메뉴 건너뛰기




Volumn 9, Issue 5, 2008, Pages 331-343

GABAA receptor trafficking and its role in the dynamic modulation of neuronal inhibition

Author keywords

[No Author keywords available]

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR;

EID: 42349109493     PISSN: 1471003X     EISSN: 14710048     Source Type: Journal    
DOI: 10.1038/nrn2370     Document Type: Review
Times cited : (558)

References (148)
  • 2
    • 1342344806 scopus 로고    scopus 로고
    • A receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics
    • A receptor function and dissection of the pharmacology of benzodiazepines and general anesthetics through mouse genetics. Annu. Rev. Pharmacol. Toxicol. 44, 475-498 (2004).
    • (2004) Annu. Rev. Pharmacol. Toxicol , vol.44 , pp. 475-498
    • Rudolph, U.1    Mohler, H.2
  • 6
    • 0031799363 scopus 로고    scopus 로고
    • A receptors: Classification on the basis of subunit structure and receptor function
    • A receptors: classification on the basis of subunit structure and receptor function. Pharmacol. Rev. 50, 291-313 (1998).
    • (1998) Pharmacol. Rev , vol.50 , pp. 291-313
    • Barnard, E.A.1
  • 7
    • 0024848780 scopus 로고
    • The structure of ion channels in membranes of excitable cells
    • Unwin, N. The structure of ion channels in membranes of excitable cells. Neuron 3, 665-676 (1989).
    • (1989) Neuron , vol.3 , pp. 665-676
    • Unwin, N.1
  • 8
  • 11
    • 0029670123 scopus 로고    scopus 로고
    • A-receptor subtypes really occur in the brain?
    • A-receptor subtypes really occur in the brain? Trends Neurosci. 19, 139-143 (1996).
    • (1996) Trends Neurosci , vol.19 , pp. 139-143
    • McKernan, R.M.1    Whiting, P.J.2
  • 12
    • 0036771570 scopus 로고    scopus 로고
    • A receptor assembly and trafficking: Implications for the modulation of inhibitory neurotransmission
    • A receptor assembly and trafficking: implications for the modulation of inhibitory neurotransmission. Mol. Neurobiol. 26, 251-268 (2002).
    • (2002) Mol. Neurobiol , vol.26 , pp. 251-268
    • Kittler, J.T.1    McAinsh, K.2    Moss, S.J.3
  • 14
    • 0030611247 scopus 로고    scopus 로고
    • A receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts
    • A receptors composed of α1 and β2 subunits in both cultured neurons and fibroblasts. J. Neurosci. 17, 6587-6596 (1997).
    • (1997) J. Neurosci , vol.17 , pp. 6587-6596
    • Gorrie, G.H.1
  • 15
    • 0032589253 scopus 로고    scopus 로고
    • A receptor subunits in cerebellar granule cells after the disruption of the α6 subunit gene
    • A receptor subunits in cerebellar granule cells after the disruption of the α6 subunit gene. Eur. J. Neurosci. 11, 1685-1697 (1999).
    • (1999) Eur. J. Neurosci , vol.11 , pp. 1685-1697
    • Nusser, Z.1
  • 16
    • 0037193041 scopus 로고    scopus 로고
    • A receptor changes in δ subunit-deficient mice: Altered expression of α4 and γ2 subunits in the forebrain
    • A receptor changes in δ subunit-deficient mice: altered expression of α4 and γ2 subunits in the forebrain. J. Comp. Neurol. 446, 179-197 (2002).
    • (2002) J. Comp. Neurol , vol.446 , pp. 179-197
    • Peng, Z.1
  • 17
    • 0037154971 scopus 로고    scopus 로고
    • A receptor δ subunit-deficient mice: Recruitment of γ2 subunits
    • A receptor δ subunit-deficient mice: recruitment of γ2 subunits. Neuroscience 109, 733-743 (2002).
    • (2002) Neuroscience , vol.109 , pp. 733-743
    • Korpi, E.R.1
  • 18
    • 17944363387 scopus 로고    scopus 로고
    • A receptor cell surface number and subunit stability are regulated by the ubiquitin-like protein Plic-1
    • ARs are stabilized by a direct interaction with the ubiquitin-like protein PLIC1
    • ARs are stabilized by a direct interaction with the ubiquitin-like protein PLIC1.
    • (2001) Nature Neurosci , vol.4 , pp. 908-916
    • Bedford, F.K.1
  • 19
    • 33847410541 scopus 로고    scopus 로고
    • Emerging roles for ubiquitin and protein degradation in neuronal function
    • Yi, J. J. & Ehlers, M. D. Emerging roles for ubiquitin and protein degradation in neuronal function. Pharmacol. Rev. 59, 14-39 (2007).
    • (2007) Pharmacol. Rev , vol.59 , pp. 14-39
    • Yi, J.J.1    Ehlers, M.D.2
  • 21
    • 0033636785 scopus 로고    scopus 로고
    • The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome
    • Kleijnen, M. F. et al. The hPLIC proteins may provide a link between the ubiquitination machinery and the proteasome. Mol. Cell 6, 409-419 (2000).
    • (2000) Mol. Cell , vol.6 , pp. 409-419
    • Kleijnen, M.F.1
  • 22
    • 0033531225 scopus 로고    scopus 로고
    • ARs.
    • ARs.
