Development of a new class of potential antiatherosclerosis agents: NO-donor antioxidants

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 24, 2004, Pages 5971-5974

  Cena, Clara ^a   Boschi, Donatella ^a   Tron, Gian Cesare ^b   Chegaev, Kostantin ^a   Lazzarato, Loretta ^a   Stilo, Antonella Di ^a   Aragno, Manuela ^c   Fruttero, Roberta ^a   Gasco, Alberto ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF EASTERN PIEDMONT   (Italy)

^c Dipto di Med e Oncol Sperimentale   (Italy)

Author keywords

Nitric oxide; NO donors; NO donor phenol antioxidants; Phenol antioxidants

Indexed keywords

ANTIOXIDANT; ASCORBIC ACID 2 PHOSPHATE; BENZENE DERIVATIVE; ESTER DERIVATIVE; FERROUS ION; LIPID; NITRIC OXIDE DONOR; PHENOL DERIVATIVE; PHENYLEPHRINE;

ANIMAL CELL; AORTA STRIP; ARTICLE; CONTROLLED STUDY; DRUG SYNTHESIS; LIPID PEROXIDATION; LIVER CELL; NONHUMAN; RAT; SMOOTH MUSCLE CONTRACTION;

ANIMALS; ANTILIPEMIC AGENTS; ANTIOXIDANTS; AORTA; ARTERIOSCLEROSIS; ASCORBIC ACID; FERROUS COMPOUNDS; HEPATOCYTES; LIPID PEROXIDATION; MALE; MEMBRANE LIPIDS; NITRIC OXIDE DONORS; PHENOLS; PHENYLEPHRINE; RATS; RATS, WISTAR; STRUCTURE-ACTIVITY RELATIONSHIP; THIOBARBITURIC ACID REACTIVE SUBSTANCES;

EID: 8844265397     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.10.006     Document Type: Article

References (11)

1. M.K. Eberhardt Reactive Oxygen Metabolites 2000 CRC BocaRaton
2. J.F. Keaney, and J.A. Vita Prog. Cardiovasc. Dis. 38 1995 129
3. G.A. Dillon, and J.A. Vita J. Loscalzo A.J. Vita Nitric Oxide and the Cardiovascular System 2000 Humana Totowa 207 226
4. M. Civelli, M. Giossi, P. Caruso, R. Razzetti, M. Bergamaschi, S. Bongrani, and A. Gasco Br. J. Pharmacol. 118 1996 923 928
5. M. Luccarini, P. Pedrielli, G.F. Pedulli, S. Cabiddu, and C. Fattuoni J. Org. Chem. 61 1996 9259 9263
6. 7S) C, H, N
7. 6) C, H, N
8. 50 values were calculated by non linear regression analysis
9. The experiments were assessed according to the procedure described in J. Med. Chem. 1997, 40, 463-469 with little modification: the aortic strips were contracted with 1 μM l-phenylephrine; the effect of 1 μM ODQ on relaxation was evaluated in a separate series of experiments in which it was added to the bath at least 5 min before the contraction; responses were recorded by isometric transducer connected to the MacLab System PowerLab
10. A. Schrammel, S. Behrends, K. Schmidt, D. Koesling, and B. Mayer Mol. Pharmacol. 50 1996 1 5
11. R. Mastrocola, M. Aragno, S. Betteto, E. Brignardello, M.G. Catalano, O. Danni, and G. Boccuzzi Life Sci. 73 2003 289 299