Heteroallyl-containing 5-nitrofuranes as new anti-Trypanosoma cruzi agents with a dual mechanism of action

Bioorganic and Medicinal Chemistry

Volumn 16, Issue 1, 2008, Pages 569-577

  Gerpe, Alejandra ^a   Odreman Nuñez, Imeria ^b   Draper, Patricia ^a   Boiani, Lucía ^a   Urbina, Julio A ^b   González, Mercedes ^a   Cerecetto, Hugo ^a  

^a UNIVERSIDAD DE LA REPÚBLICA   (Uruguay)

^b INSTITUTO VENEZOLANO DE INVESTIGACIONES CIENTÍFICAS   (Venezuela)

Author keywords

Anti T. cruzi compounds; Heteroallyl nitrofuranes; Oxygen redox cycling; Squalene epoxidase; Sterol biosynthesis inhibitors

Indexed keywords

1 (5 NITROFURFURYLIDENE) 4 PHENYLCARBAZATE; 1 [3 (5 NITRO 2 FURYL) 2 PROPENYLIDENE] 4 (3 PHENYL 2 PROPEN 1 YL)CARBAZATE; 4 (2 METHYL 2 PROPEN 1 YL) 1 (5 NITROFURFURYLIDENE)SEMICARBAZIDE; 5 NITROFURANE DERIVATIVE; ALLYL COMPOUND; CYANIDE; NIFURTIMOX; NITROFURAN DERIVATIVE; SQUALENE MONOOXYGENASE; TERBINAFINE; UNCLASSIFIED DRUG;

AMASTIGOTE; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; DRUG MECHANISM; DRUG POTENCY; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; GAS LIQUID CHROMATOGRAPHY; IC 50; MASS SPECTROMETRY; NONHUMAN; NUCLEAR OVERHAUSER EFFECT; OXIDATIVE STRESS; PROTON NUCLEAR MAGNETIC RESONANCE; REACTION ANALYSIS; STEROL SYNTHESIS; STRUCTURE ANALYSIS; THIN LAYER CHROMATOGRAPHY; TRYPANOSOMA CRUZI;

ANIMALS; ANTIPROTOZOAL AGENTS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; INHIBITORY CONCENTRATION 50; NITROFURANS; OXIDATIVE STRESS; SQUALENE; SQUALENE MONOOXYGENASE; STEROLS; TANDEM MASS SPECTROMETRY; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 38049100672     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmc.2007.07.031     Document Type: Article

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