  • 25
    • 34248227248 scopus 로고    scopus 로고
    • Cellular functions of NSF: Not just SNAPs and SNAREs
    • Zhao, C., Slevin, J. T. & Whiteheart, S. W. Cellular functions of NSF: not just SNAPs and SNAREs. FEBS Lett. 581, 2140-2149 (2007).
    • (2007) FEBS Lett , vol.581 , pp. 2140-2149
    • Zhao, C.1    Slevin, J.T.2    Whiteheart, S.W.3
  • 26
    • 0034682461 scopus 로고    scopus 로고
    • AR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse
    • AR)-associated protein GABARAP interacts with gephyrin but is not involved in receptor anchoring at the synapse. Proc. Natl Acad. Sci. USA 97, 8594-8599 (2000).
    • (2000) Proc. Natl Acad. Sci. USA , vol.97 , pp. 8594-8599
    • Kneussel, M.1
  • 34
    • 24944493275 scopus 로고    scopus 로고
    • A receptor β subunits
    • A receptor β subunits. Mol. Cell. Neurosci. 30, 197-206 (2005).
    • (2005) Mol. Cell. Neurosci , vol.30 , pp. 197-206
    • Goto, H.1
  • 35
    • 0032127472 scopus 로고    scopus 로고
    • NSF binding to GluR2 regulates synaptic transmission
    • Nishimune, A. et al. NSF binding to GluR2 regulates synaptic transmission. Neuron 21, 87-97 (1998).
    • (1998) Neuron , vol.21 , pp. 87-97
    • Nishimune, A.1
  • 36
    • 0032143945 scopus 로고    scopus 로고
    • Interaction of the N-ethylmaleimide- sensitive factor with AMPA receptors
    • Song, I. et al. Interaction of the N-ethylmaleimide- sensitive factor with AMPA receptors. Neuron 21, 393-400 (1998).
    • (1998) Neuron , vol.21 , pp. 393-400
    • Song, I.1
  • 37
    • 0034068989 scopus 로고    scopus 로고
    • Domain organization of p130, PLC-related catalytically inactive protein, and structural basis for the lack of enzyme activity
    • Kanematsu, T. et al. Domain organization of p130, PLC-related catalytically inactive protein, and structural basis for the lack of enzyme activity. Eur. J. Biochem. 267, 2731-2737 (2000).
    • (2000) Eur. J. Biochem , vol.267 , pp. 2731-2737
    • Kanematsu, T.1
  • 38
    • 0037146874 scopus 로고    scopus 로고
    • Uji, A. et al. Molecules interacting with PRIP-2, a novel Ins(1,4,5)P3 binding protein type 2: comparison with PRIP-1. Life Sci. 72, 443-453 (2002).
    • Uji, A. et al. Molecules interacting with PRIP-2, a novel Ins(1,4,5)P3 binding protein type 2: comparison with PRIP-1. Life Sci. 72, 443-453 (2002).
  • 40
    • 33847091732 scopus 로고    scopus 로고
    • A receptors to the cell surface
    • A receptors to the cell surface. J. Neurosci. 27, 1692-1701 (2007).
    • (2007) J. Neurosci , vol.27 , pp. 1692-1701
    • Mizokami, A.1
  • 41
    • 0038383457 scopus 로고    scopus 로고
    • A receptor activity by phosphorylation and receptor trafficking: Implications for the efficacy of synaptic inhibition
    • A receptor activity by phosphorylation and receptor trafficking: implications for the efficacy of synaptic inhibition. Curr. Opin. Neurobiol. 13, 341-347 (2003).
    • (2003) Curr. Opin. Neurobiol , vol.13 , pp. 341-347
    • Kittler, J.T.1    Moss, S.J.2
  • 42
    • 4143067020 scopus 로고    scopus 로고
    • A receptor phosphodependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein
    • A receptor phosphodependent modulation is regulated by phospholipase C-related inactive protein type 1, a novel protein phosphatase 1 anchoring protein. J. Neurosci. 24, 7074-7084 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 7074-7084
    • Terunuma, M.1
  • 43
    • 0242721606 scopus 로고    scopus 로고
    • Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1α
    • Yoshimura, K. et al. Interaction of p130 with, and consequent inhibition of, the catalytic subunit of protein phosphatase 1α. J. Biol. Chem. 276, 17908-17913 (2001).
    • (2001) J. Biol. Chem , vol.276 , pp. 17908-17913
    • Yoshimura, K.1
  • 44
    • 33847111516 scopus 로고    scopus 로고
    • A receptors mediated by clathrin and AP2 adaptor complex
    • A receptors mediated by clathrin and AP2 adaptor complex. J. Neurochem. 101, 898-905 (2007).
    • (2007) J. Neurochem , vol.101 , pp. 898-905
    • Kanematsu, T.1
  • 45
    • 25844522857 scopus 로고    scopus 로고
    • Modulation of neuronal protein trafficking and function by palmitoylation
    • Huang, K. & El-Husseini, A. Modulation of neuronal protein trafficking and function by palmitoylation. Curr. Opin. Neurobiol. 15, 527-535 (2005).
    • (2005) Curr. Opin. Neurobiol , vol.15 , pp. 527-535
    • Huang, K.1    El-Husseini, A.2
  • 46
    • 3042714804 scopus 로고    scopus 로고
    • A receptors is a substrate for palmitoylation by GODZ
    • ARs
    • ARs.
