Synthesis and biological evaluation of new 2-arylcarbonyl-3- trifluoromethylquinoxaline 1,4-di-N-oxide derivatives and their reduced analogues

Journal of Medicinal Chemistry

Volumn 50, Issue 22, 2007, Pages 5485-5492

  Solano, Beatriz ^a   Junnotula, Venkatraman ^b   Marín, Adoración ^a   Villar, Raquel ^a   Burguete, Asunción ^a   Vicente, Esther ^a   Pérez Silanes, Silvia ^a   Aldana, Ignacio ^a   Monge, Antonio ^a   Dutta, Sanjay ^b   Sarkar, Ujjal ^b   Gates, Kent S ^b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

3 TRIFLUOROMETHYLQUINOXALINE 1,4 DI N OXIDE DERIVATIVE; QUINOXALINE DERIVATIVE; UNCLASSIFIED DRUG;

ANTINEOPLASTIC ACTIVITY; ARTICLE; BRAIN CANCER; BREAST CANCER; CANCER GROWTH; CONTROLLED STUDY; DRUG ACTIVITY; DRUG CYTOTOXICITY; DRUG SYNTHESIS; ELECTRON TRANSPORT; ENZYME ACTIVITY; GROWTH INHIBITION; HUMAN; HUMAN CELL; IN VIVO STUDY; LUNG CANCER; MOLECULAR MECHANICS; OXIDATION REDUCTION REACTION; PROTON NUCLEAR MAGNETIC RESONANCE; REDUCTION KINETICS; STRUCTURE ACTIVITY RELATION;

ANTINEOPLASTIC AGENTS; CELL LINE, TUMOR; CYCLIC N-OXIDES; CYTOCHROME P-450 ENZYME SYSTEM; DNA DAMAGE; DRUG SCREENING ASSAYS, ANTITUMOR; HUMANS; NAD; OXIDATION-REDUCTION; QUINOXALINES; REACTIVE OXYGEN SPECIES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 35848964831     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm0703993     Document Type: Article

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