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Volumn 16, Issue 3, 2015, Pages 221-242

Glucose addiction in cancer therapy: Advances and drawbacks

Author keywords

Cancer metabolism; Drug resistance; Glucose; Targeted therapy; Warburg effect

Indexed keywords

3 BROMOPYRUVATE; 6 PHOSPHOFRUCTO 2 KINASE FRUCTOSE 2,6 ISPHOSPHATASE 3; ANGIOGENESIS INHIBITOR; AZD 3965; B RAF KINASE INHIBITOR; BCR ABL PROTEIN; BIGUANIDE DERIVATIVE; DEOXYGLUCOSE; DICHLOROACETIC ACID; GLUCOSE; GLUCOSE TRANSPORTER 1; GLUCOSE TRANSPORTER 3; GLUCOSE TRANSPORTER 4; GOSSYPOL; HEXOKINASE; HUMAN IMMUNODEFICIENCY VIRUS PROTEINASE INHIBITOR; LACTATE DEHYDROGENASE; LACTIC ACID; LONIDAMINE; MONOCARBOXYLATE TRANSPORTER; OXIDOREDUCTASE INHIBITOR; PHLORETIN; PYRUVATE DEHYDROGENASE KINASE; PYRUVATE KINASE ISOZYME M2; SILIBININ; STF 31; TLN 232; UNCLASSIFIED DRUG; WZB 117; ANTINEOPLASTIC AGENT; GLUCOSE TRANSPORTER;

EID: 84940833346     PISSN: 13892002     EISSN: 18755453     Source Type: Journal    
DOI: 10.2174/1389200216666150602145145     Document Type: Article
Times cited : (58)

References (264)
  • 1
    • 79952284127 scopus 로고    scopus 로고
    • Hallmarks of cancer: The next generation
    • Hanahan, D.; Weinberg, R. A. Hallmarks of cancer: The next generation. Cell, 2011, 144(5), 646-74.
    • (2011) Cell , vol.144 , Issue.5 , pp. 646-674
    • Hanahan, D.1    Weinberg, R.A.2
  • 2
    • 12444279265 scopus 로고
    • On the origin of cancer cells
    • Warburg, O. On the origin of cancer cells. Science, 1956, 123(3191), 309-14.
    • (1956) Science , vol.123 , Issue.3191 , pp. 309-314
    • Warburg, O.1
  • 3
    • 8144228566 scopus 로고    scopus 로고
    • Why do cancers have high aerobic glycolysis?
    • Gatenby, R. A.; Gillies, R. J. Why do cancers have high aerobic glycolysis? Nat. Rev. Cancer, 2004, 4(11), 891-9.
    • (2004) Nat. Rev. Cancer , vol.4 , Issue.11 , pp. 891-899
    • Gatenby, R.A.1    Gillies, R.J.2
  • 4
    • 33746879141 scopus 로고    scopus 로고
    • Glycolysis inhibition for anticancer treatment
    • Pelicano, H.; Martin, D. S.; Xu, R. H.; Huang, P. Glycolysis inhibition for anticancer treatment. Oncogene, 2006, 25(34), 4633-46.
    • (2006) Oncogene , vol.25 , Issue.34 , pp. 4633-4646
    • Pelicano, H.1    Martin, D.S.2    Xu, R.H.3    Huang, P.4
  • 5
    • 35448961939 scopus 로고    scopus 로고
    • The Warburg effect and its cancer therapeutic implications
    • Chen, Z.; Lu, W.; Garcia-Prieto, C.; Huang, P. The Warburg effect and its cancer therapeutic implications. J. Bioenerg. Biomembr., 2007, 39(3), 267-74.
    • (2007) J. Bioenerg. Biomembr. , vol.39 , Issue.3 , pp. 267-274
    • Chen, Z.1    Lu, W.2    Garcia-Prieto, C.3    Huang, P.4
  • 7
    • 10744221423 scopus 로고    scopus 로고
    • Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer
    • Isidoro, A.; Martinez, M.; Fernandez, P. L.; Ortega, A. D.; Santamaria, G.; Chamorro, M.; Reed, J. C.; Cuezva, J. M. Alteration of the bioenergetic phenotype of mitochondria is a hallmark of breast, gastric, lung and oesophageal cancer. Biochem. J., 2004, 378(Pt 1), 17-20.
    • (2004) Biochem. J. , vol.378 , pp. 17-20
    • Isidoro, A.1    Martinez, M.2    Fernandez, P.L.3    Ortega, A.D.4    Santamaria, G.5    Chamorro, M.6    Reed, J.C.7    Cuezva, J.M.8
  • 9
    • 33744826296 scopus 로고    scopus 로고
    • Cancer's sweet tooth
    • Bui, T. and Thompson, C. B. Cancer's sweet tooth. Cancer Cell, 2006, 9(6), 419-20.
    • (2006) Cancer Cell , vol.9 , Issue.6 , pp. 419-420
    • Bui, T.1    Thompson, C.B.2
  • 10
    • 0034904776 scopus 로고    scopus 로고
    • Growth factors can influence cell growth and survival through effects on glucose metabolism
    • Vander Heiden, M. G.; Plas, D. R.; Rathmell, J. C. Growth factors can influence cell growth and survival through effects on glucose metabolism. Mol. Cell. Biol., 2001, 21(17), 5899-912.
    • (2001) Mol. Cell. Biol. , vol.21 , Issue.17 , pp. 5899-5912
    • Vander Heiden, M.G.1    Plas, D.R.2    Rathmell, J.C.3
  • 11
    • 84875459340 scopus 로고    scopus 로고
    • Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation
    • Ran, C.; Liu, H.; Hitoshi, Y. Proliferation-independent control of tumor glycolysis by PDGFR-mediated AKT activation. Cancer Res., 2013, 73(6), 1831-43.
    • (2013) Cancer Res , vol.73 , Issue.6 , pp. 1831-1843
    • Ran, C.1    Liu, H.2    Hitoshi, Y.3
  • 13
    • 84872478184 scopus 로고    scopus 로고
    • Expression of glucose transporters in cancers
    • Szablewski, L. Expression of glucose transporters in cancers. Biochim. Biophys. Acta, 2013, 1835(2), 164-9.
    • (2013) Biochim. Biophys. Acta , vol.1835 , Issue.2 , pp. 164-169
    • Szablewski, L.1
  • 14
    • 0036769690 scopus 로고    scopus 로고
    • Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs)
    • Van den Abbeele, A. D.; Badawi, R. D. Use of positron emission tomography in oncology and its potential role to assess response to imatinib mesylate therapy in gastrointestinal stromal tumors (GISTs). Eur. J. Cancer, 2002, 38 Suppl 5, S60-5.
    • (2002) Eur. J. Cancer , Issue.38 , pp. S60-S65
    • Van Den Abbeele, A.D.1    Badawi, R.D.2
  • 15
    • 13144273797 scopus 로고    scopus 로고
    • Cerebral relapse of metastatic gastrointestinal stromal tumor during treatment with imatinib mesylate: Case report
    • Hughes, B.; Yip, D.; Goldstein, D.; Waring, P.; Beshay, V.; Chong, G. Cerebral relapse of metastatic gastrointestinal stromal tumor during treatment with imatinib mesylate: case report. BMC Cancer, 2004, 4, 74.
    • (2004) BMC Cancer , vol.4 , pp. 74
    • Hughes, B.1    Yip, D.2    Goldstein, D.3    Waring, P.4    Beshay, V.5    Chong, G.6
  • 16
    • 16544383592 scopus 로고    scopus 로고
    • Imatinib mesylate may improve fasting blood glucose in diabetic Ph+ chronic myelogenous leukemia patients responsive to treatment
    • Breccia, M.; Muscaritoli, M.; Aversa, Z.; Mandelli, F.; Alimena, G. Imatinib mesylate may improve fasting blood glucose in diabetic Ph+ chronic myelogenous leukemia patients responsive to treatment. J. Clin. Oncol., 2004, 22(22), 4653-5.
    • (2004) J. Clin. Oncol. , vol.22 , Issue.22 , pp. 4653-4655
    • Breccia, M.1    Muscaritoli, M.2    Aversa, Z.3    Mandelli, F.4    Alimena, G.5
  • 17
    • 44749094403 scopus 로고    scopus 로고
    • Fasting glucose improvement under dasatinib treatment in an accelerated phase chronic myeloid leukemia patient unresponsive to imatinib and nilotinib
    • Breccia, M.; Muscaritoli, M.; Cannella, L.; Stefanizzi, C.; Frustaci, A.; Alimena, G. Fasting glucose improvement under dasatinib treatment in an accelerated phase chronic myeloid leukemia patient unresponsive to imatinib and nilotinib. Leuk. Res., 2008, 32(10), 1626-8.
    • (2008) Leuk. Res , vol.32 , Issue.10 , pp. 1626-1628
    • Breccia, M.1    Muscaritoli, M.2    Cannella, L.3    Stefanizzi, C.4    Frustaci, A.5    Alimena, G.6
  • 19
    • 84875912189 scopus 로고    scopus 로고
    • FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973
    • Baudy, A. R.; Dogan, T.; Flores-Mercado, J. E.; Hoeflich, K. P.; Su, F.; van Bruggen, N.; Williams, S. P. FDG-PET is a good biomarker of both early response and acquired resistance in BRAFV600 mutant melanomas treated with vemurafenib and the MEK inhibitor GDC-0973. EJNMMI Res., 2012, 2(1), 22.
    • (2012) EJNMMI Res , vol.2 , Issue.1 , pp. 22
    • Baudy, A.R.1    Dogan, T.2    Flores-Mercado, J.E.3    Hoeflich, K.P.4    Su, F.5    Van Bruggen, N.6    Williams, S.P.7
  • 20
    • 24044434901 scopus 로고    scopus 로고
    • Resistance to imatinib, lowgrade FDG-avidity on PET, and acquired KIT exon 17 mutation in gastrointestinal stromal tumour
    • Grimpen, F.; Yip, D.; McArthur, G.; Waring, P.; Goldstein, D.; Loughrey, M.; Beshay, V.; Chong, G. Resistance to imatinib, lowgrade FDG-avidity on PET, and acquired KIT exon 17 mutation in gastrointestinal stromal tumour. Lancet Oncol., 2005, 6(9), 724-7.
    • (2005) Lancet Oncol , vol.6 , Issue.9 , pp. 724-727
    • Grimpen, F.1    Yip, D.2    McArthur, G.3    Waring, P.4    Goldstein, D.5    Loughrey, M.6    Beshay, V.7    Chong, G.8
  • 24
    • 84915766835 scopus 로고    scopus 로고
    • Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations
    • Luo, Y.; Yang, C.; Ye, M.; Jin, C.; Abbruzzese, J. L.; Lee, M. H.; Yeung, S. C.; McKeehan, W. L. Deficiency of metabolic regulator FGFR4 delays breast cancer progression through systemic and microenvironmental metabolic alterations. Cancer Metab., 2013, 1(1), 21.
    • (2013) Cancer Metab , vol.1 , Issue.1 , pp. 21
    • Luo, Y.1    Yang, C.2    Ye, M.3    Jin, C.4    Abbruzzese, J.L.5    Lee, M.H.6    Yeung, S.C.7    McKeehan, W.L.8
  • 27
    • 63449097322 scopus 로고    scopus 로고
    • In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter
    • Wu, C. H.; Ho, Y. S.; Tsai, C. Y.; Wang, Y. J.; Tseng, H.; Wei, P. L.; Lee, C. H.; Liu, R. S.; Lin, S. Y. In vitro and in vivo study of phloretin-induced apoptosis in human liver cancer cells involving inhibition of type II glucose transporter. Int. J. Cancer, 2009, 124(9), 2210-9.
    • (2009) Int. J. Cancer , vol.124 , Issue.9 , pp. 2210-2219
    • Wu, C.H.1    Ho, Y.S.2    Tsai, C.Y.3    Wang, Y.J.4    Tseng, H.5    Wei, P.L.6    Lee, C.H.7    Liu, R.S.8    Lin, S.Y.9
  • 28
    • 0033113591 scopus 로고    scopus 로고
    • Phloretininduced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells
    • Kobori, M.; Iwashita, K.; Shinmoto, H.; Tsushida, T. Phloretininduced apoptosis in B16 melanoma 4A5 cells and HL60 human leukemia cells. Biosci. Biotechnol. Biochem., 1999, 63(4), 719-25.
    • (1999) Biosci. Biotechnol. Biochem , vol.63 , Issue.4 , pp. 719-725
    • Kobori, M.1    Iwashita, K.2    Shinmoto, H.3    Tsushida, T.4
  • 29
    • 0030662604 scopus 로고    scopus 로고
    • Phloretininduced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport
    • Kobori, M.; Shinmoto, H.; Tsushida, T.; Shinohara, K. Phloretininduced apoptosis in B16 melanoma 4A5 cells by inhibition of glucose transmembrane transport. Cancer Lett., 1997, 119(2), 207-12.