    • (2004) J. Neurosci , vol.24 , pp. 5881-5891
    • Keller, C.A.1
  • 48
    • 33845451067 scopus 로고    scopus 로고
    • A receptors is required for normal assembly and function of GABAergic inhibitory synapses
    • A receptors is required for normal assembly and function of GABAergic inhibitory synapses. J. Neurosci. 26, 12758-12768 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 12758-12768
    • Fang, C.1
  • 50
    • 0029015710 scopus 로고
    • Structure and function of ARF proteins: Activators of cholera toxin and critical components of intracellular vesicular transport processes
    • Moss, J. & Vaughan, M. Structure and function of ARF proteins: activators of cholera toxin and critical components of intracellular vesicular transport processes. J. Biol. Chem. 270, 12327-12330 (1995).
    • (1995) J. Biol. Chem , vol.270 , pp. 12327-12330
    • Moss, J.1    Vaughan, M.2
  • 51
    • 0037119360 scopus 로고    scopus 로고
    • A receptor-associated protein, GRIF-1
    • A receptor-associated protein, GRIF-1. J. Biol. Chem. 277, 30079-30090 (2002).
    • (2002) J. Biol. Chem , vol.277 , pp. 30079-30090
    • Beck, M.1
  • 52
    • 17644379638 scopus 로고    scopus 로고
    • GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: Association in vivo and in vitro with kinesin
    • Brickley, K., Smith, M. J., Beck, M. & Stephenson, F. A. GRIF-1 and OIP106, members of a novel gene family of coiled-coil domain proteins: association in vivo and in vitro with kinesin. J. Biol. Chem. 280, 14723-14732 (2005).
    • (2005) J. Biol. Chem , vol.280 , pp. 14723-14732
    • Brickley, K.1    Smith, M.J.2    Beck, M.3    Stephenson, F.A.4
  • 53
    • 33748749048 scopus 로고    scopus 로고
    • Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes
    • Smith, M. J., Pozo, K., Brickley, K. & Stephenson, F. A. Mapping the GRIF-1 binding domain of the kinesin, KIF5C, substantiates a role for GRIF-1 as an adaptor protein in the anterograde trafficking of cargoes. J. Biol. Chem. 281, 27216-27228 (2006).
    • (2006) J. Biol. Chem , vol.281 , pp. 27216-27228
    • Smith, M.J.1    Pozo, K.2    Brickley, K.3    Stephenson, F.A.4
  • 54
    • 31744447625 scopus 로고    scopus 로고
    • A receptor homeostasis in hypertonic mice
    • A receptor homeostasis in hypertonic mice. Nature Genet. 38, 245-250 (2006).
    • (2006) Nature Genet , vol.38 , pp. 245-250
    • Gilbert, S.L.1
  • 55
    • 27744463295 scopus 로고    scopus 로고
    • A receptors
    • A receptors. J. Neurosci. 25, 10469-10478 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 10469-10478
    • Jacob, T.C.1
  • 57
    • 33748921568 scopus 로고    scopus 로고
    • A receptors are directly recruited from their extrasynaptic counterparts
    • A receptors are directly recruited from their extrasynaptic counterparts. EMBO J. 25, 4381-4389 (2006).
    • (2006) EMBO J , vol.25 , pp. 4381-4389
    • Bogdanov, Y.1
  • 58
    • 0038044682 scopus 로고    scopus 로고
    • A receptors varies during development in cultured hippocampal neurons
    • A receptors varies during development in cultured hippocampal neurons. Mol. Cell. Neurosci. 23, 264-278 (2003).
    • (2003) Mol. Cell. Neurosci , vol.23 , pp. 264-278
    • Danglot, L.1    Triller, A.2    Bessis, A.3
  • 59
    • 7944226960 scopus 로고    scopus 로고
    • A receptors in hippocampal granule cells
    • A receptors in hippocampal granule cells. Brain Res. 1029, 207-216 (2004).
    • (2004) Brain Res , vol.1029 , pp. 207-216
    • Sun, C.1    Sieghart, W.2    Kapur, J.3
  • 61
    • 0344442662 scopus 로고    scopus 로고
    • A receptors and their activation by GABA spillover in the mouse dentate gyrus
    • A receptors and their activation by GABA spillover in the mouse dentate gyrus. J. Neurosci. 23, 10650-10661 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 10650-10661
    • Wei, W.1    Zhang, N.2    Peng, Z.3    Houser, C.R.4    Mody, I.5
  • 62
    • 0020405932 scopus 로고
    • Purification by affinity chromatography of the glycine receptor of rat spinal cord
    • Pfeiffer, F., Graham, D. & Betz, H. Purification by affinity chromatography of the glycine receptor of rat spinal cord. J. Biol. Chem. 257, 9389-9393 (1982).
    • (1982) J. Biol. Chem , vol.257 , pp. 9389-9393
    • Pfeiffer, F.1    Graham, D.2    Betz, H.3
  • 63
    • 0029124881 scopus 로고
    • Identification of a gephyrin binding motif on the glycine receptor β subunit
    • Meyer, G., Kirsch, J., Betz, H. & Langosch, D. Identification of a gephyrin binding motif on the glycine receptor β subunit. Neuron 15, 563-572 (1995).
