-
(2001)
Bioorg. Med. Chem. Lett.
, vol.11
, pp. 2143-2146
-
-
Tagat, J.R.1
McCombie, S.W.2
Steensma, R.W.3
Lin, S.-I.4
Nazareno, D.V.5
Baroudy, B.6
Vantuno, N.7
Xu, S.8
Liu, J.9
-
119
-
-
0035846074
-
Discovery of 4- [(Z)-(4- bromophenyl)-(ethoxyimino)methyl]-1'- [(2, 4-dimethyl-3-pyridinyl) carbonyl]-4'-methyl-1, 4'-bipiperidine N-oxide (SCH 351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection
-
Palani, A.; Shapiro, S.; Clader, J.W.; Greenlee, W.J.; Cox, K.; Strizki, J.; Endres, M.; Baroudy, B.M. Discovery of 4- [(Z)-(4- bromophenyl)-(ethoxyimino)methyl]-1'- [(2, 4-dimethyl-3-pyridinyl) carbonyl]-4'-methyl-1, 4'-bipiperidine N-oxide (SCH 351125): An orally bioavailable human CCR5 antagonist for the treatment of HIV infection. J. Med. Chem., 2001, 44(21), 3339-3342.
-
(2001)
J. Med. Chem.
, vol.44
, Issue.21
, pp. 3339-3342
-
-
Palani, A.1
Shapiro, S.2
Clader, J.W.3
Greenlee, W.J.4
Cox, K.5
Strizki, J.6
Endres, M.7
Baroudy, B.M.8
-
120
-
-
0035940445
-
SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo
-
Strizki, J.M.; Xu, S.; Wagner, N.E.; Wojcik, L.; Liu, J.; Hou, Y.; Endres, M.; Palani, A.; Shapiro, S.; Clader, J.W.; Greenlee, W.J.; Tagat, J.R.; McCombie, S.; Cox, K.; Fawzi, A.B.; Chou, C.C.; Pugliese- Sivo, C.; Davies, L.; Moreno, M.E.; Ho, D.D.; Trkola, A.; Stoddart, C.A.; Moore, J.P.; Reyes, G.R.; Baroudy, B.M. SCH-C (SCH 351125), an orally bioavailable, small molecule antagonist of the chemokine receptor CCR5, is a potent inhibitor of HIV-1 infection in vitro and in vivo. Proc. Natl. Acad. Sci. U.S.A., 2001, 98(22), 12718-12723.
-
(2001)
Proc. Natl. Acad. Sci. U.S.A.
, vol.98
, Issue.22
, pp. 12718-12723
-
-
Strizki, J.M.1
Xu, S.2
Wagner, N.E.3
Wojcik, L.4
Liu, J.5
Hou, Y.6
Endres, M.7
Palani, A.8
Shapiro, S.9
Clader, J.W.10
Greenlee, W.J.11
Tagat, J.R.12
McCombie, S.13
Cox, K.14
Fawzi, A.B.15
Chou, C.C.16
Pugliese-Sivo, C.17
Davies, L.18
Moreno, M.E.19
Ho, D.D.20
Trkola, A.21
Stoddart, C.A.22
Moore, J.P.23
Reyes, G.R.24
Baroudy, B.M.25
more..
-
121
-
-
28944454412
-
Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1
-
Strizki J.M.; Tremblay, C.; Xu, S.; Wojcik, L.; Wagner, N.; Gonsiorek, W.; Hipkin, R.W.; Chou, C.C.; Pugliese-Sivo, C.; Xiao, Y.; Tagat, J.R.; Cox, K.; Priestley, T.; Sorota, S.; Huang, W.; Hirsch, M.; Reyes, G.R.; Baroudy, B.M. Discovery and characterization of vicriviroc (SCH 417690), a CCR5 antagonist with potent activity against human immunodeficiency virus type 1. Antimicrob. Agents Chemother., 2005, 49, 4911-4919.
-
(2005)
Antimicrob. Agents Chemother.
, vol.49
, pp. 4911-4919
-
-
Strizki, J.M.1
Tremblay, C.2
Xu, S.3
Wojcik, L.4
Wagner, N.5
Gonsiorek, W.6
Hipkin, R.W.7
Chou, C.C.8
Pugliese-Sivo, C.9
Xiao, Y.10
Tagat, J.R.11
Cox, K.12
Priestley, T.13
Sorota, S.14
Huang, W.15
Hirsch, M.16
Reyes, G.R.17
Baroudy, B.M.18
-
122
-
-
0038471102
-
The impact of drug-induced QT interval prolongation on drug discovery and development
-
Fermini, B.; Fossa, A.A. The impact of drug-induced QT interval prolongation on drug discovery and development. Nat. Rev. Drug Discov., 2003, 2(6), 439-447.
-
(2003)
Nat. Rev. Drug Discov.
, vol.2
, Issue.6
, pp. 439-447
-
-
Fermini, B.1
Fossa, A.A.2
-
123
-
-
77952573272
-
Keeping the rhythm: HERG and beyond in cardiovascular safety pharmacology
-
Moller, C. Keeping the rhythm: hERG and beyond in cardiovascular safety pharmacology. Expert Rev. Clin. Pharmacol., 2010, 3, 321-329.
-
(2010)
Expert Rev. Clin. Pharmacol.
, vol.3
, pp. 321-329
-
-
Moller, C.1
-
124
-
-
2442618847
-
CD4 down-modulating compounds with potent anti-HIV activity
-
Vermeire, K.; Schols, D.; Bell, T.W. CD4 down-modulating compounds with potent anti-HIV activity. Curr. Pharm. Des., 2004, 10, 1795-1803.
-
(2004)
Curr. Pharm. Des.
, vol.10
, pp. 1795-1803
-
-
Vermeire, K.1
Schols, D.2
Bell, T.W.3
-
125
-
-
0031656983
-
Enzymology of tirapazamine metabolism: A review
-
Patterson, A.V.; Saunders, M.P.; Chinje, E.C.; Patterson, L.H.; Stratford, I.J. Enzymology of tirapazamine metabolism: A review. Anti-Cancer Drug Des., 1998, 13, 541-573.
-
(1998)
Anti-Cancer Drug Des
, vol.13
, pp. 541-573
-
-
Patterson, A.V.1
Saunders, M.P.2
Chinje, E.C.3
Patterson, L.H.4
Stratford, I.J.5
-
126
-
-
0022493495
-
SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells
-
Zeman, E.M.; Brown, J.M.; Lemon, M.J.; Hirst, V.K.; Lee, W.W. SR-4233: A new bioreductive agent with high selective toxicity for hypoxic mammalian cells. Int. J. Radiat. Oncol. Biol. Phys., 1986, 12, 1239-1242.
-
(1986)
Int. J. Radiat. Oncol. Biol. Phys.
, vol.12
, pp. 1239-1242
-
-
Zeman, E.M.1
Brown, J.M.2
Lemon, M.J.3
Hirst, V.K.4
Lee, W.W.5
-
127
-
-
37049045236
-
Polyazabicyclic compounds. Part II. Further derivatives of benzo-1, 2, 4-triazine
-
Robbins, R.F.; Schofield, K. Polyazabicyclic compounds. Part II. Further derivatives of benzo-1, 2, 4-triazine. J. Chem. Soc., 1957, 3186-3194.
-
(1957)
J. Chem. Soc.
, pp. 3186-3194
-
-
Robbins, R.F.1
Schofield, K.2
-
128
-
-
33751169387
-
Hypoxia-Inducible Factor-1 (HIF-1)
-
Ke, Q.; Costa, M. Hypoxia-Inducible Factor-1 (HIF-1). Mol. Pharmacol., 2006, 70, 1469-1480.
-
(2006)
Mol. Pharmacol.
, vol.70
, pp. 1469-1480
-
-
Ke, Q.1
Costa, M.2
-
129
-
-
0033587146
-
The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis
-
Maxwell, P.H.; Wiesener, M.S.; Chang, G.W.; Clifford, S.C.; Vaux, E.C.; Cockman, M.E.; Wykoff, C.C.; Pugh, C.W.; Maher, E.R.; Ratcliffe, P.J. The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis. Nature, 1999, 399, 271-275.
-
(1999)
Nature
, vol.399
, pp. 271-275
-
-
Maxwell, P.H.1
Wiesener, M.S.2
Chang, G.W.3
Clifford, S.C.4
Vaux, E.C.5
Cockman, M.E.6
Wykoff, C.C.7
Pugh, C.W.8
Maher, E.R.9
Ratcliffe, P.J.10
-
130
-
-
8344237449
-
Hydroxylation of HIF-1: Oxygen sensing at the molecular level
-
Semenza, G.L. Hydroxylation of HIF-1: oxygen sensing at the molecular level. Physiology, 2004, 19, 176-182.
-
(2004)
Physiology
, vol.19
, pp. 176-182
-
-
Semenza, G.L.1
-
131
-
-
84966192535
-
The histological structure of some human lung cancers and the possible implications for radiotherapy
-
Thomlinson, R.H.; Gray, L.H. The histological structure of some human lung cancers and the possible implications for radiotherapy. Br. J. Cancer, 1955, 9, 539-549.
-
(1955)
Br. J. Cancer
, vol.9
, pp. 539-549
-
-
Thomlinson, R.H.1
Gray, L.H.2
-
132
-
-
79957534572
-
Targeting hypoxia in cancer therapy
-
Wilson, W.R.; Hay, M.P. Targeting hypoxia in cancer therapy. Nat. Rev. Cancer, 2011, 11, 393-410.
-
(2011)
Nat. Rev. Cancer
, vol.11
, pp. 393-410
-
-
Wilson, W.R.1
Hay, M.P.2
-
133
-
-
33746565896
-
Scheduling cisplatin and radiotherapy in the treatment of squamous cell carcinomas of the head and neck: A modelling approach
-
Marcu, L.; Bezak, E.; Olver, I. Scheduling cisplatin and radiotherapy in the treatment of squamous cell carcinomas of the head and neck: A modelling approach. Phys. Med. Biol., 2006, 51, 3625- 3637.
-
(2006)
Phys. Med. Biol.
, vol.51
, pp. 3625-3637
-
-
Marcu, L.1
Bezak, E.2
Olver, I.3
-
134
-
-
0025646401
-
Potentiation by the hypoxic cytotoxin SR-4233 of cell killing produced by fractionated irradiation of mouse tumors
-
Brown, J.M.; Lemmon, M.J. Potentiation by the hypoxic cytotoxin SR-4233 of cell killing produced by fractionated irradiation of mouse tumors. Cancer Res., 1990, 50, 7745-7749.
