Reaction of the hypoxia-selective antitumor agent tirapazamine with a C1'-radical in single-stranded and double-stranded DNA: The drug and its metabolites can serve as surrogates for molecular oxygen in radical-mediated DNA damage reactions

Biochemistry

Volumn 38, Issue 43, 1999, Pages 14248-14255

  Hwang, Jae Taeg ^a   Greenberg, Marc M ^a   Fuchs, Tarra ^b   Gates, Kent S ^b  

^a Department of Environmental and Radiological Health Sciences   (United States)

^b UNIVERSITY OF MISSOURI   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,2,6,6 TETRAMETHYLPIPERIDINE NITROXIDE; 3 AMINO 1,2,4 BENZOTRIAZINE 1 OXIDE; 3 AMINO 1,2,4 BENZOTRIAZINE 4 OXIDE; ANTINEOPLASTIC AGENT; DOUBLE STRANDED DNA; DRUG METABOLITE; MISONIDAZOLE; OXYGEN; PIPERIDINE DERIVATIVE; RADICAL; SINGLE STRANDED DNA; TIRAPAZAMINE; UNCLASSIFIED DRUG;

ARTICLE; CONTROLLED STUDY; DNA CLEAVAGE; DNA DAMAGE; DRUG MECHANISM; DRUG METABOLISM; DRUG SELECTIVITY; HYPOXIA; PRIORITY JOURNAL;

ANTINEOPLASTIC AGENTS; ANTIOXIDANTS; CELL HYPOXIA; CYCLIC N-OXIDES; DNA; DNA DAMAGE; DNA, SINGLE-STRANDED; FREE RADICALS; MISONIDAZOLE; REACTIVE OXYGEN SPECIES; SUGAR ACIDS; TRIAZINES;

EID: 0033607196     PISSN: 00062960     EISSN: None     Source Type: Journal    
DOI: 10.1021/bi991488n     Document Type: Article

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