    • (1995) Neuron , vol.15 , pp. 563-572
    • Meyer, G.1    Kirsch, J.2    Betz, H.3    Langosch, D.4
  • 64
    • 0033048625 scopus 로고    scopus 로고
    • Hydrophobic interactions mediate binding of the glycine receptor β subunit to gephyrin
    • Kneussel, M., Hermann, A., Kirsch, J. & Betz, H. Hydrophobic interactions mediate binding of the glycine receptor β subunit to gephyrin. J. Neurochem. 72, 1323-1326 (1999).
    • (1999) J. Neurochem , vol.72 , pp. 1323-1326
    • Kneussel, M.1    Hermann, A.2    Kirsch, J.3    Betz, H.4
  • 65
    • 0032514872 scopus 로고    scopus 로고
    • Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity
    • Feng, G. et al. Dual requirement for gephyrin in glycine receptor clustering and molybdoenzyme activity. Science 282, 1321-1324 (1998).
    • (1998) Science , vol.282 , pp. 1321-1324
    • Feng, G.1
  • 66
    • 0842301334 scopus 로고    scopus 로고
    • Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons
    • Levi, S., Logan, S. M., Tovar, K. R. & Craig, A. M. Gephyrin is critical for glycine receptor clustering but not for the formation of functional GABAergic synapses in hippocampal neurons. J. Neurosci. 24, 207-217 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 207-217
    • Levi, S.1    Logan, S.M.2    Tovar, K.R.3    Craig, A.M.4
  • 67
    • 0027723681 scopus 로고
    • Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons
    • Kirsch, J., Wolters, I., Triller, A. & Betz, H. Gephyrin antisense oligonucleotides prevent glycine receptor clustering in spinal neurons. Nature 366, 745-748 (1993).
    • (1993) Nature , vol.366 , pp. 745-748
    • Kirsch, J.1    Wolters, I.2    Triller, A.3    Betz, H.4
  • 68
    • 0038362175 scopus 로고    scopus 로고
    • Formation and plasticity of GABAergic synapses: Physiological mechanisms and pathophysiological implications
    • Fritschy, J. M. & Brunig, I. Formation and plasticity of GABAergic synapses: physiological mechanisms and pathophysiological implications. Pharmacol. Ther. 98, 299-323 (2003).
    • (2003) Pharmacol. Ther , vol.98 , pp. 299-323
    • Fritschy, J.M.1    Brunig, I.2
  • 69
    • 33644665247 scopus 로고    scopus 로고
    • AR and gephyrin clusters, indicating that a γ2-dependent mechanism is involved in the formation of inhibitory synapses. More recently, γ2 was also demonstrated to be required for the maintenance of mature synapses (see reference 75).
    • AR and gephyrin clusters, indicating that a γ2-dependent mechanism is involved in the formation of inhibitory synapses. More recently, γ2 was also demonstrated to be required for the maintenance of mature synapses (see reference 75).
  • 71
    • 0343729350 scopus 로고    scopus 로고
    • A receptor clustering in gephyrin-deficient mice
    • A receptor clustering in gephyrin-deficient mice. J. Neurosci. 19, 9289-9297 (1999).
    • (1999) J. Neurosci , vol.19 , pp. 9289-9297
    • Kneussel, M.1
  • 72
    • 0033994755 scopus 로고    scopus 로고
    • Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin
    • Kins, S., Betz, H. & Kirsch, J. Collybistin, a newly identified brain-specific GEF, induces submembrane clustering of gephyrin. Nature Neurosci. 3, 22-29 (2000).
    • (2000) Nature Neurosci , vol.3 , pp. 22-29
    • Kins, S.1    Betz, H.2    Kirsch, J.3
  • 73
    • 3042774411 scopus 로고    scopus 로고
    • The GDP-GTP exchange factor collybistin: An essential determinant of neuronal gephyrin clustering
    • Harvey, K. et al. The GDP-GTP exchange factor collybistin: an essential determinant of neuronal gephyrin clustering. J. Neurosci. 24, 5816-5826 (2004).
    • (2004) J. Neurosci , vol.24 , pp. 5816-5826
    • Harvey, K.1
  • 74
    • 34548383128 scopus 로고    scopus 로고
    • Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice
    • Papadopoulos, T. et al. Impaired GABAergic transmission and altered hippocampal synaptic plasticity in collybistin-deficient mice. EMBO J. 26, 3888-3899 (2007).
    • (2007) EMBO J , vol.26 , pp. 3888-3899
    • Papadopoulos, T.1
  • 75
    • 0142157619 scopus 로고    scopus 로고
    • A receptors is required for maintenance of receptors at mature synapses
    • A receptors is required for maintenance of receptors at mature synapses. Mol. Cell. Neurosci. 24, 442-450 (2003).
    • (2003) Mol. Cell. Neurosci , vol.24 , pp. 442-450
    • Schweizer, C.1
  • 78
    • 0028848501 scopus 로고
    • Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells
    • Kirsch, J., Kuhse, J. & Betz, H. Targeting of glycine receptor subunits to gephyrin-rich domains in transfected human embryonic kidney cells. Mol. Cell. Neurosci. 6, 450-461 (1995).
    • (1995) Mol. Cell. Neurosci , vol.6 , pp. 450-461
    • Kirsch, J.1    Kuhse, J.2    Betz, H.3
  • 79
    • 38949182650 scopus 로고    scopus 로고
    • A receptor subtypes at inhibitory synapses is facilitated via the direct binding of receptor α2 subunits to gephyrin
    • ARs bind directly to gephyrin and that disruption of this binding alters the synaptic targeting of receptor subtypes containing α2 subunits
    • ARs bind directly to gephyrin and that disruption of this binding alters the synaptic targeting of receptor subtypes containing α2 subunits.