-
(1990)
Cancer Res
, vol.50
, pp. 7745-7749
-
-
Brown, J.M.1
Lemmon, M.J.2
-
135
-
-
0037413529
-
Structure-activity relationships of 1, 2, 4-benzotriazine 1, 4-dioxides as hypoxia-selective analogues of tirapazamine
-
Hay, M.P.; Gamage, S.A.; Kovacs, M.S.; Pruijn, F.B.; Anderson, R.F.; Patterson, A.V.; Wilson, W.R.; Brown, J.M.; Denny, W.A. Structure-activity relationships of 1, 2, 4-benzotriazine 1, 4-dioxides as hypoxia-selective analogues of tirapazamine. J. Med. Chem., 2003, 46, 169-182.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 169-182
-
-
Hay, M.P.1
Gamage, S.A.2
Kovacs, M.S.3
Pruijn, F.B.4
Anderson, R.F.5
Patterson, A.V.6
Wilson, W.R.7
Brown, J.M.8
Denny, W.A.9
-
136
-
-
77958060317
-
Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogs with improved tissue penetration and hypoxic cell killing in tumors
-
Hicks, K.O.; Siim, B.G.; Jaiswal, J.K.; Pruijn, F.B.; Fraser, A.M.; Patel, R.; Hogg, A.; Sarath Liyanage, H.D.; Dorie, M.J.; Brown, J.M.; Denny, W.A.; Hay, M.P.; Wilson, W.R. Pharmacokinetic/pharmacodynamic modeling identifies SN30000 and SN29751 as tirapazamine analogs with improved tissue penetration and hypoxic cell killing in tumors. Clin. Cancer Res., 2010, 16, 4946-4957.
-
(2010)
Clin. Cancer Res.
, vol.16
, pp. 4946-4957
-
-
Hicks, K.O.1
Siim, B.G.2
Jaiswal, J.K.3
Pruijn, F.B.4
Fraser, A.M.5
Patel, R.6
Hogg, A.7
Sarath Liyanage, H.D.8
Dorie, M.J.9
Brown, J.M.10
Denny, W.A.11
Hay, M.P.12
Wilson, W.R.13
-
137
-
-
35848964831
-
Synthesis and biological evaluation of new 2-arylcarbonyl-3- trifluoromethyl-quinoxaline 1, 4-di-N-oxide derivatives and their reduced analogues
-
Solano, B.; Junnotula, V.; Marin, A.; Villar, R.; Burguete A.; Vicente E.; Perez-Silanes, S.; Aldana, I.; Monge, A.; Dutta, S. Synthesis and biological evaluation of new 2-arylcarbonyl-3- trifluoromethyl-quinoxaline 1, 4-di-N-oxide derivatives and their reduced analogues. J. Med. Chem., 2007, 50, 5485-5492.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 5485-5492
-
-
Solano, B.1
Junnotula, V.2
Marin, A.3
Villar, R.4
Burguete, A.5
Vicente, E.6
Perez-Silanes, S.7
Aldana, I.8
Monge, A.9
Dutta, S.10
-
138
-
-
33745727137
-
Synthesis and hypoxic-cytotoxic activity of some 3-amino-1, 2, 4- benzotriazine-1, 4-dioxide derivatives
-
Jiang, F.Q.; Yang, B.; Fan, L.L.; He, Q.J.; Hu, Y.Z. Synthesis and hypoxic-cytotoxic activity of some 3-amino-1, 2, 4- benzotriazine-1, 4-dioxide derivatives. Bioorg. Med. Chem. Lett., 2006, 16, 4209-4213.
-
(2006)
Bioorg. Med. Chem. Lett.
, vol.16
, pp. 4209-4213
-
-
Jiang, F.Q.1
Yang, B.2
Fan, L.L.3
He, Q.J.4
Hu, Y.Z.5
-
139
-
-
79951670097
-
Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide derivatives
-
Xia, Q.; Zhang, L.; Zhang, J.; Sheng, R.; Yang, B.; He, Q.J.; Hu, Y.Z. Synthesis, hypoxia-selective cytotoxicity of new 3-amino-1, 2, 4-benzotriazine-1, 4-dioxide derivatives. Eur. J. Med. Chem., 2011, 46, 919-926.
-
(2011)
Eur. J. Med. Chem.
, vol.46
, pp. 919-926
-
-
Xia, Q.1
Zhang, L.2
Zhang, J.3
Sheng, R.4
Yang, B.5
He, Q.J.6
Hu, Y.Z.7
-
140
-
-
34250772853
-
Synthesis, structure and hypoxic cytotoxicity of 3-amino-1, 2, 4-benzotriazine- 1, 4-dioxide derivatives
-
Jiang, F.Q.; Weng, Q.J.; Sheng, R.; Xia, Q.; He, Q.J.; Yang, B.; Hu, Y.Z. Synthesis, structure and hypoxic cytotoxicity of 3-amino-1, 2, 4-benzotriazine- 1, 4-dioxide derivatives. Arch. Pharm., 2007, 340, 258-263.
-
(2007)
Arch. Pharm.
, vol.340
, pp. 258-263
-
-
Jiang, F.Q.1
Weng, Q.J.2
Sheng, R.3
Xia, Q.4
He, Q.J.5
Yang, B.6
Hu, Y.Z.7
-
141
-
-
84861610334
-
Synthesis and cytotoxic activity of 3-phenyl-2-thioquinoxaline 1, 4-dioxide derivatives in hypoxia and in normoxia
-
Sheng, R.; Xu, Y.; Weng, Q. J.; Xia, Q.; He, Q.J.; Yang, B.; Hu, Y.Z. Synthesis and cytotoxic activity of 3-phenyl-2-thioquinoxaline 1, 4-dioxide derivatives in hypoxia and in normoxia. Drug. Discov. Ther., 2007, 1, 119-123.
-
(2007)
Drug. Discov. Ther.
, vol.1
, pp. 119-123
-
-
Sheng, R.1
Xu, Y.2
Weng, Q.J.3
Xia, Q.4
He, Q.J.5
Yang, B.6
Hu, Y.Z.7
-
142
-
-
38949124380
-
Q39, A novel synthetic quinoxaline 1, 4-di-N-oxide compound with anti-cancer activity in hypoxia
-
Weng, Q.J.; Wang, D.D.; Guo, P.; Fang, L.; Hu, Y.Z., He, Q.J.; Yang, B. Q39, a novel synthetic quinoxaline 1, 4-di-N-oxide compound with anti-cancer activity in hypoxia. Eur. J. Pharmacol., 2008, 581, 262-269.
-
(2008)
Eur. J. Pharmacol.
, vol.581
, pp. 262-269
-
-
Weng, Q.J.1
Wang, D.D.2
Guo, P.3
Fang, L.4
Hu, Y.Z.5
He, Q.J.6
Yang, B.7
-
143
-
-
84856064603
-
Q39, a quinoxaline 1, 4- di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells
-
Weng, Q.J.; Zhang, J.; Cao, J.; Xia, Q.; Wang, D.D.; Hu, Y.Z.; Sheng, R.; Wu, H.H.; Zhu, D.F.; Zhu, H.; He, Q.; Yang, B. Q39, a quinoxaline 1, 4- di-N-oxide derivative, inhibits hypoxia-inducible factor-1α expression and the Akt/mTOR/4E-BP1 signaling pathway in human hepatoma cells. Invest. New Drugs, 2011, 29, 1177-1187.
-
(2011)
Invest. New Drugs
, vol.29
, pp. 1177-1187
-
-
Weng, Q.J.1
Zhang, J.2
Cao, J.3
Xia, Q.4
Wang, D.D.5
Hu, Y.Z.6
Sheng, R.7
Wu, H.H.8
Zhu, D.F.9
Zhu, H.10
He, Q.11
Yang, B.12
-
144
-
-
84865527506
-
Synthesis and biological evaluation of 3-aryl-quinoxaline-2-carbonitrile 1, 4-di-N-oxide derivatives as hypoxic selective anti-tumor agents
-
Hu, Y.; Xia, Q.; Shangguan, S.; Liu, X.; Hu, Y.; Sheng, R. Synthesis and biological evaluation of 3-aryl-quinoxaline-2-carbonitrile 1, 4-di-N-oxide derivatives as hypoxic selective anti-tumor agents. Molecules, 2012, 17, 9683-9696.
-
(2012)
Molecules
, vol.17
, pp. 9683-9696
-
-
Hu, Y.1
Xia, Q.2
Shangguan, S.3
Liu, X.4
Hu, Y.5
Sheng, R.6
-
145
-
-
77949904798
-
Design of novel hypoxia-targeting IDO hybrid inhibitors conjugated with an unsubstituted L-TRP as an IDO affinity moiety
-
Nakashima, H.; Ikkyu, K.; Nakashima, K.; Sano, K.; Uto, Y.; Nakata, E.; Nagasawa, H.; Sugimoto, H.; Shiro, Y.; Nakagawa, Y.; Hori, H. Design of novel hypoxia-targeting IDO hybrid inhibitors conjugated with an unsubstituted L-TRP as an IDO affinity moiety. Adv. Exp. Med. Biol., 2010, 662, 415-421.
-
(2010)
Adv. Exp. Med. Biol.
, vol.662
, pp. 415-421
-
-
Nakashima, H.1
Ikkyu, K.2
Nakashima, K.3
Sano, K.4
Uto, Y.5
Nakata, E.6
Nagasawa, H.7
Sugimoto, H.8
Shiro, Y.9
Nakagawa, Y.10
Hori, H.11
-
146
-
-
51449096209
-
Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2, 3-dioxygenase inhibitors
-
Nakashima, H.; Uto, Y.; Nakata, E.; Nagasawa, H.; Ikkyu, K.; Hiraoka, N.; Nakashima, K.; Sasaki, Y.; Sugimoto, H.; Shiro, Y.; Hashimoto, T.; Okamoto, Y.; Asakawa, Y.; Hori, H. Synthesis and biological activity of 1-methyl-tryptophan-tirapazamine hybrids as hypoxia-targeting indoleamine 2, 3-dioxygenase inhibitors. Bioorg. Med. Chem., 2008, 16, 8661-8669.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 8661-8669
-
-
Nakashima, H.1
Uto, Y.2
Nakata, E.3
Nagasawa, H.4
Ikkyu, K.5
Hiraoka, N.6
Nakashima, K.7
Sasaki, Y.8
Sugimoto, H.9
Shiro, Y.10
Hashimoto, T.11
Okamoto, Y.12
Asakawa, Y.13
Hori, H.14
-
147
-
-
84857590567
-
The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness
-
Adams Wilson, J.R.; Morandi, A.; Girard, T.D.; Thompson, J.L.; Boomershine, C.S.; Shintani, A.K.; Ely, E.W.; Pandharipande, P.P. The association of the kynurenine pathway of tryptophan metabolism with acute brain dysfunction during critical illness. Crit. Care Med., 2012, 40, 835-841.
