The role of viral phenotype and CCR-5 gene defects in HIV-1 transmission and disease progression

Nature Medicine

Volumn 3, Issue 3, 1997, Pages 338-340

  Michael, Nelson L ^a   Chang, George ^b   Louie, Leslie G ^c   Mascola, John R ^a,d   Dondero, Dale ^e   Birx, Deborah L ^a   Sheppard, Haynes W ^e  

^a WALTER REED ARMY INSTITUTE OF RESEARCH   (United States)

^b HENRY M JACKSON FOUNDATION FOR THE ADVANCEMENT OF MILITARY MEDICINE   (United States)

^c UNIVERSITY OF CALIFORNIA   (United States)

^d NAVAL MEDICAL RESEARCH INSTITUTE   (United States)

^e CALIFORNIA DEPARTMENT OF PUBLIC HEALTH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD4 ANTIGEN; CHEMOKINE RECEPTOR;

ARTICLE; CLINICAL ARTICLE; DISEASE COURSE; GENE DELETION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; PRIORITY JOURNAL; VIRUS REPLICATION;

CD4-POSITIVE T-LYMPHOCYTES; CELL LINE; HIV INFECTIONS; HIV-1; HOMOZYGOTE; HUMANS; MUTATION; RECEPTORS, CCR5; RECEPTORS, CYTOKINE; RECEPTORS, HIV;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0031041571     PISSN: 10788956     EISSN: None     Source Type: Journal    
DOI: 10.1038/nm0397-338     Document Type: Article

References (22)

1. Clapham, P.R., Blanc, D. & Weiss, R.A. Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by Simian immunodeficiency virus. Virology 181, 703-715 (1991).
2. Maddon, P.J. et al. The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell 47, 333-348 (1986).
3. Alkhatib, G. et al. CC CKR5: A RANTES, MIP-1α, MIP-1β receptor as a fusion cofactor for macrophage-tropic HIV-1. Science 272, 1955-1958 (1996).
4. Berson, J.F. et al. A seven-transmembrane domain receptor involved in fusion and entry of T-cell-tropic human immunodeficiency virus type 1 strains. J. Virol. 70, 6288-6295 (1996).
5. Bleul, C.C. et al. The lymphocyte chemoattractant SDF-1 is a ligand for LESTER/fusin and blocks HIV-1 entry. Nature 382, 829-832 (1996).
6. Choe, H. et al. The β-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates. Cell 85, 1135-1148 (1996).
7. Deng, H. et al. Identification of a major coreceptor for primary isolates of HIV-1. Nature 381, 661-666 (1996).
8. Doranz, B.J. et al. A dual-tropic primary HIV-1 isolate that uses fusin and the β-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors. Cell 85, 1149-1158 (1996).
9. Dragic, T. et al. HIV-1 entry in to CD4+ cells is mediated by the chemokine receptor CC-CKR-5. Nature 381, 667-673 (1996).
10. Feng, Y., Broder, C., Kennedy, P.E. & Berger, E.A. HIV-1 entry cofactor: Functional cDNA cloning of a seven-transmembrane G protein-coupled receptor. Science 272, 872-877 (1996).
11. Oberlin, E. et al. The CXC chemokine SDF-1 is the ligand fo LESTER/fusin and prevents infection by T-cell-line-adapted HIV-1. Nature 382, 833-835 (1996).
12. Liu, R. et al. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection. Cell 86, 367-377 (1996).
13. Sampson, M. et al. Resistance to HIV-1 infection in Caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene. Nature 382, 722-725 (1996).
14. Dean, M. et al. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Science 273, 1856-1862 (1996).
15. Cao, Y. et al. Virologic and immunologic characterization of long-term survivors of human immunodeficiency virus type 1 infection. New Engl. J. Med. 332, 201-208 (1995).
16. Sheppard, H.W. et al. The characterization of non-progressors: Long-term HIV-1 infection with stable CD4+ T-cell levels. AIDS 7, 1159-1166 (1993).
17. Jurriaans, S. et al. The natural history of HIV-1 infection: Virus load and virus phenotype independent determinants of clinical course? Virology 204, 223-233 (1994).
18. Huang, Y. et al. The role of a mutant CCR5 allele in HIV-1 transmission and disease progression. Nature Med. 2, 1240-1243 (1996).
19. Zhang, L. et al. HIV-1 subtype and second-receptor use. Nature 383, 768 (1996).
20. Winkelstein, W., Jr. et al. Sexual practices and risk of infection by the human immunodeficiency virus. The San Francisco Men's Health Study. JAMA 257, 321-325 (1987).
21. Centers for Disease Control and Prevention. 1993 revised classification system for HIV infection and expanded surveillance case definition for AIDS among adolescents and adults. Morb. Mortal Wkly Rep. 41, 1-19 (1992).
22. Delwart, E.L. et al. Genetic relationships determined by a DNA heteroduplex mobility assay: Analysis of HIV-1 env genes. Science 262, 1257-1261 (1993).