    • (1997) Cancer Lett , vol.119 , Issue.2 , pp. 207-212
    • Kobori, M.1    Shinmoto, H.2    Tsushida, T.3    Shinohara, K.4
  • 30
    • 0027764394 scopus 로고
    • The efficacy of phloridzin and phloretin on tumor cell growth
    • Nelson, J. A.; Falk, R. E. The efficacy of phloridzin and phloretin on tumor cell growth. Anticancer Res., 1993, 13(6A), 2287-92.
    • (1993) Anticancer Res. , vol.13 , Issue.6 A , pp. 2287-2292
    • Nelson, J.A.1    Falk, R.E.2
  • 31
    • 40849145722 scopus 로고    scopus 로고
    • Inhibitor binding in the human renal low- And high-affinity Na+/glucose cotransporters
    • Pajor, A. M.; Randolph, K. M.; Kerner, S. A.; Smith, C. D. Inhibitor binding in the human renal low- And high-affinity Na+/glucose cotransporters. J. Pharmacol. Exp. Ther., 2008, 324(3), 985-91.
    • (2008) J. Pharmacol. Exp. Ther. , vol.324 , Issue.3 , pp. 985-991
    • Pajor, A.M.1    Randolph, K.M.2    Kerner, S.A.3    Smith, C.D.4
  • 32
    • 33846270366 scopus 로고    scopus 로고
    • Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia
    • Cao, X.; Fang, L.; Gibbs, S.; Huang, Y.; Dai, Z.; Wen, P.; Zheng, X.; Sadee, W.; Sun, D. Glucose uptake inhibitor sensitizes cancer cells to daunorubicin and overcomes drug resistance in hypoxia. Cancer Chemother. Pharmacol., 2007, 59(4), 495-505.
    • (2007) Cancer Chemother. Pharmacol. , vol.59 , Issue.4 , pp. 495-505
    • Cao, X.1    Fang, L.2    Gibbs, S.3    Huang, Y.4    Dai, Z.5    Wen, P.6    Zheng, X.7    Sadee, W.8    Sun, D.9
  • 33
    • 65649147198 scopus 로고    scopus 로고
    • Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human hep G2 cells
    • Yang, K. C.; Tsai, C. Y.; Wang, Y. J.; Wei, P. L.; Lee, C. H.; Chen, J. H.; Wu, C. H.; Ho, Y. S. Apple polyphenol phloretin potentiates the anticancer actions of paclitaxel through induction of apoptosis in human hep G2 cells. Mol. Carcinog., 2009, 48(5), 420-31.
    • (2009) Mol. Carcinog , vol.48 , Issue.5 , pp. 420-431
    • Yang, K.C.1    Tsai, C.Y.2    Wang, Y.J.3    Wei, P.L.4    Lee, C.H.5    Chen, J.H.6    Wu, C.H.7    Ho, Y.S.8
  • 35
    • 79951782239 scopus 로고    scopus 로고
    • Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins
    • Zhan, T.; Digel, M.; Kuch, E. M.; Stremmel, W.; Fullekrug, J. Silybin and dehydrosilybin decrease glucose uptake by inhibiting GLUT proteins. J. Cell. Biochem., 2011, 112(3), 849-59.
    • (2011) J. Cell. Biochem , vol.112 , Issue.3 , pp. 849-859
    • Zhan, T.1    Digel, M.2    Kuch, E.M.3    Stremmel, W.4    Fullekrug, J.5
  • 36
    • 77957598340 scopus 로고    scopus 로고
    • Antimetastatic efficacy of silibinin: Molecular mechanisms and therapeutic potential against cancer
    • Deep, G.; Agarwal, R. Antimetastatic efficacy of silibinin: molecular mechanisms and therapeutic potential against cancer. Cancer Metastasis Rev., 2010, 29(3), 447-63.
    • (2010) Cancer Metastasis Rev , vol.29 , Issue.3 , pp. 447-463
    • Deep, G.1    Agarwal, R.2
  • 40
    • 84883465250 scopus 로고    scopus 로고
    • Silibinin reverses drug resistance in human small-cell lung carcinoma cells
    • Sadava, D.; Kane, S. E. Silibinin reverses drug resistance in human small-cell lung carcinoma cells. Cancer Lett., 2013, 339(1), 102-6.
    • (2013) Cancer Lett. , vol.339 , Issue.1 , pp. 102-106
    • Sadava, D.1    Kane, S.E.2
  • 41
    • 80052296632 scopus 로고    scopus 로고
    • Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel
    • Chang, H. R.; Chen, P. N.; Yang, S. F.; Sun, Y. S.; Wu, S. W.; Hung, T. W.; Lian, J. D.; Chu, S. C.; Hsieh, Y. S. Silibinin inhibits the invasion and migration of renal carcinoma 786-O cells in vitro, inhibits the growth of xenografts in vivo and enhances chemosensitivity to 5-fluorouracil and paclitaxel. Mol. Carcinog., 2011, 50(10), 811-23.
    • (2011) Mol. Carcinog. , vol.50 , Issue.10 , pp. 811-823
    • Chang, H.R.1    Chen, P.N.2    Yang, S.F.3    Sun, Y.S.4    Wu, S.W.5    Hung, T.W.6    Lian, J.D.7    Chu, S.C.8    Hsieh, Y.S.9
  • 42
    • 78650442303 scopus 로고    scopus 로고
    • Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation
    • Rho, J. K.; Choi, Y. J.; Jeon, B. S.; Choi, S. J.; Cheon, G. J.; Woo, S. K.; Kim, H. R.; Kim, C. H.; Choi, C. M.; Lee, J. C. Combined treatment with silibinin and epidermal growth factor receptor tyrosine kinase inhibitors overcomes drug resistance caused by T790M mutation. Mol. Cancer Ther., 2010, 9(12), 3233-43.
    • (2010) Mol. Cancer Ther , vol.9 , Issue.12 , pp. 3233-3243
    • Rho, J.K.1    Choi, Y.J.2    Jeon, B.S.3    Choi, S.J.4    Cheon, G.J.5    Woo, S.K.6    Kim, H.R.7    Kim, C.H.8    Choi, C.M.9    Lee, J.C.10
  • 43
    • 84899119331 scopus 로고    scopus 로고
    • The multidrug resistance pumps are inhibited by silibinin and apoptosis induced in K562 and KCL22 leukemia cell lines
    • Noori-Daloii, M. R.; Saffari, M.; Raoofian, R.; Yekaninejad, M.; Dinehkabodi, O. S.; Noori-Daloii, A. R. The multidrug resistance pumps are inhibited by silibinin and apoptosis induced in K562 and KCL22 leukemia cell lines. Leuk. Res., 2014, 38(5), 575-80.
    • (2014) Leuk. Res , vol.38 , Issue.5 , pp. 575-580
    • Noori-Daloii, M.R.1    Saffari, M.2    Raoofian, R.3    Yekaninejad, M.4    Dinehkabodi, O.S.5    Noori-Daloii, A.R.6
  • 44
    • 0043025262 scopus 로고    scopus 로고
    • Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- And carboplatin-induced growth inhibition and apoptotic death
    • Dhanalakshmi, S.; Agarwal, P.; Glode, L. M.; Agarwal, R. Silibinin sensitizes human prostate carcinoma DU145 cells to cisplatin- And carboplatin-induced growth inhibition and apoptotic death. Int. J. Cancer, 2003, 106(5), 699-705.
    • (2003) Int. J. Cancer , vol.106 , Issue.5 , pp. 699-705
    • Dhanalakshmi, S.1    Agarwal, P.2    Glode, L.M.3    Agarwal, R.4
  • 45
    • 3242786628 scopus 로고    scopus 로고
    • Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells
    • Tyagi, A. K.; Agarwal, C.; Chan, D. C.; Agarwal, R. Synergistic anti-cancer effects of silibinin with conventional cytotoxic agents doxorubicin, cisplatin and carboplatin against human breast carcinoma MCF-7 and MDA-MB468 cells. Oncol. Rep., 2004, 11(2), 493-9.
    • (2004) Oncol. Rep. , vol.11 , Issue.2 , pp. 493-499
    • Tyagi, A.K.1    Agarwal, C.2    Chan, D.C.3    Agarwal, R.4
  • 46
    • 33947195450 scopus 로고    scopus 로고
    • Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells
    • Flaig, T. W.; Su, L. J.; Harrison, G.; Agarwal, R.; Glode, L. M. Silibinin synergizes with mitoxantrone to inhibit cell growth and induce apoptosis in human prostate cancer cells. Int J. Cancer, 2007, 120(9), 2028-33.
    • (2007) Int J. Cancer , vol.120 , Issue.9 , pp. 2028-2033
    • Flaig, T.W.1    Su, L.J.2    Harrison, G.3    Agarwal, R.4    Glode, L.M.5
  • 48
    • 84888878711 scopus 로고    scopus 로고
    • Silibinin improves the cytotoxicity of methotrexate in chemo resistant human rhabdomyosarcoma cell lines
    • Hussain, S. A.; Marouf, B. H. Silibinin improves the cytotoxicity of methotrexate in chemo resistant human rhabdomyosarcoma cell lines. Saudi. Med. J., 2013, 34(11), 1145-50.
    • (2013) Saudi. Med. J. , vol.34 , Issue.11 , pp. 1145-1150
    • Hussain, S.A.1    Marouf, B.H.2
  • 51
    • 16544387068 scopus 로고    scopus 로고
    • Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells
    • Thelen, P.; Wuttke, W.; Jarry, H.; Grzmil, M.; Ringert, R. H. Inhibition of telomerase activity and secretion of prostate specific antigen by silibinin in prostate cancer cells. J. Urol., 2004, 171(5), 1934-8.
    • (2004) J. Urol , vol.171 , Issue.5 , pp. 1934-1938
    • Thelen, P.1    Wuttke, W.2    Jarry, H.3    Grzmil, M.4    Ringert, R.H.5
  • 52
    • 84893629663 scopus 로고    scopus 로고
    • Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells
    • Zhang, S.; Yang, Y.; Liang, Z.; Duan, W.; Yang, J.; Yan, J.; Wang, N.; Feng, W.; Ding, M.; Nie, Y.; Jin, Z. Silybin-mediated inhibition of Notch signaling exerts antitumor activity in human hepatocellular carcinoma cells. PLoS One, 2013, 8(12), e83699.
    • (2013) PLoS One , vol.8 , Issue.12 , pp. e83699
    • Zhang, S.1    Yang, Y.2    Liang, Z.3    Duan, W.4    Yang, J.5    Yan, J.6    Wang, N.7    Feng, W.8    Ding, M.9    Nie, Y.10    Jin, Z.11
  • 53
    • 84898820422 scopus 로고    scopus 로고
    • Silibinin induces cell death through reactive oxygen species-dependent downregulation of notch-1/ERK/Akt signaling in human breast cancer cells
    • Kim, T. H.; Woo, J. S.; Kim, Y. K.; Kim, K. H. Silibinin induces cell death through reactive oxygen species-dependent downregulation of notch-1/ERK/Akt signaling in human breast cancer cells. J. Pharmacol. Exp. Ther., 2014, 349(2), 268-78.
    • (2014) J. Pharmacol. Exp. Ther. , vol.349 , Issue.2 , pp. 268-278
    • Kim, T.H.1    Woo, J.S.2    Kim, Y.K.3    Kim, K.H.4
  • 54
    • 84899881654 scopus 로고    scopus 로고
    • Silibinin induces apoptosis and inhibits proliferation of estrogen receptor (ER)-negative breast carcinoma cells through suppression of nuclear factor kappa B activation
    • Yousefi, M.; Ghaffari, S. H.; Zekri, A.; Hassani, S.; Alimoghaddam, K.; Ghavamzadeh, A. Silibinin induces apoptosis and inhibits proliferation of estrogen receptor (ER)-negative breast carcinoma cells through suppression of nuclear factor kappa B activation. Arch. Iran. Med., 2014, 17(5), 366-71.
    • (2014) Arch. Iran. Med. , vol.17 , Issue.5 , pp. 366-371
    • Yousefi, M.1    Ghaffari, S.H.2    Zekri, A.3    Hassani, S.4    Alimoghaddam, K.5    Ghavamzadeh, A.6
  • 55
    • 77957355392 scopus 로고    scopus 로고
    • Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules
    • Velmurugan, B.; Gangar, S. C.; Kaur, M.; Tyagi, A.; Deep, G.; Agarwal, R. Silibinin exerts sustained growth suppressive effect against human colon carcinoma SW480 xenograft by targeting multiple signaling molecules. Pharm. Res., 2010, 27(10), 2085-97.