-
(2012)
Crit. Care Med.
, vol.40
, pp. 835-841
-
-
Adams Wilson, J.R.1
Morandi, A.2
Girard, T.D.3
Thompson, J.L.4
Boomershine, C.S.5
Shintani, A.K.6
Ely, E.W.7
Pandharipande, P.P.8
-
148
-
-
0142137237
-
Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase
-
Uyttenhove, C.; Pilotte, L.; Theate, I.; Stroobant, V.; Colau, D.; Parmentier, N.; Boon, T.; Van den Eynde, B.J. Evidence for a tumoral immune resistance mechanism based on tryptophan degradation by indoleamine 2, 3-dioxygenase. Nat. Med., 2003, 9, 1269- 1274.
-
(2003)
Nat. Med.
, vol.9
, pp. 1269-1274
-
-
Uyttenhove, C.1
Pilotte, L.2
Theate, I.3
Stroobant, V.4
Colau, D.5
Parmentier, N.6
Boon, T.7
Van Den Eynde, B.J.8
-
149
-
-
0035878747
-
Inhibition of DNA replication by tirapazamine
-
Peters, K.B.; Wang, H.; Brown, J.M.; Iliakis, G. Inhibition of DNA replication by tirapazamine. Cancer Res., 2001, 61, 5425-5431.
-
(2001)
Cancer Res
, vol.61
, pp. 5425-5431
-
-
Peters, K.B.1
Wang, H.2
Brown, J.M.3
Iliakis, G.4
-
150
-
-
0037105653
-
Tirapazamine: A hypoxia-activated topoisomerase II poison
-
Peters, K.B.; Brown, J.M. Tirapazamine: A hypoxia-activated topoisomerase II poison. Cancer Res., 2002, 62, 5248-5253.
-
(2002)
Cancer Res
, vol.62
, pp. 5248-5253
-
-
Peters, K.B.1
Brown, J.M.2
-
151
-
-
0038054178
-
Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting
-
Delahoussaye, Y.M.; Hay, M.P.; Pruijn, F.B.; Denny, W.A.; Brown, J.M. Improved potency of the hypoxic cytotoxin tirapazamine by DNA-targeting. Biochem. Pharmacol., 2003, 65, 1807-1815.
-
(2003)
Biochem. Pharmacol.
, vol.65
, pp. 1807-1815
-
-
Delahoussaye, Y.M.1
Hay, M.P.2
Pruijn, F.B.3
Denny, W.A.4
Brown, J.M.5
-
152
-
-
0035504709
-
Metabolism of tirapazamine by multiple reductases in the nucleus
-
Delahoussaye, Y.M.; Evans, J.W.; Brown, J.M. Metabolism of tirapazamine by multiple reductases in the nucleus. Biochem. Pharmacol., 2001, 62, 1201-1209.
-
(2001)
Biochem. Pharmacol.
, vol.62
, pp. 1201-1209
-
-
Delahoussaye, Y.M.1
Evans, J.W.2
Brown, J.M.3
-
153
-
-
0026073332
-
SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures
-
Biedermann, K.A.; Wang, J.; Graham, R.P.; Brown, J.M. SR 4233 cytotoxicity and metabolism in DNA repair-competent and repair-deficient cell cultures. Br. J. Cancer, 1991, 63, 358-362.
-
(1991)
Br. J. Cancer
, vol.63
, pp. 358-362
-
-
Biedermann, K.A.1
Wang, J.2
Graham, R.P.3
Brown, J.M.4
-
154
-
-
0029862714
-
Dual action of tirapazamine in the induction of DNA strand breaks
-
Jones, G.D.; Weinfeld, M. Dual action of tirapazamine in the induction of DNA strand breaks. Cancer Res., 1996, 56, 1584-1590.
-
(1996)
Cancer Res.
, vol.56
, pp. 1584-1590
-
-
Jones, G.D.1
Weinfeld, M.2
-
155
-
-
3643111389
-
Direct evidence for bimodal DNA damage induced by tirapazamine
-
Daniels, J.S.; Gates, K.S.; Tronche, C.; Greenberg, M.M. Direct evidence for bimodal DNA damage induced by tirapazamine. Chem. Res. Toxicol., 1998, 11, 1254-1257.
-
(1998)
Chem. Res. Toxicol.
, vol.11
, pp. 1254-1257
-
-
Daniels, J.S.1
Gates, K.S.2
Tronche, C.3
Greenberg, M.M.4
-
156
-
-
0033607196
-
Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'- radical in single-stranded and double-stranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA-damage reactions
-
Hwang, J.T.; Greenberg, M.M.; Fuchs, T.; Gates, K.S. Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'- radical in single-stranded and double-stranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA-damage reactions. Biochemistry, 1999, 38, 14248-14255.
-
(1999)
Biochemistry
, vol.38
, pp. 14248-14255
-
-
Hwang, J.T.1
Greenberg, M.M.2
Fuchs, T.3
Gates, K.S.4
-
157
-
-
1642475109
-
Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317
-
Siim, B.G.; Pruijn, F.B.; Sturman, J.R.; Hogg, A.; Hay, M.P.; Brown, J.M.; Wilson, W.R. Selective potentiation of the hypoxic cytotoxicity of tirapazamine by its 1-N-oxide metabolite SR 4317. Cancer Res., 2004, 64, 736-742.
-
(2004)
Cancer Res.
, vol.64
, pp. 736-742
-
-
Siim, B.G.1
Pruijn, F.B.2
Sturman, J.R.3
Hogg, A.4
Hay, M.P.5
Brown, J.M.6
Wilson, W.R.7
-
158
-
-
2342562556
-
Mitogen-activated protein kinases in apoptosis regulation
-
Wada, T.; Penninger, J.M. Mitogen-activated protein kinases in apoptosis regulation. Oncogene, 2004 23, 2838-2849.
-
(2004)
Oncogene
, vol.23
, pp. 2838-2849
-
-
Wada, T.1
Penninger, J.M.2
-
159
-
-
84861309037
-
P38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination
-
Yang, D.P.; Kim, J.; Syed, N.; Tung, Y.J.; Bhaskaran, A.; Mindos, T.; Mirsky, R.; Jessen, K.R.; Maurel, P.; Parkinson, D.B.; Kim, H.A. p38 MAPK activation promotes denervated Schwann cell phenotype and functions as a negative regulator of Schwann cell differentiation and myelination. J. Neurosci., 2012, 32, 7158-7168.
-
(2012)
J. Neurosci.
, vol.32
, pp. 7158-7168
-
-
Yang, D.P.1
Kim, J.2
Syed, N.3
Tung, Y.J.4
Bhaskaran, A.5
Mindos, T.6
Mirsky, R.7
Jessen, K.R.8
Maurel, P.9
Parkinson, D.B.10
Kim, H.A.11
-
160
-
-
3142688849
-
Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen- specific
-
Fernandes, D.J.; Ravenhall, C.E.; Harris, T.; Tran, T.; Vlahos, R.; Stewart, A.G. Contribution of the p38MAPK signalling pathway to proliferation in human cultured airway smooth muscle cells is mitogen- specific. Br. J. Pharmacol., 2004, 142, 1182-1190.
-
(2004)
Br. J. Pharmacol.
, vol.142
, pp. 1182-1190
-
-
Fernandes, D.J.1
Ravenhall, C.E.2
Harris, T.3
Tran, T.4
Vlahos, R.5
Stewart, A.G.6
-
161
-
-
79952738701
-
Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells
-
Svensson, C.; Part, K.; Kunnis-Beres, K.; Kaldmae, M.; Fernaeus, S.Z.; Land, T. Pro-survival effects of JNK and p38 MAPK pathways in LPS-induced activation of BV-2 cells. Biochem. Biophys. Res. Commun., 2011, 406, 488-492.
-
(2011)
Biochem. Biophys. Res. Commun.
, vol.406
, pp. 488-492
-
-
Svensson, C.1
Part, K.2
Kunnis-Beres, K.3
Kaldmae, M.4
Fernaeus, S.Z.5
Land, T.6
-
162
-
-
84872390677
-
P38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts
-
Sinfield, J.K.; Das, A.; O'Regan, D.J.; Ball, S.G.; Porter, K.E.; Turner, N.A. p38 MAPK alpha mediates cytokine-induced IL-6 and MMP-3 expression in human cardiac fibroblasts. Biochem. Biophys. Res. Commun., 2013, 430, 419-424.
-
(2013)
Biochem. Biophys. Res. Commun.
, vol.430
, pp. 419-424
-
-
Sinfield, J.K.1
Das, A.2
O'Regan, D.J.3
Ball, S.G.4
Porter, K.E.5
Turner, N.A.6
-
163
-
-
72249120832
-
The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer
-
Yong, H.Y.; Koh, M.S.; Moon, A. The p38 MAPK inhibitors for the treatment of inflammatory diseases and cancer. Expert Opin. Invest. Drugs, 2009, 18, 1893-1905.
-
(2009)
Expert Opin. Invest. Drugs
, vol.18
, pp. 1893-1905
-
-
Yong, H.Y.1
Koh, M.S.2
Moon, A.3
-
164
-
-
0028605318
-
A protein kinase involved in the regulation of inflammatory cytokine biosynthesis
-
Lee, J.C.; Laydon, J.T.; McDonnell, P.C.; Gallagher, T.F.; Kumar, S.; Green, D.; McNulty, D.; Blumenthal, M.J.; Heyes, J.R.; Landvatter, S.W.; Strickler, J.E.; McLaughlin, M.M.; Siemens, I.R.; Fisher, S.M.; Livi, G.P.; White, J.R.; Adams, J.L.; Young, P.R. A protein kinase involved in the regulation of inflammatory cytokine biosynthesis. Nature, 1994, 372, 739-746.
-
(1994)
Nature
, vol.372
, pp. 739-746
-
-
Lee, J.C.1
Laydon, J.T.2
McDonnell, P.C.3
Gallagher, T.F.4
Kumar, S.5
Green, D.6
McNulty, D.7
Blumenthal, M.J.8
Heyes, J.R.9
Landvatter, S.W.10
Strickler, J.E.11
McLaughlin, M.M.12
Siemens, I.R.13
Fisher, S.M.14
Livi, G.P.15
White, J.R.16
Adams, J.L.17
Young, P.R.18
-
165
-
-
0041318841
-
Structural basis for p38 MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity
-
Fitzgerald, C.E.; Patel, S.B.; Becker, J.W.; Cameron, P.M.; Zaller, D.; Pikounis, V.B.; O'Keefe, S.J.; Scapin, G. Structural basis for p38 MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity. Nat. Struct. Biol., 2003, 10, 764-769.
