Pharmaceuticals: A new grammar for drug discovery

Nature

Volumn 437, Issue 7058, 2005, Pages 491-493

  Fishman, Mark C ^a   Porter, Jeffery A ^a  

^a NOVARTIS INSTITUTES FOR BIOMEDICAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELL CULTURE; DRUG DOSAGE; PROTEINS;

CANDIDATE DRUGS;

GENES;

GENE PRODUCT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMATINIB; IMMUNOSUPPRESSIVE AGENT; MACROLIDE; RAPAMYCIN;

MEDICINE;

CHOLESTEROL BLOOD LEVEL; CHRONIC MYELOID LEUKEMIA; CYSTIC FIBROSIS; DROSOPHILA; DRUG EFFICACY; DRUG INDUSTRY; DRUG SAFETY; GENE ACTIVATION; GENE EXPRESSION; GENE INACTIVATION; GENE MUTATION; GENOME; GRAFT REJECTION; HUMAN; MULTIGENE FAMILY; NONHUMAN; PRIORITY JOURNAL; RESTENOSIS; SHORT SURVEY; SICKLE CELL ANEMIA; SIGNAL TRANSDUCTION; UNITED STATES; VALIDATION PROCESS; ARTICLE; DRUG DESIGN; DRUG SCREENING; ENZYME SPECIFICITY; GENE EXPRESSION PROFILING; GENERAL ASPECTS OF DISEASE; GENOMICS; METHODOLOGY;

DISEASE; DRUG DESIGN; DRUG EVALUATION, PRECLINICAL; GENE EXPRESSION PROFILING; GENOMICS; HUMANS; SIGNAL TRANSDUCTION; SUBSTRATE SPECIFICITY;

EID: 25644454404     PISSN: 00280836     EISSN: 14764687     Source Type: Journal    
DOI: 10.1038/437491a     Document Type: Short Survey

References (32)

1. Tobert, J. A. Nature Rev. Drug Discov. 2, 517-526 (2003).
2. Nowell, P. C. & Hungerford, D. A. Science 132, 1487-1501 (1960).
3. Drews, J. Science 287, 1960-1964 (2000).
4. Brown, D. & Superti-Furga, G. Drug Discov. Today 8, 1067-1077 (2003).
5. Hamosh, A. et al. Nucleic Acids Res. 30, 52-55 (2002).
6. Schuener, M. T., Yoon, P. W. & Khuory, M. J. Am. J. Med. Genet. 125C, 50-65 (2004).
7. Mabuchi, H. et al. N. Engl. J. Med. 305, 478-482 (1981).
8. Mabuchi, H. et al. N. Engl. J. Med. 308, 609-613 (1983).
9. Gerhart, J. & Kirschner, M. W. Cells, Embryos, and Evolution (Blackwell, Malden, MA, 1997).
10. www.biocarta.com/genes/allPathways.asp
11. Nüsslein-Volhard, C. & Wieschaus, E. Nature 287, 795-801 (1980).
12. Harris, T. E. & Lawrence, J. C. Jr Science STKE2003, re15 (2003).
13. Metzstein, M. M., Stanfield, G. M. & Horvitz, H. R. Trends Genet. 10, 410-416 (1998).
14. Fishman, M. C. & Olson, E. N. Cell 91, 153-156 (1997).
15. Lee, E., Salic, A., Kruger, R., Heinrich, R. & Kirschner, M. W. PLoS Biol. 1, 116-132 (2003).
16. Emami, K. H. et al. Proc. Natl Acad. Sci. USA 101, 12682-12687 (2004).
17. Lepourcelet, M. et al. Cancer Cell 5, 91-102 (2004).
18. Stockwell, B. R. Nature Rev. Genet. 1, 116-125 (2000).
19. Giaever, G. et al. Nature Genet. 21, 278-283 (1999).
20. Hughes, T. R. et al. Cell 102, 109-126 (2000).
21. Lum, P. Y. et al. Cell 116, 121-137 (2004).
22. Parsons, A. B. et al. Nature Biotechnol. 22, 62-69 (2004).
23. Tsang, M. & Dawid, I. B. Science STKE 2004, pe17 (2004).
24. Ruiz i Altaba, A., Nguyen, V. & Palma, V. Curr. Opin. Genet. Dev. 13, 513-521 (2003).
25. Siegel, P. M. & Massagué, J. Nature Rev. Cancer 3, 807-821 (2003).
26. Hacohen, N., Kramer, S., Sutherland, D., Hiromi, Y. & Krasnow, M. A. Cell 92, 253-263 (1998).
27. Logan, C. Y. & Nusse, R. Annu. Rev. Cell Dev. Biol. 20, 781-810 (2004).
28. Bouwmeester, T. et al. Nature Cell Biol. 6, 97-105 (2004).
29. Giot, L. et al. Science 302, 1727-1736 (2003).
30. Mootha, V. K. et al. Nature Genet. 34, 267-273 (2003).
31. www.emedicine.com/ped/topic890.htm
32. Berman, D. M. et al. Nature 425, 846-851 (2003).