Identification and initial structure-activity relationships of a novel class of nonpeptide inhibitors of blood coagulation factor Xa

Journal of Medicinal Chemistry

Volumn 41, Issue 4, 1998, Pages 437-450

  Klein, Scott I ^a   Czekaj, Mark ^a   Gardner, Charles J ^a   Guertin, Kevin R ^b   Cheney, Daniel L ^a   Spada, Alfred P ^a   Bolton, Scott A ^c   Brown, Karen ^a   Colussi, Dennis ^a   Heran, Christopher L ^a   Morgan, Suzanne R ^a   Leadley, Robert J ^a   Dunwiddie, Christopher T ^a   Perrone, Mark H ^a   Chu, Valeria ^a  

^a Rhône Poulenc Rarer ^*  (United States)

^b Hoffman La Roche Department of Metabolic Diseases   (United States)

^c BRISTOL MYERS SQUIBB   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BETA ALANINE; BLOOD CLOTTING FACTOR 10A; BLOOD CLOTTING FACTOR 10A INHIBITOR; N (4 PHENYLBENZOYL) [2 (3 AMIDINOBENZYL) 3 STYRYL] BETA ALANINE METHYL ESTER; N BENZOYL [2 (3 AMIDINOBENZYL) 3 STYRYL] BETA ALANINE METHYL ESTER; THROMBIN; TRYPSIN; UNCLASSIFIED DRUG;

ARTICLE; DRUG POTENCY; DRUG SYNTHESIS; ENANTIOMER; HUMAN; HYDROPHOBICITY; STRUCTURE ACTIVITY RELATION;

ANIMALS; BETA-ALANINE; BINDING SITES; CATTLE; DRUG DESIGN; FACTOR XA; HUMANS; HYDROGEN BONDING; INDICATORS AND REAGENTS; INFANT, NEWBORN; MODELS, MOLECULAR; MOLECULAR CONFORMATION; PROTEIN CONFORMATION; STRUCTURE-ACTIVITY RELATIONSHIP; THROMBIN; TRYPSIN INHIBITORS;

EID: 15444348427     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm970482y     Document Type: Article

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