-
(2003)
Nat. Struct. Biol.
, vol.10
, pp. 764-769
-
-
Fitzgerald, C.E.1
Patel, S.B.2
Becker, J.W.3
Cameron, P.M.4
Zaller, D.5
Pikounis, V.B.6
O'Keefe, S.J.7
Scapin, G.8
-
167
-
-
0034887261
-
VX-745 (Vertex pharmaceuticals)
-
Haddad, J.J. VX-745 (Vertex Pharmaceuticals). Curr. Opin. Invest. Drugs, 2001, 2, 1070-1076.
-
(2001)
Curr. Opin. Invest. Drugs
, vol.2
, pp. 1070-1076
-
-
Haddad, J.J.1
-
168
-
-
69949095173
-
-
WO Patent, September 4
-
Alonso-Alija, C.; Michels, M.; Schirok, H.; Schlemmer, K.-H.; Bell, J.; Fitzgerald, M.F.; Dodd, S.; Gill, A. Monocyclic aroylpyridinones as antiinflammatory agents. WO Patent 076405, September 4, 2003.
-
(2003)
Monocyclic Aroylpyridinones as Antiinflammatory Agents
-
-
Alonso-Alija, C.1
Michels, M.2
Schirok, H.3
Schlemmer, K.-H.4
Bell, J.5
Fitzgerald, M.F.6
Dodd, S.7
Gill, A.8
-
169
-
-
27744509094
-
Efficient regioselective synthesis of 6-amino-5-benzoyl-1-substituted 2(1H)- pyridinones
-
Schirok, H.; Alonso-Alija, C.; Benet-Buchholz, J.; Goller, A.H.; Grosser, R.; Michels, M.; Paulsen, H. Efficient regioselective synthesis of 6-amino-5-benzoyl-1-substituted 2(1H)- pyridinones. J. Org. Chem., 2005, 70, 9463-9469.
-
(2005)
J. Org. Chem.
, vol.70
, pp. 9463-9469
-
-
Schirok, H.1
Alonso-Alija, C.2
Benet-Buchholz, J.3
Goller, A.H.4
Grosser, R.5
Michels, M.6
Paulsen, H.7
-
170
-
-
27744544566
-
Suppression of p38 activity in vitro and THF alpha production in vivo with BIRB-796 BS, a novel p38 kinase inhibitor
-
Zimmiti, C.S.; Schwartz, R.; Torcellini, C.A.; Pargellis, C.A.; Madwed, J.B.; Weldon, S.M. Suppression of p38 activity in vitro and THF alpha production in vivo with BIRB-796 BS, a novel p38 kinase inhibitor. Arthritis Rheum., 2001, 44, S114.
-
(2001)
Arthritis Rheum
, vol.44
, pp. S114
-
-
Zimmiti, C.S.1
Schwartz, R.2
Torcellini, C.A.3
Pargellis, C.A.4
Madwed, J.B.5
Weldon, S.M.6
-
171
-
-
0142028917
-
Structureactivity relationships of the p38R MAP kinase inhibitor 1-(5-tert- Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3- [4-(2-morpholin-4-yl-ethoxy) napthalen-1-yl]urea (BIRB-796)
-
Regan, J.; Capolino, A.; Cirillo, P.F.; Gilmore, T.; Graham, A.G.; Hickey, E.; Kroe, R.R.; Madwed, J.; Moriak, M.; Nelson, R.; Pargellis, C.A.; Swinamer, A.; Torcellini, C.; Tsang, M.; Moss, N. Structureactivity relationships of the p38R MAP kinase inhibitor 1-(5-tert- Butyl-2-p-tolyl-2H-pyrazol-3-yl)-3- [4-(2-morpholin-4-yl-ethoxy) napthalen-1-yl]urea (BIRB-796). J. Med. Chem., 2003, 46, 4676- 4686.
-
(2003)
J. Med. Chem.
, vol.46
, pp. 4676-4686
-
-
Regan, J.1
Capolino, A.2
Cirillo, P.F.3
Gilmore, T.4
Graham, A.G.5
Hickey, E.6
Kroe, R.R.7
Madwed, J.8
Moriak, M.9
Nelson, R.10
Pargellis, C.A.11
Swinamer, A.12
Torcellini, C.13
Tsang, M.14
Moss, N.15
-
172
-
-
84940864756
-
Discovery and development of orally active p38 Kinase Inhibitors as Anti-TNF agents
-
Abstracts of Papers of the, San Diego, CA, March 13-17, 2005; American Chemical Society: Washington, DC, MEDI-296
-
Devraj, R.V. Discovery and Development of Orally Active p38 Kinase Inhibitors as Anti-TNF Agents. In: Abstracts of Papers of the 229th National Meeting of the American Chemical Society, San Diego, CA, March 13-17, 2005; American Chemical Society: Washington, DC, 2005; MEDI-296.
-
(2005)
229th National Meeting of the American Chemical Society
-
-
Devraj, R.V.1
-
173
-
-
85039835412
-
Efficacy of AMG 548, a novel p38 kinase inhibitor, in rats with adjuvant-induced or collagen-induced arthritis
-
Abstracts of the, Orlando, FL, October 23-28 834
-
Zack, D.J.; Campagnuolo, G.; Middleton, S.; Koch, A.; Zhu, L.; Bolon, B.; Feige, U. Efficacy of AMG 548, a Novel p38 Kinase Inhibitor, in Rats with Adjuvant-Induced or Collagen-Induced Arthritis. In: Abstracts of the 67th Annual Scientific Meeting of the American College of Rheumatology, Orlando, FL, October 23-28, 2003, Abstract 834.
-
(2003)
67th Annual Scientific Meeting of the American College of Rheumatology
-
-
Zack, D.J.1
Campagnuolo, G.2
Middleton, S.3
Koch, A.4
Zhu, L.5
Bolon, B.6
Feige, U.7
-
174
-
-
84940849234
-
P38 MAP kinase: An exciting target for the treatment of inflammatory diseases
-
Abstracts of Papers of the, Philadelphia, PA; American Chemical Society: Washington, DC, MEDI-189
-
Dominguez, C.; Liu, L.; Zhang, D.; Tamayo, N.; Powers, D.; Min, W.; Feige, F.; Harris, R.; Wild, S.; Neervannan, S.; Rashid, S.; Harvey, T. p38 MAP Kinase: An Exciting Target for the Treatment of Inflammatory Diseases. In: Abstracts of Papers of the 228th National Meeting of the American Chemical Society, Philadelphia, PA; American Chemical Society: Washington, DC, 2004; MEDI-189.
-
(2004)
228th National Meeting of the American Chemical Society
-
-
Dominguez, C.1
Liu, L.2
Zhang, D.3
Tamayo, N.4
Powers, D.5
Min, W.6
Feige, F.7
Harris, R.8
Wild, S.9
Neervannan, S.10
Rashid, S.11
Harvey, T.12
-
176
-
-
69949090676
-
Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase
-
Lumeras, W.; Caturla, F.; Vidal, L.; Esteve, C.; Balague, C.; Orellana, A.; Dominguez, M.; Roca, R.; Huerta, J.M.; Godessart, N.; Vidal, B. Design, synthesis, and structure-activity relationships of aminopyridine N-oxides, a novel scaffold for the potent and selective inhibition of p38 mitogen activated protein kinase. J. Med. Chem., 2009, 52, 5531-5545.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 5531-5545
-
-
Lumeras, W.1
Caturla, F.2
Vidal, L.3
Esteve, C.4
Balague, C.5
Orellana, A.6
Dominguez, M.7
Roca, R.8
Huerta, J.M.9
Godessart, N.10
Vidal, B.11
-
177
-
-
81555218659
-
1, 7- Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase
-
Lumeras, W.; Vidal, L.; Vidal, B., Balague, C.; Orellana, A.; Maldonado, M.; Dominguez, M.; Segarra, V.; Caturla, F. 1, 7- Naphthyridine 1-oxides as novel potent and selective inhibitors of p38 mitogen activated protein kinase. J. Med. Chem., 2011, 54, 7899-7910.
-
(2011)
J. Med. Chem.
, vol.54
, pp. 7899-7910
-
-
Lumeras, W.1
Vidal, L.2
Vidal, B.3
Balague, C.4
Orellana, A.5
Maldonado, M.6
Dominguez, M.7
Segarra, V.8
Caturla, F.9
-
178
-
-
3042654141
-
A rationally designed universal catalyst for Suzuki-Miyaura coupling processes
-
Walker, S.D.; Barder, T.E.; Martinelli, J.R.; Buchwald, S.L. A rationally designed universal catalyst for Suzuki-Miyaura coupling processes. Angew. Chem., Int. Ed., 2004, 43, 1871-1876.
-
(2004)
Angew. Chem., Int. Ed.
, vol.43
, pp. 1871-1876
-
-
Walker, S.D.1
Barder, T.E.2
Martinelli, J.R.3
Buchwald, S.L.4
-
179
-
-
33847088408
-
Selective carbon-carbon bond formation via transition-metal catalysis. 3. Highly selective synthesis of unsymmetrical biaryls and diarylmethanes by nickelcatalyzed or palladium-catalyzed reaction of aryl derivatives and benzylzinc derivatives with aryl
-
Negishi, E.-I.; King, A.O.; Okukado, N. Selective carbon-carbon bond formation via transition-metal catalysis. 3. Highly selective synthesis of unsymmetrical biaryls and diarylmethanes by nickelcatalyzed or palladium-catalyzed reaction of aryl derivatives and benzylzinc derivatives with aryl. J. Org. Chem., 1977, 42, 1821- 1823.
-
(1977)
J. Org. Chem.
, vol.42
, pp. 1821-1823
-
-
Negishi, E.-I.1
King, A.O.2
Okukado, N.3
-
180
-
-
0001764402
-
Regiospecific synthesis of carbosubstituted heteroaromatic derivatives via Pd-catalyzed cross coupling
-
Negishi, E.-I.; Luo, F.-T.; Frisbee, R.; Matsushita, H.A. Regiospecific synthesis of carbosubstituted heteroaromatic derivatives via Pd-catalyzed cross coupling. Heterocycles, 1982, 18, 117- 122.
