Identification of a residue in the γ-aminobutyric acid type A receptor α subunit that differentially affects diazepam-sensitive and -insensitive benzodiazepine site binding

Journal of Neurochemistry

Volumn 88, Issue 6, 2004, Pages 1431-1438

  Derry, Jason M C ^a   Dunn, Susan M J ^a   Davies, Martin ^a  

^a UNIVERSITY OF ALBERTA   (Canada)

Author keywords

Benzodiazepine; Chimera; Diazepam insensitive; GABA A; Ro15 4513; carboline

Indexed keywords

4 AMINOBUTYRIC ACID A RECEPTOR; 4 AMINOBUTYRIC ACID A RECEPTOR STIMULATING AGENT; 4 ETHYL 6,7 DIMETHOXY BETA CARBOLINE 3 CARBOXYLIC ACID METHYL ESTER; 8 AZIDO 5,6 DIHYDRO 5 METHYL 6 OXO 4H IMIDAZO[1,5 A][1,4]BENZODIAZEPINE 3 CARBOXYLIC ACID ETHYL ESTER; AMINO ACID; BENZODIAZEPINE DERIVATIVE; BETA CARBOLINE 3 CARBOXYLIC ACID ETHYL ESTER; BETA CARBOLINE DERIVATIVE; DIAZEPAM; FLUMAZENIL; FLUNITRAZEPAM; LIGAND; PROTEIN SUBUNIT; RADIOLIGAND; RECEPTOR SUBUNIT;

AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ARTICLE; CHIMERA; DRUG BINDING SITE; DRUG RECEPTOR BINDING; GENE MUTATION; LIGAND BINDING; NONHUMAN; PRIORITY JOURNAL; RECEPTOR AFFINITY; SITE DIRECTED MUTAGENESIS; WILD TYPE;

EID: 1642288469     PISSN: 00223042     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1471-4159.2003.02264.x     Document Type: Article

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