Inhibition of lactic dehydrogenase as a way to increase the anti-proliferative effect of multi-targeted kinase inhibitors

Pharmacological Research

Volumn 63, Issue 4, 2011, Pages 328-334

  Fiume, Luigi ^a   Vettraino, Marina ^a   Manerba, Marcella ^a   Di Stefano, Giuseppina ^a  

^a UNIVERSITY OF BOLOGNA   (Italy)

Author keywords

Aerobic glycolysis; Hepatocellular carcinoma; Kinase inhibitors; Lactic dehydrogenase

Indexed keywords

ADENOSINE TRIPHOSPHATE; GLUCOSE; IMATINIB; LACTATE DEHYDROGENASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OXAMIC ACID; PHOSPHOTRANSFERASE INHIBITOR; SORAFENIB; SUNITINIB;

ANAEROBIC GLYCOLYSIS; ANTINEOPLASTIC ACTIVITY; ARTICLE; CANCER CELL CULTURE; CELL METABOLISM; CELL STRUCTURE; CELL VIABILITY; CONCENTRATION RESPONSE; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; DRUG POTENTIATION; DRUG TARGETING; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; LIVER CELL CARCINOMA; PRIORITY JOURNAL;

ADENOSINE TRIPHOSPHATE; ANTINEOPLASTIC AGENTS; BENZENESULFONATES; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CELL SURVIVAL; DRUG SYNERGISM; GLYCOLYSIS; HUMANS; L-LACTATE DEHYDROGENASE; LIVER NEOPLASMS; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; OXAMIC ACID; PROTEIN KINASE INHIBITORS; PYRIDINES; THYMIDINE;

EID: 79951811448     PISSN: 10436618     EISSN: 10961186     Source Type: Journal    
DOI: 10.1016/j.phrs.2010.12.005     Document Type: Article

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