-
(1982)
Heterocycles
, vol.18
, pp. 117-122
-
-
Negishi, E.-I.1
Luo, F.-T.2
Frisbee, R.3
Matsushita, H.A.4
-
182
-
-
33846597467
-
Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety
-
Fang, L.; Zhang, Y.; Lehmann, J.; Wang, Y.; Ji, H.; Ding, D. Design and synthesis of furoxan-based nitric oxide-releasing glucocorticoid derivatives with potent anti-inflammatory activity and improved safety. Bioorg. Med. Chem. Lett., 2007, 17, 1062-1066.
-
(2007)
Bioorg. Med. Chem. Lett.
, vol.17
, pp. 1062-1066
-
-
Fang, L.1
Zhang, Y.2
Lehmann, J.3
Wang, Y.4
Ji, H.5
Ding, D.6
-
183
-
-
20644470328
-
Novel benzo [1, 2-c]1, 2, 5-oxadiazole N-oxide derivatives as antichagasic agents: Chemical and biological studies
-
Olea-Azar, C.; Rigo, C.; Mendizabal, F.; Cerecetto, H.; Di Maio, R.; Gonzalez, M.; Porcal, W.; Morello, A.; Repetto, Y.; Maya, J.D.; Novel benzo [1, 2-c]1, 2, 5-oxadiazole N-oxide derivatives as antichagasic agents: chemical and biological studies. Lett. Drug Des. Discov., 2005, 4, 294-301.
-
(2005)
Lett. Drug Des. Discov.
, vol.4
, pp. 294-301
-
-
Olea-Azar, C.1
Rigo, C.2
Mendizabal, F.3
Cerecetto, H.4
Di Maio, R.5
Gonzalez, M.6
Porcal, W.7
Morello, A.8
Repetto, Y.9
Maya, J.D.10
-
184
-
-
0014259078
-
7-Chloro-4-nitrobenzo-2-oxa- 1, 3-diazole: A new fluorigenic reagent for amino acids and other amines
-
Ghosh, P.B.; Whitehouse, M.W. 7-Chloro-4-nitrobenzo-2-oxa- 1, 3-diazole: A new fluorigenic reagent for amino acids and other amines. J. Med. Chem., 1968, 11, 305-311.
-
(1968)
J. Med. Chem.
, vol.11
, pp. 305-311
-
-
Ghosh, P.B.1
Whitehouse, M.W.2
-
185
-
-
0014232990
-
4-Nitrobenzofurazans and 4-nitrobenzofuroxans: A new class of thiol-neutralising agents and potent inhibitors of nucleic acid synthesis in leucocytes
-
Whitehouse, M.W.; Ghosh, P.B. 4-Nitrobenzofurazans and 4-nitrobenzofuroxans: A new class of thiol-neutralising agents and potent inhibitors of nucleic acid synthesis in leucocytes. Biochem. Pharmacol., 1968, 17, 158-161.
-
(1968)
Biochem. Pharmacol.
, vol.17
, pp. 158-161
-
-
Whitehouse, M.W.1
Ghosh, P.B.2
-
186
-
-
31144458094
-
Furoxan derivatives as cytotoxic agents: Preliminary in vivo antitumoral activity studies
-
Aguirre, G.; Boiani, M.; Cerecetto, H.; Fernandez, M.; Gonzalez, M.; Leon, E.; Pintos, C.; Raymondo, S.; Arredondo, C.; Pacheco, J.P.; Basombrio, M. Furoxan derivatives as cytotoxic agents: preliminary in vivo antitumoral activity studies. Pharmazie, 2006, 61, 54-59.
-
(2006)
Pharmazie
, vol.61
, pp. 54-59
-
-
Aguirre, G.1
Boiani, M.2
Cerecetto, H.3
Fernandez, M.4
Gonzalez, M.5
Leon, E.6
Pintos, C.7
Raymondo, S.8
Arredondo, C.9
Pacheco, J.P.10
Basombrio, M.11
-
187
-
-
50349103256
-
Furoxan-, alkylnitrate- derivatives and related compounds as anti-trypanosomatid agents: Mechanism of action studies
-
Boiani, L.; Aguirre, G.; Gonzalez, M.; Cerecetto, H.; Chidichimo, A.; Cazzulo, J.J.; Bertinaria, M.; Guglielmo, S. Furoxan-, alkylnitrate- derivatives and related compounds as anti-trypanosomatid agents: mechanism of action studies. Bioorg. Med. Chem., 2008, 16, 7900-7907.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 7900-7907
-
-
Boiani, L.1
Aguirre, G.2
Gonzalez, M.3
Cerecetto, H.4
Chidichimo, A.5
Cazzulo, J.J.6
Bertinaria, M.7
Guglielmo, S.8
-
188
-
-
4644231576
-
Nitrates and NO release: Contemporary aspects in biological and medicinal chemistry
-
Thatcher, G.R.J.; Nicolescu, A.C.; Bennett, B.M.; Toader, V. Nitrates and NO release: contemporary aspects in biological and medicinal chemistry. Free Radic. Biol. Med., 2004, 37, 1122-1143.
-
(2004)
Free Radic. Biol. Med.
, vol.37
, pp. 1122-1143
-
-
Thatcher, G.R.J.1
Nicolescu, A.C.2
Bennett, B.M.3
Toader, V.4
-
189
-
-
0028275855
-
Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation
-
Zhuo, M.; Hu, Y.; Schultz, C.; Kandel, E. R.; Hawkins, R.D. Role of guanylyl cyclase and cGMP-dependent protein kinase in long-term potentiation. Nature, 1994, 368, 635-639.
-
(1994)
Nature
, vol.368
, pp. 635-639
-
-
Zhuo, M.1
Hu, Y.2
Schultz, C.3
Kandel, E.R.4
Hawkins, R.D.5
-
190
-
-
0033493229
-
Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus
-
Lu, Y.F.; Kandel, E.R.; Hawkins, R. D. Nitric oxide signaling contributes to late-phase LTP and CREB phosphorylation in the hippocampus. J. Neurosci., 1999, 19, 10250-10261.
-
(1999)
J. Neurosci.
, vol.19
, pp. 10250-10261
-
-
Lu, Y.F.1
Kandel, E.R.2
Hawkins, R.D.3
-
191
-
-
0037338353
-
On the role of nitric oxide in hippocampal long-term potentiation
-
Bon, C.L.; Garthwaite, J. On the role of nitric oxide in hippocampal long-term potentiation. J. Neurosci., 2003, 23, 1941-1948.
-
(2003)
J. Neurosci.
, vol.23
, pp. 1941-1948
-
-
Bon, C.L.1
Garthwaite, J.2
-
192
-
-
0026603066
-
The role of nitric oxide in hippocampal long-term potentiation
-
Haley, J.E.; Wilcox, G.L.; Chapman, P.F. The role of nitric oxide in hippocampal long-term potentiation. Neuron, 1992, 8, 211-216.
-
(1992)
Neuron
, vol.8
, pp. 211-216
-
-
Haley, J.E.1
Wilcox, G.L.2
Chapman, P.F.3
-
193
-
-
0034671184
-
Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system
-
Cirelli, C.; Tonon, G. Differential expression of plasticity-related genes in waking and sleep and their regulation by the noradrenergic system. J. Neurosci., 2000, 20, 9187-9194.
-
(2000)
J. Neurosci.
, vol.20
, pp. 9187-9194
-
-
Cirelli, C.1
Tonon, G.2
-
194
-
-
0030582674
-
Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons
-
Arancio, O.; Kiebler, M.; Lee, C.J.; Lev-Ram, V.; Tsien, R.Y.; Kandel, E.R.; Hawkins, R.D. Nitric oxide acts directly in the presynaptic neuron to produce long-term potentiation in cultured hippocampal neurons. Cell, 1996, 87, 1025-1035.
-
(1996)
Cell
, vol.87
, pp. 1025-1035
-
-
Arancio, O.1
Kiebler, M.2
Lee, C.J.3
Lev-Ram, V.4
Tsien, R.Y.5
Kandel, E.R.6
Hawkins, R.D.7
-
195
-
-
34948845602
-
CREB, neurogenesis and depression
-
Gass, P.; Riva, M.A. CREB, neurogenesis and depression. Bioessays, 2007, 29, 957-961.
-
(2007)
Bioessays
, vol.29
, pp. 957-961
-
-
Gass, P.1
Riva, M.A.2
-
196
-
-
20744434559
-
Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease
-
Peng, S.; Wu, J.; Mufson, E.J.; Fahnestock, M. Precursor form of brain-derived neurotrophic factor and mature brain-derived neurotrophic factor are decreased in the pre-clinical stages of Alzheimer's disease. J. Neurochem., 2005, 93, 1412-1421.
-
(2005)
J. Neurochem.
, vol.93
, pp. 1412-1421
-
-
Peng, S.1
Wu, J.2
Mufson, E.J.3
Fahnestock, M.4
-
197
-
-
70350059120
-
Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis
-
Rai, G.; Sayed, A.A.; Lea, W.A.; Luecke, H.F.; Chakrapani, H.; Prast-Nielsen, S.; Jadhav, A.; Leister, W.; Shen, M.; Inglese, J.; Austin, C. P.; Keefer, L.; Arner, E.S.; Simeonov, A.; Maloney, D.J.; Williams, D.L.; Thomas, C.J. Structure mechanism insights and the role of nitric oxide donation guide the development of oxadiazole-2-oxides as therapeutic agents against schistosomiasis. J. Med. Chem., 2009, 52, 6474-6483.
-
(2009)
J. Med. Chem.
, vol.52
, pp. 6474-6483
-
-
Rai, G.1
Sayed, A.A.2
Lea, W.A.3
Luecke, H.F.4
Chakrapani, H.5
Prast-Nielsen, S.6
Jadhav, A.7
Leister, W.8
Shen, M.9
Inglese, J.10
Austin, C.P.11
Keefer, L.12
Arner, E.S.13
Simeonov, A.14
Maloney, D.J.15
Williams, D.L.16
Thomas, C.J.17
-
198
-
-
0031043139
-
Water soluble furoxan derivatives as NO prodrugs
-
Sorba, G.; Medana, C.; Fruttero, R.; Cena, C.; Di Stilo, A.; Galli, U.; Gasco, A. Water soluble furoxan derivatives as NO prodrugs. J. Med. Chem., 1997, 40, 463-469.