    • (2008) J. Neurosci , vol.28 , pp. 1356-1365
    • Tretter, V.1
  • 80
    • 0026748781 scopus 로고
    • Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein
    • Prior, P. et al. Primary structure and alternative splice variants of gephyrin, a putative glycine receptor-tubulin linker protein. Neuron 8, 1161-1170 (1992).
    • (1992) Neuron , vol.8 , pp. 1161-1170
    • Prior, P.1
  • 81
    • 31944448850 scopus 로고    scopus 로고
    • Neuronal cotransport of glycine receptor and the scaffold protein gephyrin
    • Maas, C. et al. Neuronal cotransport of glycine receptor and the scaffold protein gephyrin. J. Cell Biol. 172, 441-451 (2006).
    • (2006) J. Cell Biol , vol.172 , pp. 441-451
    • Maas, C.1
  • 82
    • 33646850883 scopus 로고    scopus 로고
    • Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses
    • This paper, along with reference 81, used live imaging of fluorescently tagged gephyrin to reveal constant synaptic movements of gephyrin that could be controlled by activity. This showed that gephyrin is a significant dynamic force at inhibitory synapses
    • Hanus, C., Ehrensperger, M. V. & Triller, A. Activity-dependent movements of postsynaptic scaffolds at inhibitory synapses. J. Neurosci. 26, 4586-4595 (2006). This paper, along with reference 81, used live imaging of fluorescently tagged gephyrin to reveal constant synaptic movements of gephyrin that could be controlled by activity. This showed that gephyrin is a significant dynamic force at inhibitory synapses.
    • (2006) J. Neurosci , vol.26 , pp. 4586-4595
    • Hanus, C.1    Ehrensperger, M.V.2    Triller, A.3
  • 83
    • 34247204919 scopus 로고    scopus 로고
    • Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function
    • Zita, M. M. et al. Post-phosphorylation prolyl isomerisation of gephyrin represents a mechanism to modulate glycine receptors function. EMBO J. 26, 1761-1771 (2007).
    • (2007) EMBO J , vol.26 , pp. 1761-1771
    • Zita, M.M.1
  • 85
  • 87
    • 0034310719 scopus 로고    scopus 로고
    • A receptors by an association with the adaptin AP2 complex modulates inhibitory synaptic currents in hippocampal neurons
    • ARs undergo constitutive endocytosis and described the role that this process has in regulating the efficacy of synaptic inhibition
    • ARs undergo constitutive endocytosis and described the role that this process has in regulating the efficacy of synaptic inhibition.
    • (2000) J. Neurosci , vol.20 , pp. 7972-7977
    • Kittler, J.T.1
  • 88
    • 4344624896 scopus 로고    scopus 로고
    • ARs with HAP1.
    • ARs with HAP1.
  • 89
    • 0037929806 scopus 로고    scopus 로고
    • A receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the β2 subunit of the receptor
    • A receptor endocytosis is dynamin-mediated and dependent on a dileucine AP2 adaptin-binding motif within the β2 subunit of the receptor. J. Biol. Chem. 278, 24046-24052 (2003).
    • (2003) J. Biol. Chem , vol.278 , pp. 24046-24052
    • Herring, D.1
  • 90
    • 12744279760 scopus 로고    scopus 로고
    • A receptor subunits are transferred to an intracellular pool associated with the postsynaptic density
    • A receptor subunits are transferred to an intracellular pool associated with the postsynaptic density. Eur. J. Neurosci. 21, 327-338 (2005).
    • (2005) Eur. J. Neurosci , vol.21 , pp. 327-338
    • van Rijnsoever, C.1    Sidler, C.2    Fritschy, J.M.3
  • 92
    • 26844466893 scopus 로고    scopus 로고
    • ARs can regulate endocytosis and receptor cell-surface levels.
    • ARs can regulate endocytosis and receptor cell-surface levels.
  • 95
    • 33645637616 scopus 로고    scopus 로고
    • A receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens
    • A receptor function through a phospho-dependent endocytosis mechanism in nucleus accumbens. J. Neurosci. 26, 2513-2521 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 2513-2521
    • Chen, G.1    Kittler, J.T.2    Moss, S.J.3    Yan, Z.4
  • 96
    • 0035448855 scopus 로고    scopus 로고
    • A receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons
    • A receptor channels through activation of anchored protein kinase C in prefrontal cortical neurons. J. Neurosci. 21, 6502-6511 (2001).
    • (2001) J. Neurosci , vol.21 , pp. 6502-6511
    • Feng, J.1    Cai, X.2    Zhao, J.3    Yan, Z.4
  • 97
    • 0031279109 scopus 로고    scopus 로고
    • A currents in striatal cholinergic interneurons through a PKA/PP1 cascade. Neuron 19, 1115-1126 (1997).
    • A currents in striatal cholinergic interneurons through a PKA/PP1 cascade. Neuron 19, 1115-1126 (1997).
  • 98
    • 0028803757 scopus 로고
    • A huntingtin-associated protein enriched in brain with implications for pathology
    • Li, X.-J. et al. A huntingtin-associated protein enriched in brain with implications for pathology. Nature 378, 398-402 (1995).