    • (2010) Pharm. Res. , vol.27 , Issue.10 , pp. 2085-2097
    • Velmurugan, B.1    Gangar, S.C.2    Kaur, M.3    Tyagi, A.4    Deep, G.5    Agarwal, R.6
  • 59
    • 84864875404 scopus 로고    scopus 로고
    • A smallmolecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo
    • Liu, Y.; Cao, Y.; Zhang, W.; Bergmeier, S.; Qian, Y.; Akbar, H.; Colvin, R.; Ding, J.; Tong, L.; Wu, S.; Hines, J.; Chen, X. A smallmolecule inhibitor of glucose transporter 1 downregulates glycolysis, induces cell-cycle arrest, and inhibits cancer cell growth in vitro and in vivo. Mol. Cancer Ther., 2012, 11(8), 1672-82.
    • (2012) Mol. Cancer Ther , vol.11 , Issue.8 , pp. 1672-1682
    • Liu, Y.1    Cao, Y.2    Zhang, W.3    Bergmeier, S.4    Qian, Y.5    Akbar, H.6    Colvin, R.7    Ding, J.8    Tong, L.9    Wu, S.10    Hines, J.11    Chen, X.12
  • 60
    • 0034617191 scopus 로고    scopus 로고
    • The mechanism of insulin resistance caused by HIV protease inhibitor therapy
    • Murata, H.; Hruz, P. W.; Mueckler, M. The mechanism of insulin resistance caused by HIV protease inhibitor therapy. J. Biol. Chem., 2000, 275(27), 20251-4.
    • (2000) J. Biol. Chem. , vol.275 , Issue.27 , pp. 20251-20254
    • Murata, H.1    Hruz, P.W.2    Mueckler, M.3
  • 61
    • 78449233456 scopus 로고    scopus 로고
    • Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice
    • Vyas, A. K.; Koster, J. C.; Tzekov, A.; Hruz, P. W. Effects of the HIV protease inhibitor ritonavir on GLUT4 knock-out mice. J. Biol. Chem., 2010, 285(47), 36395-400.
    • (2010) J. Biol. Chem. , vol.285 , Issue.47 , pp. 36395-36400
    • Vyas, A.K.1    Koster, J.C.2    Tzekov, A.3    Hruz, P.W.4
  • 62
    • 84861215287 scopus 로고    scopus 로고
    • Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: Implications for glucose transporter- directed therapy
    • McBrayer, S. K.; Cheng, J. C.; Singhal, S.; Krett, N. L.; Rosen, S. T.; Shanmugam, M. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter- directed therapy. Blood, 2012, 119(20), 4686-97.
    • (2012) Blood , vol.119 , Issue.20 , pp. 4686-4697
    • McBrayer, S.K.1    Cheng, J.C.2    Singhal, S.3    Krett, N.L.4    Rosen, S.T.5    Shanmugam, M.6
  • 63
    • 77956809165 scopus 로고    scopus 로고
    • Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression
    • Le Calve, B.; Rynkowski, M.; Le Mercier, M.; Bruyere, C.; Lonez, C.; Gras, T.; Haibe-Kains, B.; Bontempi, G.; Decaestecker, C.; Ruysschaert, J. M.; Kiss, R.; Lefranc, F. Long-term in vitro treatment of human glioblastoma cells with temozolomide increases resistance in vivo through up-regulation of GLUT transporter and aldo-keto reductase enzyme AKR1C expression. Neoplasia, 2010, 12(9), 727-39.
    • (2010) Neoplasia , vol.12 , Issue.9 , pp. 727-739
    • Le Calve, B.1    Rynkowski, M.2    Le Mercier, M.3    Bruyere, C.4    Lonez, C.5    Gras, T.6    Haibe-Kains, B.7    Bontempi, G.8    Decaestecker, C.9    Ruysschaert, J.M.10    Kiss, R.11    Lefranc, F.12
  • 65
    • 60249083822 scopus 로고    scopus 로고
    • Hexokinase-2 bound to mitochondria: Cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy
    • Mathupala, S. P.; Ko, Y. H.; Pedersen, P. L. Hexokinase-2 bound to mitochondria: cancer's stygian link to the "Warburg Effect" and a pivotal target for effective therapy. Semin. Cancer Biol., 2009, 19(1), 17-24.
    • (2009) Semin. Cancer Biol. , vol.19 , Issue.1 , pp. 17-24
    • Mathupala, S.P.1    Ko, Y.H.2    Pedersen, P.L.3
  • 66
    • 80052242132 scopus 로고    scopus 로고
    • Targeting cancer metabolism: A therapeutic window opens
    • Vander Heiden, M. G. Targeting cancer metabolism: A therapeutic window opens. Nat. Rev. Drug Discov., 2011, 10(9), 671-84.
    • (2011) Nat. Rev. Drug Discov. , vol.10 , Issue.9 , pp. 671-684
    • Vander Heiden, M.G.1
  • 69
    • 84877752572 scopus 로고    scopus 로고
    • Stalling the engine of resistance: Targeting cancer metabolism to overcome therapeutic resistance
    • Butler, E. B.; Zhao, Y.; Munoz-Pinedo, C.; Lu, J.; Tan, M. Stalling the engine of resistance: Targeting cancer metabolism to overcome therapeutic resistance. Cancer Res., 2013, 73(9), 2709-17.
    • (2013) Cancer Res , vol.73 , Issue.9 , pp. 2709-2717
    • Butler, E.B.1    Zhao, Y.2    Munoz-Pinedo, C.3    Lu, J.4    Tan, M.5
  • 70
    • 0001422847 scopus 로고
    • Certain metabolic and pharmacologic effects in cancer patients given infusions of 2- deoxy-D-glucose
    • Landau, B. R.; Laszlo, J.; Stengle, J.; Burk, D. Certain metabolic and pharmacologic effects in cancer patients given infusions of 2- deoxy-D-glucose. J. Natl. Cancer Inst., 1958, 21(3), 485-94.
    • (1958) J. Natl. Cancer Inst. , vol.21 , Issue.3 , pp. 485-494
    • Landau, B.R.1    Laszlo, J.2    Stengle, J.3    Burk, D.4
  • 74
    • 77956627000 scopus 로고    scopus 로고
    • Targeting tumor metabolism with 2-deoxyglucose in patients with castrateresistant prostate cancer and advanced malignancies
    • Stein, M.; Lin, H.; Jeyamohan, C.; Dvorzhinski, D.; Gounder, M.; Bray, K.; Eddy, S.; Goodin, S.; White, E.; Dipaola, R. S. Targeting tumor metabolism with 2-deoxyglucose in patients with castrateresistant prostate cancer and advanced malignancies. Prostate, 2010, 70(13), 1388-94.
    • (2010) Prostate , vol.70 , Issue.13 , pp. 1388-1394
    • Stein, M.1    Lin, H.2    Jeyamohan, C.3    Dvorzhinski, D.4    Gounder, M.5    Bray, K.6    Eddy, S.7    Goodin, S.8    White, E.9    Dipaola, R.S.10
  • 75
    • 0017075596 scopus 로고
    • 1-Halobenzyl-1H-indazole-3-carboxylic acids. A new class of antispermatogenic agents
    • Corsi, G.; Palazzo, G. 1-Halobenzyl-1H-indazole-3-carboxylic acids. A new class of antispermatogenic agents. J. Med. Chem., 1976, 19(6), 778-83.
    • (1976) J. Med. Chem. , vol.19 , Issue.6 , pp. 778-783
    • Corsi, G.1    Palazzo, G.2
  • 77
    • 0037368877 scopus 로고    scopus 로고
    • Lonidamine: Efficacy and safety in clinical trials for the treatment of solid tumors
    • Barc
    • Di, C. S.; Ferretti, G.; Papaldo, P.; Carlini, P.; Fabi, A.; Cognetti, F. Lonidamine: Efficacy and safety in clinical trials for the treatment of solid tumors. Drugs Today(Barc.), 2003, 39(3), 157-174.
    • (2003) Drugs Today , vol.39 , Issue.3 , pp. 157-174
    • Di, C.S.1    Ferretti, G.2    Papaldo, P.3    Carlini, P.4    Fabi, A.5    Cognetti, F.6
  • 78
    • 80255123508 scopus 로고    scopus 로고
    • Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation
    • Calvino, E.; Estan, M. C.; Simon, G. P.; Sancho, P.; Boyano- Adanez Mdel, C.; de Blas, E.; Breard, J.; Aller, P. Increased apoptotic efficacy of lonidamine plus arsenic trioxide combination in human leukemia cells. Reactive oxygen species generation and defensive protein kinase (MEK/ERK, Akt/mTOR) modulation. Biochem. Pharmacol., 2011, 82(11), 1619-29.
    • (2011) Biochem. Pharmacol , vol.82 , Issue.11 , pp. 1619-1629
    • Calvino, E.1    Estan, M.C.2    Simon, G.P.3    Sancho, P.4    Boyano-Adanez Mdel, C.5    De Blas, E.6    Breard, J.7    Aller, P.8
  • 81
    • 0026084854 scopus 로고
    • Lonidamine as a modulator of alkylating agent activity in vitro and in vivo
    • Teicher, B. A.; Herman, T. S.; Holden, S. A.; Epelbaum, R.; Liu, S. D.; Frei, E. Lonidamine as a modulator of alkylating agent activity in vitro and in vivo. Cancer Res., 1991, 51(3), 780-4.
    • (1991) Cancer Res , vol.51 , Issue.3 , pp. 780-784
    • Teicher, B.A.1    Herman, T.S.2    Holden, S.A.3    Epelbaum, R.4    Liu, S.D.5    Frei, E.6
  • 82
    • 0025802881 scopus 로고
    • Modulation of alkylating agents by lonidamine in vivo
    • Teicher, B. A.; Holden, S. A.; Herman, T. S.; Frei, E. Modulation of alkylating agents by lonidamine in vivo. Semin. Oncol., 1991, 18(2 Suppl 4), 7-10.
    • (1991) Semin. Oncol , vol.18 , Issue.2 , pp. 7-10
    • Teicher, B.A.1    Holden, S.A.2    Herman, T.S.3    Frei, E.4
  • 83
    • 0025894124 scopus 로고
    • Etoposide with lonidamine or pentoxifylline as modulators of alkylating agent activity in vivo
    • Tanaka, J.; Teicher, B. A.; Herman, T. S.; Holden, S. A.; Dezube, B.; Frei, E. Etoposide with lonidamine or pentoxifylline as modulators of alkylating agent activity in vivo. Int. J. Cancer, 1991, 48(4), 631-7.
    • (1991) Int. J. Cancer , vol.48 , Issue.4 , pp. 631-637
    • Tanaka, J.1    Teicher, B.A.2    Herman, T.S.3    Holden, S.A.4    Dezube, B.5    Frei, E.6
  • 84
    • 0034089167 scopus 로고    scopus 로고
    • Energy metabolism of human LoVo colon carcinoma cells: Correlation to drug resistance and influence of lonidamine
    • Fanciulli, M.; Bruno, T.; Giovannelli, A.; Gentile, F. P.; Di Padova, M.; Rubiu, O.; Floridi, A. Energy metabolism of human LoVo colon carcinoma cells: correlation to drug resistance and influence of lonidamine. Clin. Cancer Res., 2000, 6(4), 1590-7.
    • (2000) Clin. Cancer Res. , vol.6 , Issue.4 , pp. 1590-1597
    • Fanciulli, M.1    Bruno, T.2    Giovannelli, A.3    Gentile, F.P.4    Di Padova, M.5    Rubiu, O.6    Floridi, A.7
  • 85
    • 0037174915 scopus 로고    scopus 로고
    • Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells
    • Li, Y. C.; Fung, K. P.; Kwok, T. T.; Lee, C. Y.; Suen, Y. K.; Kong, S. K. Mitochondrial targeting drug lonidamine triggered apoptosis in doxorubicin-resistant HepG2 cells. Life Sci., 2002, 71(23), 2729- 40.
    • (2002) Life Sci. , vol.71 , Issue.23 , pp. 2729-2740
    • Li, Y.C.1    Fung, K.P.2    Kwok, T.T.3    Lee, C.Y.4    Suen, Y.K.5    Kong, S.K.6
  • 90
    • 84865976786 scopus 로고    scopus 로고
    • Anticancer targets in the glycolytic metabolism of tumors: A comprehensive review
    • Porporato, P. E.; Dhup, S.; Dadhich, R. K.; Copetti, T.; Sonveaux, P. Anticancer targets in the glycolytic metabolism of tumors: A comprehensive review. Front. Pharmacol., 2011, 2, 49.
    • (2011) Front. Pharmacol , vol.2 , pp. 49
    • Porporato, P.E.1    Dhup, S.2    Dadhich, R.K.3    Copetti, T.4    Sonveaux, P.5
  • 92
    • 80052552395 scopus 로고    scopus 로고
    • Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer
    • Milane, L.; Duan, Z.; Amiji, M. Therapeutic efficacy and safety of paclitaxel/lonidamine loaded EGFR-targeted nanoparticles for the treatment of multi-drug resistant cancer. PLoS One, 2011, 6(9), e24075.