-
(1997)
J. Med. Chem.
, vol.40
, pp. 463-469
-
-
Sorba, G.1
Medana, C.2
Fruttero, R.3
Cena, C.4
Di Stilo, A.5
Galli, U.6
Gasco, A.7
-
199
-
-
0028941364
-
A new class of furoxan derivatives as NO donors: Mechanism of action and biological activity
-
Ferioli, R.; Folco, G.C.; Ferretti, C.; Gasco, A.M.; Medana, C.; Fruttero, R.; Civelli, M.; Gasco, A. A new class of furoxan derivatives as NO donors: mechanism of action and biological activity Br. J. Pharmacol., 1995, 114, 816-820.
-
(1995)
Br. J. Pharmacol.
, vol.114
, pp. 816-820
-
-
Ferioli, R.1
Folco, G.C.2
Ferretti, C.3
Gasco, A.M.4
Medana, C.5
Fruttero, R.6
Civelli, M.7
Gasco, A.8
-
200
-
-
33845204402
-
Techniques for assessing neuroprotective drugs in vitro
-
Goldberg, M.P.; Strasser, U.; Dugan, L.L. Techniques for assessing neuroprotective drugs in vitro. Int. Rev. Neurobiol., 1997, 40, 69-93.
-
(1997)
Int. Rev. Neurobiol.
, vol.40
, pp. 69-93
-
-
Goldberg, M.P.1
Strasser, U.2
Dugan, L.L.3
-
201
-
-
0025826867
-
Inhibition of proteolysis protects hippocampal neurons from ischemia
-
Lee, K.S.; Frank, S.; Vanderklish, P.; Arai, A.; Lynch, G. Inhibition of proteolysis protects hippocampal neurons from ischemia. Proc. Natl. Acad. Sci. U.S.A., 1991, 88, 7233-7237.
-
(1991)
Proc. Natl. Acad. Sci. U.S.A.
, vol.88
, pp. 7233-7237
-
-
Lee, K.S.1
Frank, S.2
Vanderklish, P.3
Arai, A.4
Lynch, G.5
-
202
-
-
0025368577
-
Reactions of a free radical intermediate in the oxidation of amodiaquine
-
Bisby, R.H. Reactions of a free radical intermediate in the oxidation of amodiaquine. Biochem. Pharmacol., 1990, 39, 2051-2055.
-
(1990)
Biochem. Pharmacol.
, vol.39
, pp. 2051-2055
-
-
Bisby, R.H.1
-
203
-
-
84870040156
-
A furoxanamodiaquine hybrid as a potential therapeutic for three parasitic diseases
-
Mott, B.T.; Cheng, K.C.; Guha, R.; Kommer, V.P.; Williams, D.L.; Vermeire, J.J.; Cappello, M.; Maloney, D.J.; Rai, G.; Jadhav, A.; Simeonov, A.; Inglese, J.; Posner, G.H.; Thomas, C.J. A furoxanamodiaquine hybrid as a potential therapeutic for three parasitic diseases. Medchemcomm., 2012, 12, 1505-1511.
-
(2012)
Medchemcomm
, vol.12
, pp. 1505-1511
-
-
Mott, B.T.1
Cheng, K.C.2
Guha, R.3
Kommer, V.P.4
Williams, D.L.5
Vermeire, J.J.6
Cappello, M.7
Maloney, D.J.8
Rai, G.9
Jadhav, A.10
Simeonov, A.11
Inglese, J.12
Posner, G.H.13
Thomas, C.J.14
-
204
-
-
0035153917
-
Quinoline antimalarials
-
Egan T.J. Quinoline antimalarials. Expert Opin. Ther. Pat., 2001, 11, 185-209.
-
(2001)
Expert Opin. Ther. Pat.
, vol.11
, pp. 185-209
-
-
Egan, T.J.1
-
205
-
-
0035352584
-
Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials
-
Egan, T.J. Structure-function relationships in chloroquine and related 4-aminoquinoline antimalarials. Mini- Rev. Med. Chem., 2001, 1, 113-123.
-
(2001)
Mini- Rev. Med. Chem.
, vol.1
, pp. 113-123
-
-
Egan, T.J.1
-
206
-
-
77953028103
-
Chagas disease: A Latin American health problem becoming a world health problem
-
Schmunis, G.A.; Yadon, Z.E. Chagas disease: A Latin American health problem becoming a world health problem. Acta Trop., 2010, 115(1-2), 14-21.
-
(2010)
Acta Trop
, vol.115
, Issue.1-2
, pp. 14-21
-
-
Schmunis, G.A.1
Yadon, Z.E.2
-
207
-
-
77952171991
-
Synthetic medicinal chemistry in Chagas' disease: Compounds at the final stage of "Hit-To-Lead" phase
-
Cerecetto, H.; Gonzalez, M. Synthetic medicinal chemistry in Chagas' disease: compounds at the final stage of "Hit-To-Lead" phase. Pharmaceuticals, 2010, 3, 810-838.
-
(2010)
Pharmaceuticals
, vol.3
, pp. 810-838
-
-
Cerecetto, H.1
Gonzalez, M.2
-
208
-
-
33744811422
-
Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets
-
Otero, L.; Vieites, M.; Boiani, L.; Denicola, A.; Rigol, C.; Opazo, L.; Olea-Azar, C.; Maya, J.D.; Morello, A.; Krauth-Siegel, R.L.; Piro, O.E.; Castellano, E.; Gonzalez, M.; Gambino, D.; Cerecetto, H. Novel antitrypanosomal agents based on palladium nitrofurylthiosemicarbazone complexes: DNA and redox metabolism as potential therapeutic targets. J. Med. Chem., 2006, 49, 3322-3331.
-
(2006)
J. Med. Chem.
, vol.49
, pp. 3322-3331
-
-
Otero, L.1
Vieites, M.2
Boiani, L.3
Denicola, A.4
Rigol, C.5
Opazo, L.6
Olea-Azar, C.7
Maya, J.D.8
Morello, A.9
Krauth-Siegel, R.L.10
Piro, O.E.11
Castellano, E.12
Gonzalez, M.13
Gambino, D.14
Cerecetto, H.15
-
209
-
-
38049100672
-
Heteroallyl-containing 5- nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action
-
Gerpe, A.; Odreman-Nunez, I.; Draper, P.; Boiani, l.; Urbina, J.A.; Gonzalez, M.; Cerecetto, H. Heteroallyl-containing 5- nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action. Bioorg. Med. Chem., 2008, 16, 569-577.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 569-577
-
-
Gerpe, A.1
Odreman-Nunez, I.2
Draper, P.3
Boiani, L.4
Urbina, J.A.5
Gonzalez, M.6
Cerecetto, H.7
-
210
-
-
73949135846
-
5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene
-
Gerpe, A.; Alvarez, G.; Benitez, D.; Boiani, L.; Quiroga, M.; Hernandez, P.; Sortino, M.; Zacchino, S.; Gonzalez, M.; Cerecetto, H. 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. Bioorg. Med. Chem., 2009, 17, 7500-7509.
-
(2009)
Bioorg. Med. Chem.
, vol.17
, pp. 7500-7509
-
-
Gerpe, A.1
Alvarez, G.2
Benitez, D.3
Boiani, L.4
Quiroga, M.5
Hernandez, P.6
Sortino, M.7
Zacchino, S.8
Gonzalez, M.9
Cerecetto, H.10
-
211
-
-
37849011377
-
In vivo anti-chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives
-
Porcal, W.; Hernandez, P.; Boiani, M.; Aguirre, G.; Boiani, L.; Chidichimo, A.; Cazzulo, J.J.; Campillo, N.E.; Paez, J.A.; Castro, A.; Krauth Siegel, R.L.; Davies, C.; Basombr, M.A.; Gonzalez, M.; Cerecetto, H. In vivo anti-chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives. J. Med. Chem., 2007, 50, 6004-6015.
-
(2007)
J. Med. Chem.
, vol.50
, pp. 6004-6015
-
-
Porcal, W.1
Hernandez, P.2
Boiani, M.3
Aguirre, G.4
Boiani, L.5
Chidichimo, A.6
Cazzulo, J.J.7
Campillo, N.E.8
Paez, J.A.9
Castro, A.10
Krauth Siegel, R.L.11
Davies, C.12
Basombr, M.A.13
Gonzalez, M.14
Cerecetto, H.15
-
212
-
-
47349092118
-
New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle
-
Porcal, W.; Hernandez, P.; Boiani, L.; Boiani, M.; Ferreira, A.; Chidichimo, A.; Cazzulo, J.J.; Olea-Azar, C.; Gonzalez, M.; Cerecetto, H. New trypanocidal hybrid compounds from the association of hydrazone moieties and benzofuroxan heterocycle. Bioorg. Med. Chem., 2008, 16, 6995-7004;.
-
(2008)
Bioorg. Med. Chem.
, vol.16
, pp. 6995-7004
-
-
Porcal, W.1
Hernandez, P.2
Boiani, L.3
Boiani, M.4
Ferreira, A.5
Chidichimo, A.6
Cazzulo, J.J.7
Olea-Azar, C.8
Gonzalez, M.9
Cerecetto, H.10
-
213
-
-
78449244186
-
Development of second generation amidinohydrazones, thio- and semicarbazones as Trypanosoma cruzi-inhibitors bearing benzofuroxan and benzimidazole 1, 3-dioxide core scaffolds
-
Merlino, A.; Benitez, D.; Chavez, S.; Da Cunha, J.; Hernandez, P.; Tinoco, L.W.; Campillo, N.E.; Paez, J.A.; Cerecetto, H.; Gonzalez, M. Development of second generation amidinohydrazones, thio- and semicarbazones as Trypanosoma cruzi-inhibitors bearing benzofuroxan and benzimidazole 1, 3-dioxide core scaffolds. Medchemcomm, 2010, 1, 216-228.
-
(2010)
Medchemcomm
, vol.1
, pp. 216-228
-
-
Merlino, A.1
Benitez, D.2
Chavez, S.3
Da Cunha, J.4
Hernandez, P.5
Tinoco, L.W.6
Campillo, N.E.7
Paez, J.A.8
Cerecetto, H.9
Gonzalez, M.10
-
214
-
-
84855704061
-
Amidines bearing benzofuroxan or benzimidazole 1, 3-dioxide core scaffolds as Trypanosoma cruziinhibitors: Structural basis for their interactions with cruzipain
-
Merlino, A.; Benitez, D.; Campillo, N.E.; Paez, J.A.; Tinoco, L.W.; Gonzalez, M.; Cerecetto, H. Amidines bearing benzofuroxan or benzimidazole 1, 3-dioxide core scaffolds as Trypanosoma cruziinhibitors: structural basis for their interactions with cruzipain. Medchemcomm, 2012, 3, 90-101.