    • (1995) Nature , vol.378 , pp. 398-402
    • Li, X.-J.1
  • 99
    • 33646556703 scopus 로고    scopus 로고
    • ARs in the hypothalamus and result in a functional change in food intake and body weight in rodents.
    • ARs in the hypothalamus and result in a functional change in food intake and body weight in rodents.
  • 100
    • 33847182396 scopus 로고    scopus 로고
    • A receptor heterogeneity, function, and implications for epilepsy. Neurology 68, 612-614 (2007).
    • A receptor heterogeneity, function, and implications for epilepsy. Neurology 68, 612-614 (2007).
  • 101
    • 0344861822 scopus 로고    scopus 로고
    • A receptor subunit and gephyrin protein changes differ in the globus pallidus in Huntington's diseased brain
    • A receptor subunit and gephyrin protein changes differ in the globus pallidus in Huntington's diseased brain. Brain Res. 994, 265-270 (2003).
    • (2003) Brain Res , vol.994 , pp. 265-270
    • Thompson-Vest, N.M.1    Waldvogel, H.J.2    Rees, M.I.3    Faull, R.L.4
  • 102
    • 0032837062 scopus 로고    scopus 로고
    • GABA and epileptogenesis: Comparing gabrb3 gene-deficient mice with Angelman syndrome in man
    • DeLorey, T. M. & Olsen, R. W. GABA and epileptogenesis: comparing gabrb3 gene-deficient mice with Angelman syndrome in man. Epilepsy Res. 36, 123-132 (1999).
    • (1999) Epilepsy Res , vol.36 , pp. 123-132
    • DeLorey, T.M.1    Olsen, R.W.2
  • 103
    • 34447621203 scopus 로고    scopus 로고
    • A receptor: A novel target for treatment of fragile X?
    • A receptor: a novel target for treatment of fragile X? Trends Neurosci. 30, 425-431 (2007).
    • (2007) Trends Neurosci , vol.30 , pp. 425-431
    • D'Hulst, C.1    Kooy, R.F.2
  • 104
    • 33748474553 scopus 로고    scopus 로고
    • Pathophysiologically based treatment interventions in schizophrenia
    • Lewis, D. A. & Gonzalez-Burgos, G. Pathophysiologically based treatment interventions in schizophrenia. Nature Med. 12, 1016-1022 (2006).
    • (2006) Nature Med , vol.12 , pp. 1016-1022
    • Lewis, D.A.1    Gonzalez-Burgos, G.2
  • 105
    • 33748316516 scopus 로고    scopus 로고
    • A receptors and alcoholism: Intoxication, dependence, vulnerability, and treatment
    • A receptors and alcoholism: intoxication, dependence, vulnerability, and treatment. Arch. Gen. Psychiatry 63, 957-968 (2006).
    • (2006) Arch. Gen. Psychiatry , vol.63 , pp. 957-968
    • Krystal, J.H.1
  • 106
    • 0035202121 scopus 로고    scopus 로고
    • Epilepsy-associated plasticity in γ-aminobutyric acid receptor expression, function, and inhibitory synaptic properties
    • Coulter, D. A. Epilepsy-associated plasticity in γ-aminobutyric acid receptor expression, function, and inhibitory synaptic properties. Int. Rev. Neurobiol. 45, 237-252 (2001).
    • (2001) Int. Rev. Neurobiol , vol.45 , pp. 237-252
    • Coulter, D.A.1
  • 108
    • 23944507074 scopus 로고    scopus 로고
    • A receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus
    • A receptors, loss of inhibition, and a mechanism for pharmacoresistance in status epilepticus. J. Neurosci. 25, 7724-7733 (2005).
    • (2005) J. Neurosci , vol.25 , pp. 7724-7733
    • Naylor, D.E.1    Liu, H.2    Wasterlain, C.G.3
  • 110
    • 38349004774 scopus 로고    scopus 로고
    • A receptors by intimately associated protein kinase C activity underlies compromised synaptic inhibition during status epilepticus
    • A receptors by intimately associated protein kinase C activity underlies compromised synaptic inhibition during status epilepticus. J. Neurosci. 28, 37-84 (2008).
    • (2008) J. Neurosci , vol.28 , pp. 37-84
    • Terunuma, M.1
  • 112
    • 0035063257 scopus 로고    scopus 로고
    • Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy
    • Knuesel, I., Zuellig, R. A., Schaub, M. C. & Fritschy, J. M. Alterations in dystrophin and utrophin expression parallel the reorganization of GABAergic synapses in a mouse model of temporal lobe epilepsy. Eur. J. Neurosci. 13, 1113-1124 (2001).
    • (2001) Eur. J. Neurosci , vol.13 , pp. 1113-1124
    • Knuesel, I.1    Zuellig, R.A.2    Schaub, M.C.3    Fritschy, J.M.4
  • 115
    • 0030787385 scopus 로고    scopus 로고
    • A receptor subunits in the rat hippocampus II: Altered distribution in kainic acidinduced temporal lobe epilepsy
    • A receptor subunits in the rat hippocampus II: altered distribution in kainic acidinduced temporal lobe epilepsy. Neuroscience 80, 1001-1017 (1997).
    • (1997) Neuroscience , vol.80 , pp. 1001-1017
    • Schwarzer, C.1
  • 117
    • 0042835643 scopus 로고    scopus 로고
    • A receptor β subunits in the hippocampus of patients with temporal lobe epilepsy
    • A receptor β subunits in the hippocampus of patients with temporal lobe epilepsy. J. Neuropathol. Exp. Neurol. 62, 820-834 (2003).
