Structural basis for p38α MAP kinase quinazolinone and pyridol-pyrimidine inhibitor specificity

Nature Structural Biology

Volumn 10, Issue 9, 2003, Pages 764-769

  Fitzgerald, Catherine E ^a   Patel, Sangita B ^a   Becker, Joseph W ^a   Cameron, Patricia M ^a   Zaller, Dennis ^a   Pikounis, Vasilis Bill ^a   O'Keefe, Stephen J ^a   Scapin, Giovanna ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 14; MUTANT PROTEIN; PYRIMIDINE DERIVATIVE; QUINAZOLINONE DERIVATIVE; UNCLASSIFIED DRUG; 4 (4 FLUOROPHENYL) 1 (4 PIPERIDINYL) 5 (4 PYRIDYL) IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4-(4-FLUOROPHENYL)-1-(4-PIPERIDINYL)-5-(4-PYRIDYL)-IMIDAZOLE; 5 (2,6 DICHLOROPHENYL) 2 (2,4 DIFLUOROPHENYLTHIO)PYRIMIDO[1,6 B]PYRIDAZIN 6 ONE; ENZYME INHIBITOR; GLYCINE; IMIDAZOLE DERIVATIVE; ISOPROTEIN; PEPTIDE; PYRIDAZINE DERIVATIVE; PYRIDINE DERIVATIVE; QUINAZOLINE DERIVATIVE; VX-745;

ARTICLE; BINDING AFFINITY; CRYSTAL STRUCTURE; ENZYME INHIBITION; ENZYME SPECIFICITY; ENZYME STRUCTURE; GENE EXPRESSION; MOLECULAR CLONING; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; AMINO ACID SEQUENCE; ANIMAL; CHEMICAL MODEL; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; IC 50; KINETICS; MOLECULAR GENETICS; MUTATION; PROTEIN BINDING; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

AMINO ACID SEQUENCE; ANIMALS; CLONING, MOLECULAR; ENZYME INHIBITORS; GLYCINE; IMIDAZOLES; INHIBITORY CONCENTRATION 50; KINETICS; MICE; MITOGEN-ACTIVATED PROTEIN KINASE 14; MITOGEN-ACTIVATED PROTEIN KINASES; MODELS, CHEMICAL; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; MUTATION; PEPTIDES; PROTEIN BINDING; PROTEIN ISOFORMS; PROTEIN STRUCTURE, TERTIARY; PYRIDAZINES; PYRIDINES; PYRIMIDINES; QUINAZOLINES; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 0041318841     PISSN: 10728368     EISSN: None     Source Type: Journal    
DOI: 10.1038/nsb949     Document Type: Article

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