-
(2012)
Medchemcomm
, vol.3
, pp. 90-101
-
-
Merlino, A.1
Benitez, D.2
Campillo, N.E.3
Paez, J.A.4
Tinoco, L.W.5
Gonzalez, M.6
Cerecetto, H.7
-
215
-
-
0012874342
-
Synthesis and QSAR of herbicidal 3-pyrazolyl α, α, α-trifluorotolyl ethers
-
Clark, R.D. Synthesis and QSAR of herbicidal 3-pyrazolyl α, α, α-trifluorotolyl ethers. J. Agric. Food Chem., 1996, 44, 3643- 3652.
-
(1996)
J. Agric. Food Chem.
, vol.44
, pp. 3643-3652
-
-
Clark, R.D.1
-
216
-
-
0028042015
-
Enantioselectivity of protoporphyrinogen oxidase-inhibiting herbicides
-
Nandihalli, U.B.; Duke, M.V.; Ashmore, J.A.; Musco, V.A.; Clark, R.D.; Duke, O.S. Enantioselectivity of protoporphyrinogen oxidase-inhibiting herbicides. Pestic. Sci., 1994, 40, 265- 277.
-
(1994)
Pestic. Sci.
, vol.40
, pp. 265-277
-
-
Nandihalli, U.B.1
Duke, M.V.2
Ashmore, J.A.3
Musco, V.A.4
Clark, R.D.5
Duke, O.S.6
-
217
-
-
84987111860
-
New herbicidal derivatives of 1, 2, 4-triazolo [1, 5-a] pyrimidine
-
Kleschick, W.A.; Costales, M.J.; Dunbar, J.E.; Meikle, R.W.; Monte, W.T.; Pearson, N.R.; Snider, S.W.; Vinogradoff, A.P. New herbicidal derivatives of 1, 2, 4-triazolo [1, 5-a] pyrimidine. Pestic. Sci., 1990, 29, 341-355.
-
(1990)
Pestic. Sci.
, vol.29
, pp. 341-355
-
-
Kleschick, W.A.1
Costales, M.J.2
Dunbar, J.E.3
Meikle, R.W.4
Monte, W.T.5
Pearson, N.R.6
Snider, S.W.7
Vinogradoff, A.P.8
-
218
-
-
84987063889
-
Imidazolinone herbicides: Synthesis and novel chemistry
-
Wepplo, P. Imidazolinone herbicides: synthesis and novel chemistry. Pestic. Sci., 1990, 39, 293-315.
-
(1990)
Pestic. Sci.
, vol.39
, pp. 293-315
-
-
Wepplo, P.1
-
219
-
-
0012872698
-
Herbicides and photosynthesis
-
Elsevier Science Publishers: Amsterdam, The Netherlands
-
Baker, N.R.; Percival, M.P. Herbicides and Photosynthesis. In: Herbicides, . Topics in Photosynthesis; Elsevier Science Publishers: Amsterdam, The Netherlands, 1990, Vol. 10, pp. 1-26.
-
(1990)
Herbicides, Topics in Photosynthesis
, vol.10
, pp. 1-26
-
-
Baker, N.R.1
Percival, M.P.2
-
220
-
-
0014733806
-
Quinoxaline-1, 4-di-N-oxides. I. Inhibition of deoxyribonucleic acid synthesis in Escherichia coli by 2, 3-dihydroxymethyl-quinoxaline-1, 4-di-N-oxide
-
English, A.R., Dunegan, C.M. Quinoxaline-1, 4-di-N-oxides. I. Inhibition of deoxyribonucleic acid synthesis in Escherichia coli by 2, 3-dihydroxymethyl-quinoxaline-1, 4-di-N-oxide. Proc. Soc. Exp. Biol. Med., 1970 133, 398-400.
-
(1970)
Proc. Soc. Exp. Biol. Med.
, vol.133
, pp. 398-400
-
-
English, A.R.1
Dunegan, C.M.2
-
221
-
-
0018086175
-
Mode of action of quindoxin and substituted quinoxaline-di-Noxides on Escherichia coli
-
Suter, W.; Rosselet, A.; Knusel, F. Mode of action of quindoxin and substituted quinoxaline-di-Noxides on Escherichia coli. Antimicrob. Agents Chemother., 1978, 13, 770-783.
-
(1978)
Antimicrob. Agents Chemother.
, vol.13
, pp. 770-783
-
-
Suter, W.1
Rosselet, A.2
Knusel, F.3
-
222
-
-
0021808049
-
Guanine- 7-oxide, a novel antitumor antibiotic
-
Kern, D.L.; Hokanson, G.C.; French, J.C.; Dally, N.K. Guanine- 7-oxide, a novel antitumor antibiotic. J. Antibiot., 1985, 38, 572-574.
-
(1985)
J. Antibiot.
, vol.38
, pp. 572-574
-
-
Kern, D.L.1
Hokanson, G.C.2
French, J.C.3
Dally, N.K.4
-
223
-
-
0021932086
-
7- Hydroxyguanine, a novel anti-metabolite from a strain of Streptomyces purpurascens. I. Taxonomy of producing organism, fermentation, isolation and biological activity
-
Kitahara, M.; Ishii, K.; Kumada, Y.; Shiraishi, T.; Furuta, T.; Miwa, T.; Kawaharada, H.; Watanabe, K. 7- Hydroxyguanine, a novel anti-metabolite from a strain of Streptomyces purpurascens. I. Taxonomy of producing organism, fermentation, isolation and biological activity. J. Antibiot., 1985, 38, 972- 976.
-
(1985)
J. Antibiot.
, vol.38
, pp. 972-976
-
-
Kitahara, M.1
Ishii, K.2
Kumada, Y.3
Shiraishi, T.4
Furuta, T.5
Miwa, T.6
Kawaharada, H.7
Watanabe, K.8
-
224
-
-
0022004952
-
7-Hydroxyguanine, a novel antimetabolite from a strain of Streptomyces purpurascens. II. Physico- chemical properties and structure determination
-
Kitahara, M.; Ishii, K.; Kawaharada, H.; Watanabe, K.; Suga, T.; Hirata, T.; Nakamura, S. 7-Hydroxyguanine, a novel antimetabolite from a strain of Streptomyces purpurascens. II. Physico- chemical properties and structure determination. J. Antibiot., 1985, 38, 977-980.
-
(1985)
J. Antibiot.
, vol.38
, pp. 977-980
-
-
Kitahara, M.1
Ishii, K.2
Kawaharada, H.3
Watanabe, K.4
Suga, T.5
Hirata, T.6
Nakamura, S.7
-
225
-
-
0022358086
-
A new antitumor antibiotic, guanine 7-N-oxide produced by Streptomyces sp
-
Nishii, M.; Inagaki, J.; Nohara, F.; Isono, K.; Kusakabe, H.; Kobayashi, K.; Sakurai, T.; Koshimura, S.; Sethi, S.K.; McCloskey, J.A. A new antitumor antibiotic, guanine 7-N-oxide produced by Streptomyces sp. J. Antibiot., 1985, 38, 1440-1443.
-
(1985)
J. Antibiot.
, vol.38
, pp. 1440-1443
-
-
Nishii, M.1
Inagaki, J.2
Nohara, F.3
Isono, K.4
Kusakabe, H.5
Kobayashi, K.6
Sakurai, T.7
Koshimura, S.8
Sethi, S.K.9
McCloskey, J.A.10
-
226
-
-
0023078472
-
Biochemical pharmacology and experimental chemotherapy studies with guanine-7-oxide, a novel purine antibiotic
-
Jackson, R.C.; Boritzki, T.J.; Besserer, J.A.; Hamelehle, K.L.; Shillis, J.L.; Leopold, W.R.; Fry, D.W. Biochemical pharmacology and experimental chemotherapy studies with guanine-7-oxide, a novel purine antibiotic. Adv. Enzyme Regul., 1987, 26, 301-316.
-
(1987)
Adv. Enzyme Regul.
, vol.26
, pp. 301-316
-
-
Jackson, R.C.1
Boritzki, T.J.2
Besserer, J.A.3
Hamelehle, K.L.4
Shillis, J.L.5
Leopold, W.R.6
Fry, D.W.7
-
227
-
-
0022413323
-
Antiviral activity and its mechanism of guanine 7-N-oxide on DNA and RNA viruses derived from salmonid
-
Hasobe, M.; Saneyoshi, M.; Isono, K. Antiviral activity and its mechanism of guanine 7-N-oxide on DNA and RNA viruses derived from salmonid. J. Antibiot., 1985, 38, 1581-1587.
-
(1985)
J. Antibiot.
, vol.38
, pp. 1581-1587
-
-
Hasobe, M.1
Saneyoshi, M.2
Isono, K.3
-
228
-
-
0014082002
-
Purine N-oxides. XIX. On the oncogenic N-oxide derivatives of guanine and xanthine and a nononcogenic isomer of xanthine N-oxide
-
Kanematsu, S.; Brown, G.B. Purine N-oxides. XIX. On the oncogenic N-oxide derivatives of guanine and xanthine and a nononcogenic isomer of xanthine N-oxide. Cancer Res., 1967, 27, 925-931.
-
(1967)
Cancer Res
, vol.27
, pp. 925-931
-
-
Kanematsu, S.1
Brown, G.B.2
-
229
-
-
0009739583
-
The 7-N-oxides of purines related to nucleic acid: Their chemistry, synthesis and biological evaluation
-
Fujii, T.; Itaya, T.; Ogawa, K. The 7-N-oxides of purines related to nucleic acid: Their chemistry, synthesis and biological evaluation. Heterocycles, 1997, 44, 573-592.
-
(1997)
Heterocycles
, vol.44
, pp. 573-592
-
-
Fujii, T.1
Itaya, T.2
Ogawa, K.3
-
230
-
-
0021932086
-
7-Hydroxyguanine, a novel antimetabolite from a strain of Streptomyces purpurascens. I. Taxonomy of producing organism, fermentation, isolation and biological activity
-
Kitahara, M.; Ishii, K.; Kumada, Y.; Shiraishi, T.; Furuta, T.; Miwa, T.; Kawaharada, H.; Watanabe, K. 7-Hydroxyguanine, a novel antimetabolite from a strain of Streptomyces purpurascens. I. Taxonomy of producing organism, fermentation, isolation and biological activity. J. Antibiot., 1985, 38, 972-976.