    • (2003) J. Neuropathol. Exp. Neurol , vol.62 , pp. 820-834
    • Pirker, S.1
  • 118
    • 0034660692 scopus 로고    scopus 로고
    • AR subtypes in the hippocampus of temporal lobe epilepsy patients.
    • AR subtypes in the hippocampus of temporal lobe epilepsy patients.
  • 119
    • 0035033520 scopus 로고    scopus 로고
    • A receptor γ2 subunit in childhood absence epilepsy and febrile seizures
    • A receptor γ2 subunit in childhood absence epilepsy and febrile seizures. Nature Genet. 28, 49-52 (2001).
    • (2001) Nature Genet , vol.28 , pp. 49-52
    • Wallace, R.H.1
  • 120
    • 0035030766 scopus 로고    scopus 로고
    • A receptor dysfunction in epilepsy: A mutation in the γ2 subunit gene
    • AR subunits being associated with human epilepsy
    • AR subunits being associated with human epilepsy.
    • (2001) Nature Genet , vol.28 , pp. 46-48
    • Baulac, S.1
  • 121
    • 0036318060 scopus 로고    scopus 로고
    • A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions
    • Kananura, C. et al. A splice-site mutation in GABRG2 associated with childhood absence epilepsy and febrile convulsions. Arch. Neurol. 59, 1137-1141 (2002).
    • (2002) Arch. Neurol , vol.59 , pp. 1137-1141
    • Kananura, C.1
  • 122
    • 18544364797 scopus 로고    scopus 로고
    • Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy
    • Cossette, P. et al. Mutation of GABRA1 in an autosomal dominant form of juvenile myoclonic epilepsy. Nature Genet. 31, 184-189 (2002).
    • (2002) Nature Genet , vol.31 , pp. 184-189
    • Cossette, P.1
  • 123
    • 33744811658 scopus 로고    scopus 로고
    • A receptor α1 subunit is associated with absence epilepsy
    • A receptor α1 subunit is associated with absence epilepsy. Ann. Neurol. 59, 983-987 (2006).
    • (2006) Ann. Neurol , vol.59 , pp. 983-987
    • Maljevic, S.1
  • 124
    • 32544442006 scopus 로고    scopus 로고
    • A receptors
    • A receptors. J. Neurosci. 26, 1499-1506 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 1499-1506
    • Feng, H.J.1
  • 125
    • 33750599989 scopus 로고    scopus 로고
    • A new paradigm of channelopathy in epilepsy syndromes: Intracellular trafficking abnormality of channel molecules
    • Hirose, S. A new paradigm of channelopathy in epilepsy syndromes: intracellular trafficking abnormality of channel molecules. Epilepsy Res. 70 (Suppl. 1), S206-S217 (2006).
    • (2006) Epilepsy Res , vol.70 , Issue.SUPPL. 1
    • Hirose, S.1
  • 127
    • 38449100485 scopus 로고    scopus 로고
    • A receptor γ2 subunit mutations linked to human epileptic syndromes differentially affect phasic and tonic inhibition
    • A receptor γ2 subunit mutations linked to human epileptic syndromes differentially affect phasic and tonic inhibition. J. Neurosci. 27, 14108-14116 (2007).
    • (2007) J. Neurosci , vol.27 , pp. 14108-14116
    • Eugene, E.1
  • 128
    • 34548717515 scopus 로고    scopus 로고
    • AR cell-surface expression.
    • AR cell-surface expression.
  • 129
    • 34247402952 scopus 로고    scopus 로고
    • Neurobiology of cocaine addiction: Implications for new pharmacotherapy
    • Kalivas, P. W. Neurobiology of cocaine addiction: implications for new pharmacotherapy. Am. J. Addict. 16, 71-78 (2007).
    • (2007) Am. J. Addict , vol.16 , pp. 71-78
    • Kalivas, P.W.1
  • 131
    • 12344260655 scopus 로고    scopus 로고
    • A receptor subtypes: any clues to the mechanism of benzodiazepine dependence? Curr. Opin. Pharmacol. 5, 47-52 (2005).
    • A receptor subtypes: any clues to the mechanism of benzodiazepine dependence? Curr. Opin. Pharmacol. 5, 47-52 (2005).
  • 132
    • 36049019559 scopus 로고    scopus 로고
    • A receptor plasticity after ethanol intoxication
    • A receptor plasticity after ethanol intoxication. J. Neurosci. 27, 12367-12377 (2007).
    • (2007) J. Neurosci , vol.27 , pp. 12367-12377
    • Liang, J.1
  • 133
    • 32544436243 scopus 로고    scopus 로고
    • A receptors
    • A receptors. J. Neurosci. 26, 1749-1758 (2006).
    • (2006) J. Neurosci , vol.26 , pp. 1749-1758
    • Liang, J.1
  • 134
    • 0036314804 scopus 로고    scopus 로고
    • A receptors containing ?1 and α4 subunits in the cerebral cortex: Selective effects of chronic ethanol consumption
    • A receptors containing ?1 and α4 subunits in the cerebral cortex: selective effects of chronic ethanol consumption. J. Neurochem. 82, 110-117 (2002).