    • (2011) PLoS One , vol.6 , Issue.9 , pp. e24075
    • Milane, L.1    Duan, Z.2    Amiji, M.3
  • 93
    • 79960704268 scopus 로고    scopus 로고
    • Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer
    • Milane, L.; Duan, Z. F.; Amiji, M. Pharmacokinetics and biodistribution of lonidamine/paclitaxel loaded, EGFR-targeted nanoparticles in an orthotopic animal model of multi-drug resistant breast cancer. Nanomedicine, 2011, 7(4), 435-44.
    • (2011) Nanomedicine , vol.7 , Issue.4 , pp. 435-444
    • Milane, L.1    Duan, Z.F.2    Amiji, M.3
  • 94
    • 79952955367 scopus 로고    scopus 로고
    • Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells
    • Milane, L.;Duan, Z.; Amiji, M. Development of EGFR-targeted polymer blend nanocarriers for combination paclitaxel/lonidamine delivery to treat multi-drug resistance in human breast and ovarian tumor cells. Mol. Pharm., 2011, 8(1), 185-203.
    • (2011) Mol. Pharm. , vol.8 , Issue.1 , pp. 185-203
    • Milane, L.1    Duan, Z.2    Amiji, M.3
  • 96
    • 12544256565 scopus 로고    scopus 로고
    • Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia
    • Xu, R. H.; Pelicano, H.; Zhou, Y.; Carew, J. S.; Feng, L.; Bhalla, K. N.; Keating, M. J.; Huang, P. Inhibition of glycolysis in cancer cells: A novel strategy to overcome drug resistance associated with mitochondrial respiratory defect and hypoxia. Cancer Res., 2005, 65(2), 613-21.
    • (2005) Cancer Res. , vol.65 , Issue.2 , pp. 613-621
    • Xu, R.H.1    Pelicano, H.2    Zhou, Y.3    Carew, J.S.4    Feng, L.5    Bhalla, K.N.6    Keating, M.J.7    Huang, P.8
  • 97
    • 41549113465 scopus 로고    scopus 로고
    • Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor
    • Cao, X.; Bloomston, M.; Zhang, T.; Frankel, W. L.; Jia, G.; Wang, B.; Hall, N. C.; Koch, R. M.; Cheng, H.; Knopp, M. V.; Sun, D. Synergistic antipancreatic tumor effect by simultaneously targeting hypoxic cancer cells with HSP90 inhibitor and glycolysis inhibitor. Clin. Cancer Res., 2008, 14(6), 1831-9.
    • (2008) Clin. Cancer Res. , vol.14 , Issue.6 , pp. 1831-1839
    • Cao, X.1    Bloomston, M.2    Zhang, T.3    Frankel, W.L.4    Jia, G.5    Wang, B.6    Hall, N.C.7    Koch, R.M.8    Cheng, H.9    Knopp, M.V.10    Sun, D.11
  • 100
    • 0035829074 scopus 로고    scopus 로고
    • Glucose catabolism in the rabbit VX2 tumor model for liver cancer: Characterization and targeting hexokinase
    • Ko, Y. H.; Pedersen, P. L.; Geschwind, J. F. Glucose catabolism in the rabbit VX2 tumor model for liver cancer: characterization and targeting hexokinase. Cancer Lett., 2001, 173(1), 83-91.
    • (2001) Cancer Lett , vol.173 , Issue.1 , pp. 83-91
    • Ko, Y.H.1    Pedersen, P.L.2    Geschwind, J.F.3
  • 101
    • 84858704865 scopus 로고    scopus 로고
    • 3-Bromopyruvate: Targets and outcomes
    • Shoshan, M. C. 3-Bromopyruvate: Targets and outcomes. J. Bioenerg. Biomembr., 2012, 44(1), 7-15.
    • (2012) J. Bioenerg. Biomembr. , vol.44 , Issue.1 , pp. 7-15
    • Shoshan, M.C.1
  • 102
    • 84873027161 scopus 로고    scopus 로고
    • Anticancer efficacy of the metabolic blocker 3-bromopyruvate: Specific molecular targeting
    • Ganapathy-Kanniappan, S.; Kunjithapatham, R.; Geschwind, J. F. Anticancer efficacy of the metabolic blocker 3-bromopyruvate: specific molecular targeting. Anticancer Res., 2013, 33(1), 13-20.
    • (2013) Anticancer Res. , vol.33 , Issue.1 , pp. 13-20
    • Ganapathy-Kanniappan, S.1    Kunjithapatham, R.2    Geschwind, J.F.3
  • 105
    • 84862809596 scopus 로고    scopus 로고
    • A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: From bench side to bedside
    • Ko, Y. H.; Verhoeven, H. A.; Lee, M. J.; Corbin, D. J.; Vogl, T. J.; Pedersen, P. L. A translational study "case report" on the small molecule "energy blocker" 3-bromopyruvate (3BP) as a potent anticancer agent: from bench side to bedside. J. Bioenerg. Biomembr., 2012, 44(1), 163-70.
    • (2012) J. Bioenerg. Biomembr. , vol.44 , Issue.1 , pp. 163-170
    • Ko, Y.H.1    Verhoeven, H.A.2    Lee, M.J.3    Corbin, D.J.4    Vogl, T.J.5    Pedersen, P.L.6
  • 107
    • 84881027891 scopus 로고    scopus 로고
    • Balancing glycolytic flux: The role of 6- phosphofructo-2-kinase/fructose 2, 6-bisphosphatases in cancer metabolism
    • Ros, S.; Schulze, A. Balancing glycolytic flux: The role of 6- phosphofructo-2-kinase/fructose 2, 6-bisphosphatases in cancer metabolism. Cancer Metab., 2013, 1(1), 8.
    • (2013) Cancer Metab , vol.1 , Issue.1 , pp. 8
    • Ros, S.1    Schulze, A.2
  • 108
    • 0037108709 scopus 로고    scopus 로고
    • High expression of inducible 6- phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (iPFK-2; PFKFB3) in human cancers
    • Atsumi, T.; Chesney, J.; Metz, C.; Leng, L.; Donnelly, S.; Makita, Z.; Mitchell, R.; Bucala, R. High expression of inducible 6- phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (iPFK-2; PFKFB3) in human cancers. Cancer Res., 2002, 62(20), 5881-7.
    • (2002) Cancer Res. , vol.62 , Issue.20 , pp. 5881-5887
    • Atsumi, T.1    Chesney, J.2    Metz, C.3    Leng, L.4    Donnelly, S.5    Makita, Z.6    Mitchell, R.7    Bucala, R.8
  • 109
    • 38049077430 scopus 로고    scopus 로고
    • 6-Phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas
    • Kessler, R.; Bleichert, F.; Warnke, J. P.; Eschrich, K. 6- Phosphofructo-2-kinase/fructose-2, 6-bisphosphatase (PFKFB3) is up-regulated in high-grade astrocytomas. J. Neurooncol., 2008, 86(3), 257-64.
    • (2008) J. Neurooncol , vol.86 , Issue.3 , pp. 257-264
    • Kessler, R.1    Bleichert, F.2    Warnke, J.P.3    Eschrich, K.4
  • 110
    • 33846131233 scopus 로고    scopus 로고
    • Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers
    • Bobarykina, A. Y.; Minchenko, D. O.; Opentanova, I. L.; Moenner, M.; Caro, J.; Esumi, H.; Minchenko, O. H. Hypoxic regulation of PFKFB-3 and PFKFB-4 gene expression in gastric and pancreatic cancer cell lines and expression of PFKFB genes in gastric cancers. Acta Biochim. Pol., 2006, 53(4), 789-99.
    • (2006) Acta Biochim. Pol. , vol.53 , Issue.4 , pp. 789-799
    • Bobarykina, A.Y.1    Minchenko, D.O.2    Opentanova, I.L.3    Moenner, M.4    Caro, J.5    Esumi, H.6    Minchenko, O.H.7
  • 111
    • 33746037631 scopus 로고    scopus 로고
    • PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells
    • Calvo, M. N.; Bartrons, R.; Castano, E.; Perales, J. C.; Navarro- Sabate, A.; Manzano, A. PFKFB3 gene silencing decreases glycolysis, induces cell-cycle delay and inhibits anchorage-independent growth in HeLa cells. FEBS Lett., 2006, 580(13), 3308-14.
    • (2006) FEBS Lett , vol.580 , Issue.13 , pp. 3308-3314
    • Calvo, M.N.1    Bartrons, R.2    Castano, E.3    Perales, J.C.4    Navarro- Sabate, A.5    Manzano, A.6
  • 119
    • 84905097406 scopus 로고    scopus 로고
    • Pyruvate kinase M2 and cancer: An updated assessment
    • Iqbal, M. A.; Gupta, V.; Gopinath, P.; Mazurek, S.; Bamezai, R. N. Pyruvate kinase M2 and cancer: An updated assessment. FEBS Lett., 2014, 588(16), 2685-92.
    • (2014) FEBS Lett , vol.588 , Issue.16 , pp. 2685-2692
    • Iqbal, M.A.1    Gupta, V.2    Gopinath, P.3    Mazurek, S.4    Bamezai, R.N.5
  • 120
    • 21844468220 scopus 로고    scopus 로고
    • Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis
    • Dombrauckas, J. D.; Santarsiero, B. D.; Mesecar, A. D. Structural basis for tumor pyruvate kinase M2 allosteric regulation and catalysis. Biochemistry, 2005, 44(27), 9417-29.
    • (2005) Biochemistry , vol.44 , Issue.27 , pp. 9417-9429
    • Dombrauckas, J.D.1    Santarsiero, B.D.2    Mesecar, A.D.3
  • 121
    • 84906334150 scopus 로고    scopus 로고
    • The multifaceted regulation and functions of PKM2 in tumor progression
    • Li, Z.; Yang, P.; Li, Z. The multifaceted regulation and functions of PKM2 in tumor progression. Biochim. Biophys. Acta, 2014, 1846(2), 285-296.
    • (2014) Biochim. Biophys. Acta , vol.1846 , Issue.2 , pp. 285-296
    • Li, Z.1    Yang, P.2    Li, Z.3
  • 124
    • 82555170271 scopus 로고    scopus 로고
    • Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation
    • Yang, W.; Xia, Y.; Ji, H.; Zheng, Y.; Liang, J.; Huang, W.; Gao, X.; Aldape, K.; Lu, Z. Nuclear PKM2 regulates beta-catenin transactivation upon EGFR activation. Nature, 2011, 480(7375), 118- 22.
    • (2011) Nature , vol.480 , Issue.7375 , pp. 118-122
    • Yang, W.1    Xia, Y.2    Ji, H.3    Zheng, Y.4    Liang, J.5    Huang, W.6    Gao, X.7    Aldape, K.8    Lu, Z.9
  • 126
    • 84883514161 scopus 로고    scopus 로고
    • Targeting lactate metabolism for cancer therapeutics
    • Doherty, J. R.; Cleveland, J. L. Targeting lactate metabolism for cancer therapeutics. J. Clin. Invest., 2013, 123(9), 3685-92.
    • (2013) J. Clin. Invest. , vol.123 , Issue.9 , pp. 3685-3692
    • Doherty, J.R.1    Cleveland, J.L.2
  • 127
    • 0029101515 scopus 로고
    • Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements
    • Firth, J. D.; Ebert, B. L.; Ratcliffe, P. J. Hypoxic regulation of lactate dehydrogenase A. Interaction between hypoxia-inducible factor 1 and cAMP response elements. J. Biol. Chem., 1995, 270(36), 21021-7.
    • (1995) J. Biol. Chem. , vol.270 , Issue.36 , pp. 21021-21027
    • Firth, J.D.1    Ebert, B.L.2    Ratcliffe, P.J.3
  • 128
    • 84888433384 scopus 로고    scopus 로고
    • Lactate dehydrogenase A in cancer: A promising target for diagnosis and therapy
    • Miao, P.; Sheng, S.; Sun, X.; Liu, J.; Huang, G. Lactate dehydrogenase A in cancer: A promising target for diagnosis and therapy. IUBMB Life, 2013, 65(11), 904-10.
    • (2013) IUBMB Life , vol.65 , Issue.11 , pp. 904-910
    • Miao, P.1    Sheng, S.2    Sun, X.3    Liu, J.4    Huang, G.5
  • 129
    • 84905858435 scopus 로고    scopus 로고
    • Serum level of lactate dehydrogenase is a useful clinical marker to monitor progressive Multiple Myeloma Diseases: A Case Report
    • Teke, H. U.; Basak, M.; Teke, D.; Kanbay, M. Serum Level of Lactate Dehydrogenase is a Useful Clinical Marker to Monitor Progressive Multiple Myeloma Diseases: A Case Report. Turk. J. Haematol., 2014, 31(1), 84-7.