-
(1985)
J. Antibiot.
, vol.38
, pp. 972-976
-
-
Kitahara, M.1
Ishii, K.2
Kumada, Y.3
Shiraishi, T.4
Furuta, T.5
Miwa, T.6
Kawaharada, H.7
Watanabe, K.8
-
231
-
-
0025365974
-
Preparation of new 7- hydroxyguanine derivatives and their biological activities
-
Kitahara, M.; Shinjyo, K.; Fukae, M.; Hosoe, K.; Shiraishi, T.; Ishii, K.; Watanabe, K.; Kawaharada, H. Preparation of new 7- hydroxyguanine derivatives and their biological activities. J. Antibiot., 1990, 43, 352-356.
-
(1990)
J. Antibiot.
, vol.43
, pp. 352-356
-
-
Kitahara, M.1
Shinjyo, K.2
Fukae, M.3
Hosoe, K.4
Shiraishi, T.5
Ishii, K.6
Watanabe, K.7
Kawaharada, H.8
-
232
-
-
0026563188
-
Purines. Part 51, Synthesis and biological activity of hypoxanthine 7-N-oxide and related compounds
-
Ogawa, K.; Nishii, M.; Nohara, F.; Saito, T.; Itaya, T.; Fujii, T. Purines. Part 51. Synthesis and biological activity of hypoxanthine 7-N-oxide and related compounds. Chem. Pharm. Bull., 1992, 40, 612-616.
-
(1992)
Chem. Pharm. Bull.
, vol.40
, pp. 612-616
-
-
Ogawa, K.1
Nishii, M.2
Nohara, F.3
Saito, T.4
Itaya, T.5
Fujii, T.6
-
233
-
-
0028928368
-
Purines. LXX. An extension of the "phenacylamine route" to the syntheses of the 7-N-oxides of 6-mercaptopurine and 6-methylthiopurine, and antileukemic activity of some purine Noxides
-
Fujii, T.; Ogawa, K.; Itaya, T.; Date, T.; Inagaki, J.; Nohara, F. Purines. LXX. An extension of the "phenacylamine route" to the syntheses of the 7-N-oxides of 6-mercaptopurine and 6-methylthiopurine, and antileukemic activity of some purine Noxides. Chem. Pharm. Bull., 1995, 43, 408-413.
-
(1995)
Chem. Pharm. Bull.
, vol.43
, pp. 408-413
-
-
Fujii, T.1
Ogawa, K.2
Itaya, T.3
Date, T.4
Inagaki, J.5
Nohara, F.6
-
234
-
-
70349774255
-
The synthetic substance hypoxanthine 3-N-oxide elicits alarm reactions in zebrafish (Danio rerio)
-
Parra, K.V.; Adrian, J.C.; Gerlai, R. The synthetic substance hypoxanthine 3-N-oxide elicits alarm reactions in zebrafish (Danio rerio). Behav. Brain Res., 2009, 205, 336-341.
-
(2009)
Behav. Brain Res.
, vol.205
, pp. 336-341
-
-
Parra, K.V.1
Adrian, J.C.2
Gerlai, R.3
-
235
-
-
0023093521
-
Synthesis of guanine 7-oxide, an antitumor antibiotic from Streptomyces species
-
Nohara, F.; Nishii, M.; Ogawa, K.; Isono, K.; Ubukata, M.; Fujii, T.; Itaya, T.; Saito, T. Synthesis of guanine 7-oxide, an antitumor antibiotic from Streptomyces species. Tetrahedron Lett., 1987, 28, 1287-1290.
-
(1987)
Tetrahedron Lett
, vol.28
, pp. 1287-1290
-
-
Nohara, F.1
Nishii, M.2
Ogawa, K.3
Isono, K.4
Ubukata, M.5
Fujii, T.6
Itaya, T.7
Saito, T.8
-
237
-
-
33645237455
-
Inhibitorbinding mode of homobelactosin C to proteasomes: New insights into class I MHC ligand generation
-
Groll, M.; Larionov, O.V.; Huber, R.; de Meijere, A. Inhibitorbinding mode of homobelactosin C to proteasomes: new insights into class I MHC ligand generation. Proc. Natl. Acad. Sci. U.S.A., 2006, 103(12), 4576-4579.
-
(2006)
Proc. Natl. Acad. Sci. U.S.A.
, vol.103
, Issue.12
, pp. 4576-4579
-
-
Groll, M.1
Larionov, O.V.2
Huber, R.3
De Meijere, A.4
-
238
-
-
84863934169
-
Synthesis and biological activity of simplified belactosin C analogues
-
de Meijere, A.; Korotkov, V.S.; Lygin, A.V.; Larionov, O.V.; Sokolov, V.V.; Graef, T.; Es-Sayed, M. Synthesis and biological activity of simplified belactosin C analogues. Org. Biomol. Chem., 2012, 10(31), 6363-6374.
-
(2012)
Org. Biomol. Chem.
, vol.10
, Issue.31
, pp. 6363-6374
-
-
De Meijere, A.1
Korotkov, V.S.2
Lygin, A.V.3
Larionov, O.V.4
Sokolov, V.V.5
Graef, T.6
Es-Sayed, M.7
-
239
-
-
0009788080
-
Transition metal complexes of pyridine N-oxide
-
Carlin, R.L. Transition metal complexes of pyridine N-oxide. J. Am. Chem. Soc., 1961, 83(18), 3773-3775.
-
(1961)
J. Am. Chem. Soc.
, vol.83
, Issue.18
, pp. 3773-3775
-
-
Carlin, R.L.1
-
240
-
-
49049146235
-
Transition metal complexes of diazine N-oxides
-
Popp, C.J.; Garlough, G.D. Transition metal complexes of diazine N-oxides. J. Inorg. Nucl. Chem., 1981, 43(3), 501-507.
-
(1981)
J. Inorg. Nucl. Chem.
, vol.43
, Issue.3
, pp. 501-507
-
-
Popp, C.J.1
Garlough, G.D.2
-
241
-
-
41749088281
-
Synthesis and characterization of pyridine N-oxide complexes of manganese, copper and zinc
-
Sarma, R.; Karmakar, A.; Baruah, J.B. Synthesis and characterization of pyridine N-oxide complexes of manganese, copper and zinc. Inorg. Chim. Acta, 2008, 361, 2081-2086.
-
(2008)
Inorg. Chim. Acta
, vol.361
, pp. 2081-2086
-
-
Sarma, R.1
Karmakar, A.2
Baruah, J.B.3
-
242
-
-
2142760181
-
A simple and efficient method for the preparation of pyridine N-oxides
-
Coperet, C.; Adolfsson, H.; Khuong, T.-A.W.; Yudin, A.K.; Sharpless, K.B. A simple and efficient method for the preparation of pyridine N-oxides. J. Org. Chem., 1998, 63, 1740-1741.
-
(1998)
J. Org. Chem.
, vol.63
, pp. 1740-1741
-
-
Coperet, C.1
Adolfsson, H.2
Khuong, T.-A.W.3
Yudin, A.K.4
Sharpless, K.B.5
-
243
-
-
84898781251
-
Insights into the mechanistic and synthetic aspects of the Mo/P-catalyzed oxidation of N-heterocycles
-
Larionov, O.V.; Stephens, D.; Mfuh, A.M.; Arman, H.D.; Naumova, A.S.; Chavez, G.; Skenderi, B. Insights into the mechanistic and synthetic aspects of the Mo/P-catalyzed oxidation of N-heterocycles. Org. Biomol. Chem., 2014, 12(19), 3026-3036.
-
(2014)
Org. Biomol. Chem.
, vol.12
, Issue.19
, pp. 3026-3036
-
-
Larionov, O.V.1
Stephens, D.2
Mfuh, A.M.3
Arman, H.D.4
Naumova, A.S.5
Chavez, G.6
Skenderi, B.7
-
244
-
-
84893855798
-
Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides
-
Larionov, O.V.; Stephens, D.; Mfuh, A.; Chavez, G. Direct, catalytic, and regioselective synthesis of 2-alkyl-, aryl-, and alkenyl-substituted N-heterocycles from N-oxides. Org. Lett., 2014, 16(3), 864-867.
-
(2014)
Org. Lett.
, vol.16
, Issue.3
, pp. 864-867
-
-
Larionov, O.V.1
Stephens, D.2
Mfuh, A.3
Chavez, G.4
-
245
-
-
84904750019
-
Synthetic and mechanistic aspects of the regioselective base-mediated reaction of perfluoroalkyl- and perfluoroarylsilanes with heterocyclic N-oxides
-
Stephens, D.E.; Chavez, G.; Valdes, M.; Dovalina, M.; Arman, H.D.; Larionov, O.V. Synthetic and mechanistic aspects of the regioselective base-mediated reaction of perfluoroalkyl- and perfluoroarylsilanes with heterocyclic N-oxides. Org. Biomol. Chem., 2014, 12(32), 6190-6199.
-
(2014)
Org. Biomol. Chem.
, vol.12
, Issue.32
, pp. 6190-6199
-
-
Stephens, D.E.1
Chavez, G.2
Valdes, M.3
Dovalina, M.4
Arman, H.D.5
Larionov, O.V.6
-
246
-
-
84926384917
-
Palladium-catalyzed C8-selective C-H arylation of quinoline N-oxides: Insights into the electronic, steric and solvation effects on the site-selectivity by mechanistic and DFT computational studies
-
Stephens, D.E.; Lakey-Beitia, J.; Atesin, A.C.; Atesin, T.A.; Chavez, G.; Arman, H.D.; Larionov, O.V. Palladium-catalyzed C8-selective C-H arylation of quinoline N-oxides: insights into the electronic, steric and solvation effects on the site-selectivity by mechanistic and DFT computational studies. ACS Catal., 2015, 5(1), 167-175.
-
(2015)
ACS Catal.
, vol.5
, Issue.1
, pp. 167-175
-
-
Stephens, D.E.1
Lakey-Beitia, J.2
Atesin, A.C.3
Atesin, T.A.4
Chavez, G.5
Arman, H.D.6
Larionov, O.V.7
-
247
-
-
84930225671
-
Experimental and mechanistic analysis of the palladium- catalyzed oxidative C8-selective C-H homocoupling of quinoline N-oxides
-
Stephens, D.E.; Lakey-Beitia, J.; Chavez, G.; Ilie, C.; Arman, H.D.; Larionov, O.V. Experimental and mechanistic analysis of the palladium- catalyzed oxidative C8-selective C-H homocoupling of quinoline N-oxides. Chem. Commun., 2015, 51, 9507-9510.
-
(2015)
Chem. Commun.
, vol.51
, pp. 9507-9510
-
-
Stephens, D.E.1
Lakey-Beitia, J.2
Chavez, G.3
Ilie, C.4
Arman, H.D.5
Larionov, O.V.6
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