    • (2002) J. Neurochem , vol.82 , pp. 110-117
    • Kumar, S.1    Sieghart, W.2    Morrow, A.L.3
  • 136
    • 0032007269 scopus 로고    scopus 로고
    • Rapid tolerance and crosstolerance to motor impairment effects of benzodiazepines, barbiturates, and ethanol
    • Khanna, J. M., Kalant, H., Chau, A. & Shah, G. Rapid tolerance and crosstolerance to motor impairment effects of benzodiazepines, barbiturates, and ethanol. Pharmacol. Biochem. Behav. 59, 511-519 (1998).
    • (1998) Pharmacol. Biochem. Behav , vol.59 , pp. 511-519
    • Khanna, J.M.1    Kalant, H.2    Chau, A.3    Shah, G.4
  • 137
    • 0036784474 scopus 로고    scopus 로고
    • Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia
    • Volk, D. W. et al. Reciprocal alterations in pre- and postsynaptic inhibitory markers at chandelier cell inputs to pyramidal neurons in schizophrenia. Cereb. Cortex 12, 1063-1070 (2002).
    • (2002) Cereb. Cortex , vol.12 , pp. 1063-1070
    • Volk, D.W.1
  • 138
    • 0344033607 scopus 로고    scopus 로고
    • GABA and schizophrenia: A review of basic science and clinical studies
    • Wassef, A., Baker, J. & Kochan, L. D. GABA and schizophrenia: a review of basic science and clinical studies. J. Clin. Psychopharmacol. 23, 601-640 (2003).
    • (2003) J. Clin. Psychopharmacol , vol.23 , pp. 601-640
    • Wassef, A.1    Baker, J.2    Kochan, L.D.3
  • 139
    • 28044453713 scopus 로고    scopus 로고
    • A receptors to a dopamine hyperfunction
    • A receptors to a dopamine hyperfunction. Proc. Natl Acad. Sci. USA 102, 17154-17159 (2005).
    • (2005) Proc. Natl Acad. Sci. USA , vol.102 , pp. 17154-17159
    • Yee, B.K.1
  • 140
    • 0034891977 scopus 로고    scopus 로고
    • Human studies of prepulse inhibition of startle: Normal subjects, patient groups, and pharmacological studies
    • Braff, D. L., Geyer, M. A. & Swerdlow, N. R. Human studies of prepulse inhibition of startle: normal subjects, patient groups, and pharmacological studies. Psychopharmacology (Berl.) 156, 234-258 (2001).
    • (2001) Psychopharmacology (Berl.) , vol.156 , pp. 234-258
    • Braff, D.L.1    Geyer, M.A.2    Swerdlow, N.R.3
  • 141
    • 33748745370 scopus 로고    scopus 로고
    • A receptor α3 subunit-null mice
    • A receptor α3 subunit-null mice. Eur. J. Neurosci. 24, 1307-1315 (2006).
    • (2006) Eur. J. Neurosci , vol.24 , pp. 1307-1315
    • Studer, R.1
  • 142
    • 0028977843 scopus 로고
    • A receptor heterogeneity in the adult rat brain: Differential regional and cellular distribution of seven major subunits
    • A receptor heterogeneity in the adult rat brain: differential regional and cellular distribution of seven major subunits. J. Comp. Neurol. 359, 154-194 (1995).
    • (1995) J. Comp. Neurol , vol.359 , pp. 154-194
    • Fritschy, J.M.1    Mohler, H.2
  • 143
    • 13244268304 scopus 로고    scopus 로고
    • A receptors modulate the expression of prepulse inhibition
    • A receptors modulate the expression of prepulse inhibition. Mol. Psychiatry 10, 201-207 (2005).
    • (2005) Mol. Psychiatry , vol.10 , pp. 201-207
    • Hauser, J.1
  • 144
    • 0035319805 scopus 로고    scopus 로고
    • Constructing inhibitory synapses
    • Moss, S. J. & Smart, T. G. Constructing inhibitory synapses. Nature Rev. Neurosci. 2, 240-250 (2001).
    • (2001) Nature Rev. Neurosci , vol.2 , pp. 240-250
    • Moss, S.J.1    Smart, T.G.2
  • 146
    • 33749023600 scopus 로고    scopus 로고
    • Molecular organization and assembly of the central inhibitory postsynapse
    • Arancibia-Carcamo, I. L, & Moss, S. J. Molecular organization and assembly of the central inhibitory postsynapse. Results Probl. Cell Differ. 43, 25-47 (2006).
    • (2006) Results Probl. Cell Differ , vol.43 , pp. 25-47
    • Arancibia-Carcamo, I.L.1    Moss, S.J.2
  • 147
    • 0141632907 scopus 로고    scopus 로고
    • Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and mena: A possible link to the microfilament system
    • Giesemann, T. et al. Complex formation between the postsynaptic scaffolding protein gephyrin, profilin, and mena: a possible link to the microfilament system. J. Neurosci. 23, 8330-8339 (2003).
    • (2003) J. Neurosci , vol.23 , pp. 8330-8339
    • Giesemann, T.1
  • 148
    • 0032481298 scopus 로고    scopus 로고
    • Interactions of drebrin and gephyrin with profilin
    • Mammoto, A. et al. Interactions of drebrin and gephyrin with profilin. Biochem. Biophys. Res. Commun. 243, 86-89 (1998).
    • (1998) Biochem. Biophys. Res. Commun , vol.243 , pp. 86-89
    • Mammoto, A.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.