    • (2014) Turk. J. Haematol. , vol.31 , Issue.1 , pp. 84-87
    • Teke, H.U.1    Basak, M.2    Teke, D.3    Kanbay, M.4
  • 136
    • 84870198491 scopus 로고    scopus 로고
    • The SLC16A family of monocarboxylate transporters (MCTs)-physiology and function in cellular metabolism, pH homeostasis, and fluid transport
    • Adijanto, J.; Philp, N. J. The SLC16A family of monocarboxylate transporters (MCTs)-physiology and function in cellular metabolism, pH homeostasis, and fluid transport. Curr. Top. Membr., 2012, 70, 275-311.
    • (2012) Curr. Top. Membr. , vol.70 , pp. 275-311
    • Adijanto, J.1    Philp, N.J.2
  • 138
    • 74349094033 scopus 로고    scopus 로고
    • AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10
    • Ovens, M. J.; Davies, A. J.; Wilson, M. C., et al. AR-C155858 is a potent inhibitor of monocarboxylate transporters MCT1 and MCT2 that binds to an intracellular site involving transmembrane helices 7-10. Biochem. J., 2010, 425(3), 523-30.
    • (2010) Biochem. J. , vol.425 , Issue.3 , pp. 523-530
    • Ovens, M.J.1    Davies, A.J.2    Wilson, M.C.3
  • 139
    • 0043212093 scopus 로고    scopus 로고
    • Molecular features, regulation, and function of monocarboxylate transporters: Implications for drug delivery
    • Enerson, B. E.; Drewes, L. R. Molecular features, regulation, and function of monocarboxylate transporters: implications for drug delivery. J. Pharm. Sci., 2003, 92(8), 1531-44.
    • (2003) J. Pharm. Sci , vol.92 , Issue.8 , pp. 1531-1544
    • Enerson, B.E.1    Drewes, L.R.2
  • 148
    • 78649327877 scopus 로고    scopus 로고
    • Coexpression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression
    • Chen, H.; Wang, L.; Beretov, J.; Hao, J.; Xiao, W.; Li, Y. Coexpression of CD147/EMMPRIN with monocarboxylate transporters and multiple drug resistance proteins is associated with epithelial ovarian cancer progression. Clin. Exp. Metastasis, 2010, 27(8), 557-69.
    • (2010) Clin. Exp. Metastasis , vol.27 , Issue.8 , pp. 557-569
    • Chen, H.1    Wang, L.2    Beretov, J.3    Hao, J.4    Xiao, W.5    Li, Y.6
  • 150
    • 60549091044 scopus 로고    scopus 로고
    • Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells
    • Slomiany, M. G.; Grass, G. D.; Robertson, A. D.; Yang, X. Y.; Maria, B. L.; Beeson, C.; Toole, B. P. Hyaluronan, CD44, and emmprin regulate lactate efflux and membrane localization of monocarboxylate transporters in human breast carcinoma cells. Cancer Res., 2009, 69(4), 1293-301.
    • (2009) Cancer Res , vol.69 , Issue.4 , pp. 1293-1301
    • Slomiany, M.G.1    Grass, G.D.2    Robertson, A.D.3    Yang, X.Y.4    Maria, B.L.5    Beeson, C.6    Toole, B.P.7
  • 151
    • 47749114537 scopus 로고    scopus 로고
    • Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism
    • Baba, M.; Inoue, M.; Itoh, K.; Nishizawa, Y. Blocking CD147 induces cell death in cancer cells through impairment of glycolytic energy metabolism. Biochem. Biophys. Res. Commun., 2008, 374(1), 111-6.
    • (2008) Biochem. Biophys. Res. Commun. , vol.374 , Issue.1 , pp. 111-116
    • Baba, M.1    Inoue, M.2    Itoh, K.3    Nishizawa, Y.4
  • 152
    • 70349307027 scopus 로고    scopus 로고
    • CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models
    • Schneiderhan, W.; Scheler, M.; Holzmann, K. H., et al. CD147 silencing inhibits lactate transport and reduces malignant potential of pancreatic cancer cells in in vivo and in vitro models. Gut, 2009, 58(10), 1391-8.
    • (2009) Gut , vol.58 , Issue.10 , pp. 1391-1398
    • Schneiderhan, W.1    Scheler, M.2    Holzmann, K.H.3
  • 153
    • 84907855682 scopus 로고    scopus 로고
    • The biological function and clinical utilization of CD147 in human diseases: A review of the current scientific literature
    • Xiong, L.; Edwards, C. K. 3rd, and Zhou, L. The biological function and clinical utilization of CD147 in human diseases: A review of the current scientific literature. Int. J. Mol. Sci., 2014, 15(10), 17411-41.
    • (2014) Int. J. Mol. Sci. , vol.15 , Issue.10 , pp. 17411-17441
    • Xiong, L.1    Edwards, C.K.2    Zhou, L.3
  • 154
    • 0032956758 scopus 로고    scopus 로고
    • CD147 monoclonal antibodies induce homotypic cell aggregation of monocytic cell line U937 via LFA-1/ICAM-1 pathway
    • Kasinrerk, W.; Tokrasinwit, N.; Phunpae, P. CD147 monoclonal antibodies induce homotypic cell aggregation of monocytic cell line U937 via LFA-1/ICAM-1 pathway. Immunology, 1999, 96(2), 184-92.
    • (1999) Immunology , vol.96 , Issue.2 , pp. 184-192
    • Kasinrerk, W.1    Tokrasinwit, N.2    Phunpae, P.3
  • 155
    • 84902530496 scopus 로고    scopus 로고
    • The pyruvate dehydrogenase complexes: Structure-based function and regulation
    • Patel, M. S.; Nemeria, N. S.; Furey, W.; Jordan, F. The pyruvate dehydrogenase complexes: structure-based function and regulation. J. Biol. Chem., 2014, 289(24), 16615-23.
    • (2014) J. Biol. Chem , vol.289 , Issue.24 , pp. 16615-16623
    • Patel, M.S.1    Nemeria, N.S.2    Furey, W.3    Jordan, F.4
  • 157
    • 0001362535 scopus 로고
    • Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate Short Communication
    • Whitehouse, S.; Randle, P. J. Activation of pyruvate dehydrogenase in perfused rat heart by dichloroacetate (Short Communication). Biochem. J., 1973, 134(2), 651-3.
    • (1973) Biochem. J. , vol.134 , Issue.2 , pp. 651-653
    • Whitehouse, S.1    Randle, P.J.2
  • 158
    • 30744469862 scopus 로고    scopus 로고
    • Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands
    • Knoechel, T. R.; Tucker, A. D.; Robinson, C. M.; Phillips, C.; Taylor, W.; Bungay, P. J.; Kasten, S. A.; Roche, T. E.; Brown, D. G. Regulatory roles of the N-terminal domain based on crystal structures of human pyruvate dehydrogenase kinase 2 containing physiological and synthetic ligands. Biochemistry, 2006, 45(2), 402-15.
    • (2006) Biochemistry , vol.45 , Issue.2 , pp. 402-415
    • Knoechel, T.R.1    Tucker, A.D.2    Robinson, C.M.3    Phillips, C.4    Taylor, W.5    Bungay, P.J.6    Kasten, S.A.7    Roche, T.E.8    Brown, D.G.9
  • 159
    • 53049103850 scopus 로고    scopus 로고
    • Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer
    • Michelakis, E. D.; Webster, L.; Mackey, J. R. Dichloroacetate (DCA) as a potential metabolic-targeting therapy for cancer. Br. J. Cancer, 2008, 99(7), 989-94.
    • (2008) Br. J. Cancer , vol.99 , Issue.7 , pp. 989-994
    • Michelakis, E.D.1    Webster, L.2    Mackey, J.R.3
  • 161
    • 0024452528 scopus 로고
    • The pharmacology of dichloroacetate
    • Stacpoole, P. W. The pharmacology of dichloroacetate. Metab., 1989, 38(11), 1124-44.
    • (1989) Metab , vol.38 , Issue.11 , pp. 1124-1144
    • Stacpoole, P.W.1
  • 167
    • 56049086590 scopus 로고    scopus 로고
    • Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro
    • Dykens, J. A.; Jamieson, J.; Marroquin, L.; Nadanaciva, S.; Billis, P. A.; Will, Y. Biguanide-induced mitochondrial dysfunction yields increased lactate production and cytotoxicity of aerobically-poised HepG2 cells and human hepatocytes in vitro. Toxicol. Appl. Pharmacol., 2008, 233(2), 203-10.
    • (2008) Toxicol. Appl. Pharmacol. , vol.233 , Issue.2 , pp. 203-210
    • Dykens, J.A.1    Jamieson, J.2    Marroquin, L.3    Nadanaciva, S.4    Billis, P.A.5    Will, Y.6
  • 168
    • 0034659785 scopus 로고    scopus 로고
    • Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain
    • Owen, M. R.; Doran, E.; Halestrap, A. P. Evidence that metformin exerts its anti-diabetic effects through inhibition of complex 1 of the mitochondrial respiratory chain. Biochem. J., 2000, 348 Pt 3, 607-14.
    • (2000) Biochem. J. , vol.348 , pp. 607-614
    • Owen, M.R.1    Doran, E.2    Halestrap, A.P.3
  • 169
    • 1542618348 scopus 로고    scopus 로고
    • The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress
    • Shaw, R. J.; Kosmatka, M.; Bardeesy, N.; Hurley, R. L.; Witters, L. A.; DePinho, R. A.; Cantley, L. C. The tumor suppressor LKB1 kinase directly activates AMP-activated kinase and regulates apoptosis in response to energy stress. Proc. Natl. Acad. Sci. U. S. A., 2004, 101(10), 3329-35.
    • (2004) Proc. Natl. Acad. Sci. U. S. A. , vol.101 , Issue.10 , pp. 3329-3335
    • Shaw, R.J.1    Kosmatka, M.2    Bardeesy, N.3    Hurley, R.L.4    Witters, L.A.5    DePinho, R.A.6    Cantley, L.C.7
  • 170
    • 33751284806 scopus 로고    scopus 로고
    • Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells
    • Zakikhani, M.; Dowling, R.; Fantus, I. G.; Sonenberg, N.; Pollak, M. Metformin is an AMP kinase-dependent growth inhibitor for breast cancer cells. Cancer Res., 2006, 66(21), 10269-73.
    • (2006) Cancer Res , vol.66 , Issue.21 , pp. 10269-10273
    • Zakikhani, M.1    Dowling, R.2    Fantus, I.G.3    Sonenberg, N.4    Pollak, M.5
  • 173
    • 84918591412 scopus 로고    scopus 로고
    • Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells
    • Haugrud, A. B.; Zhuang, Y.; Coppock, J. D.; Miskimins, W. K. Dichloroacetate enhances apoptotic cell death via oxidative damage and attenuates lactate production in metformin-treated breast cancer cells. Breast Cancer Res. Treat., 2014, 147(3), 539-50.
    • (2014) Breast Cancer Res. Treat , vol.147 , Issue.3 , pp. 539-550
    • Haugrud, A.B.1    Zhuang, Y.2    Coppock, J.D.3    Miskimins, W.K.4
  • 174
    • 20444461067 scopus 로고    scopus 로고
    • Metformin and reduced risk of cancer in diabetic patients
    • Evans, J. M.; Donnelly, L. A.; Emslie-Smith, A. M.; Alessi, D. R.; Morris, A. D. Metformin and reduced risk of cancer in diabetic patients. BMJ, 2005, 330(7503), 1304-5.
    • (2005) BMJ , vol.330 , Issue.7503 , pp. 1304-1305
    • Evans, J.M.1    Donnelly, L.A.2    Emslie-Smith, A.M.3    Alessi, D.R.4    Morris, A.D.5
  • 177
    • 79952538201 scopus 로고    scopus 로고
    • Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo
    • Algire, C.; Amrein, L.; Bazile, M.; David, S.; Zakikhani, M.; Pollak, M. Diet and tumor LKB1 expression interact to determine sensitivity to anti-neoplastic effects of metformin in vivo. Oncogene, 2011, 30(10), 1174-82.
    • (2011) Oncogene , vol.30 , Issue.10 , pp. 1174-1182
    • Algire, C.1    Amrein, L.2    Bazile, M.3    David, S.4    Zakikhani, M.5    Pollak, M.6
  • 178
    • 65349175605 scopus 로고    scopus 로고
    • Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro
    • Alimova, I. N.; Liu, B.; Fan, Z.; Edgerton, S. M.; Dillon, T.; Lind, S. E.; Thor, A. D. Metformin inhibits breast cancer cell growth, colony formation and induces cell cycle arrest in vitro. Cell Cycle, 2009, 8(6), 909-15.
    • (2009) Cell Cycle , vol.8 , Issue.6 , pp. 909-915
    • Alimova, I.N.1    Liu, B.2    Fan, Z.3    Edgerton, S.M.4    Dillon, T.5    Lind, S.E.6    Thor, A.D.7
  • 184
    • 77949323798 scopus 로고    scopus 로고
    • Incorporating the antidiabetic drug metformin in HER2- positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: An ongoing clinical-translational research experience at the Catalan Institute of Oncology
    • Martin-Castillo, B.; Dorca, J.; Vazquez-Martin, A.; Oliveras- Ferraros, C.; Lopez-Bonet, E.; Garcia, M.; Del Barco, S.; Menendez, J. A. Incorporating the antidiabetic drug metformin in HER2- positive breast cancer treated with neo-adjuvant chemotherapy and trastuzumab: An ongoing clinical-translational research experience at the Catalan Institute of Oncology. Ann. Oncol., 2010, 21(1), 187- 9.
    • (2010) Ann. Oncol. , vol.21 , Issue.1 , pp. 187-189
    • Martin-Castillo, B.1    Dorca, J.2    Vazquez-Martin, A.3    Oliveras-Ferraros, C.4    Lopez-Bonet, E.5    Garcia, M.6    Del Barco, S.7    Menendez, J.A.8
  • 185
    • 84888798201 scopus 로고    scopus 로고
    • Tumor glycolysis as a target for cancer therapy: Progress and prospects
    • Ganapathy-Kanniappan, S.; Geschwind, J. F. Tumor glycolysis as a target for cancer therapy: progress and prospects. Mol. Cancer, 2013, 12, 152.
    • (2013) Mol. Cancer , vol.12 , pp. 152
    • Ganapathy-Kanniappan, S.1    Geschwind, J.F.2
  • 186
    • 84900343418 scopus 로고    scopus 로고
    • Tumor hypoxia: A key player in the regulation of stromal and anti-tumor responses
    • Paris
    • Hasmim, M.; Messai, Y.; Noman, M. Z.; Chouaib, S. [Tumor hypoxia: A key player in the regulation of stromal and anti-tumor responses]. Med. Sci. (Paris), 2014, 30(4), 422-8.
    • (2014) Med. Sci. , vol.30 , Issue.4 , pp. 422-428
    • Hasmim, M.1    Messai, Y.2    Noman, M.Z.3    Chouaib, S.4
  • 187
    • 33847377377 scopus 로고    scopus 로고
    • Tumor acidity, chemoresistance and proton pump inhibitors
    • De Milito, A.; Fais, S. Tumor acidity, chemoresistance and proton pump inhibitors. Future Oncol., 2005, 1(6), 779-86.
    • (2005) Future Oncol. , vol.1 , Issue.6 , pp. 779-786
    • De Milito, A.1    Fais, S.2
  • 188
    • 84858008628 scopus 로고    scopus 로고
    • The role of glutathione in brain tumor drug resistance. Biochem
    • Backos, D. S.; Franklin, C. C.; Reigan, P. The role of glutathione in brain tumor drug resistance. Biochem. Pharmacol., 2012, 83(8), 1005-12.
    • (2012) Pharmacol , vol.83 , Issue.8 , pp. 1005-1012
    • Backos, D.S.1    Franklin, C.C.2    Reigan, P.3
  • 189
    • 1642494855 scopus 로고    scopus 로고
    • 2- deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo
    • Maschek, G.; Savaraj, N.; Priebe, W.; Braunschweiger, P.; Hamilton, K.; Tidmarsh, G. F.; De Young, L. R.; Lampidis, T. J. 2- deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res., 2004, 64(1), 31-4.
    • (2004) Cancer Res , vol.64 , Issue.1 , pp. 31-34
    • Maschek, G.1    Savaraj, N.2    Priebe, W.3    Braunschweiger, P.4    Hamilton, K.5    Tidmarsh, G.F.6    De Young, L.R.7    Lampidis, T.J.8
  • 190
    • 84896048826 scopus 로고    scopus 로고
    • Targeting cisplatin-resistant human tumor cells with metabolic inhibitors. Cancer Chemother
    • Sullivan, E. J.; Kurtoglu, M.; Brenneman, R.; Liu, H.; Lampidis, T. J. Targeting cisplatin-resistant human tumor cells with metabolic inhibitors. Cancer Chemother. Pharmacol., 2014, 73(2), 417-27.
    • (2014) Pharmacol , vol.73 , Issue.2 , pp. 417-427
    • Sullivan, E.J.1    Kurtoglu, M.2    Brenneman, R.3    Liu, H.4    Lampidis, T.J.5
  • 192
    • 77949967131 scopus 로고    scopus 로고
    • Targeting metabolic transformation for cancer therapy
    • Tennant, D. A.; Duran, R. V.; Gottlieb, E. Targeting metabolic transformation for cancer therapy. Nat. Rev. Cancer, 2010, 10(4), 267-77.
    • (2010) Nat. Rev. Cancer , vol.10 , Issue.4 , pp. 267-277
    • Tennant, D.A.1    Duran, R.V.2    Gottlieb, E.3
  • 193
    • 8944237973 scopus 로고    scopus 로고
    • Cisplatin, epirubicin, and vindesine with or without lonidamine in the treatment of inoperable nonsmall cell lung carcinoma: A multicenter randomized clinical trial
    • Ianniello, G. P.; De Cataldis, G.; Comella, P.; Scarpati, M. D.; Maiorino, A.; Brancaccio, L.; Cioffi, R.; Lombardi, A.; Carnicelli, P.; Tinessa, V. Cisplatin, epirubicin, and vindesine with or without lonidamine in the treatment of inoperable nonsmall cell lung carcinoma: A multicenter randomized clinical trial. Cancer, 1996, 78(1), 63-9.
    • (1996) Cancer , vol.78 , Issue.1 , pp. 63-69
    • Ianniello, G.P.1    De Cataldis, G.2    Comella, P.3    Scarpati, M.D.4    Maiorino, A.5    Brancaccio, L.6    Cioffi, R.7    Lombardi, A.8    Carnicelli, P.9    Tinessa, V.10
  • 194
    • 0027998736 scopus 로고
    • Potentiation of cisplatin cytotoxicity by lonidamine in primary cultures of human ovarian cancer
    • Orlandi, L.; Zaffaroni, N.; Gornati, D.; Veneroni, S.; Silvestrini, R. Potentiation of cisplatin cytotoxicity by lonidamine in primary cultures of human ovarian cancer. Anticancer Res., 1994, 14(3a), 1161-4.
    • (1994) Anticancer Res , vol.14 , Issue.3 A , pp. 1161-1164
    • Orlandi, L.1    Zaffaroni, N.2    Gornati, D.3    Veneroni, S.4    Silvestrini, R.5
  • 196
    • 84901816878 scopus 로고    scopus 로고
    • Glycolysis inhibition and its effect in doxorubicin resistance in neuroblastoma
    • discussion 984
    • Bean, J. F.; Qiu, Y. Y.; Yu, S.; Clark, S.; Chu, F.; Madonna, M. B. Glycolysis inhibition and its effect in doxorubicin resistance in neuroblastoma. J. Pediatr. Surg., 2014, 49(6), 981-4; discussion 984.
    • (2014) J. Pediatr. Surg. , vol.49 , Issue.6 , pp. 981-984
    • Bean, J.F.1    Qiu, Y.Y.2    Yu, S.3    Clark, S.4    Chu, F.5    Madonna, M.B.6
  • 197
    • 84892411852 scopus 로고    scopus 로고
    • Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells
    • Zhai, X.; Yang, Y.; Wan, J.; Zhu, R.; Wu, Y. Inhibition of LDH-A by oxamate induces G2/M arrest, apoptosis and increases radiosensitivity in nasopharyngeal carcinoma cells. Oncol. Rep., 2013, 30(6), 2983-91.
    • (2013) Oncol. Rep. , vol.30 , Issue.6 , pp. 2983-2991
    • Zhai, X.1    Yang, Y.2    Wan, J.3    Zhu, R.4    Wu, Y.5
  • 198
    • 84902146394 scopus 로고    scopus 로고
    • Targeting glucose metabolism in chondrosarcoma cells enhances the sensitivity to doxorubicin through the inhibition of lactate dehydrogenase-A
    • Hua, G.; Liu, Y.; Li, X.; Xu, P.; Luo, Y. Targeting glucose metabolism in chondrosarcoma cells enhances the sensitivity to doxorubicin through the inhibition of lactate dehydrogenase-A. Oncol. Rep., 2014, 31(6), 2727-34.
    • (2014) Oncol. Rep. , vol.31 , Issue.6 , pp. 2727-2734
    • Hua, G.1    Liu, Y.2    Li, X.3    Xu, P.4    Luo, Y.5
  • 199
    • 84916224736 scopus 로고    scopus 로고
    • Inhibition of lactate dehydrogenase A by microRNA34a resensitizes colon cancer cells to 5fluorouracil
    • Li, X.; Zhao, H.; Zhou, X.; Song, L. Inhibition of lactate dehydrogenase A by microRNA34a resensitizes colon cancer cells to 5fluorouracil. Mol. Med. Rep., 2015, 11(1), 577-82.
    • (2015) Mol. Med. Rep. , vol.11 , Issue.1 , pp. 577-582
    • Li, X.1    Zhao, H.2    Zhou, X.3    Song, L.4
  • 200
    • 84887206895 scopus 로고    scopus 로고
    • DCA increases the antitumor effects of capecitabine in a mouse B16 melanoma allograft and a human non-small cell lung cancer A549 xenograft
    • Zheng, M. F.; Shen, S. Y.; Huang, W. D. DCA increases the antitumor effects of capecitabine in a mouse B16 melanoma allograft and a human non-small cell lung cancer A549 xenograft. Cancer Chemother. Pharmacol., 2013, 72(5), 1031-41.
    • (2013) Cancer Chemother. Pharmacol. , vol.72 , Issue.5 , pp. 1031-1041
    • Zheng, M.F.1    Shen, S.Y.2    Huang, W.D.3
  • 201
    • 79551519970 scopus 로고    scopus 로고
    • In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines
    • Fiebiger, W.; Olszewski, U.; Ulsperger, E.; Geissler, K.; Hamilton, G. In vitro cytotoxicity of novel platinum-based drugs and dichloroacetate against lung carcinoid cell lines. Clin. Transl. Oncol., 2011, 13(1), 43-9.
    • (2011) Clin. Transl. Oncol. , vol.13 , Issue.1 , pp. 43-49
    • Fiebiger, W.1    Olszewski, U.2    Ulsperger, E.3    Geissler, K.4    Hamilton, G.5
  • 202
    • 84895065125 scopus 로고    scopus 로고
    • Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism
    • Xuan, Y.; Hur, H.; Ham, I. H.; Yun, J.; Lee, J. Y.; Shim, W.; Kim, Y. B.; Lee, G.; Han, S. U.; Cho, Y. K. Dichloroacetate attenuates hypoxia-induced resistance to 5-fluorouracil in gastric cancer through the regulation of glucose metabolism. Exp. Cell Res., 2014, 321(2), 219-30.
    • (2014) Exp. Cell Res. , vol.321 , Issue.2 , pp. 219-230
    • Xuan, Y.1    Hur, H.2    Ham, I.H.3    Yun, J.4    Lee, J.Y.5    Shim, W.6    Kim, Y.B.7    Lee, G.8    Han, S.U.9    Cho, Y.K.10
  • 203
    • 84884706737 scopus 로고    scopus 로고
    • Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: A role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation
    • Kumar, A.; Kant, S.; Singh, S. M. Antitumor and chemosensitizing action of dichloroacetate implicates modulation of tumor microenvironment: A role of reorganized glucose metabolism, cell survival regulation and macrophage differentiation. Toxicol. Appl. Pharmacol., 2013, 273(1), 196-208.
    • (2013) Toxicol. Appl. Pharmacol. , vol.273 , Issue.1 , pp. 196-208
    • Kumar, A.1    Kant, S.2    Singh, S.M.3
  • 204
    • 2642536197 scopus 로고    scopus 로고
    • Alkylating DNA damage stimulates a regulated form of necrotic cell death
    • Zong, W. X.; Ditsworth, D.; Bauer, D. E.; Wang, Z. Q.; Thompson, C. B. Alkylating DNA damage stimulates a regulated form of necrotic cell death. Genes Dev., 2004, 18(11), 1272-82.
    • (2004) Genes Dev , vol.18 , Issue.11 , pp. 1272-1282
    • Zong, W.X.1    Ditsworth, D.2    Bauer, D.E.3    Wang, Z.Q.4    Thompson, C.B.5
  • 205
    • 77953896432 scopus 로고    scopus 로고
    • Cell signaling by receptor tyrosine kinases
    • Lemmon, M. A.; Schlessinger, J. Cell signaling by receptor tyrosine kinases. Cell, 2010, 141(7), 1117-34.
    • (2010) Cell , vol.141 , Issue.7 , pp. 1117-1134
    • Lemmon, M.A.1    Schlessinger, J.2
  • 206
    • 0035902180 scopus 로고    scopus 로고
    • Oncogenic kinase signalling
    • Blume-Jensen, P.; Hunter, T. Oncogenic kinase signalling. Nature, 2001, 411(6835), 355-365.
    • (2001) Nature , vol.411 , Issue.6835 , pp. 355-365
    • Blume-Jensen, P.1    Hunter, T.2
  • 207
    • 36849068465 scopus 로고    scopus 로고
    • Evolvable signaling networks of receptor tyrosine kinases: Relevance of robustness to malignancy and to cancer therapy
    • Amit, I.; Wides, R.; Yarden, Y. Evolvable signaling networks of receptor tyrosine kinases: Relevance of robustness to malignancy and to cancer therapy. Mol. Syst. Biol., 2007, 3, 151.
    • (2007) Mol. Syst. Biol. , vol.3 , pp. 151
    • Amit, I.1    Wides, R.2    Yarden, Y.3
  • 208
  • 209
    • 84923083951 scopus 로고    scopus 로고
    • New strategies in personalized medicine for solid tumors: Molecular markers and clinical trial designs
    • Jurgensmeier, J. M.; Eder, J. P.; Herbst, R. S. New strategies in personalized medicine for solid tumors: molecular markers and clinical trial designs. Clin. Cancer Res., 2014, 20(17), 4425-35.
    • (2014) Clin. Cancer Res. , vol.20 , Issue.17 , pp. 4425-4435
    • Jurgensmeier, J.M.1    Eder, J.P.2    Herbst, R.S.3
  • 210
    • 77951494873 scopus 로고    scopus 로고
    • Targeted cancer therapies in the twenty-first century: Lessons from imatinib
    • Stegmeier, F.; Warmuth, M.; Sellers, W. R.; Dorsch, M. Targeted cancer therapies in the twenty-first century: lessons from imatinib. Clin. Pharmacol. Ther., 2010, 87(5), 543-52.
    • (2010) Clin. Pharmacol. Ther , vol.87 , Issue.5 , pp. 543-552
    • Stegmeier, F.1    Warmuth, M.2    Sellers, W.R.3    Dorsch, M.4
  • 211
    • 10944228766 scopus 로고    scopus 로고
    • Oncogene addiction: Sometimes a temporary slavery
    • Jonkers, J.; Berns, A. Oncogene addiction: sometimes a temporary slavery. Cancer Cell, 2004, 6(6), 535-8.
    • (2004) Cancer Cell , vol.6 , Issue.6 , pp. 535-538
    • Jonkers, J.1    Berns, A.2
  • 212
    • 84887497121 scopus 로고    scopus 로고
    • The quest to overcome resistance to EGFR-targeted therapies in cancer
    • Chong, C. R.; Janne, P. A. The quest to overcome resistance to EGFR-targeted therapies in cancer. Nat. Med., 2013, 19(11), 1389- 400.
    • (2013) Nat. Med. , vol.19 , Issue.11 , pp. 1389-1400
    • Chong, C.R.1    Janne, P.A.2
  • 213
    • 18344390418 scopus 로고    scopus 로고
    • ERBB receptors and cancer: The complexity of targeted inhibitors
    • Hynes, N. E.; Lane, H. A. ERBB receptors and cancer: The complexity of targeted inhibitors. Nat. Rev. Cancer, 2005, 5(5), 341-54.
    • (2005) Nat. Rev. Cancer , vol.5 , Issue.5 , pp. 341-354
    • Hynes, N.E.1    Lane, H.A.2
  • 214
    • 77952800807 scopus 로고    scopus 로고
    • Receptor tyrosine kinase coactivation networks in cancer
    • Xu, A. M.; Huang, P. H. Receptor tyrosine kinase coactivation networks in cancer. Cancer Res., 2010, 70(10), 3857-60.
    • (2010) Cancer Res , vol.70 , Issue.10 , pp. 3857-3860
    • Xu, A.M.1    Huang, P.H.2
  • 215
    • 0036490442 scopus 로고    scopus 로고
    • Smart drugs: Tyrosine kinase inhibitors in cancer therapy
    • Shawver, L. K.; Slamon, D.; Ullrich, A. Smart drugs: Tyrosine kinase inhibitors in cancer therapy. Cancer Cell, 2002, 1(2), 117- 23.
    • (2002) Cancer Cell , vol.1 , Issue.2 , pp. 117-123
    • Shawver, L.K.1    Slamon, D.2    Ullrich, A.3
  • 217
    • 78049295120 scopus 로고    scopus 로고
    • Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl
    • Mason, E. F.; Zhao, Y.; Goraksha-Hicks, P.; Coloff, J. L.; Gannon, H.; Jones, S. N.; Rathmell, J. C. Aerobic glycolysis suppresses p53 activity to provide selective protection from apoptosis upon loss of growth signals or inhibition of BCR-Abl. Cancer Res., 2010, 70(20), 8066-76.
    • (2010) Cancer Res , vol.70 , Issue.20 , pp. 8066-8076
    • Mason, E.F.1    Zhao, Y.2    Goraksha-Hicks, P.3    Coloff, J.L.4    Gannon, H.5    Jones, S.N.6    Rathmell, J.C.7
  • 218
    • 5144225468 scopus 로고    scopus 로고
    • Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells
    • Gottschalk, S.; Anderson, N.; Hainz, C.; Eckhardt, S. G.; Serkova, N. J.Imatinib (STI571)-mediated changes in glucose metabolism in human leukemia BCR-ABL-positive cells. Clin. Cancer Res., 2004, 10(19), 6661-8.
    • (2004) Clin. Cancer Res. , vol.10 , Issue.19 , pp. 6661-6668
    • Gottschalk, S.1    Anderson, N.2    Hainz, C.3    Eckhardt, S.G.4    Serkova, N.J.5
  • 222
    • 0037085584 scopus 로고    scopus 로고
    • Metabolic profiling of cell growth and death in cancer: Applications in drug discovery
    • Boros, L. G.; Cascante, M.; Lee, W. N. Metabolic profiling of cell growth and death in cancer: Applications in drug discovery. Drug Discov. Today, 2002, 7(6), 364-72.
    • (2002) Drug Discov. Today , vol.7 , Issue.6 , pp. 364-372
    • Boros, L.G.1    Cascante, M.2    Lee, W.N.3
  • 223
    • 26444469502 scopus 로고    scopus 로고
    • Detection of resistance to imatinib by metabolic profiling: Clinical and drug development implications
    • Serkova, N.; Boros, L. G. Detection of resistance to imatinib by metabolic profiling: clinical and drug development implications. Am. J. Pharmacogenomics, 2005, 5(5), 293-302.
    • (2005) Am. J. Pharmacogenomics , vol.5 , Issue.5 , pp. 293-302
    • Serkova, N.1    Boros, L.G.2
  • 224
    • 18844440190 scopus 로고    scopus 로고
    • Chronic myeloid leukaemia: An investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation
    • Barnes, K.; McIntosh, E.; Whetton, A. D.; Daley, G. Q.; Bentley, J.; Baldwin, S. A. Chronic myeloid leukaemia: An investigation into the role of Bcr-Abl-induced abnormalities in glucose transport regulation. Oncogene, 2005, 24(20), 3257-67.
    • (2005) Oncogene , vol.24 , Issue.20 , pp. 3257-3267
    • Barnes, K.1    McIntosh, E.2    Whetton, A.D.3    Daley, G.Q.4    Bentley, J.5    Baldwin, S.A.6
  • 225
    • 0035851102 scopus 로고    scopus 로고
    • Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells
    • Boren, J.; Cascante, M.; Marin, S.; Comin-Anduix, B.; Centelles, J. J.; Lim, S.; Bassilian, S.; Ahmed, S.; Lee, W. N.; Boros, L. G. Gleevec (STI571) influences metabolic enzyme activities and glucose carbon flow toward nucleic acid and fatty acid synthesis in myeloid tumor cells. J. Biol. Chem., 2001, 276(41), 37747-53.
    • (2001) J. Biol. Chem , vol.276 , Issue.41 , pp. 37747-37753
    • Boren, J.1    Cascante, M.2    Marin, S.3    Comin-Anduix, B.4    Centelles, J.J.5    Lim, S.6    Bassilian, S.7    Ahmed, S.8    Lee, W.N.9    Boros, L.G.10
  • 227
    • 0141891296 scopus 로고    scopus 로고
    • Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface
    • Bentley, J.; Itchayanan, D.; Barnes, K.; McIntosh, E.; Tang, X.; Downes, C. P.; Holman, G. D.; Whetton, A. D.; Owen-Lynch, P. J.; Baldwin, S. A. Interleukin-3-mediated cell survival signals include phosphatidylinositol 3-kinase-dependent translocation of the glucose transporter GLUT1 to the cell surface. J. Biol. Chem., 2003, 278(41), 39337-48.
    • (2003) J. Biol. Chem , vol.278 , Issue.41 , pp. 39337-39348
    • Bentley, J.1    Itchayanan, D.2    Barnes, K.3    McIntosh, E.4    Tang, X.5    Downes, C.P.6    Holman, G.D.7    Whetton, A.D.8    Owen-Lynch, P.J.9    Baldwin, S.A.10
  • 229
    • 79551635753 scopus 로고    scopus 로고
    • Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate
    • Giuntoli, S.; Tanturli, M.; Di Gesualdo, F.; Barbetti, V.; Rovida, E.; Dello Sbarba, P. Glucose availability in hypoxia regulates the selection of chronic myeloid leukemia progenitor subsets with different resistance to imatinib-mesylate. Haematologica, 2011, 96(2), 204-12.
    • (2011) Haematologica , vol.96 , Issue.2 , pp. 204-212
    • Giuntoli, S.1    Tanturli, M.2    Di Gesualdo, F.3    Barbetti, V.4    Rovida, E.5    Dello Sbarba, P.6
  • 230
    • 84891904194 scopus 로고    scopus 로고
    • Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic reprogramming
    • Martinez Marignac, V. L.; Smith, S.; Toban, N.; Bazile, M.; Aloyz, R. Resistance to Dasatinib in primary chronic lymphocytic leukemia lymphocytes involves AMPK-mediated energetic reprogramming. Oncotarget, 2013, 4(12), 2550-66.
    • (2013) Oncotarget , vol.4 , Issue.12 , pp. 2550-2566
    • Martinez Marignac, V.L.1    Smith, S.2    Toban, N.3    Bazile, M.4    Aloyz, R.5
  • 232
    • 84901007722 scopus 로고    scopus 로고
    • Resistance to the tyrosine kinase inhibitor axitinib is associated with increased glucose metabolism in pancreatic adenocarcinoma
    • Hudson, C. D.; Hagemann, T.; Mather, S. J.; Avril, N. Resistance to the tyrosine kinase inhibitor axitinib is associated with increased glucose metabolism in pancreatic adenocarcinoma. Cell Death Dis., 2014, 5, e1160.
    • (2014) Cell Death Dis , vol.5 , pp. e1160
    • Hudson, C.D.1    Hagemann, T.2    Mather, S.J.3    Avril, N.4
  • 233
    • 84905371455 scopus 로고    scopus 로고
    • Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma
    • Makinoshima, H.; Takita, M.; Matsumoto, S.; Yagishita, A.; Owada, S.; Esumi, H.; Tsuchihara, K. Epidermal Growth Factor Receptor (EGFR) Signaling Regulates Global Metabolic Pathways in EGFR-mutated Lung Adenocarcinoma. J. Biol. Chem., 2014, 289(30), 20813-20823.
    • (2014) J. Biol. Chem. , vol.289 , Issue.30 , pp. 20813-20823
    • Makinoshima, H.1    Takita, M.2    Matsumoto, S.3    Yagishita, A.4    Owada, S.5    Esumi, H.6    Tsuchihara, K.7
  • 234
    • 84891273707 scopus 로고    scopus 로고
    • Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect
    • Velpula, K. K.; Bhasin, A.; Asuthkar, S.; Tsung, A. J. Combined targeting of PDK1 and EGFR triggers regression of glioblastoma by reversing the Warburg effect. Cancer Res., 2013, 73(24), 7277- 89.
    • (2013) Cancer Res , vol.73 , Issue.24 , pp. 7277-7289
    • Velpula, K.K.1    Bhasin, A.2    Asuthkar, S.3    Tsung, A.J.4
  • 235
    • 33750341917 scopus 로고    scopus 로고
    • Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors
    • Su, H.; Bodenstein, C.; Dumont, R. A.; Seimbille, Y.; Dubinett, S.; Phelps, M. E.; Herschman, H.; Czernin, J.; Weber, W. Monitoring tumor glucose utilization by positron emission tomography for the prediction of treatment response to epidermal growth factor receptor kinase inhibitors. Clin. Cancer Res., 2006, 12(19), 5659-67.
    • (2006) Clin. Cancer Res. , vol.12 , Issue.19 , pp. 5659-5667
    • Su, H.1    Bodenstein, C.2    Dumont, R.A.3    Seimbille, Y.4    Dubinett, S.5    Phelps, M.E.6    Herschman, H.7    Czernin, J.8    Weber, W.9
  • 236
    • 49849084552 scopus 로고    scopus 로고
    • Requirement of hypoxia-inducible factor-1alpha down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab
    • Li, X.; Lu, Y.; Liang, K.; Pan, T.; Mendelsohn, J.; Fan, Z. Requirement of hypoxia-inducible factor-1alpha down-regulation in mediating the antitumor activity of the anti-epidermal growth factor receptor monoclonal antibody cetuximab. Mol. Cancer Ther., 2008, 7(5), 1207-17.
    • (2008) Mol. Cancer Ther. , vol.7 , Issue.5 , pp. 1207-1217
    • Li, X.1    Lu, Y.2    Liang, K.3    Pan, T.4    Mendelsohn, J.5    Fan, Z.6
  • 237
    • 36949007159 scopus 로고    scopus 로고
    • Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1alpha
    • Lu, Y.; Liang, K.; Li, X.; Fan, Z. Responses of cancer cells with wild-type or tyrosine kinase domain-mutated epidermal growth factor receptor (EGFR) to EGFR-targeted therapy are linked to downregulation of hypoxia-inducible factor-1alpha. Mol. Cancer, 2007, 6, 63.
    • (2007) Mol. Cancer , vol.6 , pp. 63
    • Lu, Y.1    Liang, K.2    Li, X.3    Fan, Z.4
  • 238
    • 84885585514 scopus 로고    scopus 로고
    • Cetuximab reverses the Warburg effect by inhibiting HIF-1-regulated LDH-A
    • Lu, H.; Li, X.; Luo, Z.; Liu, J.; Fan, Z. Cetuximab reverses the Warburg effect by inhibiting HIF-1-regulated LDH-A. Mol. Cancer Ther., 2013, 12(10), 2187-99.
    • (2013) Mol. Cancer Ther. , vol.12 , Issue.10 , pp. 2187-2199
    • Lu, H.1    Li, X.2    Luo, Z.3    Liu, J.4    Fan, Z.5
  • 240
    • 84864200812 scopus 로고    scopus 로고
    • The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2- positive breast cancer cells
    • KKomurov, K.; Tseng, J. T.; Muller, M.; Seviour, E. G.; Moss, T. J.; Yang, L.; Nagrath, D.; Ram, P. T. The glucose-deprivation network counteracts lapatinib-induced toxicity in resistant ErbB2- positive breast cancer cells. Mol. Syst. Biol., 2012, 8, 596.
    • (2012) Mol. Syst. Biol. , vol.8 , pp. 596
    • K'Komurov, K.1    Tseng, J.T.2    Muller, M.3    Seviour, E.G.4    Moss, T.J.5    Yang, L.6    Nagrath, D.7    Ram, P.T.8
  • 241
    • 84885619223 scopus 로고    scopus 로고
    • Glycolysis inhibition sensitizes non-small cell lung cancer with T790M mutation to irreversible EGFR inhibitors via translational suppression of Mcl-1 by AMPK activation
    • Kim, S. M.; Yun, M. R.; Hong, Y. K.; Solca, F.; Kim, J. H.; Kim, H. J.; Cho, B. C. Glycolysis inhibition sensitizes non-small cell lung cancer with T790M mutation to irreversible EGFR inhibitors via translational suppression of Mcl-1 by AMPK activation. Mol. Cancer Ther., 2013, 12(10), 2145-56.
    • (2013) Mol. Cancer Ther , vol.12 , Issue.10 , pp. 2145-2156
    • Kim, S.M.1    Yun, M.R.2    Hong, Y.K.3    Solca, F.4    Kim, J.H.5    Kim, H.J.6    Cho, B.C.7
  • 245
    • 84880066583 scopus 로고    scopus 로고
    • Beloueche-Babari, M. MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells
    • Falck Miniotis, M.; Arunan, V.; Eykyn, T. R.; Marais, R.; Workman, P.; Leach, M. O.; Beloueche-Babari, M. MEK1/2 inhibition decreases lactate in BRAF-driven human cancer cells. Cancer Res., 2013, 73(13), 4039-49.
    • (2013) Cancer Res , vol.73 , Issue.13 , pp. 4039-4049
    • Falck Miniotis, M.1    Arunan, V.2    Eykyn, T.R.3    Marais, R.4    Workman, P.5    Leach, M.O.6
  • 247
    • 84904063631 scopus 로고    scopus 로고
    • Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers
    • Strohecker, A. M.; White, E. Targeting mitochondrial metabolism by inhibiting autophagy in BRAF-driven cancers. Cancer Discov., 2014, 4(7), 766-72.
    • (2014) Cancer Discov , vol.4 , Issue.7 , pp. 766-772
    • Strohecker, A.M.1    White, E.2
  • 253
    • 84872425530 scopus 로고    scopus 로고
    • HIF-1alpha activation mediates resistance to antiangiogenic therapy in neuroblastoma xenografts
    • Hartwich, J.; Orr, W. S.; Ng, C. Y.; Spence, Y.; Morton, C.; Davidoff, A. M. HIF-1alpha activation mediates resistance to antiangiogenic therapy in neuroblastoma xenografts. J. Pediatr. Surg., 2013, 48(1), 39-46.
    • (2013) J. Pediatr. Surg. , vol.48 , Issue.1 , pp. 39-46
    • Hartwich, J.1    Orr, W.S.2    Ng, C.Y.3    Spence, Y.4    Morton, C.5    Davidoff, A.M.6
  • 254
    • 84877673601 scopus 로고    scopus 로고
    • Colorectal cancer cells refractory to anti-VEGF treatment are vulnerable to glycolytic blockade due to persistent impairment of mitochondria
    • Xu, J.; Wang, J.; Xu, B.; Ge, H.; Zhou, X.; Fang, J. Y. Colorectal cancer cells refractory to anti-VEGF treatment are vulnerable to glycolytic blockade due to persistent impairment of mitochondria. Mol. Cancer Ther., 2013, 12(5), 717-24.
    • (2013) Mol. Cancer Ther , vol.12 , Issue.5 , pp. 717-724
    • Xu, J.1    Wang, J.2    Xu, B.3    Ge, H.4    Zhou, X.5    Fang, J.Y.6
  • 255
    • 80052273035 scopus 로고    scopus 로고
    • Inhibition of VEGF induces cellular senescence in colorectal cancer cells
    • Hasan, M. R.; Ho, S. H.; Owen, D. A.; Tai, I. T. Inhibition of VEGF induces cellular senescence in colorectal cancer cells. Int. J. Cancer, 2011, 129(9), 2115-23.
    • (2011) Int. J. Cancer , vol.129 , Issue.9 , pp. 2115-2123
    • Hasan, M.R.1    Ho, S.H.2    Owen, D.A.3    Tai, I.T.4
  • 256
    • 84859385707 scopus 로고    scopus 로고
    • Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma
    • Hu, Y. L.; DeLay, M.; Jahangiri, A.; Molinaro, A. M.; Rose, S. D.; Carbonell, W. S.; Aghi, M. K. Hypoxia-induced autophagy promotes tumor cell survival and adaptation to antiangiogenic treatment in glioblastoma. Cancer Res., 2012, 72(7), 1773-83.
    • (2012) Cancer Res. , vol.72 , Issue.7 , pp. 1773-1783
    • Hu, Y.L.1    DeLay, M.2    Jahangiri, A.3    Molinaro, A.M.4    Rose, S.D.5    Carbonell, W.S.6    Aghi, M.K.7
  • 258
    • 0034654174 scopus 로고    scopus 로고
    • Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: Implications for tumor angiogenesis and therapeutics
    • Zhong, H.; Chiles, K.; Feldser, D.; Laughner, E.; Hanrahan, C.; Georgescu, M. M.; Simons, J. W.; Semenza, G. L. Modulation of hypoxia-inducible factor 1alpha expression by the epidermal growth factor/phosphatidylinositol 3-kinase/PTEN/AKT/FRAP pathway in human prostate cancer cells: implications for tumor angiogenesis and therapeutics. Cancer Res., 2000, 60(6), 1541-5.
    • (2000) Cancer Res. , vol.60 , Issue.6 , pp. 1541-1545
    • Zhong, H.1    Chiles, K.2    Feldser, D.3    Laughner, E.4    Hanrahan, C.5    Georgescu, M.M.6    Simons, J.W.7    Semenza, G.L.8
  • 259
    • 20444445920 scopus 로고    scopus 로고
    • Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha
    • Phillips, R. J.; Mestas, J.; Gharaee-Kermani, M.; Burdick, M. D.; Sica, A.; Belperio, J. A.; Keane, M. P.; Strieter, R. M. Epidermal growth factor and hypoxia-induced expression of CXC chemokine receptor 4 on non-small cell lung cancer cells is regulated by the phosphatidylinositol 3-kinase/PTEN/AKT/mammalian target of rapamycin signaling pathway and activation of hypoxia inducible factor-1alpha. J. Biol. Chem., 2005, 280(23), 22473-81.
    • (2005) J. Biol. Chem. , vol.280 , Issue.23 , pp. 22473-22481
    • Phillips, R.J.1    Mestas, J.2    Gharaee-Kermani, M.3    Burdick, M.D.4    Sica, A.5    Belperio, J.A.6    Keane, M.P.7    Strieter, R.M.8
  • 260
    • 23844450576 scopus 로고    scopus 로고
    • A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma
    • Das, B.; Yeger, H.; Tsuchida, R.; Torkin, R.; Gee, M. F.; Thorner, P. S.; Shibuya, M.; Malkin, D.; Baruchel, S. A hypoxia-driven vascular endothelial growth factor/Flt1 autocrine loop interacts with hypoxia-inducible factor-1alpha through mitogen-activated protein kinase/extracellular signal-regulated kinase 1/2 pathway in neuroblastoma. Cancer Res., 2005, 65(16), 7267-75.
    • (2005) Cancer Res , vol.65 , Issue.16 , pp. 7267-7275
    • Das, B.1    Yeger, H.2    Tsuchida, R.3    Torkin, R.4    Gee, M.F.5    Thorner, P.S.6    Shibuya, M.7    Malkin, D.8    Baruchel, S.9
  • 261
    • 77952671059 scopus 로고    scopus 로고
    • Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: Implications for antiangiogenic mechanisms of multikinase inhibitors
    • Nilsson, M. B.; Zage, P. E.; Zeng, L.; Xu, L.; Cascone, T.; Wu, H. K.; Saigal, B.; Zweidler-McKay, P. A.; Heymach, J. V. Multiple receptor tyrosine kinases regulate HIF-1alpha and HIF-2alpha in normoxia and hypoxia in neuroblastoma: implications for antiangiogenic mechanisms of multikinase inhibitors. Oncogene, 2010, 29(20), 2938-49.
    • (2010) Oncogene , vol.29 , Issue.20 , pp. 2938-2949
    • Nilsson, M.B.1    Zage, P.E.2    Zeng, L.3    Xu, L.4    Cascone, T.5    Wu, H.K.6    Saigal, B.7    Zweidler-McKay, P.A.8    Heymach, J.V.9
  • 262
    • 79951811448 scopus 로고    scopus 로고
    • Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors
    • Fiume, L.; Vettraino, M.; Manerba, M.; Di Stefano, G. Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors. Pharmacol. Res., 2011, 63(4), 328-34.
    • (2011) Pharmacol. Res. , vol.63 , Issue.4 , pp. 328-334
    • Fiume, L.1    Vettraino, M.2    Manerba, M.3    Di Stefano, G.4
  • 263
    • 84869009687 scopus 로고    scopus 로고
    • How cancer metabolism is tuned for proliferation and vulnerable to disruption
    • Schulze, A.; Harris, A. L. How cancer metabolism is tuned for proliferation and vulnerable to disruption. Nature, 2012, 491(7424), 364-73.
    • (2012) Nature , vol.491 , Issue.7424 , pp. 364-373
    • Schulze, A.1    Harris, A.L.2
  • 264
    • 37449024702 scopus 로고    scopus 로고
    • The biology of cancer: Metabolic reprogramming fuels cell growth and proliferation
    • DeBerardinis, R. J.; Lum, J. J.; Hatzivassiliou, G.; Thompson, C. B. The biology of cancer: metabolic reprogramming fuels cell growth and proliferation. Cell Metab., 2008, 7(1), 11-20.
    • (2008) Cell Metab , vol.7 , Issue.1 , pp. 11-20
    • DeBerardinis, R.J.1    Lum, J.J.2    Hatzivassiliou, G.3    Thompson, C.B.4


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